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Key original publications of the KFO119


Brakensiek K, Langer F, Kreipe H, Lehmann U. Low level of DAP-kinase DNA methylation in myelodysplastic syndrome. Blood 1;104(5):1586-7, 2004.


Buitrago-Molina LE, Pothiraju D, Lamlé J, Marhenke S, Kossatz U, Breuhahn K, Manns MP, Malek N, Vogel A. Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage. Hepatology Aug;50(2):500-9, 2009.


Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S, Harley CB, Rudolph KL. Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 42:1127-36, 2005.


Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology. 39: 970-7, 2004.


Gamrekelashvili J, Krüger C, von Wasielewski R, Hoffmann M, Huster KM, Busch DH, Manns MP, Korangy F, Greten TF. Necrotic tumor cell death in vivo impairs tumor-specific immune responses. J Immunol. 2007 Feb 1;178(3):1573-80.


Garbe,A.I, Vermeer,B., Gamrekelashvili,J., von Wasielewski,R., Greten,F.R., Westendorf,A.M., Buer,J., Schmid,R.M., Manns,M.P., Korangy,F., and Greten,F. Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Research 66, 508-516, 2006.


Greten FR, Eckmann L, Greten TF, Park J-M, Li Z-W, Egan LL, Kagnoff MF, Karin M. IKK links inflammation and cancer and is a possible target für prevention of colitis associated cancer. Cell 118: 285 – 296, 2004.


Greten TF, Papendorf F, Bleck JS, Kirchhoff T, Wohlberedt T, Kubicka S, Klempnauer J, Galanski M, Manns MP. Survival rate in patients with Hepatocellular carcinoma: A retro-spective analysis of 389 patients. Br. J. Cancer 92:1862-8, 2005.


Gürlevik E, Woller N, Schache P, Malek NP, Wirth TC, Zender L, Manns MP, Kubicka S, Kühnel F. p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication. Nucleic Acids Res. 2009 Jul;37(12):e84. Epub 2009 May 14.


Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Krüger C, Manns MP, Greten TF, Korangy F. A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology. 2008 Jul;135(1):234-43. Epub 2008 Mar 21.


Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H, Lehner F, Manns MP, Greten TF, Korangy F. Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology. 2009 May 1. [Epub ahead of print]


Ito H, Aoki H, Kuhnel F, Kondo Y, Kubicka S, Wirth T, Iwado E, Iwamaru A, Fujiwara K, Hess KR, Lang FF, Sawaya R, Kondo S. Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus. J Natl Cancer Inst. 3;98(9):625-36, 2006.


Korangy F, Ormandy L, Heller A, Bleck JS, Klempnauer J, Manns MP, Greten TF. Humoral and Cellular immune responses to the NY-ESO-1 tumor antigen in Hepatocellular Carcinoma. Clinical Cancer Research 10:4332-41, 2004.


Kossatz U, Vervoorts J, Nickeleit I, Sundberg HA, Arthur JS, Manns MP, Malek NP. C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 2006 Nov 1;25(21):5159-70. Epub 2006 Oct 19.


Kossatz, U., Dietrich,N., Zender,L., Buer,J., Manns,M.P., and Malek,N.P. Skp2 dependent degradtion of p27kip1 is essential for cell cycle progression. Genes and Development 18, 2602-2607, 2004.


Kuhnel F, Fritsch C, Krause S, Mundt B, Wirth T, Paul Y, Malek NP, Zender L, Manns MP, Kubicka S. Doxycyline regulation in a single retroviral vector by an autoregulatory loop facilitates controlled gene expression in liver cells. Nucleic Acids Res. 13;32(3):e30, 2004.


Kühnel F, Schulte B, Wirth T, Woller N, Schäfers S, Zender L, Manns M, Kubicka S. Protein transduction domains fused to virus receptor improve cellular virus uptake and enhance oncolysis by tumor specific replicating vectors. J. Virology  78(24):13743-54. 2004.


Lankisch TO, Behrens G, Ehmer U, Möbius U, Rockstroh J, Wehmeier M, Kalthoff S, Freiberg N, Manns MP, Schmidt RE, Strassburg CP. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. J Hepatol. 2009 May;50(5):1010-8. Epub 2009 Mar 5


Lankisch TO, Vogel A, Eilermann S, Fiebeler A, Krone B, Barut A, Manns MP, Strassburg CP. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol. 67(5):1732-9, 2005.


Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, Kubicka S, Schirmacher P, Jonkers J, Rudolph KL. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology. 2007 Apr;132(4):1465-75.


Lechel A, Satyanarayana A, J u Z, Plentz RR, Schaetzlein S, Rudolph C, Wilkens L, Wiemann SU, Saretzki G, Malek NP, Manns MP, Buer J and Rudolph KL. The Cellular Level of Telomere Dysfunction Determines Induction of Senescence or Apoptosis in vivo. EMBO Rep., 6:275-81, 2005.


Lehmann U, Berg-Ribbe I, Wingen LU, Brakensiek K, Becker T, Klempnauer J, Schlegelberger B, Kreipe H, Flemming P. Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. Clinical Cancer Res. 11, 3654-60, 2005.


McEvoy JD, Kossatz U, Malek N, Singer JD. Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol Cell Biol. 2007 May;27(10):3651-66. Epub 2007 Mar 5.


Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol.  24(24):10868-81, 2004.


Mundt B, Wirth T, Zender L, Waltemathe M, Trautwein C, Manns MP, Kuhnel F, Kubicka S. Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. Gut 54(11):1590-6, 2005.


Nickeleit I, Zender S, Sasse F, Geffers R, Brandes G, Sörensen I, Steinmetz H, Kubicka S,  Carlomagno T, Menche D, Gütgemann I, Buer J, Gossler A; Manns M, Kalesse M, Frank R, Malek NP. Argyrin A reveals a critical role for the tumor suppressor protein p27kip1 in mediating antitumor activities in response to proteasome inhibition. Cancer Cell, 8;14(1):23-35, 2008.


Ormandy L, Hillemann T, Wedemeyer H, Manns MP, Greten TF*, Korangy F*(*) co-senior authors. Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma. Cancer Research 65:2457 – 2464, 2005.


Plentz RR, Caselitz M, Bleck JS, Gebel M, Flemming P, Kubicka S, Manns MP, Rudolph KL. Hepatocellular Telomere Shortening correlates with Chromosomal Instability and the Development of Human Hepatocellular Carcinoma. Hepatology 40:80-6, 2004.


Plentz RR, Schlegelberger B, Flemming P, Manns MP, Rudolph KL, Wilkens L. Telomere shortening correlates with increasing aneuploidy of chromosome 8 on a cellular level in primary human hepatocellular carcinoma. Hepatology; 42:522-6, 2005.


Ramakrishna E, Woller N, Mundt B, Knocke S, Gürlevik E, Saborowski M, Malek N, Manns MP, Wirth T, Kühnel F, Kubicka S. Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses. Cancer Research, Feb 15;69(4):1448-58, 2009.


Satyanarayana A, Greenberg RA, Schaetzlein S, Buer J, Masutomi K, Hahn WC, Zimmermann S, Martens U, Manns MP, Rudolph KL. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol. 24(12):5459-74, 2004.


Schache P, Gürlevik E, Strüver N, Malek NP, Zender L, Manns MP, Wirth T, Kühnel F, Kubicka S. VSV virotherapy improves chemotherapy by triggering of apoptosis due to proteasomal degradation of MCL-1. Gene Therapy, Jul;16(7):849-61. 2009.


Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell. 2007 Sep 7;130(5):863-77


Schaetzlein S, Lucas-Hahn A, Lemme E, Kues WA, Dorsch M, Manns MP, Niemann H, Rudolph KL. Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A. 25;101(21):8034-8, 2004.


Timmerbeul I, Garrett-Engele GM, Kossatz U, Chen X, Firpo E, Grünwald V, Kamino K, Wilkens L, Lehmann U, Buer J, Geffers R, Kubicka S, Manns MP, Porter PL, Roberts JM and Malek NP. Testing the importance of p27 degradation by the SCF Skp2 pathway in murine models of lung and colon cancer. Proc Natl Acad Sci USA, Sep 19;103(38):14009-14, 2006.


Wiemann SU, Satyanarayana A, Buer J, Kamino K, Manns MP, Rudolph KL. Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic organ damage. Oncogene 24:1501-9, 2005.


Wilkens L, Flemming P, Gebel M, Bleck J, Terkamp C, Wingen L, Kreipe H, Schlegelberger B. Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma. Proc Natl Acad Sci U S A 101, 1309-14, 2004.


Wirth T, Kuhnel F, Fleischmann-Mundt B, Woller N, Djojosubroto M, Rudolph KL, Manns M, Zender L, Kubicka S. Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1. Cancer Research 15;65(16):7393-402. 2005.


Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev. 2008 Jun 1;22(11):1439-44


Zender L, Hutker S, Mundt B, Waltemathe M, Klein C, Trautwein C, Malek NP, Manns MP, Kuhnel F, Kubicka S. NFkappaB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis. Hepatology 41(2):280-8, 2005.


Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125(7):1253-67, 2006.


Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, Lowe SW. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell,  Nov 28;135(5):852-64, 2008.