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Medizinische Hochschule Hannover | Carl-Neuberg-Str.1 | 30625 Hannover | Tel.:(+49) 0511-532-0

Group Prinz

Research Profile:

Prof. Dr. Immo Prinz
Institute of Immunology , OE 5240

Phone: 0511 532 9739
Fax:    0511 532 9722

E-Mail: Prinz.Immo (at) mh-hannover.de

 

 

Research focus of the working group

 

We are exploring the development, homeostasis, and function of innate lymphocytes such as NK cells and γδ T cells. These cells likely play an important role in the immediate immune response to invading pathogens. The focus of our group is clearly the investigation of γδ T cells, in particular of the mechanisms that lead to their differentiation into interferon-γ or interleukin-17 producing effector cells. Thereby, we are very interested in the role of the γδ TCR and the relation of TCR specificity and γδ T cell function. To this end, we established protocols for high-throughput TCR sequencing. Furthermore, we investigate the dynamics of γδ T cells using a TcrdH2BeGFP reporter „knock-in“ system, which allows us to track γδ T cells by means of an intrinsic bright green fluorescence in their nuclei. In parallel, we are generating additional „knock-in“ und „knock-out” models to study the function of γδ T cells and other innate lymphocytes.

 

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