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Publikationen


Originalpublikationen und Übersichtsartikel nach Erstautoren sortiert
(2014-2018)

 

2018

 

Kloth C, Schirmer B, Munder A, Stelzer T, Rothschuh J, Seifert R. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Toxins (Basel). 2018;10: pii: E185.

 

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F.
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. J Neuroinflammation 2018; 15: 20.

 

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C. The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates. Open Biol 2018; 8: pii: 170250.

 

Ostermeyer J, Golly F, Kaever V, Dove S, Seifert R, Schneider EH. cUMP hydrolysis by PDE3B. Naunyn Schmiedebergs Arch Pharmacol 2018; 391: 891-905

 

Schäper S, Yau HCL, Krol E, Skotnicka D, Heimerl T, Gray J, Kaever V, Søgaard-Andersen L, Vollmer W, Becker A. Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. PLoS Genet. 2018; 14: e1007594.

 

Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2017—Metabolism in Health and Disease. Int J Mol Sci 2018; 19: 549

 

Seifert R. Rethinking Pharmacological Nomenclature. Trends Pharmacol Sci 2018; 39: 785-797

 

Zhang Y, Sass A, Van Acker H, Wille J, Verhasselt B, Van Nieuwerburgh F, Kaever V, Crabbé A, Coenye T.
Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels. Front Microbiol. 2018; 9:1952.

 

2017

 

Abeln M, Borst KM, Cajic S, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B. Sialylation is dispensable for early murine embryonic development in vitro. Chembiochem 2017; 18: 1305-1316

 

Angerer V, Schwenk P, Wallner T, Kaever V, Hiltbrunner A, Wilde A. The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2. Microbiology 2017; 163: 920-930

 

Bähre H, Kaever V. Identification and Quantification of Cyclic Di-Guanosine Monophosphate and Its Linear Metabolites by Reversed-Phase LC-MS/MS. Methods Mol Biol 2017; 1657:45-58

 

Bähre H, Kaever V. Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides. Handb Exp Pharmacol 2017; 238:293-306

 

Bähre H, Kaever V. Analytical Methods for the Quantification of Histamine and Histamine Metabolites. Handb Exp Pharmacol 2017; 241:3-19

 

Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. cUMP hydrolysis by PDE3A. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 269-280

 

Blötz C, Treffon K, Kaever V, Schwede F, Hammer E, Stülke J. Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae. Front Microbiol 2017; 8: 1328

 

Dessauer CW, Watts VJ2, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev 2017; 69: 93-139

 

Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S. Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. MBio 2017; 8: e02312-16

 

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T. Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB. Microbiologyopen 2017; 6

 

Gundlach J, Herzberg C, Kaever V, Gunka K, Hoffmann T, Weiß M, Gibhardt J, Thürmer A, Hertel D, Daniel R, Bremer E, Commichau FM, Stülke J. Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis. Sci Signal 2017; 10: pii: eaal3011

 

Merfort I, Michel MC, Seifert R. Revised editorial guidelines for manuscripts on the pharmacology of plant extracts. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 765-766

 

Moreira RN, Dressaire C, Barahona S, Galego L, Kaever V, Jenal U, Arraiano CM.olA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation. MBio 2017; 8: e00443-17

 

Neumann D. Role of the Histamine H4-Receptor in Bronchial Asthma. Handb Exp Pharmacol 2017; 241:347-359

 

Paijo J, Kaever V, Kalinke U. cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry. Methods Mol Biol 2017; 1656: 153-166.

 

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H,Kaever V, Wenck H, Staeb F, Terstegen L, Kolbe L, Roggenkamp D. Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells. Exp Dermatol 2017; 26: 44-50

 

Sarenko O, Klauck G, Wilke FM, Pfiffer V, Richter AM, Herbst S, Kaever V, Hengge R. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. MBio. 2017; 8: e01639-17.

 

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology 2017; 163: 754-764

 

Schneider EH. New perspectives for a well-known biogenic amine: mast cell-derived histamine as pathophysiological agent in vincristine-induced neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 1085-1086.

 

Schneider EH, Seifert R. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
Handb Exp Pharmacol 2017; 238:169-205

 

Schneider EH, Seifert R. Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutantsin the Sf9 Cell Expression System. Handb Exp Pharmacol 2017;241:63-118. 


Seifert R. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. Handb Exp Pharmacol 2017; 238:3-23

 

Sprecher KS, Hug I, Nesper J, Potthoff E, Mahi MA, Sangermani M, Kaever V, Schwede T, Vorholt J, Jenal U. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. MBio 2017; 8: pii: e00294-17

 

Strasser A, Wittmann HJ, Seifert R. Binding Kinetics and Pathways of Ligands to GPCRs. Trends Pharmacol Sci. 2017; 38: 717-732

 

Wolter S, Dittmar F, Seifert R. cCMP and cUMP in Apoptosis: Concepts and Methods. Handb Exp Pharmacol 2017; 238: 25-47

 

Wunschel EJ, Schirmer B, Seifert R, Neumann D. Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice. Front Pharmacol 2017; 8: 642.

 

Zhang Y, Agrebi R, Bellows LE, Collet JF, Kaever V, Gründling A. Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria. J Biol Chem 2017;  292: 313-327

 

2016 

 

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep 2016; 6: 20007.

 

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Länger F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Strüber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant 2016; 16: 1371-82

 

Bæk KT, Bowman L, Millership C, Dupont Søgaard M, Kaever V, Siljamäki P, Savijoki K, Varmanen P, Nyman TA, Gründling A, Frees D. The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone. MBio 2016; 7: e01228-16.

 

Bowman L, Zeden MS, Schuster CF, Kaever V, Grundling A. New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus. J Biol Chem 2016; 291: 26970-26986

 

Dittmar F, Wolter S, Seifert R. Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells. Biochem Pharmacol 2016; 112: 13-23.

 

Gaupels F, Furch AC, Zimmermann MR, Chen F, Kaever V, Buhtz A, Kehr J, Sarioglu H, Kogel KH, Durner J. Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding. Front Plant Sci 2016; 7: 154. Corrigendum: Front Plant Sci 2016; 7: 281.

 

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T. The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation. Microbiology 2016; 162: 1797-1807

 

Krol E, Klaner C, Gnau P, Kaever V, Essen LO, Becker A. Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology 2016; 162: 1840-1856

 

Lacanna E, Bigosch C, Kaever V, Boehm A, Becker A. Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes. J Bacteriol 2016; 198: 2524-2535

 

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U. cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog 2016; 12: e1005546.

 

Pawar SV, Messina M, Rinaldo S, Cutruzzolà F, Kaever V, Rampioni G, Leoni L. Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa. J Appl Microbiol 2016; 120: 205-217.

 

Reinartz MT, Wetzke M, Happle C, Kälble S, Scherer R, Kabesch M, Seifert R. Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects. Allergy 2016; 71: 1223-1227.

 

Rother S, Bartels M, Schweda AT, Resch K, Pallua N, Nourbakhsh M. NF-κB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'→3' exoribonuclease 2 and negative elongation factor. FASEB J 2016; 30: 174-185 

 

Schenk H, Neumann D, Kloth C. Histamine regulates murine primary dendritic cell functions. Immunopharmacol Immunotoxicol 2016; 38: 379-384

 

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G. Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol 2016; 18: 3390-3402

 

Schneider EH, Seifert R. The histamine H4-receptor and the central and peripheral nervous system: A critical analysis of the literature. Neuropharmacology 2016; 106:116-28. 

 

Seifert R. Distinct Signaling Roles of cIMP, cCMP, and cUMP.  Structure 2016; 24: 1627-1628

 

Seifert R. Does Vidarabine Mediate Cardioprotection via Inhibition of AC5? J Pharmacol Exp Ther 2016; 358: 242-243

 

Seifert R. Naunyn-Schmiedeberg's Archives of Pharmacology under new editorship: change and continuity. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 667-670.

 

Seifert R. Recent progress in the field of cIMP research. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 1045-1047.

 

Seifert R. Towards rational drug treatment of Lesch-Nyhan disease. Mol Genet Metab 2016; 118: 145-146.

 

Skotnicka D, Smaldone GT, Petters T, Trampari E, Liang J, Kaever V, Malone JG, Singer M, Søgaard-Andersen L. A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus. PLoS Genet 2016; 12: e1006080.

 

Suppiger A, Eshwar AK, Stephan R, Kaever V, Eberl L, Lehner A. The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter. Sci Rep 2016; 6: 18753.

 

Tschirner SK, Bähre H, Kaever A, Schneider EH, Seifert R, Kaever V.
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice. Life Sci 2016; 156: 68-73.

 

Tschirner SK, Gutzki F, Schneider EH, Seifert R, Kaever V. Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain. J Neurol Sci 2016; 365: 169-174

 

Werner K, Neumann D, Seifert R. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 87-101

 

 

 

2015

 

Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R. cCMP and cUMP occur in vivo. Biochem Biophys Res Commun 2015; 460: 909-914

 

Beermann S, Bernhardt G, Seifert R, Buschauer A, Neumann D. Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation. Biochem Pharmacol 2015; 98: 432-439

 

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T. Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2015; 21: 414

 

Beyer C, Zenzmaier C, Palumbo-Zerr K, Mancuso R, Distler A, Dees C, Zerr P, Huang J, Maier C, Pachowsky ML, Friebe A, Sandner P, Distler O, Schett G, Berger P, Distler JH. Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling. Ann Rheum Dis 2015; 74: 1408-1416

 

Blanka A, Düvel J, Dötsch A, Klinkert B, Abraham WR, Kaever V, Ritter C, Narberhaus F, Häussler S. Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition. Sci Signal 2015; 8 (372): ra36

 

Bridgeman A, Maelfait J, Davenne T, Partridge T, Peng Y, Mayer A, Dong T, Kaever V, Borrow P, Rehwinkel J. Viruses transfer the antiviral second messenger cGAMP between cells. Science 2015; 349: 1228-1232

 

Cohen D, Mechold U, Nevenzal H, Yarmiyhu Y, Randall TE, Bay DC, Rich JD, Parsek MR, Kaever V, Harrison JJ, Banin E. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci USA 2015; 112: 11359-11364

 

Corrigan RM, Bowman L, Willis AR, Kaever V, Gründling A. Cross-talk between Two Nucleotide-signaling Pathways in Staphylococcus aureus. J Biol Chem 2015; 290: 5826-5839

 

Dees C, Beyer C, Distler A, Soare A, Zhang Y, Palumbo-Zerr K, Distler O, Schett G, Sandner P, Distler JH. Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies. Ann Rheum Dis 2015; 74: 1621-1625

 

Dittmar F, Abdelilah-Seyfried S, Tschirner SK, Kaever V, Seifert R. Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. Biochem Biophys Res Commun 2015; 468:708-712

 

Friebe A, Sandner P, Seifert R. From bedside to bench - Meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1237-1246

 

Füllhase C, Hennenberg M, Sandner P, Strittmatter F, Niedworok C, Bauer RM, Gratzke C, Soler R, Stief C, Andersson KE. Reduction of obstruction related bladder overactivity by the guanylyl cyclase modulators BAY 41-2272 and BAY 60-2770 alone or in combination with a phosphodiesterase type 5 inhibitor. Neurourol Urodyn 2015; 34: 787-793

 

Goy SD, Olling A, Neumann D, Pich A, Gerhard R. Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor. Cell Microbiol 2015; 17: 893-909

 

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R. Identification, characterization and structure analysis of the c-di-AMP binding PII-like signal transduction protein DarA. J Biol Chem 2015; 290: 3069-3080 

 

Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, Neumann D. The histamine H4-receptor (H4R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice. Eur J Immunol 2015; 45: 1129-1140

 

Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, Hodgson S, Bodkin MJ, Singh S, Law RJ, Biggin PC. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 883-903  

 

Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, Buschauer A. Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorg Med Chem 2015; pii: S0968-0896(15)00015-2

 

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-kinase (dCK) knock-down as a novel myeloprotective strategy in the context of fludarabine, cytarabine, or cladribine therapy. Leukemia 2015; 29: 2266-2269 

 

Littmann T, Göttle M, Reinartz MT, Kälble S, Wainer IW, Ozawa T, Seifert R. Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands. J Pharmacol Exp Ther 2015; 355: 183-190

 

Lübker C, Dove S, Tang WJ, Urbauer RJ, Moskovitz J, Urbauer JL, Seifert R. Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. Toxins (Basel) 2015; 7: 2598-2614

 

Lübker C, Seifert R. Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. PLoS One 2015; 10: e0124017

 

Lübker C, Urbauer RJ, Moskovitz J, Dove S, Weisemann J, Fedorova M, Urbauer JL, Seifert R. Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. Biochem Pharmacol 2015; 93: 196-209

 

Michel MC, Seifert R. Selectivity of pharmacological tools: implications for use in cell physiology. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. Am J Physiol Cell Physiol 2015; 3087: C505-C520

 

Morrow KA, Seifert R, Kaever V, Britain AL, Sayner SL, Ochoa CD, Cioffi EA, Frank DW, Rich TC, Stevens T. Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas aeruginosa ExoY Infection. Am J Physiol Lung Cell Mol Physiol 2015; 309: L1199–L1207

 

Peltier J, Shaw HA, Couchman EC, Dawson LF, Yu L, Choudhary JS, Kaever V, Wren BW, Fairweather NF. Cyclic-di-GMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage. J Biol Chem 2015; 290: 24453-24469

 

Reichert O, Kolbe L, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G. UV Radiation Induces CXCL5 Expression in Human Skin. Exp Dermatol 2015; 24: 309-312

 

Reinartz MT, Kälble S, Littmann T, Ozawa T, Dove S, Kaever V, Wainer IW, Seifert R. Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 51-65

 

Reinartz MT, Kälble S, Wainer IW, Seifert R. Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 517-524

 

Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation. Biochim Biophys Acta 2015;1849: 1145-1154

 

Rismondo J, Gibhardt J, Rosenberg J, Kaever V, Halbedel S, Commichau FM. Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes. J Bacteriol 2015; 198: 416-426

 

Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stulke J, Ficner R, Commichau FM. Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J Biol Chem 2015; 290: 6596-6606

  

Sandner P, Tinel H, Affaitati G, Costantini R, Giamberardino MA. Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis. PLoS One 2015; 10: e0141477

 

Schäper S, Krol E, Skotnicka D, Kaever V, Hilker R, Søgaard-Andersen L, Becker A. Cyclic di-GMP regulates multiple cellular functions in the symbiotic α-proteobacterium Sinorhizobium meliloti. J Bacteriol 2015; 198: 521-35

  

Schirmer B, Rezniczek T, Seifert R, Neumann D. Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis.
Biochem Pharmacol 2015; 98: 102-109

 

Schirmer B, Wedekind D, Glage S, Neumann D. Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice. PLoS One 2015; 10: e0140173

 

Schneider EH, Neumann D, Seifert R. Histamine H4-receptor expression in the brain? Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 5-9

 

Schneider EH, Seifert R. Report on the Third Symposium "cCMP and cUMP as New Second Messengers". Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1-3

 

Seifert R. Adrenaline as the medication of choice. Dtsch Arztebl Int. 2015; 112: 59

 

Seifert R. cCMP and cUMP: emerging second messengers. Trends Biochem Sci 2015; 40: 8-15

 

Seifert R. Emerging Role of Phosphodiesterase 2A in Hypertension. Hypertension 2015; 66: 13-14

 

Seifert R. How do basic secretagogues activate mast cells? Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 279-281

 

Seifert R, Schneider EH, Bähre H. From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological implications. Pharmacol Ther 2015; 148C: 154-184

 

Skotnicka D, Petters T, Heering J, Hoppert M, Kaever V, Søgaard-Andersen L. c-di-GMP regulates type IV pili-dependent-motility in Myxococcus xanthus. J Bacteriol 2015; 198: 77-90

 

Strasser A, Wittmann HJ, Schneider EH, Seifert R. Modulation of GPCRs by monovalent cations and anions. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 363-380

 

Tschernig T, Hartwig C, Jeron A, Dinh QT, Gereke M, Bruder D. First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma. Int J Genomics 2015; 2015: 638032

 

Tschirner SK, Gutzki F, Kaever V, Seifert R, Schneider EH. Altered histamine neurotransmission in HPRT-deficient mice. Neurosci Lett. 2015; 609:74-80

 

Visaggio D, Pasqua M, Bonchi C, Kaever V, Visca P, Imperi F. Cell aggregation promotes pyoverdine-dependent iron uptake and virulence in Pseudomonas aeruginosa. Front Microbiol 2015; 6: 902

 

Werner K, Kälble S, Wolter S, Schneider EH, Buschauer A, Neumann D, Seifert R. Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1039-1052

 

Wifling D, Löffel K, Nordemann U, Strasser A, Bernhardt G, Dove S, Seifert R, Buschauer A. Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants. Br J Pharmacol 2015; 172: 785-798

 

Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochem Pharmacol 2015;98: 119-131

 

Yang Y, Bucan V, Baehre H, von der Ohe J, Otte A, Hass R. Acquisition of new tumor cell properties by MSC-derived exosomes. Int J Oncol 2015; 244-252

 

Zenzmaier C, Kern J, Heitz M, Plas E, Zwerschke W, Mattesich M, Sandner P, Berger P. Activators and stimulators of soluble guanylate cyclase counteract myofibroblast differentiation of prostatic and dermal stromal cells. Exp Cell Res 2015: 338: 162-169.

 

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bähre H, Kaever V, Thum T, Bauersachs J, Heineke J. Anti-Androgenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation 2015; 131: 1071-81

 

2014

 

Bähre H, Danker KY, Stasch JP, Kaever V, Seifert R. Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. Biochem Biophys Res Commun 443; 1195-1199.

 

Bähre H, Kaever V. Measurement of 2',3'-cyclic nucleotides by liquid chromatography-tandem mass spectrometry in cells. J Chromatogr B Analyt Technol Biomed Life Sci 2014; S1570-0232.

 

Basic M, Keubler LM, Buettner M, Achard M, Breves G, Schröder B, Smoczek A, Jörns A, Wedekind D, Zschemisch NH, Günther C, Neumann D, Lienenklaus S, Weiss S, Hornef MW, Mähler M, Bleich A. Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice. Inflamm Bowel Dis 2014; 20: 431-443.

 

Beckert U, Grundmann M, Wolter S, Schwede F, Rehmann H, Kaever V, Kostenis E, Seifert R. cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. Biochem Biophys Res Commun 2014; 451: 497-502.

 

Beckert U, Wolter S, Hartwig C, Bähre H, Kaever V, Ladant D, Frank DW, Seifert R. ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. Biochem Biophys Res Commun 2014; 450; 870-874.

 

Beermann S, Vauth M, Hein R, Seifert R, Neumann D. Distinct Signalling Pathways of Murine Histamine H1- and H4-Receptors Expressed at Comparable Levels in HEK293 Cells. PLoS One 2014; 9: e107481.

 

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2014; 20: 1327-1333.

 

Blanka A, Schulz S, Eckweiler D, Franke R, Bielecka A, Nicolai T, Casilag F, Düvel J, Abraham WR, Kaever V, Häussler S. Identification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity. J Bacteriol 2014; 196: 345-356.

 

Bräunig JH, Albrecht-Küpper B, Seifert R. Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats. Naunyn Schmiedebergs Arch Pharmacol 387: 389-398.

 

Czerner CP, Klos A, Seifert R, Neumann D. Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor. Inflamm Res 2014; 63: 239-247.

 

Diethmaier C, Newman JA, Kovács AT, Kaever V, Herzberg C, Rodrigues C, Boonstra M, Kuipers OP, Lewis RJ, Stülke J. The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. J Bacteriol 2014; 196: 265-275.

 

Dove S, Danker KY, Stasch JP, Kaever V, Seifert R. Structure/activity Relationships of (M)ANT- and TNP-nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase Alpha1beta1. Mol Pharmacol 2014; 85: 598-607.

 

Frangipani E, Visaggio D, Heeb S, Kaever V, Cámara M, Visca P, Imperi F. The Gac/Rsm and cyclic-di-GMP signalling networks coordinately regulate iron uptake in Pseudomonas aeruginosa. Environ Microbiol 2014; 16: 676-688.

  

Gao S, Romdhane SB, Beullens S, Kaever V, Lambrichts I, Fauvart M, Michiels J. Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli. Appl Microbiol Biotechnol 2014; 98: 4589-4602.

  

Hartwig C, Bähre H, Wolter S, Beckert U, Kaever V, Seifert R. cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes. Neurosci Lett 2014; 579C:183-187.

  

Hasan A, Danker KY, Wolter S, Bähre H, Kaever V, Seifert R. Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells. Biochem Biophys Res Commun 2014; 448; 236-240.

 

Laue S, Winterhoff M, Kaever V, van den Heuvel JJ, Russel FG, Seifert R. cCMP is a substrate for MRP5. Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 893-895.

  

Mahapatra S, Albrecht M, Behrens B, Jirmo A, Behrens G, Hartwig C, Neumann D, Raap U, Bähre H, Herrick C, Dittrich AM. Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. PLoS One 2014; 9: e87296.

 

Mehne FM, Schröder-Tittmann K, Eijlander RT, Herzberg C, Hewitt L, Kaever V, Lewis RJ, Kuipers OP, Tittmann K, Stülke J. Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production. J Biol Chem 2014; 289: 21098-21107

 

Michel MC, Seifert R, Bond RA. Dynamic bias and its implications for GPCR drug discovery. Nat Rev Drug Discov. 2014; 13: 869.

 

Monzel M, Kuhn M, Bähre H, Seifert R, Schneider E. PDE7A1 hydrolyzes cCMP. FEBS Lett 2014; 588: 3469-3474.

 

Neumann D, Schneider EH, Seifert R. Analysis of histamine receptor knock-out mice in models of inflammation. J Pharmacol Exp Ther 2014; 348: 2-11.

 

Neumann D, Seifert R. The therapeutic potential of histamine receptor ligands in inflammatory bowel disease. Biochem Pharmacol 2014; 91: 12-17.

 

Ring J, Beyer K, Biedermann T, Bircher A, Duda D, Fischer J, Friedrichs F, Fuchs T, Gieler U, Jakob T, Klimek L, Lange L, Merk HF, Niggemann B, Pfaar O, Przybilla B, Ruëff F, Rietschel E, Schnadt S, Seifert R, Sitter H, Varga E-M, Worm M, Brockow K. Akuttherapie und Management der Anaphylaxie. Allergo J Int 2014; 23: 1

 

Schneider EH, Fowler SC, Lionakis MS, Swamydas M, Holmes G, Diaz V, Munasinghe J, Peiper SC, Gao JL, Murphy PM. Regulation of motor function and behavior by atypical chemokine receptor 1. Behav Genet 2014; 44: 498-515.

 

Schneider EH, Neumann D, Seifert R. Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice. Neurosci Biobehav Rev 2014; 42: 252-266.

 

Schneider EH, Neumann D, Seifert R. Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice. Neurosci Biobehav Rev 2014; 47C: 101-121.

 

Seifert R. Is cIMP a second messenger with functions opposite to those of cGMP? Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 897-899.

 

Seifert R. Therapeutic efficacy of a H4 receptor antagonist in humans: a milestone in histamine research. J Pharmacol Exp Ther 2014; 350: 2-4.

 

Seifert R. Vidarabine is neither a potent nor a selective AC5 inhibitor. Biochem Pharmacol 2014; 87: 543-546.

 

Werner K, Neumann D, Buschauer A, Seifert R. No evidence for histamine H4-receptor in human monocytes. J Pharmacol Exp Ther 2014; 351: 519-526.

 

Werner K, Neumann D, Seifert R. Analysis of the histamine H2-receptor in human monocytes. Biochem Pharmacol 2014; 92: 369-379.

 

Wittmann HJ, Seifert R, Strasser A. Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In Silico Pharmacology 2014; 2: 1.

 

Wittmann HJ, Seifert R, Strasser A. Sodium binding to hH3R and hH4R - a molecular modeling study. J Mol Model 2014; 20: 2394.

 

Wolter S, Dove S, Golombek M, Schwede F, Seifert R. N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo. Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 1163-1175.