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Publications

 

 

Publications of the Institute of Clinical Biochemistry since 2017 and the former Institute for Cellular Chemistry since 2003 sorted by year and first author; linked to PubMed. An asterisk (*) indicates equal contribution of authors. Authors of the institute are given in bold.

2019

 

Albuquerque-Wendt A, Huette JH, Buettner FR, Bakker H, (2019), Membrane Topological Model of Glycosyltransferases of the GT-C Superfamily,  International Journal of Molecular Sciences 20(19), September 2019, DOI: 10.3390/ijms20194842

 

Bandini G, Albuquerque-Wendt A, Hegermann J, Samuelson J, Routier FH, (2019), Protein O- and C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum, Parasitology, doi: 10.1017/S0031182019000040

 

Curto Y, Alcaide J, Röckle I, Hildebrandt H, Nacher J, (2019), Effects of the genetic depletion of polysialyltransferases on the structure and connectivity of interneurons in the adult prefrontal cortex, Front Neuroanat, 13:6. doi: 10.3389/fnana.2019.00006

 

Diekmann U, Wolling H, Dettmer R, Niwolik I, Naujok O, Buettner FFR, (2019), Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture, Scientific Reports

 

Fewou SN, Röckle I, Hildebrandt H, Eckhardt M (2019) Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior. Glycobiology 29(9):657-668. doi: 10.1093/glycob/cwz040, e-pub: May 30, 2019.

 

Niculovic KM, Blume L, Wedekind H, Kats E, Albers I, Groos S, Abeln M, Schmitz J, Beuke E, Bräsen JH, Melk A, Schiffer M, Weinhold B, Münster-Kühnel AK (2019). Podocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2019 Jun;30(6):1021-1035.

Niemann J, Woller N, Brooks J, Fleischmann-Mundt B, Nikolas T., Martin NT, Kloos A, Knocke S, Ernst MA , Manns MP, Kubicka S, Wirth TC, Gerardy-Schahn R, Kühnel F. (2019), Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy. Nat Commun. 2019; 10: 3236, Published online 2019 Jul 19. doi: 10.1038/s41467-019-11137-5

 

Prakash O, Fuehring J, Post J, Shepherd S, Eadsforth T, Gray D, Fedorov R, Routier F, (2019), Identification of Inhibitors of Leishmania major UDP-sugar pyrophosphorylases by Biosensor based small molecules fragment library screening, Molecules

 

Rossdam C, Konze SA, Oberbeck A, Rapp E, Gerardy-Schahn R, von Itzstein M, Buettner FFR, (2019), Approach for Profiling of Glycosphingolipid Glycosylation by Multiplexed Capillary Gel Electrophoresis Coupled to Laser-Induced Fluorescence Detection To Identify Cell-Surface Markers of Human Pluripotent Stem Cells and Derived Cardiomyocytes. Anal Chem. 2019 May 9. doi: 10.1021/acs.analchem.9b01114. [Epub ahead of print]

 

Schuster UE, Rossdam C, Röckle I, Schiff M, Hildebrandt H (2019) Cell-autonomous impact of polysialic acid-producing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons. J Neurochem, e-pub: Oct. 14, 2019 (unedited manuscript). doi: 10.1111/jnc.14896.

 

Tyka K, Jörns A, Turatsinze J-V, Eizirik DL, Lenzen S, Gurgul-Convey E, (2019), MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity, Cell Death & Disease, 10:29. doi: 10.1038/s41419-018-1268-4

 

Wojciechowski D., Thiemann S., Schaal C., Rahtz A., de la Roche J., Begemann B., Becher T., Fischer M., Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin. J Biol Chem, 2018. 293(22): p. 8626-8637.

2018

 

Abeln M, Albers I, Peters-Bernard U, Flächsig-Schulz K, Kats E, Kispert A, Tomlinson S, Gerardy-Schahn R, Münster-Kühnel A, Weinhold B, (2018), Sialic acid is a critical fetal defense against maternal complement attack, J Clin Invest. 129(1), 422-436.

 

Arndt T, Jörns A, Wedekind D (2018) Changes in immune cell frequencies in primary and secondary lymphatic organs of LEW.1AR1-iddm rats, a model of human type 1 diabetes compared to other MHC congenic LEW inbred strains. Immunol Res. 2018 Aug 24. doi: 10.1007/s12026-018-9015-6. [Epub ahead of print]

 

Bandini G, Leon DR, Hoppe CM, Zhang Y, Agop-Nersesian C, Shears MJ, Mahal LK, Routier FH, Costello CE, Samuelson J. (2018) O-fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites. J Biol Chem. 2018 Dec 11. pii: jbc.RA118.005179. doi: 10.1074/jbc.RA118.005179. [Epub ahead of print]

 

Cramer J., Führing J. I., Baruch P., Brütting C., Knölker H. J., Gerardy-Schahn R., Fedorov R. V. (2018). Decoding Allosteric Networks in Biocatalysts: A Rational Approach to Therapies and Biotechnologies, ACS Catalysis, DOI10.1021/acscatal.7b03714

 

van Diepen L, Buettner FFR, Hoffmann D, Thiesler CT, von Bohlen Und Halbach O, von Bohlen Und Halbach V, Jensen LR, Steinemann D, Edvardson S, Elpeleg O, Schambach A, Gerardy-Schahn R, Kuss AW8, (2018), A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency. Eur J Hum Genet. 2018 Aug 8. doi: 10.1038/s41431-018-0220-5. [Epub ahead of print]

 

Fitas AL, Martins C, Borrego LM, Lopes L, Jörns A, Lenzen S, Limbert C (2018), Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study. Pediatr Diabetes. 2018 Aug;19(5):963-971. doi: 10.1111/pedi.12671

 

Hoppe C.M., Albuquerque A., Bandini G., Leon D.R., Shcherbakova A., Buettner F.F.R., Izquierdo L., Costello C.E., Bakker H., Routier F.H. (2018), Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-Containing Adhesins of the TRAP Family, (2018), Glycobiology, cwy013

 

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N, Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B, Dahl-Jørgensen K, Dor Y (2018) Beta cell DNA damage response promotes islet inflammation in type 1 diabetes. Diabetes. 2018 Aug 27. pii: db171006. doi: 10.2337/db17-1006. [Epub ahead of print]

 

Joo EJ, Wasik BR, Parrish C, Paz H, Mühlenhoff M, Abdel-Azim H, Groffen J, Heisterkamp N (2018) Pre-B acute lymphoblastic leukemia expresses cell surface nucleolin as a 9-O-acetylated sialoglycoprotein. Sci Rep 8: 17174 PMID: 30464179 DOI: 10.1038/s41598-018-33873-2

 

Laporte A, Nordenbrock A, Lenzen S, Elsner M (2018), Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1, Free Radical Research 2018, 52:10, 1070-1181, doi: 10.1080/10715762.2018.1540042.

 

Lenzen H, Qian J, Manns M, Seidler U, Jörns A (2018) Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis. J Mol Med: 96(8):831-843. doi: 10.1007/s00109-018-1658-1

 

Lenzen S (2018), An editorial on the article 'Patents in the Diabetes Area in the Years 2008-2016'. (2018), Expert opinion on therapeutic patents 28 (3) 173-174

 

Litschko C., Oldrini D., Budde I., Berger M., Meens J., Gerardy-Schahn R., Berti F., Schubert M., Fiebig T. (2018). A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers in Gram-Negative Pathogens. MBio. 9, e00641-18

 

Moeller-Gnangra H, Ernst J, Pfeifer M, Heger S (2018) ErbB4 point mutation in CU3 inbred rats affects gonadotropin-releasing-hormone neuronal function via compromised neuregulin-stimulated prostaglandin E2 release from astrocytes. Glia. 2018 Nov 28. doi: 10.1002/glia.23541.

 

Oldrini D., Fiebig T., Romano M. R., Proietti D., Berger M., Tontini M., De Ricco R., Santini L., Morelli L., Lay L., Gerardy-Schahn R., Berti F., Adamo R. (2018). Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens. ACS Chem. Biol. 13, 984–994

 

Pandey A, Li-Kroeger D, Sethi MK, Lee TV, Buettner FFR, Bakker H, Jafar-Nejad H., (2018), Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology, 2018 Aug 30. doi: 10.1093/glycob/cwy080. [Epub ahead of print], PMID:30169771

 

Sieve I, Münster-Kühnel AK, Hilfiker-Kleiner D (2018), Regulation and function of endothelial glycocalyx layer in vascular diseases, Vascul Pharmacol. 2018 Jan;100:26-33. doi: 10.1016/j.vph.2017.09.002. Epub 2017 Sep 12.

 

Stumpp N. S., Konze S. A., Gerardy-Schahn R., Stiesch M., Buettner F. F. R. (2018). A single-step transconjugation system for gene deletion in Aggregatibacter actinomycetemcomitans. J Microbiol Methods. 148:74-77.

 

Thorenz A, Derlin K, Schroeder C, Dressler L, Vijayan V, Pradhan P, Immenschuh S, Jörns A, Echtermeyer F, Herzog C, Chen R, Rong S, Brasen J H, von Kooten C, Kirsch T, Klemann C, Meier M, Klos A, Haller H, Hensen B, Gueler F (2018) Enhanced activation of interleukin-10 and AKT signaling in C5aR2 deficient mice is associated with protection from ischemia reperfusion injury induced inflammation and fibrosis. Kidney Int: pii: S0085-2538(18)30282-5. doi: 10.1016/j.kint.2018.04.005

 

Tsikas D, Hanff E, Bollenbach A, Kruger R, Pham VV, Chobanyan-Jürgens K, Wedekind D, Arndt T, Jörns A, Berbée JFP, Princen HMG, Lücke T, Mariotti F, Huneau JF, Ückert S, Frölich JC, Lenzen S (2018). Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings. Amino Acids May 4. DOI: 10.1007/s00726-018-2573-z

 

Wolling H., Konze S. A. , Höfer A., Erdmann J., Pich A., Zweigerdt R., Buettner F. F. R.(2018). Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis. Proteomics. Jul;18(14):e1800102. doi: 10.1002/pmic.201800102. Epub 2018 Jun 27.

 

 

2017

 

Abeln M, Borst KM*, Cajic S*, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B (2017). Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. Chembiochem. doi: 10.1002/cbic.201700083. [Epub ahead of print]

 

Albuquerque A, Campino L, Cardoso L, Cortes S, (2017), Evaluation of four molecular methods to detect Leishmania infection in dogs. Parasites & Vectors, 10(1):57. doi: 10.1186/s13071-017-2002-2.

 

Bakker H, Gerardy-Schahn R, (2017), A sweet development in Notch regulation, J Biol Chem., Sep 22;292(38): 15974-15975. doi: 10.1074/jbc.H117.800102.

 

Bokiniec P, Shahbazian S, McDougall SJ, Berning BA, Cheng D, Llewellyn-Smith IJ, Burke PG, McMullan S, Mühlenhoff M, Hildebrandt H, Braet F, Connor M, Packer NH, Goodchild AK (2017) Polysialic acid regulates sympathetic outflow by facilitating information transfer within the nucleus of the solitary tract. J Neurosci. 37(27):6558-6574. doi: 10.1523/JNEUROSCI.0200-17.2017, e-pub Jun 2, 2017.

 

Ehrit J, Keys TG, Sutherland M, Meier C, Wolf S, Falconer R, Gerardy-Schahn R, (2017). Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen. Chembiochem, May 4. doi: 10.1002/cbic.201700157. [Epub ahead of print]

 

Fiebig T, Litschko C, Freiberger F, Bethe A, Berger M, Gerardy-Schahn R (2017). Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production. J Biol Chem, e-pub ahead of print: Nov 29, 2017, doi: 10.1074/jbc.RA117.000488.

 

Jahn K, Wieltsch C, Blumer N, Mehlich M, Pathak H, Kahn A, Hildebrandt H, Frieling H (2017).  A cell culture model for investigation of synapse influence-ability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid. J Neural Transm, e-pub ahead of print: Sep 8 2017, doi: 10.1007/s00702-017-1769-9.

 

Konze SA, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner FF (2017). Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. Chembiochem. 18(13):1317-1331

 

Konze SA, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner FF (2017). Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms. J Proteome Res. 16(3):1133-1149. doi: 10.1021/acs.jproteome.6b00534.

 

Mehmeti I, Lortz S, Avezov E, Jörns A, Lenzen S, (2017). ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity. Free Radic Biol Med. 2017 Nov;112:121-130. doi: 10.1016/j.freeradbiomed. 2017.07.021. Epub 2017 Jul 24. PMID: 28751022

 

Plötz T, Krümmel B, Laporte A, Pingitore A, Persaud SJ, Jörns A, Elsner M, Mehmeti I, Lenzen S, (2017). The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells. Nutr Diabetes. 2017 Dec 21;7(12):305

 

Shcherbakova A, Tiemann B, Buettner FF, Bakker H, (2017). Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proc Natl Acad Sci U S A. 114(10):2574-2579

 

Sieve I, Münster-Kühnel AK, Hilfiker-Kleiner D, (2017). Regulation and function of endothelial glycocalyx layer in vascular diseases, Vascul Pharmacol. 2017 Sep 12. pii: S1537-1891(17)30180-5. doi: 10.1016/j.vph.2017.09.002. [Epub ahead of print] Review.

 

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P. (2017). Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia. 2017 Nov 28. doi: 10.1007/s00125-017-4500-3. [Epub ahead of print], PMID: 29185012

 

Somplatzki S, Mühlenhoff M, Kröger A, Gerardy-Schahn R, Böldicke T. (2017). Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells. BMC Biotechnol. 2017 May 12;17(1):42

 

Szewczyk LM, Nagalski A, Brozko N, Sawicka K, Werneburg S, Röckle I, Hildebrandt H, Wisniewska MB, Kuznicki J., (2017). ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons. Glia, 65 (1):34-49

 

 

Werneburg S, Fuchs HLS, Albers I, Burkhardt H, Gudi V, Skripuletz T, Stangel M, Gerardy-Schahn R, Hildebrandt H (2017). Polysialylation at early stages of oligodendrocyte differentiation promotes myelin repair. J Neurosci 37 (34): 8131-8141

 

 

2016

 

Behrens W, Schweinitzer T, McMurry JL, Loewen PC, Buettner FF, Menz S, Josenhans C. Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions. Sci Rep. 2016 Apr 5;6:23582. doi: 10.1038/srep23582.

 

Fiebig T., Romano M.R., Oldrini D., Adamo R., Tontini M., Brogioni B., Santini L., Berger M., Costantino P., Berti F., Gerardy-Schahn R. (2016) An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate. npj Vaccines 1: B71-B77

 

Kallolimath S, Castilho A, Strasser R, Grünwald-Gruber C, Altmann F, Strubl S, Galuska CE, Zlatina K, Galuska PS, Werner S, Thiesler H, Werneburg S, Hildebrandt H, Gerardy-Schahn R, Steinkellner H. (2016) Engineering of complex protein sialylation in plants. Proc Natl Acad Sci USA 113 (34):9498–9503. doi: 10.1073/pnas.1604371113, e-pub July 21, 2016.

 

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Göhring G, Dräger G, Pötz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R., Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602.

 

Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de V, I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Forster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M. 2016. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science 351 (6269):186-190. (epub Dec 10, 2015)

 

Li LX, Ashikov A, Liu H, Griffith CL, Bakker H, Doering TL (2016) Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter Glycobiology 10.1093/glycob/cww078

 

Martin NT, Martin MU (2016). Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol. 17(2):122-31. doi: 10.1038/ni.3370 (Review).

  

Mehrabian M, Hildebrandt H, Schmitt-Ulms G. 2016. NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being? ASN Neuro 8:1759091416679074, e-pub Nov 22, 2016, doi:10.1177/1759091416679074, Review.

 

Röckle I. and Hildebrandt H. (2016) Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice. Dev Neurobiol 76 (4): 421-433. doi:10.1002/dneu.22324, e-pub Jul 17, 2015.

 

Thiesler CT*, Cajic S*, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weißmann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Körner C, Schambach A, Rapp E, Buettner FF (2016) Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation. Mol Cell Proteomics 15(4): 1435-52. doi: 10.1074/mcp.M115.054122, epub Jan 19, 2016 (* shared first authorship).

 

Werneburg S., Buettner F.F., Erben L., Mathews M., Neumann H., Mühlenhoff M., Hildebrandt H. (2016) Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages. Glia, 64 (8):1314-1330. doi:10.1002/glia.23004.

 

 

2015

 

Baumann A.-M.T., Bakkers M.J.G., Buettner F.F.R., Hartmann M., Grove M., Langereis M.A., de Groot R.J., and Mühlenhoff M. (2015) 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nature Communications, 6: doi: 10.1038/ncomm8673

 

Koulaxouzidis G., Reutter W., Hildebrandt H., Stark G.B., Witzel C. (2015) In vivo stimulation of early peripheral axon regeneration by N-propionylmannosamine in the presence of polysialyltransferase ST8SIA2. J. Neural. Transm. 122 (9): 1211–1219. doi:10.1007/s00702-015-1397-1.

 

Kröcher T, Malinovskaja K, Jürgenson M, Aonurm-Helm A, Zharkovskaya T, Kalda A, Röckle I, Schiff M, Weinhold B, Gerardy-Schahn R, Hildebrandt H (corresponding author), Zharkovsky A (2015) Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct. Funct. 220:71-83.

 

Litschko C., Romano M.R., Pinto V., Claus H., Vogel U., Berti F., Gerardy-Schahn R., Fiebig T. (2015) The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyzes the Synthesis of a Complex Trimeric Repeating Unit Comprising Glycosidic and Phosphodiester Linkages. J Biol Chem 290: 24355-24366

 

Piras F., Schiff M., Chiapponi C., Bossù P., Mühlenhoff M., Caltagirone C., Gerardy-Schahn R., Hildebrandt H.*, Spalletta G.* Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM. Transl. Psychiatry, 5, e658, doi:10.1038/tp.2015.156 (*equally contributing last authors).

 

Werneburg S, Buettner FFR, Mühlenhoff M, Hildebrandt H. (2015) Polysialic acid modification of the synaptic cell adhesion molecule SynCAM 1 in human embryonic stem cell-derived oligodendrocyte precursor cells. Stem Cell Res. 14:339–346. doi: 10.1016/j.scr.2015.03.001

 

Werneburg S, Mühlenhoff M, Stangel M, Hildebrandt H (2015) Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin-2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation. Glia 63 (7): 1240-1255. doi: 10.1002/glia.22815

 

 

2014

 

Bartel J, Feuerstacke C, Galuska C, Weinhold B, Gerardy-Schahn R, Geyer R, Münster-Kühnel A, Middendorff R, and Galuska S (2014) Laser microdissection of paraffin embedded tissue as a tool to estimate the sialylation status of selected cell populations. Analytical Chemistry

 

Boeer U, Buettner FF, Klingenberg M, Antonopoulos GC, Meyer H, Haverich A, Wilhelmi M (2014). Immunogenicity of Intensively Decellularized Equine Carotid Arteries Is Conferred by the Extracellular Matrix Protein Collagen Type VI. PLoS One. 2014 Aug 26;9(8):e105964

 

Fiebig T, Freiberger F, Pinto V, Romano MR, Black A, Litschko C, Bethe A, Yashunsky D, Adamo R, Nikolaev A, Berti F, and Gerardy-Schahn R (2014) Molecular Cloning and Functional Characterization of Components of the Capsule Biosynthesis Complex of Neisseria meningitidis Serogroup A. J Biol Chem 

 

Keys TG, Fuchs HLS, Ehrit J, Alves J, Freiberger R and Gerardy-Schahn R (2014) Engineering the product profile of a polysialyltransferase. Nat Chem Biol

 

Konze SA, van Diepen L, Schröder A, Olmer R, Möller H, Pich A, Weissmann R, Kuss AW, Zweigerdt R, Buettner FF (2014). Cleavage of E-cadherin and β-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells. Mol Cell Proteomics. 2014 Jan 30. [Epub ahead of print]

 

Kröcher T*, Röckle I*, Diederichs U, Weinhold B, Burkhardt H, Yanagawa Y, Gerardy-Schahn R, and Hildebrandt H. (2014) A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex. Development 141 (15): 3022-3032. doi: 10.1242/dev.111773. (* equally contributing)

 

Schnaar RL, Gerardy-Schahn R, Hildebrandt H. (2014) Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease and regeneration. Physiol. Rev. 94(2):461-518.

 

Tantra M., Kröcher T., Papiol S., Winkler D., Röckle I., Jatho J., Burkhardt H., Ronnenberg A., Gerardy-Schahn R., Ehrenreich H.*, Hildebrandt H.* (2014) St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood. Behav. Brain Res. 275:166-175. doi: 10.1016/j.bbr.2014.08.062 (*equally contributing corresponding authors)

 

Tsuchiya A, Lu WY, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, Mackinnon AC, Schwarzer D, Ichida T, Nomoto M, Aoyagi Y, Gerardy-Schahn R, Forbes SJ. 2014. PolySia-NCAM modulates the formation of ductular reactions in liver injury. Hepatology e-pub ahead of print, doi: 10.1002/hep.27099

 

2013

 

Al-Saraireh YMJ, Sutherland M, Springett BR, Freiberger F, Ribeiro Morais G, Loadman PM., Errington RJ, Smith PJ, Fukuda M, Gerardy-Schahn R, Patterson LH, Shnyder SD, and Falconer RA (2013) Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration. PLOS ONE, 8, e73366

 

Buettner FF, Ashikov A, Tiemann B, Lehle L, Bakker H (2013) C. elegans DPY-19 Is a C-Mannosyltransferase Glycosylating Thrombospondin Repeats. Mol Cell. 2013 Apr 2. pii: S1097-2765(13)00206-2. doi: 10.1016/j.molcel.2013.03.003. [Epub ahead of print]

 

Edvardson S*,  Ashikov A*, Jalas C, Sturiale L, Shaag A, Fedick A, Treff NR, Garozzo D, Gerardy-Schahn R*, Elpeleg O* (2013) Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis. J Med Genet in press *equally contributing

 

Fiebig T,  Berti F, Freiberger F, Pinto V, Claus H, Romano MR, Proietti D, Brogioni B, Stummeyer K, Berger M, Vogel V, Costantino P, and Gerardy-Schahn R (2013) Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: A new perspective for vaccine development. Glycobiology in press

 

Freiberger, F., Böhm, R., Schwarzer ,D., Gerardy-Schahn, R., Haselhorst, T., and von Itzstein, M. (2013) Defining a Substrate Binding Model of Polysialyltransferase. Chembiochem. in press

 

Führing J, Damerow S, Fedorov R, Schneider J, Münster-Kühnel AK, Gerardy-Schahn R., (2013) Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. Glycobiology. 2013 Apr;23(4):426-37. doi: 10.1093/glycob/cws217. Epub 2012 Dec 18.

 

Führing JI, Cramer JT, Routier FH, Lamerz A-C, Baruch P, Gerardy-Schahn R, and Fedorov RV (2013) Catalytic mechanism and allosteric regulation of UDP-glucose pyrophosphorylase from Leishmania major. ACS Catal., DOI: 10.1021/cs4007777

 

Hildebrandt H, Dityatev A. Polysialic acid in brain development and synaptic plasticity. Top Curr Chem (2013) advance online publication, 30 May 2013; doi: 10.1007/128_2013_446.

 

Hildebrandt H (corresponding author), and Dityatev A (2013) With a little help from EphA3 and polysialic acid: Ectodomain shedding of NCAM is gaining momentum. J Neurochem 128 (2): 206-209. Editorial Highlight.

 

Jakobssen, E.*, Schwarzer, D.*, Jokilammi, A., and Finne, J. (2012) Endosialidases — versatile tools for the study of polysialic acid. Top Curr Chem. Springer. in press. Review. *equally contributing

 

Keys TG, Fuchs HL, Galuska SP, Gerardy-Schahn R, Freiberger F., (2013) A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality. Glycobiology. 2013 Feb 3. [Epub ahead of print]

 

Kröcher T.*, Malinovskaja K.*, Jürgenson M., Aonurm-Helm A., Zharkovskaya T., Kalda A., Röckle I., Schiff M., Weinhold B., Gerardy-Schahn R., Hildebrandt H.* (corresponding author), Zharkovsky A.* (2013) Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct. Funct. advance online publication, 22. Sept. 2013; doi:10.1007/s00429-013-0638-z

 

Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H. Negative regulation of notch signaling by xylose. PLoS Genet. (2013) Jun;9(6):e1003547

 

Maggioni A, von Itzstein M, Rodríguez Guzmán IB, Ashikov A, Stephens AS, Haselhorst T, Tiralongo J.
(2013) Characterization of CMP-Sialic Acid Transporter Substrate Recognition. Chembiochem. 2013 Sep 6. doi: 10.1002/cbic.201300298. [Epub ahead of print]

 

Mohamed M*, Ashikov A*, Guillard M*, Robben JH, Schmidt S, van den Heuvel B, de Brouwer AP, Gerardy-Schahn R, Deen PM, Wevers RA, Lefeber DJ, Morava E, Morava (2013) Intellectual disability and bleeding diathesis due to deficient CMP sialic acid transport. NEUROLOGY MS *equally contributing

  

Mühlenhoff M., Rollenhagen M., Werneburg S, Gerardy-Schahn R. Hildebrandt H. (2013) Polysialic acid - versatile modification of NCAM, SynCAM 1 and neuropilin-2. Neurochem Res. 38 (6):1134-1143. doi: 10.1007/s11064-013-0979-2

 

Rollenhagen M, Büttner FF, Reismann M, Jirmo AC, Grove M, Behrens GMN, Gerardy-Schahn R, Hanisch F-G, Mühlenhoff M (2013) Polysialic Acid On Neuropilin-2 Is Exclusively Synthesized By The Polysialyltransferase ST8SiaIV And Attached To Mucin-Type O- Glycans Located Between b2 And c Domain. J Biol Chem.

 

Romanow A, Haselhorst T, Stummeyer K, Claus H, Bethe A, Mühlenhoff M, Vogel U, von Itzstein M, Gerardy-Schahn R. Biochemical and biophysical characterization of the sialyl/hexosyl-transferase synthesizing the meningococcal serogroup W135 heteropolysaccharide capsule. J Biol Chem. (2013) Feb 25. [Epub ahead of print] PubMed PMID: 23439648

 

Sellmeier M, Weinhold B, and Münster-Kühnel A (2013) CMP-Sialic acid Synthetase: The point of constriction in the sialylation pathway. Topics in Current Chemistry, # Springer, in press.Top Curr Chem (2013) . DOI: 10.1007/128_2013_477. # Springer-Verlag Berlin Heidelberg 2013.

 

Simon P, Bäumner S, Busch O, Röhrich R, Kaese M, Richterich P, Wehrend A, Müller K, Gerardy-Schahn R, Mühlenhoff M, Geyer H, Geyer R, Middendorff R, Galuska SP (2013) Polysialic acid is present in mammalian semen as a posttranslational modification of NCAM and the polysialyltransferase ST8SiaII. J Biol Chem

 

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galuska SP (2013) Soluble polysialylated NCAM: a novel player of the innate immune system in the lung. Cell Mol Life Sci. 2013 Apr 26. [Epub ahead of print]

 

Weinhold B, Gerardy-Schahn R, and Münster-Kühnel A,  „Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase (CMAS)” (Chapter 39) in  Handbook of Glycosyltransferases and Related Genes, N. Taniguchi et al. (eds.), DOI 10.1007/978-4-431-54240-7_39, # Springer Japan 2014, in press.

 

2012

  

Ashikov, A., Buettner, FF., Tiemann, B., Gerardy-Schahn, R., and Bakker, H. (2012) LARGE2 generates the same xylose and glucuronic acid containing glycan structures as LARGE. Glycobiology (2013) Mar; 23(3):303-9

 

Benani A, Hryhorczuk C, Gouazé A, Fioramonti X, Brenachot X, Guissard C, Krezymon A, Duparc T, Colom A, Nédélec E, Rigault C, Lemoine A, Gascuel J, Gerardy-Schahn R, Valet P, Knauf C, Lorsignol A, and Pénicaud L. (2012) Food Intake Adaptation to Dietary Fat Involves PSA-Dependent Rewiring of the Arcuate Melanocortin System in Mice. J Neurosci 32(35):11970-9.

 

Brauer, C., Hennig-Pauka, I., Hoeltig, D., Buettner, F.F., Beyerbach, M., Gasse, H., Gerlach, G.F., and Waldmann, K.H. (2012) Experimental Actinobacillus pleuropneumoniae challenge in swine: Comparison of computed tomographic and radiographic findings during disease. BMC Vet Res. 8(1):47.

 

Browning, C., Shneider, M., Bowman, V., Schwarzer, D., and Leiman, P. (2012) Phage Pierces the Host Cell Membrane With the Iron-Loaded Spike. Structure 20(2):326-39.

 

Edvardson, S.Baumann, AM., Mühlenhoff, M., Stephan, O., Kuß, A., Shaag, A., He, L., Zenvirt, S., Gerardy-Schahn, R., and Elpeleg, O. (2013) West syndrome caused by ST3GAL-III deficiency. Epilepsia, 54: e24-e27. doi: 10.1111/epi.12050

 

Elschami, M., Scherr, M., Philippens, B., and Gerardy-Schahn, R. (2012). Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells. Eur J Cell Biol, 92(1), 21-9.

 

Engel, J., Schmalhorst, PS., Routier, FH. (2012) Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose. J Biol Chem. 2012 Nov 8 [Epub ahead of print]

 

Führing, J., Damerow, S., Fedorov, R., Schneider, J., Munster-Kuhnel, A. K., Gerardy-Schahn, R,. (2012) Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. Glycobiology 2012; doi: 10.1093/glycob/cws217

 

Galuska, S.P., Geyer, H., Mink, W., Kaese, P., Kühnhardt, S., Schäfer, B., Mühlenhoff, M., Freiberger, F., Gerardy-Schahn, R., and Geyer, R. Glycomic strategy for efficient linkage  analysis of Di-, oligo- and polysialic acids. J Proteomics. 2012 Jun 20. [Epub ahead of print]

 

Hildebrandt H., Mühlenhoff M., Gerardy-Schahn, R. (2012) Polysialinsäure – ein Zucker reguliert die Hirnentwicklung. BioSpektrum 18 (1): 26-29, Review (German).

 

Jakobsson, E.*, Schwarzer, D.*, Jokilammi, A., and Finne, J. (2012) Endosialidases — versatile tools for the study of polysialic acid. Top Curr Chem. Springer. in press. Review.

 

Keys, T.G.*, Freiberger, F.*, Ehrit, J., Krueger, J., Eggers, K., Buettner, F.F., and Gerardy-Schahn, R. (2012) A universal fluorescent acceptor for high-performance liquid  chromatography analysis of pro- and eukaryotic polysialyltransferases. Anal Biochem. 427(2):107-115.

 

Keys, T.G., Berger, M., and Gerardy-Schahn, R. (2012) A high-throughput screen for polysialyltransferase activity. Anal Biochem. 427(1):60-8.

 

Kochlamazasvili, G., Bukalo, O., Senkov, O., Salmen, B., Gerardy-Schahn, R., Engel, A., Schachner, M. and Dityatev, A. (2012), Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors. J Neurosci. 32(7):2263-75.

 

Rollenhagen M, Kuckuck S, Ulm C, Hartmann M, Galuska SP, Geyer R, Geyer H, Mühlenhoff M (2012) Polysialylation of the synaptic cell adhesion molecule SynCAM 1 depends exclusively on the polysialyltransferase ST8SiaII in vivo. J Biol Chem. 2012 Aug 20. [Epub ahead of print]

 

Schaper, W., Bentrop, J., Ustinova, J., Blume, L., Kats, E., Tiralongo, J., Weinhold, B., Bastmeyer, M., and Münster-Kühnel, A. (2012) Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio. J. Biol. Chem. 287(16):13239-48. 

 

Schwarzer, D., Buettner, F.F., Browning, C., Nazarov, S., Rabsch, W., Bethe, A., Oberbeck, A., Bowman, V.D., Stummeyer, K., Mühlenhoff, M., Leiman, P.G.*, and Gerardy-Schahn, R.* (2012) A Multivalent Adsorption Apparatus Explains the Broad Host Range of Phage phi92: a Comprehensive Genomic and Structural Analysis. J Virol. 86(19):10384-98.

 

Sethi, M.K., Buettner, F.F., Ashikov, A., Krylov, V.B., Takeuchi, H., Nifantiev, N.E., Haltiwanger, R.S., Gerardy-Schahn, R., and Bakker, H. (2012) Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose to O-Glucosylated Epidermal Growth Factor Repeats of Notch. J. Biol. Chem. 287(4):2739-48.

 

Takeuchi H, Kantharia J, Sethi MK, Bakker H, Haltiwanger RS (2012) Site-specific O-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch: EFFICIENCY OF GLYCOSYLATION IS AFFECTED BY PROPER FOLDING AND AMINO ACID SEQUENCE OF INDIVIDUAL EGF REPEATS. J Biol Chem. 287(41):33934-44.  PMID: 22872643

 

Tefsen, B., Ram, A.F., van Die, I., and Routier, F.H. (2012) Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact. Glycobiology. 22(4):456-69. Review.

 

van Straaten, K.E., Routier, F.H., and Sanders, D.A. (2012) Towards the crystal structure elucidation of eukaryotic UDP-galactopyranose mutase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 4):455-9.

 

van Straaten, K.E., Routier, F.H., and Sanders, D.A. (2012) Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus. J Biol Chem. 287(14):10780-90.

 

Vogt J., Glumm R., Schlüter L., Schmitz D., Rost B.R., Streu N., Rister B., Bharathi B.S., Gaggiannis D., Hildebrandt H., Weinhold B., Mühlenhoff M., Naumann T., Savaskan N.E., Brauer A.U., Reutter W., Heimrich B., Nitsch R, Horstkorte R. (2012) Homeostatic regulation of NCAM-polysialylation is critical for correct synaptic targeting. Cell. Mol. Life Sci. 69 (7): 1179-91.

 

Weinhold, B., Sellmeier, M., Schaper, W., Blume, L., Philippens, B., Kats, E., Bernard, U., Galuska, S.P., Geyer, H., Geyer, R., Worthmann, K., Schiffer, M., Groos, S., Gerardy-Schahn, R., and Münster-Kühnel A.K. (2012) Deficits in Sialylation Impair Podocyte Maturation. J Am Soc  Nephrol. 2012 Jun 28. [Epub ahead of print]

 

Wolf, S., Warnecke, S., Ehrit, J., Freiberger, F., Gerardy-Schahn, R. and Meier, C. (2012), Chemical Synthesis and Enzymatic Testing of CMP-Sialic Acid Derivatives. ChemBioChem. doi: 10.1002/cbic.201200471. PMID: 23129454.

 

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2011

 

Bolborea M., Laran-Chich M.P., Rasri K., Hildebrandt H., Govitrapong P., Simonneaux V., Pevet P., Steinlechner S., Klosen P. (2011). Melatonin controls photoperiodic changes in tanycyte vimentin and neural cell adhesion molecule expression in the Djungarian hamster (Phodopus sungorus). Endocrinology 152 (10):3871-3883.

 

Chen, R., John, J., Rode, B., Hitzmann, B., Gerardy-Schahn, R., Kasper, C., and Scheper, T. (2011) Comparison of Polysialic Acid Production in Escherichia Coli K1 During Batch Cultivation and Fed-Batch Cultivation Applying Two Different Control Strategies. J. Biotechnol. 154(4):222-9.

 

Dickmanns, A., Damerow, S., Neumann, P., Schulz, E.C., Lamerz, A.C., Routier, F.H., and Ficner, R. (2011) Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase From Leishmania Major. J. Mol. Biol. 405(2):461-78.

 

Eggers K., Werneburg S., Schertzinger A., Abeln M., Schiff M., Scharenberg M.A., Burkhardt H., Mühlenhoff M., Hildebrandt H. (2011) Polysialic acid controls NCAM signals at cell-cell contacts to regulate focal adhesion independent from FGF receptor activity. J. Cell Sci. 124 (19):3279-3291.

 

Hu, H., Eggers, K., Chen, W., Garshasbi, M., Motazacker, M.M., Wrogemann, K., Kahrizi, K., Tzschach, A., Hosseini, M., Bahman, I., Hucho, T., Mühlenhoff, M., Gerardy-Schahn, R., Najmabadi, H., Ropers, H.H., and Kuss, A.W. (2011) ST3GAL3 Mutations Impair the Development of Higher Cognitive Functions. Am. J. Hum. Genet. 89(3):407-14.

 

Kraft, B., Johswich, A., Kauczor, G., Scharenberg, M., Gerardy-Schahn, R., and Bakker, H. (2011) "Add-on" Domains of Drosophila Beta1,4-N-Acetylgalactosaminyltransferase B in the Stem Region and Its Pilot Protein. Cell Mol. Life Sci. 68(24):4091-100.

 

Rey-Gallardo, A., Delgado-Martin, C., Gerardy-Schahn, R., Rodriguez-Fernandez, J.L., and Vega, M.A. (2011) Polysialic Acid Is Required for Neuropilin-2a/b-Mediated Control of CCL21-Driven Chemotaxis of Mature Dendritic Cells and for Their Migration in Vivo. Glycobiology 21(5):655-62.

 

Schiff M., Röckle I., Burkhardt H., Weinhold B., Hildebrandt H. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J. Neurosci. 31 (4): 1302-1312.

 

Schulz, E.C., Bergfeld, A.K., Ficner, R., and Mühlenhoff, M. (2011) Crystal Structure Analysis of the Polysialic Acid Specific O-Acetyltransferase NeuO. PLoS. One. 6(3):e17403.

 

Tefsen, B., Ram, A.F., van, D., I, and Routier, F.H. (2011) Galactofuranose in Eukaryotes: Aspects of Biosynthesis and Functional Impact. Glycobiology [Epub ahead of print]

 

Valentiner U., Mühlenhoff M., Lehmann U., Hildebrandt H., Schumacher U. (2011) Expression of the neural cell adhesion molecule and polysialic acid in human neuroblastoma cell lines. Int. J. Oncol. 39 (2): 417-424.

 

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2010

 

Böhm, R., Freiberger, F., Stummeyer, K., Gerardy-Schahn, R., von Itzstein, M., and Haselhorst, T. (2010) Neisseria meningitidis serogroup B polysialyltransferase: insights into substrate binding. Chembiochem. 11(2):170–4.

 

Chaipan, C., Steffen, I., Tsegaye, T.S., Bertram, S., Glowacka, I., Kato, Y., Schmökel, J., Münch, J., Simmons, G., Gerardy-Schahn, R., and Pöhlmann, S. (2010) Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2. Retrovirology. 7:47.

 

Damerow, S., Lamerz, A.-C., Haselhorst, T., Führing, J., Zarnovican, P., von Itzstein, M., and Routier, F. (2010) Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage? J. Biol. Chem. 285(2):878–87.

 

Dichtl, K., Ebel, F., Dirr, F., Routier, F.H., Heesemann, J., and Wagener, J. (2010) Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. Mol. Microbiol. 76(5):1191–204.

 

Galuska, S.P., Geyer, H., Bleckmann, C., Röhrich, R.C., Maass, K., Bergfeld, A.K., Mühlenhoff, M., and Geyer, R. (2010) Mass spectrometric fragmentation analysis of oligosialic and polysialic acids. Anal. Chem. 82(5):2059–66.

 

Galuska, S.P., Geyer, H., Weinhold, B., Kontou, M., Rohrich, R.C., Bernard, U., Gerardy-Schahn, R. , Reutter, W., Münster-Kühnel, A., and Geyer, R. (2010) Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling. Anal. Chem. 82(11):4591–8.

 

Galuska, S.P.*, Rollenhagen, M.*, Kaup, M., Eggers, K., Oltmann-Norden, I., Schiff, M., Hartmann, M., Weinhold, B., Hildebrandt, H., Geyer, R., Mühlenhoff, M.*, and Geyer, H.* (2010) Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc. Natl. Acad. Sci. USA. 107(22):10250-5.  

 

Haastert-Talini, K., Schaper-Rinkel, J., Schmitte, R., Bastian, R., Mühlenhoff, M., Schwarzer, D., Draeger, G., Su, Y., Scheper, T., Gerardy-Schahn, R., and Grothe, C. (2010) In Vivo Evaluation of Polysialic Acid as Part of Tissue-Engineered Nerve Transplants. Tissue Eng. Part A. 16(10):3085–98.

 

Hildebrandt, H., Mühlenhoff, M., and Gerardy-Schahn, R. (2010) Polysialylation of NCAM. Adv. Exp. Med. Biol. 663:95–109, Review.

 

Kochlamazashvili, G., Senkov, O., Grebenyuk, S., Robinson, C., Xiao, M.F., Stummeyer, K., Gerardy-Schahn, R., Engel, A.K., Feig, L., Semyanov, A., Suppiramaniam, V., Schachner, M., and Dityatev, A. (2010) Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors. J. Neurosci. 30(11):4171–83.

 

Kotz, A., Wagener, J., Engel, J., Routier, F., Echtenacher, B., Pich, A., Rohde, M., Hoffmann, P., Heesemann, J., and Ebel, F. (2010) The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity. Fungal Genet. Biol. 47(2):169–78.

 

Koutsoudaki, P.N. , Hildebrandt, H., Gudi, V., Skripuletz, T., Skuljec, J., and Stangel, M. (2010) Remyelination is accelerated in St8siaIV deficient mice after cuprizone induced demyelination. Neuroscience 171(1):235–44.

 

Kustermann, S., Hildebrandt, H., Bolz, S., Dengler, K. and Kohler, K. (2010) Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia.  J. Comp. Neurol. 518(5):636–46.

 

Lamerz, A.C., Damerow, S., Kleczka, B., Wiese, M., van Zandbergen, G., Lamerz, J., Wenzel, A., Hsu, F.F., Turk, J., Beverley, S.M., and Routier, F.H. (2010) Deletion of UDP-Glucose Pyrophosphorylase Reveals a UDP-Glucose Independent UDP-Galactose Salvage Pathway in Leishmania major. Glycobiology. 20(7):872-82.

 

Nacher, J., Guirado, R., Varea, E., Alonso-Llosa, G., Röckle, I., and Hildebrandt, H. (2010) Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid (PSA) expression in immature neurons and interneurons of the adult cerebral cortex. Neuroscience 167(3):825–37.

 

Pekcec, A., Weinhold, B., Gerardy-Schahn, R., and Potschka, H. (2010) Polysialic acid affects pathophysiological consequences of status epilepticus. Neuroreport. 21(8):549-53.

 

Rey-Gallardo, A., Escribano, C., Delgado-Martín, C., Rodriguez-Fernández, J.L., Gerardy-Schahn, R., Rutishauser, U., Corbi, A.L., and Vega, M.A. (2010) Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21 Glycobiology. 20(9):1139-46. 

 

Schulz, E.C., Dickmanns, A., Urlaub, H., Schmitt, A., Mühlenhoff, M., Stummeyer, K., Schwarzer, D., Gerardy-Schahn, R., and Ficner, R. (2010) Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat. Struct. Mol. Biol. 17(2):210–5.

 

Schulz, E.C., Neumann, P., Gerardy-Schahn, R., Sheldrick, G.M., and Ficner, R. (2010) Structure analysis of endosialidase NF at 0.98 Å resolution. Acta Crystallogr. D Biol. Crystallogr. 66(Pt 2):176–80.

 

Schulz, E.C., Schwarzer, D., Frank, M., Stummeyer, K., Mühlenhoff, M., Dickmanns, A., Gerardy-Schahn, R., and Ficner, R. (2010) Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF. J. Mol. Biol. 397(1):341–51.

 

Sethi, M.K., Büttner, F.F., Krylov, V.B., Takeuchi, H., Nifantiev, N.E., Haltiwanger, R.S., Gerardy-Schahn, R., and Bakker, H. (2010) Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J. Biol. Chem. 285(3):1582–6.

 

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2009

 

Bakker, H., Oka, T., Ashikov, A., Yadav, A., Berger, M., Rana, N.A., Bai, X., Jigami, Y., Haltiwanger, R.S., Esko, J.D., and Gerardy-Schahn, R. (2009) Functional UDP-xylose transport across the ER/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose synthase. J. Biol. Chem. 284(4):2576–83.

 

Bergfeld, A. K., Claus, H., Lorenzen, N. K., Spielmann, F., Vogel, U., and Mühlenhof, M. (2009) The polysialic acid specific O-acetyltransferase OatC from Neisseria meningitidis serogroup C evolved apart from other bacterial sialate:O-acetyltransferases. J. Biol. Chem. 284(1):6–16.

 

Boztug, K., Appaswamy, G.*, Ashikov, A.*, Schäffer, A.A., Salzer, U., Diestelhorst, J., Germeshausen, M., Brandes, G., Lee-Gossler, J., Noyan, F., Gatzke, A.K., Minkov, M., Greil, J., Kratz, C., Petropoulou, T., Pellier, I., Bellanné-Chantelot, C., Rezaei, N., Mönkemöller, K., Irani-Hakimeh, N., Bakker, H., Gerardy-Schahn, R., Zeidler, C., Grimbacher, B., Welte, K., and Klein, C. (2009) A syndrome with congenital neutropenia and mutations in G6PC3. N. Engl. J. Med. 360(1):32–43.

 

Claus, H.*, Stummeyer, K.*, Batzilla, J., Mühlenhoff, M. and Vogel, U. (2009) Amino acid 310 determines the donor substrate specificity of serogroup W-135 and Y capsule polymerases of Neisseria meningitidis. Mol. Micro. 71(4):960–71.

 

Drake, P. M, Stock, C. M, Nathan, J. K, Gip, P., Golden, K. P., Weinhold, B., Gerardy-Schahn, R., and Bertozzi, C.R. (2009) Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. U S A. 106(29):11995–2000.

 

Engel, J., Schmalhorst, P., Dörk-Bousset, T., Ferrières, V., and Routier , F. (2009) A Single UDP-galactofuranose Transporter Is Required for Galactofuranosylation in Aspergillus fumigatus. J. Biol. Chem.284(49):33859–68.

 

Hese, K., Otto, C., Routier, F.H., and Lehle, L. (2009) The yeast oligosaccharyltransferase complex can be replaced by STT3 from Leishmania major. Glycobiology. 19(2):160–71.

 

Hildebrandt, H., Mühlenhoff, M., Oltmann-Norden, I., Röckle, I., Burkhardt, H., Weinhold, B., and  Gerardy-Schahn, R. (2009) Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain. 132(Pt 10):2831–8.

 

Johswich, A., Kraft, B., Wuhrer, M., Berger, M., Deelder, A.M., Hokke, C.H., Gerardy-Schahn, R., and Bakker, H. (2009) Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. J. Cell Biol. 184(1):173–83.

 

Jungnickel, J., Brämer, C., Bronzlik, P., Lipokatic-Takacs, E., Weinhold, B., Gerardy-Schahn, R., and Grothe, C. (2009) Level and localization of polysialic acid is critical for early peripheral nerve regeneration. Mol. Cell Neurosci. 40(3):37481.

 

Klehr, M. , Koehl, U., Mühlenhoff, M., Tawadros, S., Fischer, Schomäcker T.K., Heuckmann, J.M., Bochennek, K., and Jensen, M. (2009) The Novel Chimeric Anti-NCAM (Neural Cell Adhesion Molecule) Antibody ch.MK1 Displays Antitumor Activity in SCID Mice but Does not Activate Complement-Dependent Cytolysis (CDC). J. Immunother. 32(5):442–451.

 

Koutsoudaki, P.N., Skripuletz, T., Gudi, V., Moharregh-Khiabani, D., Hildebrandt, H., Trebst, C., and Stangel, M. (2009) Demyelination of the hippocampus is prominent in the cuprizone model. Neurosci. Lett. 451(1):83–8.

 

Mordhorst, I. L., Claus, H., Ewers, C., Lappann, M., Schoen, C., Elias, J., Batzilla, J., Dobrindt, U., Wieler, L. H., Bergfeld, A. K., Mühlenhoff, M., and Vogel, U. (2009). O-acetyltransferase gene neuO is segregated according to phylogenetic background and contributes to environmental desiccation resistance in Escherichia coli K1.,  Environ. Microbiol. 11(12):3154–65.

 

Mühlenhoff, M., Oltmann-Norden, I., Weinhold, B., Hildebrandt, H., and Gerardy-Schahn, R. (2009) Brain development needs sugar: the role of polysialic acid in controlling NCAM functions. Biol Chem. 2009 Jul; 390(7):567–74, Review.

 

Oschlies, M.; Dickmanns, A.; Haselhorst, T.; Schaper, W.; Stummeyer, K.; Tiralongo, J.; Weinhold, B.; Gerardy-Schahn, R.; von Itzstein, M.; Ficner, R. ; Münster-Kühnel, A.-K., (2009) A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases  provides a tetramerization interface for the physiologically active enzyme. J. Mol. Biol. 393(1):83–97.

 

Schiff, M., Weinhold, B., Grothe, C., and Hildebrandt, H. (2009) NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system.  J. Neurochem. 110: 1661–1673.

 

Schwarzer, D., Stummeyer, K., Haselhorst, T., Freiberger, F., Rode, B., Grove, M., Scheper, T., von Itzstein, M., Mühlenhoff, M., and Gerardy-Schahn, R. (2009) Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F. J. Biol. Chem. 284(14):9465–74.

 

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2008

  

Bakker, H., Routier, F., Ashikov, A., Neumann, D., Bosch, D., and Gerardy-Schahn, R. (2008) A CMP-sialic acid transporter cloned from Arabidopsis thaliana. Carbohydr Res. 343(12):2148-52.

 

Berski, S. , van Bergeijk, J., Schwarzer, D., Stark, Y., Kasper, C., Scheper, T., Grothe, C., Gerardy-Schahn, R., Kirschning, A., and Dräger, G. (2008) Synthesis and Biological Evaluation of a Polysialic Acid Based Hydrogel as Enzymatically Degradable Scaffold Material for Tissue Engineering. Biomacromolecules. 9(9):2353-9.

 

Caffaro, C.E., Luhn, K., Bakker, H., Vestweber, D., Samuelson, J., Berninsone, P., and Hirschberg, C.B. (2008) A Single Caenorhabditis elegans Golgi Apparatus-Type Transporter of UDP-Glucose, UDP-Galactose, UDP-N-Acetylglucosamine, and UDP-N-Acetylgalactosamine. Biochemistry 47(14):4337-4344.

 

Drake, P.M., Nathan. J.K., Stock, C.M., Chang, P.V., Muench, M.O., Nakata, D., Reader, J.R., Gip, P., Golden, K.P., Weinhold, B., Gerardy-Schahn, R., Troy, F.A. 2nd, and Bertozzi, C.R. (2008) Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 181(10):6850-8.

 

Galuska, S.P., Geyer, R., Gerardy-Schahn, R., Mühlenhoff, M., and Geyer, H. (2008) Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule NCAM in vivo. J Biol Chem. 283(1):17-28.

 

Haile, Y., Berski, S., Dräger, G., Nobre, A., Stummeyer, K., Gerardy-Schahn, R., and Grothe, C. (2008) The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells. Biomaterials. 29(12):1880-91.

 

Hartlieb, S., Günzel, A., Gerardy-Schahn, R., Münster-Kühnel, A.K., Kirschning, A., and Dräger, G. (2008) Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid. Carbohydr Res. 343(12):2075-82.

 

Hildebrandt, H., Mühlenhoff, M., and Gerardy-Schahn, R. (2008) Polysialylation of NCAM. Neurochem. Res. 2008 May 7 (in press).

 

Oltmann-Norden, I., Galuska, S.P., Hildebrandt, H., Geyer, R., Gerardy-Schahn, R., Geyer, H., and Mühlenhoff, M. (2008) Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J Biol Chem. 283(3):1463-71. 

 

Pekcec, A., Fuest, C., Mühlenhoff, M., Gerardy-Schahn, R., and Potschka, H. (2008) Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development. J Neurochem. 105(2):389-400.

 

Potschka, H., Pekcec, A., Weinhold, B., and Gerardy-Schahn, R. (2008) Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX. Neuroscience 152(4):1093-8.

 

Rode, B., Endres, C., Ran, C., Stahl, F., Beutel, S., Kasper, C., Galuska, S., Geyer, R., Mühlenhoff, M., Gerardy-Schahn, R., and Scheper, T. (2008) Large scale production and homogenous purification of long chain polysialic acids from E. coli K1. J Biotech. 135(2):202-9.

 

Röckle, I., Seidenfaden, R., Weinhold, B., Mühlenhoff, M., Gerardy-Schahn, R., and Hildebrandt, H. (2008) Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol. 68(9):1170-1184.

 

Schmalhorst, P.S., Krappmann, S., Vervecken, W., Rohde, M., Müller, M., Braus, G.H., Contreras, R., Braun, A., Bakker, H., and Routier, F.H. (2008) Contribution of Galactofuranose to the Virulence of the Opportunistic Pathogen Aspergillus Fumigatus. Eukaryot Cell. 7(8):1268-77.

 

Schreiber, S.C., Giehl, K., Kastilan, C., Hasel, C., Mühlenhoff, M., Adler, G., Wedlich, D., and Menke, A. (2008) Polysialylated NCAM Represses E-Cadherin-Mediated Cell-Cell Adhesion in Pancreatic Tumor Cells. Gastroenterology. 134(5):1555-66.

 

Stolz, A., Haines, N., Pich, A., Irvine, K.D., Hokke, C.H., Deelder, A.M., Gerardy-Schahn, R., Wuhrer, M., and Bakker, H. (2008) Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis. Glycoconj J. 25(2):167-75.

 

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2007

  

Bergfeld, A.K., Claus, H., Vogel, U. and Mühlenhoff, M. (2007) Biochemical characterization of the polysialic acid specific O-acetyltransferase NeuO of Escherichia coli K1.  J. Biol. Chem. 282(30):22217-27.

 

Curreli, S., Arany, Z., Gerardy-Schahn, R., Mann, D., and Stamatos, N.M., (2007) Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.  J. Biol. Chem. 282(42):30346-56.

 

Freiberger, F., Claus, H., Günzel, A., Oltmann-Norden, I., Vionnet, J., Mühlenhoff, M., Vogel, U., Vann, W.F., Gerardy-Schahn, R., and Stummeyer, K. (2007) Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases. Mol. Microbiol. 65(5):1258-75.

 

Galuska, S.P., Geyer, R., Mühlenhoff, M., and Geyer, H., (2007) Characterization of Oligo- and Polysialic Acids by MALDI-TOF-MS. Anal. Chem. 79(18):7161-9.

 

Haile, Y., Haastert, K., Cesnulevicius, K., Stummeyer, K., Timmer, M., Berski, S., Dräger, G., Gerardy-Schahn, R., and Grothe, C. (2007) Culturing of glial and neuronal cells on polysialic acid. Biomaterials 28(6):1163-73.

 

Haselhorst, T., Münster-Kühnel, A.K.Oschlies, M., Tiralongo, J., Gerardy-Schahn, R., and Itzstein, M.V. (2007) Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy. Biochem. Biophys. Res. Commun. 359(4):866-70.

 

Hildebrandt, H.,  Mühlenhoff, M., Weinhold, B., Gerardy-Schahn, R., (2007),  Dissecting polysialic acid and NCAM functions in brain development. J. Neurochem 103(Suppl.1): 56-64, Review

 

Jensen, M., Klehr, M., Vogel, A., Schmitz, S., Tawadros, S., Mühlenhoff, M., Pluck, A., Fischer, T., Schomacker, K., Schultze, J.L., and Berthold, F. (2007) One step generation of fully chimeric antibodies using Cgamma1- and Ckappa mutant mice. J. Immunother. 30(3):338-349.

 

Kleczka, B., Lamerz, A.C., van Zandbergen, G., Wenzel, A., Gerardy-Schahn, R., Wiese, M., and Routier, F.H. (2007) Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J. Biol. Chem. 282(14):10498-505.

 

Krylov, V., Ustyuzhanina, N., Grachev, A., Bakker, H., and Nifantiev, N. (2007) Stereoselective Synthesis of the 3-Aminopropyl Glycosides of α-D-Xyl-(1->3)-β-D-Glc and α-D-Xyl-(1->3)-α-D-Xyl-(1->3)-β-D-Glc and of Their Corresponding N-Octanoyl Derivatives. Synthesis 20:3147-3154.

Leiman, P.G., Battisti, A.J., Bowman, V.D., Stummeyer, K., Mühlenhoff, M., Gerardy-Schahn, R., Scholl, D., and Molineux, I.J. (2007) The Structures of Bacteriophages K1E and K1-5 Explain Processive Degradation of Polysaccharide Capsules and Evolution of New Host Specificities. J. Mol. Biol. 371(3):836-49.

 

Maggioni, A., von Itzstein, M., Gerardy-Schahn, R., and Tiralongo, J.  (2007) Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane. Biochem. Biophys. Res. Commun. 362(3):779-84.

 

Markram, K., Gerardy-Schahn, R., and Sandi, C. (2007) Selective learning and memory impairments in mice deficient for polysialylated NCAM in adulthood. Neuroscience 144(3):788-96.

 

Marx, M., Rivera-Milla, E., Stummeyer, K., Gerardy-Schahn, R., and Bastmeyer, M. (2007) Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison.  Dev. Biol. 306(2):560-571.

 

Pekcec, A., Mühlenhoff, M., Gerardy-Schahn, R. , and Potschka, H. (2007) Impact of the PSA-NCAM system on pathophysiology in a chronic rodent model of temporal lobe epilepsy. Neurobiol. Dis. 27(1):54-66.

 

Rouwendal, G.J., Wuhrer, M., Florack, D.E., Koeleman, C.A., Deelder, A.M, Bakker, H., Stoopen, G.M., van Die, I., Helsper, J.P., Hokke, C.H., and Bosch, D. (2007) Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology. (2007) 17(3):334-44.

 

Schwarzer, D., Stummeyer, K., Gerardy-Schahn, R., and Mühlenhoff, M. (2007) Characterization of a novel intra-molecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins. J. Biol. Chem. 282(5):2821-2831.

 

Steiner, T., Lamerz, A.C., Hess, P., Breithaupt, C., Krapp, S., Bourenkov, G., Huber, R., Gerardy-Schahn, R., and Jacob, U. (2007) Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major. J. Biol. Chem. 282(17):13003-10.

 

Tiralongo, J., Fujita, A., Sato, C., Kitajima, K., Lehmann, F., Oschlies, M., Gerardy-Schahn, R., and Münster-Kühnel, A.K. (2007) The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme. Glycobiology 17(9):945-54.

 

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2006

 

Bakker, H., Rouwendal, G.J., Karnoup, A.S., Florack, D.E., Stoopen, G.M., Helsper, J.P., van Ree, R., van Die, I., and Bosch, D. (2006) An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes. Proc. Natl. Acad. Sci. U.S.A 103:7577-7582.

 

Galuska, S.P., Oltmann-Norden, I., Geyer, H., Weinhold, B., Kuchelmeister, K., Hildebrandt, H., Gerardy-Schahn, R., Geyer, R., and Mühlenhoff, M. (2006) Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J. Biol. Chem. 281(42):31605-15.

 

Haselhorst, T., Stummeyer, K., Mühlenhoff, M., Schaper, W., Gerardy-Schahn, R., and von Itzstein, M. (2006) Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation. Chembiochem. 7(12):1875-7.

 

Lamerz, A.C., Haselhorst, T., Bergfeld, A.K., von Itzstein, M., and Gerardy-Schahn, R. (2006) Molecular cloning of the leishmania major UDP-glucose pyrophosphorylase, functional characterisation and ligand binding analyses using NMR spectroscopy. J. Biol. Chem. 281(24):16314-22.

 

Seidenfaden, R., Krauter, A., Hildebrandt, H. (2006) The neural cell adhesion molecule NCAM regulates neuritogenesis by multiple mechanisms of interaction. Neurochem. Int. 49(1):1-11.

 

Senkov, O., Sun, M., Weinhold, B., Gerardy-Schahn, R., Schachner, M., and Dityatev, A. (2006) Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J. Neurosci. 26(42): 10888-109898.

 

Stoenica, L., Senkov, O., Gerardy-Schahn, R., Weinhold, B., Schachner, M., Dityatev, A. (2006) In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Eur. J. Neurosci. 23(9):2255-64.

 

Stummeyer, K., Schwarzer, D., Claus, H., Vogel, U., Gerardy-Schahn, R., Mühlenhoff, M. (2006) Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages. Mol. Microbiol. 60(5):1123-35.

 

Tiralongo, J., Ashikov, A., Routier, F., Eckhardt, M., Bakker, H., Gerardy-Schahn, R., and von Itzstein, M. (2006) Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier. Glycobiology 16(1):73-81.

 

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2005

 

 

Ashikov, A., Routier, F., Fuhlrott, J., Helmus, Y., Wild, M., Gerardy-Schahn, R., and Bakker, H. (2005) The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. J. Biol. Chem. 280: 27230-27235.

 

Bakker, H., Routier, F., Oelmann, S., Jordi, W., Lommen, A., Gerardy-Schahn, R., and Bosch, D. (2005) Molecular cloning of two Arabidopsis UDP-galactose transporters by complementation of a deficient Chinese hamster ovary cell line. Glycobiology 15: 193-201.

 

Bakker, H., Kleczka, B., Gerardy-Schahn, R., and Routier, F.H. (2005) Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases. Biol. Chem. 386: 657-661.

 

Bork, K., Reutter, W., Gerardy-Schahn, R., and Horstkorte, R. (2005) The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule. FEBS Lett.  579: 5079-5083.

 

Fujita, A., Sato, C., Münster-Kühnel, A.K., Gerardy-Schahn, R., and Kitajima, K. (2005) Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system. Anal. Biochem. 337: 12-21.

 

Haselhorst, T., Münster-Kühnel, A.K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima, K., Gerardy-Schahn, R., and von Itzstein, M. (2005) Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. Biochem. Biophys. Res. Commun. 327: 565-570.

 

Higson, A.P., Ross, A.J., Tsvetkov, Y.E., Routier, F., Sizova, O.V., Ferguson, M.A., and Nikolaev, A.V. (2005) Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase. Chemistry11: 2019-30.

 

Kabuss, R., Ashikov, A., Oelmann, S., Gerardy-Schahn, R., and Bakker, H. (2005) Endoplasmic reticulum retention of the large splice variant of the UDP-galactose transporter is caused by a dilysine motif. Glycobiology 15: 905-911.

 

Stummeyer, K., Dickmanns, A., Mühlenhoff, M., Gerardy-Schahn, R., and Ficner, R. (2005) Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nat. Struct. Mol. Biol.  12: 90-96.

 

Weinhold, B., Seidenfaden, R., Röckle, I., Mühlenhoff, M., Schertzinger, F., Conzelmann, S., Marth, J.D., Gerardy-Schahn, R., and Hildebrandt, H. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J. Biol. Chem. 280: 42971-42977.

 

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2004

 

Horstkorte, R., Mühlenhoff, M., Reutter, W., Nohring, S., Zimmermann-Kordmann, M., and Gerardy-Schahn, R. (2004) Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids. Exp. Cell Res. 298: 268-274.

 

Kean, E.L., Münster-Kühnel, A.K., and Gerardy-Schahn, R. (2004) CMP-sialic acid synthetase of the nucleus. Biochim. Biophys. Acta 1673: 56-65.

 

Münster-Kühnel, A.K. , Tiralongo, J., Krapp, S., Weinhold, B., Ritz-Sedlacek, V., Jacob, U., and Gerardy-Schahn, R. (2004) Structure and function of vertebrate CMP-sialic acid synthetases. Glycobiology 14: 43R-51R.

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2003

 

Krapp, S., Münster-Kühnel, A.K., Kaiser, J.T., Huber, R., Tiralongo, J., Gerardy-Schahn, R., and Jacob, U. (2003) The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase. J. Mol. Biol. 334: 625-637.

 

Mühlenhoff, M., Stummeyer, K., Grove, M., Sauerborn, M., and Gerardy-Schahn, R. (2003) Proteolytic processing and oligomerization of bacteriophage-derived endosialidases. J. Biol. Chem. 278: 12634-12644.

 

Seidenfaden, R., Krauter, A., Schertzinger, F., Gerardy-Schahn, R., and Hildebrandt, H. (2003) Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions. Mol. Cell Biol. 23: 5908-5918.

 

Wuhrer, M., Geyer, H., von der Ohe, M., Gerardy-Schahn, R., Schachner, M., and Geyer, R. (2003) Localization of defined carbohydrate epitopes in bovine polysialylated NCAM. Biochimie 85(1-2):207-18.

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