Interests: neuropediatrics, developmental biology
Polymorphism in the NRG gene and brain damage in preterm newborns
Neuregulins (NRGs) are cell-cell signaling proteins and ligands of the ErbB family of receptor tyrosine kinases. NRG 1 plays essential roles in the developing nervous system, heart, breast 1 and in lung development 2. In the nervous system, NRG 1 regulates radial glial formation, neurotransmitter receptor expression, oligodendrocyte development, and the onset of puberty 3.
NRG1 is also neuroprotective 4. In a Scottish population, an association between a single nucleotide polymorphism (SNP) of NRG 1 and Schizophrenia has been identified 5. Other possible associations between NRG and neurologic disorders have been reported (e.g. Alzheimer’s disease 6 and multiple sclerosis 7). We hypothesize that the presence of a SNP in the NRG promoter region might modulate the risk for brain damage in preterm newborns.
Polymerase-chain-reaction (PCR) and epidemiologic analytic methods (case control design)
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V.i.S.d.P: Christiane Dammann, updated: 12.12.2006