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Medizinische Hochschule Hannover | Carl-Neuberg-Str.1 | 30625 Hannover | Tel.:(+49) 0511-532-0


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C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages.
Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R.
Biochimica et Biophysica Acta. 2015; 1849(8):966-78.
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Transcriptional profiling of intestinal CD4+ T cells in the neonatal and adult mice.
Torow N, Dittrich-Breiholz O, Hornef MW.
Genomics Data. 2015; 5: 371–374.
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The Histamine H4 Receptor Regulates Chemokine Production in Human Natural Killer Cells.
Mommert S, Dittrich-Breiholz O, Stark H, Gutzmer R, Werfel T.
International Archives of Allergy and Immunology. 2015; 166:225-230.
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The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.
Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.
Cell Reports. 2015; pii: S2211-1247(15)00002-9.
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Stromal cells as trend-setters for cells migrating into the lymph node.
Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U.
Mucosal Immunology. 2014; 10.1038/mi.2014.97.
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THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.
Nucleic Acids Research. 2014; 42(19):12249-60.
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DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
Zmora P, Blazejewska P, Moldenhauer AS, Welsch K, Nehlmeier I, Wu Q, Schneider H, Pöhlmann S, Bertram S.
Journal of Virology. 2014; 88(20):12087-97.
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Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing.
López ML, Bruges G, Crespo G, Salazar V, Deglesne PA, Schneider H, Cabrera-Fuentes H, Schmitz ML, Preissner KT.
Thrombosis and Haemostasis. 2014; 112(5):992-1001.
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Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer.
Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.
Gastroenterology. 2014; S0016-5085(14)00461-2.
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Identification of Two Forms of TNF Tolerance in Human Monocytes: Differential Inhibition of NF-κB/AP-1- and PP1-Associated Signaling.
Günther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K.
The Journal of Immunology. 2014; 192(7):3143-55.
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Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression.
Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.
Molecular Cell. 2013; 10.1016/j.molcel.2013.12.002.
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The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells.
Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF.
PLOS Pathogens. 2013; 10.1371/journal.ppat.1003737.
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Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.
Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.
Cell Death & Disease. 2013; 4:e879.
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Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ.
Molecular and Cellular Biology. 2013; 33(13):2586-602.
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Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1.
Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2013; 288(26):19250-9.
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The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.
Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.
Nucleic Acids Research. 2012; 1–20.
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Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor.
Hansen B, Dittrich-Breiholz O, Kracht M, Windheim M.
Cellular Signalling. 2012; 25(1):214-228.
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Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCγ1 and Activating NFAT1-dependent RCAN1 Expression.
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Hävemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF.
PLoS Pathogens. 2012; 8(9):e1002927.
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Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling.
Rehren F, Ritter B, Dittrich-Breiholz O, Henke A, Lam E, Kati S, Kracht M, Heim A.
Medical Microbiology and Immunology. 2012;
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Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages.
Zeitvogel J, Dalpke A, Eiz-Vesper B, Kracht M, Dittrich-Breiholz O, Werfel T, Wittmann M.
The Journal of Biological Chemistry. 2012;
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Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo.
Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E, Förster R.
European Journal of Immunology. 2012; 42(1):48-57.
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Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal a-toxin.
Kasraie S, Niebuhr M, Kopfnagel V, Dittrich-Breiholz O, Kracht M, Werfel T.
Allergy. 2012; 67(1):41-49.
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Intranodal Interaction with Dendritic Cells Dynamically Regulates Surface Expression of the Co-stimulatory Receptor CD226 Protein on Murine T Cells.
Seth S, Qiu Q, Danisch S, Maier MK, Braun A, Ravens I, Czeloth N, Hyde R, Dittrich-Breiholz O, Förster R, Bernhardt G.
The Journal of Biological Chemistry. 2011; 286(45):39153-63.
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Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells.
Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of Virology. 2011; 85(19):10375-10388.
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Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism.
Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2011; 286(38):33279-33288.
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Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.
Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, Tamura T.
BMC Genomics. 2011; 12196.
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Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.
Gerhard R, Queisser S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
Naunyn Schmiedeberg's Archives of Pharmacology. 2011; 383(3):285-295.
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Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines.
Gregorovic G, Bosshard R, Karstegl CE, White RE, Pattle S, Chiang AK, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
Journal of Virology. 2011; 85(7):3535-45.
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Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E.
Oncogene. 2011;
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c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.
Rzeczkowski K, Beuerlein K, Müller H, Dittrich-Breiholz O, Schneider H, Kettner-Buhrow D, Holtmann H, Kracht M.
The Journal of Cell Biology. 2011; 194(4):581-596.
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IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA.
Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2010; 285(38):29165-78.
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Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H.
Cell Death and Differentiation. 2010; 17(9):1435-47.
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Role of the Kaposi's Sarcoma-Associated Herpesvirus K15 SH3 Binding Site in Inflammatory Signaling and B-Cell Activation.
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.
Journal of Virology. 2010; 84(16):8231-40.
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Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways.
Berg D, Stühmer T, Siegmund D, Müller N, Giner T, Dittrich-Breiholz O, Kracht M, Bargou R, Wajant H.
FEBS Journal. 2009; 276(23):6912-27.
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Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML.
EMBO reports. 2009; 10(4):381-86.
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Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.
Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A.
Inflammatory Bowel Diseases. 2009; 15(12):1812-23.
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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D.
The Journal of Experimental Medicine. 2009; 206(10):2161-77.
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Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner.
Mosa A, Trumstedt C, Eriksson E, Soehnlein O, Heuts F, Janik K, Klos A, Dittrich-Breiholz O, Kracht M, Hidmark Å, Wigzell H, Rottenberg ME.
Infection and Immunity. 2009; 77(7):2908-2918.
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Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus.
Wang L, Pietrek M, Brinkmann MM, Havemeier A, Fischer I, Hillenbrand B, Dittrich-Breiholz O, Kracht M, Chanas S, Blackbourn DJ, Schulz TF.
Journal of General Virology. 2009; 90(Pt 5):1190-1201.
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CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties.
del Rio ML, Rodriguez-Barbosa JI, Bölter J, Ballmaier M, Dittrich-Breiholz O, Kracht M, Jung S, Förster R.
The Journal of Immunology. 2008; 181(9):6178-88.
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Transcriptional Regulation of EGR-1 by the Interleukin-1-JNK-MKK7-c-Jun Pathway.
Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M.
The Journal of Biological Chemistry. 2008; 283(18):12120-28.
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Differential Gene Regulation by Epstein-Barr Virus Type 1 and Type 2 EBNA2.
Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
Journal of Virology. 2008; 82(15):7456-66.
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c-Jun Controls Histone Modifications, NF-κB Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene.
Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M.
Molecular and Cellular Biology. 2008; 28(13):4407-4423.
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The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK.
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.
Molecular and Cellular Biology. 2007; 27(1):170-81.
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Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus.
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of Virology. 2007; 81(1):42-58.
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Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.
Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of General Virology. 2007; 88(Pt 6):1698-707.
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Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets.
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H.
Molecular and Cellular Biology. 2007; 27(23):8388-8400.
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Identification of Mouse Genes With Highly Specific Expression Patterns in Differentiated Intestinal Epithelium.
Schröder N, Sekhar A, Geffers I, Müller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A.
Gastroenterology. 2006; 130(3):902-7.
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Inhibition of mRNA deadenylation and degradation by different types of cell stress.
Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H.
Biological Chemistry. 2006; 387(3):323-7.
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Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NF?B-MAPK signaling pathways.
Kettner-Buhrow D, Dittrich-Breiholz O, Schneider H, Wolter S, Resch K, Kracht M.
Biochemical and Biophysical Research Communications. 2006; 347(3):566-73.
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Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions.
Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzmer R, Werfel T.
The Journal of Immunology. 2006; 177(7):4444-50.
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Cell target genes of Epstein–Barr virus transcription factor EBNA-2: induction of the p55a regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ.
Journal of General Virology. 2006; 87(Pt 10):2859-67.
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Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals.
Ansari AW, Bhatnagar N, Dittrich-Breiholz O, Kracht M, Schmidt RE, Heiken H.
International Immunology. 2006; 18(10):1443-51.
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Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
Clinical & Experimental Allergy. 2005; 35(8):1088-95.
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MEK1-dependent Delayed Expression of Fos-related Antigen-1 Counteracts c-Fos and p65 NF-?B-mediated Interleukin-8 Transcription in Response to Cytokines or Growth Factors.
Hoffmann E, Thiefes A, Buhrow D, Dittrich-Breiholz O, Schneider H, Resch K, Kracht M.
The Journal of Biological Chemistry. 2005; 280(10):9706-18.
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Simultaneous Blockade of NF?B, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes.
Thiefes A, Wolter S, Mushinski JF. Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M.
The Journal of Biological Chemistry. 2005; 280(30):27728-41.
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Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing.
Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H.
Molecular and Cellular Biology. 2005; 25(15):6363-79.
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Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
Clinical & Experimental Allergy. 2005; 35(8):1088-95.
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Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.
Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML.
Blood. 2004; 104(10):3302-4.
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NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.
Kreuz S, Siegmund D, Rumpf J, Samel D, Leverkus M, Janssen O, Häcker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H.
The Journal of Cell Biology. 2004; 166(3):369-80.
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Entwicklung und Evaluierung eines DNA Mikroarrays für entzündungsrelevante Gene.
Dittrich-Breiholz O, Schneider H, Wehmeier L, Resch K, Kracht M.
Biospektrum. 2003; 1/03:88-92.
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Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess.
Wehmeier L, Dittrich-Breiholz O, Kracht M.
Managment und Krankenhaus. 2003;
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Disruption of the c-JUN-JNK Complex by a Cell-permeable Peptide Containing the c-JUN δ Domain Induces Apoptosis and Affects a Distinct Set of Interleukin-1-induced Inflammatory Genes.
Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M.
The Journal of Biological Chemistry. 2003; 278(41):40213-23.
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Multiple control of interleukin-8 gene expression.
Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M.
Journal of Leukocyte Biology. 2002; 72(5):847-855.
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Blutkonserven sind an der MHH häufig knapp. Warum?


Die Medizinische Hochschule Hannover hat sich zur größten Transplantationsklinik in Deutschland entw...