MHH Logo



Back to overview





Braun, F., Thomalla, L., van der Does, C., Quax, T.E.F., Allers, T., KAEVER, V., Albers, SV. (2019)

Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role.

Microbiologyopen, e829 


Grobe, S, Doberenz, S., Ferreira, K., Krueger, J., Brönstrup, M., KAEVER, V., Häußler, S. (2019)

Identification and quantifi.cation of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry.

Chembiochem. 20, 1430-1437


Koppenhöfer, S., Wang, H., Scharfe, M., KAEVER, V., Wagner-Döbler, I., Tomasch, J. (2019)

Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae.

Front Microbiol 10, 803


Kordes, A., Grahl, N., Koska, M., Preusse, M., Arce-Rodriguez, A., Abraham, W.R., KAEVER, V., Häussler, S. (2019)

Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host.

ISME J. 13, 2018-2030.


Li, F, Cimdins, A., Rohde, M., Jänsch, L., KAEVER, V., Nimtz, M., Römling, U. (2019)

DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31.

MBio 10, pii: e02492-18


Rossmann, F.M., Rick, T., Mrusek, D., Sprankel, L., Dörrich, A.K., Leonhard, T., Bubendorfer, S., KAEVER, V., Bange, G., Thormann, K.M. (2019)

The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP.

J. Bacteriol. 201, pii: e00534-18


Sayner, S.L., Choi, C..S, Maulucci, M.E., Ramila, K.C., Zhou, C., Scruggs, A.K., Yarbrough, T., Blair, L.A.H., King, J.A.C., Seifert, R. KAEVER, V., Bauer N.N. (2019)

Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP).

Am. J. Physiol. Lung Cell. Mol. Physiol. 316, L691-L700


Scharrenbroich, J., KAEVER, V., Dove, S., Seifert, R. Schneider, E.H. (2019)

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.

Naunyn Schmiedebergs Arch. Pharmacol. 392, 199-208


Wissig, J., Grischin, J., Bassler, J., Schubert, C., Friedrich, T., BÄHRE, H., Schultz, J.E., Unden, G. (2019)

CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain.

Mol. Microbiol. 112: 16-28.




Munder, A., Rothschuh, J., Schirmer, B., Klockgether, J., KAEVER, V., Tümmler, B., Seifert, R., Kloth, C. (2018)

The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.

Open Biol 8, pii: 170250


Ostermeyer, J., Golly, F., KAEVER, V., Dove, S., Seifert, R., Schneider, E.H. (2018)

cUMP hydrolysis by PDE3B.

Naunyn Schmiedebergs Arch Pharmacol 391, 891-905


Schäper, S., Yau, H.C.L., Krol, E., Skotnicka, D., Heimerl, T., Gray, J., KAEVER, V., Søgaard-Andersen, L., Vollmer, W., Becker, A. (2018)

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales.

PLoS Genet. 14, e1007594


Scharrenbroich, J., KAEVER, V., Dove, S., Seifert, R., Schneider, E.H. (2018)

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.

Naunyn Schmiedebergs Arch Pharmacol 2018 [Epub ahead of print]


Zhang, Y., Sass, A., Van Acker, H., Wille, J., Verhasselt, B., Van Nieuwerburgh, F., KAEVER, V., Crabbé, A., Coenye, T. (2018)

Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels.

Front Microbiol. 9, 1952




Angerer, V., Schwenk, P., Wallner, T., KAEVER, V., Wilde A. (2017)

The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.

Microbiology 163, 920-930 


BÄHRE, H., KAEVER, V. (2017)

Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides.

Handb. Exp. Pharmacol. 238; 293-306


BÄHRE, H., KAEVER, V. (2017)

Identification and quantification of cyclic d-guanosine monophosphate and its linear metabolites by reversed-phase LC-MS/MS

Methods Mol. Biol. 1657, 45-68


Berrisch, S., Ostermeyer, J., KAEVER, V., Kälble, S., Hilfiker-Kleiner, D., Seifert, R., Schneider, E.H. (2017)

cUMP hydrolysis by PDE3A.

Naunyn Schmiedeberg's Arch. Pharmacol. 390, 269-280


Blötz, C., Treffon, K., KAEVER, V., Schwede, F., Hammer, E., Stülke, J. (2017)

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.

Front Microbiol 8, 1328


Doberenz, S., Eckweiler, D., Reichert, O., Jensen, V., Bunk, B., Spröer, C., Kordes, A., Frangipani, E., Luong, K., Korlach, J., Heeb, S., Overmann, J., KAEVER, V., Häussler, S. (2017)

Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles.

MBio. 8, pii: e02312-16


Fazli, M., Rybtke, M., Steiner, E., Weidel ,E., Berthelsen, J., Groizeleau, J., Bin, W., Zhi, B.Z., Yaming, Z., KAEVER, V., Givskov, M., Hartmann, R.W., Eberl, L., Tolker-Nielsen, T. (2017)

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

Microbiologyopen 6


Gundlach, J., Herzberg, C., KAEVER, V., Gunka, K., Hoffmann, T., Weiß, M., Gibhardt, J., Thürmer, A., Hertel, D., Daniel, R., Bremer, E., Commichau, F.M., Stülke, J. (2017)

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.

Sci Signal, 10, pii: eaal3011.


Moreira, R.N., Dressaire, C., Barahona, S., Galego, L., KAEVER, V., Jenal, U., Arraiano, C.M. (2017)

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.

MBio 8, e00443-17


Paijo J., KAEVER, V., Kalinke, U. (2017) 

cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.

Methods Mol. Biol. 656, 153-166   


Sarenko, O., Klauck, G., Wilke, F.M., Pfiffer, V., Richter, A.M., Herbst, S., KAEVER, V., Hengge R. (2017) 

More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli.

MBio. 8, e01639-17.


Schmid, N., Suppiger, A., Steiner, E., Pessi, G., KAEVER, V., Fazli M., Tolker-Nielsen, T., Jenal, U., Eberl, L. (2017)

High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.

Microbiology 163: 754-764


Sprecher, K.S., Hug, I., Nesper, J., Potthoff, E., Mahi, M.A., Sangermani, M., KAEVER, V., Schwede, T., Vorholt, J., Jenal, U. (2017)

Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein.

MBio. 8, pii: e00294-17


Zhang, Y. Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2017)

Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.

J. Biol. Chem. 292, 313-327




Abbey, M., Hakim, C., Anand, R., Lafera, J., Schambach, A., Kispert, A., Taft, M.H., KAEVER, V., Kotlyarov, A., Gaestel, M., Menon, M.B. (2016)

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.

Sci. Rep. 28, 20007


Bæk, K.T., Bowman, L., Millership, C., Dupont Søgaard, M., KAEVER, V., Siljamäki,  P., Savijoki, K., Varmanen, P., Nyman, T.A., Gründling, A., Frees, D. (2016)

The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.

MBio 7, e01228-16


Bowman, L., Zeden, M.S., Schuster, C.F., KAEVER, V., Grundling, A. (2016)

New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus.

J Biol Chem. 291: 26970-26986


Gaupels, F., Furch, A.C., Zimmermann, M.R., Chen, F., KAEVER, V., Buhtz, A., Kehr, J., Sarioglu, H., Kogel, K.H., Durner, J. (2016)

Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding.

Front. Plant. Sci. 7, 154.

Corrigendum: Front. Plant. Sci. 7, 281


Groizeleau, J., Rybtke, M., Andersen, J.B., Berthelsen, J., Liu, Y., Yang, L., Nielsen, T.E., KAEVER, V., Givskov, M., Tolker-Nielsen, T. (2016)

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Microbiology 162, 1797-1807



Krol, E., Klaner, C., Gnau, P., KAEVER, V., Essen, L.O., Becker, A. (2016)

Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti.

Microbiology 162, 1840-1856 


Lacanna, E., Bigosch, C., KAEVER, V., Boehm, A., Becker, A. (2016)

Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes.

J. Bacteriol. 198: 2524-2535 


Paijo, J., Döring, M., Spanier, J., Grabski, E., Nooruzzaman, M., Schmidt, T., Witte, G., Messerle, M., Hornung, V., KAEVER, V., Kalinke, U. (2016) 

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.

PLoS Pathog. 12, e1005546.


Pawar, V.S., Messina, M., Rinaldo, S., Cutruzzola, F., KAEVER, V., Rampioni, G., Leonie, L. (2016)

Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa.

J. Appl. Microbiol. 120, 205-217


Rismondo, J., Gibhardt, J., Rosenberg, J., KAEVER, V., Halbedel, S., Commichau, F.M. (2016)

Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes.

J. Microbiol. 198, 416-426


Schäper, S., Krol, E., Skotnicka, D., KAEVER, V., Hilker, R., Sogaard-Andersen, L., Becker, A. (2016)

Cyclic di-GMP regulates multiple cellular functions in the symbiotic α-proteobacterium Sinorhizobium meliloti

J. Bacteriol. 198, 521-535


Schmidt, A., Hammerbacher, A.S., Bastian, M., Nieken, K.J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K.R., Ulrich, M., Tümmler, B., Unden, G., KAEVER, V., Lory S., Haas D., Schwarz S., Döring G. (2016)

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.

Environ. Microbiol. 18, 3390-3402


Skotnicka, D., Smaldone, G.T., Petters, T., Trampari, E., Liang, J., KAEVER, V., Malone, J.G., Singer, M., Søgaard-Andersen, L. (2016)

A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus.

PLoS Genet. 12, e1006080.


Suppiger, A., Eshwar, A.K., Stephan, R., KAEVER, V., Eberl, L., Lehner, A. (2016)

The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter

Sci. Rep. 6, 18753


Zhang,  Y., Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2016)

Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria.

J Biol Chem 2016 292, 313-327





BÄHRE, H., Hartwig, C., Munder, A., Wolter, S., Stelzer, T., Schirmer, B., Beckert, U., Frank, D.W., Tümmler, B., KAEVER, V., Seifert, R. (2015)

cCMP and cUMP occur in vivo.

Biochim. Biophys. Res. Commun. 460, 909 - 914


Blanka, A., Düvel, J., Dötsch, A., Klinkert, B., Abraham, W.-R., KAEVER, V., Ritter, C., Narberhaus, F., Häussler, S. (2015)

Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition

Sci. Signal. 8, ra36


Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., KAEVER, V., Borrow, P., Rehwinkel, J. (2015)

Viruses transfer the antiviral second messenger cGAMP between cells

Science 349, 1228 - 1232


Cohen, D., Mechold, U., Nevenzal, H., Yarmiyhu, Y., Randall, T.E., Bay, D.C., Rich, J.D., Parsek, M.R., KAEVER, V., Harrison, J.J., Banin, E. (2015)

Oligoribonuclease is a central feature of cyclic  diguanylate signaling in Pseudomonas aeruginosa

P. Natl. Acad. Sci. USA 112, 11359 - 11364


Corrigan, R.M., Bowman, L., Willis, A.R., KAEVER, V., Gründling, A. (2015)

Crosstalk between two nucleotide-signaling pathways in Staphylococcus aureus

J. Biol. Chem. 290, 5826 - 5839


Dittmar, F., Abdelilah-Seyfried, S., Tschirner, S.K., KAEVER, V., Seifert, R. (2015)

Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish

Biochem. Biophys. Res. Commun. 468, 708 - 712


Gundlach, J., Dickmanns, A., Schröder-Tittmann, K., Neumann, Piotr, Kampf, J., Herzberg, C., Hammer, E., Schwede, F., KAEVER, V., Tittmann, K., Stülke, J., Ficner, R. (2015)

Identification, characterization and structure analysis of the c-di-AMP binding PII-like protein DarA

J. Biol. Chem. 290, 3069 - 3080


Gundlach, J., Mehne, F.M., Herzberg, C., Kampf, J., Valerius, O., KAEVER, V., Stülke, J. (2015)

An essential poison: Synthesis and degradation of cyclic di-AMP in Bacillus subtilis

J. Microbiol 197, 3265 - 3274


Morrow, K.A., Seifert, R., KAEVER, V., Britain, A.L., Sayner, S.L., Ochoa, C.D., Cioffi, E.A., Frank,  D.W., Rich, T.C., Stevens, T. (2015)

Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection

Am. J. Physiol. Lung Cell Mol. Physiol. 309, L1199 – L1207


Peltier, J., Shaw, H.A., Couchman, E.C., Dawson, L.F., Yu, L., Choudhary, J.S., KAEVER, V., Brendan, W.W., Fairweather, N.F. (2015)

Cyclic-di-GMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage

J. Biol. Chem. 290, 24453 - 24469


Reinartz, M.T., Kälble, S., Littmann, T., Ozawa, T., Dove, S., KAEVER, V., Wainer, I.W., Seifert, R. (2015)

Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the ß2-adrenoceptor

Naunyn-Schmiedeberg's Arch. Pharmacol. 388, 51 - 65


Rosenberg, J., Dickmanns, A., Neumann, P., Gunka, K., Arens, J., KAEVER, V., Stülke, J., Ficner, R., Commichau, F.M. (2015)

Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes

Biol. Chem. 290, 6596 - 6606


Skotnicka, D., Petters, T., Heering, J., Hoppert, MK., KAEVER, V., Sogaard-Andersen, L. (2015)

c-di-GMP regulates type IV pili-dependent mobility in Myxococcus xanthus

J. Bacteriol. 198, 77 - 90


Visaggio, D., Pasqua, M., Bonchi, C., KAEVER, V., Visca, P., Imperi, F. (2015)

Cell aggregation promotes pyoverdine-dependent iron uptake and virulence in Pseudomonas aeruginosa

Frontiers Microbiol. 6, 902




BÄHRE, H., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)

Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells

Biochim. Biophys. Res. Commun. 443, 1195 - 1199


BÄHRE, H., KAEVER, V. (2014)

Measurement of 2´, 3´-cyclic nucleotides by liquid chromatography-tandem mass spectrometry in cells

J. Chromatogr. B 964, 208 - 211


Beckert, U., Grundmann, M., Wolter, S., Schwede, F., Rehmann, H., KAEVER, V., Kostenis, E., Seifert, R. (2014)

cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects

Biochim. Biophys. Res. Commun. 451, 497 – 502


Beckert, U., Wolter S., Hartwig, C., Bähre H., KAEVER, V., Ladant, D., Frank, D.W., Seifert, R. (2014)

ExoY from Pseudomonas aeruginosa is a nucletotidyl cyclase with preference for cGMP and cUMP formation

Biochim. Biophys. Res. Commun. 450, 870 - 874


Blanka, A., Schulz, S., Eckweiler, D., Franke, R., Bielecka, A., Nicolai, T., Casilag, F., Düvel, J., Abraham, W.-R., KAEVER, V., Häussler, S. (2014)

Identification of the alternative sigma factor SigX regulon and its implication for Pseudomonas aeruginosa pathogenicity

J. Microbiol. 196, 345 - 356


Diethmaier, C., Newman, J.A., Kovacs, A.T., KAEVER, V., Herzberg, C., Rodrigues, C., Boonstra, M., Kuipers, O.P., Lewis, R.J, Stülke, J. (2014)

The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis

J. Bacteriol. 196, 265 - 275


Dove S., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)

Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1ß1

Mol. Pharmacol. 85, 598 - 607


Frangipani, E., Visaggio, D., Heeb, S., KAEVER, V., Camara, M., Visca, P., Imperi, F. (2014)

The Gac/Rsm and cyclic-di-GMP signalling networks coordinately regulate iron uptake in Pseudomonas aeruginosa

Environ. Microbiol. 16, 676 - 688


Gao, S., Romdhane, S.B., Beullens, S., KAEVER, V., Lambrichts, I., Fauvart, M., Michiels, J. (2014)

Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli

Appl. Microbiol. Biotechnol. 98, 4589 - 4602


Hasan, A., Danker, K.Y., Wolter, S., BÄHRE, H., KAEVER, V., Seifert, R. (2014)

Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells

Biochim. Biophys. Res. Commun. 448, 236 - 240


Hartwig, C., BÄHRE, H., Wolter, S., Beckert, U., KAEVER, V., Seifert, R. (2014)

cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes

Neurosci. Lett. 579, 183 - 187


Laue, S., Winterhoff, M., KAEVER, V., van den Heuvel, J.J., Russel, F.G., Seifert, R. (2014)

cCMP is a substrate for MRP5

Naunyn-Schmiedeberg's Arch. Pharmacol. 387, 893 - 895


Mehne, F.M.P., Schröder-Tittmann, K., Eijlander, R.T., Herzberg C., Hewitt, L.,  KAEVER, V., Lewis, R.J., Kuipers, O.P., Tittmann, K., Stülke, J. (2014)

Control of diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits c-di-AMP production

J. Biol. Chem. 289, 21098 - 21107




Abel, S., Bucher, T., Nicollier, M., Hug, I., Abel zur Wiesch, P., KAEVER, V., Jenal, U. (2013)

Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the Caulobacter cell cycle

PLoS Genetics 9, e1003744


Beckert, U., Aw, W.Y., Burhenne, H., Försterling, L., KAEVER, V., Timmons, L., Seifert, R. (2013)

The receptor-bound guanylyl cyclase DAF-11 is the mediator of hydrogen peroxide-induced cGMP increase in Caenorhabditis elegans

PLOS ONE 8, e72569


Beste, K.Y., Spangler, C.M., BURHENNE, H., Koch, K.-W., Shen, Y., Tang, W.-J., KAEVER, V., Seifert, R. (2013)

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: Comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

PLOS ONE 7, e70223


Mehne, F.M.P., Gunka, K. Eilers, H., Herzberg, C., KAEVER, V., Stülke, J. (2013)

Cyclic-di-AMP homeostasis in B. subtilis: both lack and high-level accumulation of the nucleotide are detrimental for cell growth

J. Biol. Chem. 288, 2004 - 2017


Québatte, M., Dick, M.S., KAEVER, V., Schmidt, A., Dehio, C. (2013)

Dual input control: Activation of Bartonella henselae VirB/D4 Type IV secretion by the stringent sigma factor RpoH1 and the BatR/BatS two component system

Mol. Microbiol. 90, 756 – 775




Beste, K.Y., BURHENNE, H., KAEVER, V., Stasch, J.-P., Seifert, R. (2012)

Nucleotidyl cyclase activity of soluble guanylyl cyclase α1ß1

Biochemistry 51, 194 – 204

Correction to Nucleotidyl cyclase activity of soluble guanylyl cyclase α1ß1

Biochemistry 51, 2357


Hammerschmidt, A, Chatterji, B., Zeiser, J., Schröder, A., Genieser, H.-G., Pich, A., KAEVER, V., Schwede, F., Wolter, S., Seifert, R. (2012)

Binding of regulatory subunits of cAMP-dependent protein kinase to cCMP agarose

PLoS One 7, e39848



Jain, R., Behrens, A.-J., KAEVER, V., Kazmierczak, B.I. (2012)

Type IV pilus assembly in Pseudomonas aeruginosa over a broad range of cyclic-di-GMP concentrations

J. Bacteriol. 194, 4285 – 4294




Abel, S., Chien, P., Wassmann, P., Schirmer, T., KAEVER, V., Laub, M.T., Baker, T.A., Jenal, U. (2011)

Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks

Mol. Cell 43, 550 - 560


Corrigan, R.M., Abbott, J.C., BURHENNE, H., KAEVER, V., Gründling, A. (2011)

c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress

PLoS Pathogens 7, e1002217



Reinecke, D., BURHENNE, H., Sandner, P., KAEVER, V., Seifert, R. (2011)

Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated.

FEBS Lett. 585, 3259 - 3262


Spangler, C., KAEVER, V., Seifert, R. (2011)

Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2´,(3´)-substituted purine and pyrimidine nucleotides

J. Pharmacol. Exp. Ther. 336, 234 - 241




Boehm, A., Kaiser, M., Li, H., Spangler, C., Kasper, C.A., Ackermann, M., KAEVER, V., Sourjik, V., Roth, V., Jenal , U. (2010) 
Second messenger-mediated adjustment of bacterial swimming velocity

Cell 141, 107 - 116


Göttle, M., Dove, S., Kees, F., Schlossmann, J., Geduhn, J., König, B., Shen, Y., Tang, W.-J., KAEVER, V., Seifert, R. (2010)

Cytidylyl and uridylyl cyclase activity of Bacillus anthracis edema factor and Bordetella pertussis CyaA

Biochemistry 49, 5494 - 5503


Malone, J.G., Jaeger, T., Spangler, C., Ritz, D., Spang, A., Arrieumerlou, C., KAEVER, V., Landmann, R., Jenal, U. (2010)

YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa

PLoS Pathogens 6, e1000804


Spangler, C., Böhm, A., Jenal, U., Seifert, R., KAEVER, V. (2010)

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate

J. Microbiol. Methods 81, 226 - 231



Back to overview