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Dr. Iris Röckle

 

Dr. rer. nat.

Diplom-Biologin

Post-Doc

 

Geb. J3, Ebene 04, Raum 1060

Tel.: +49(0)511/532-3367

FAX: +49(0)511/532-8801

 

E-Mail: Roeckle.Iris(at)mh-hannover.de

 

 

 

Research interests

 

Role of polysialic acid and NCAM in interneuron development.

 

 

Publications

 

Fewou SN, Röckle I, Hildebrandt H, Eckhardt M (2019) Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior. Glycobiology, e-pub ahead of print: May 30. doi: 10.1093/glycob/cwz040.

 

Curto Y, Alcaide J, Röckle I, Hildebrandt H, Nacher J, (2019), Effects of the genetic depletion of polysialyltransferases on the structure and connectivity of interneurons in the adult prefrontal cortex, Front Neuroanat, 13:6. doi:

 

Szewczyk L.M., Brozko N., Nagalski A., Röckle I., Werneburg S., Hildebrandt H., Wisniewska M.B., Kuznicki J. (2017) ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons. Glia. 65(1):34-49

 

Röckle I., Hildebrandt H. (2016) Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice. Dev Neurobiol. 76(4):421-33

 

Kröcher T., Malinovskaja K., Jürgenson M., Aonurm-Helm A., Zharkovskaya T., Kalda A., Röckle I., Schiff M., Weinhold B., Gerardy-Schahn R., Hildebrandt H. (corresponding author), Zharkovsky A. (2015) Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct Funct. 220(1):71-83.

 

Tantra M., Kröcher T., Papiol S., Winkler D., Röckle I., Jatho J., Burkhardt H., Ronnenberg A., Gerardy-Schahn R., Ehrenreich H.*, Hildebrandt H.* (2014) St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood. Behav Brain Res. 275:166-175. (*equally contributing corresponding authors)

 

Kröcher T.*, Röckle I.*, Diederichs U., Weinhold B., Burkhardt H., Yanagawa Y., Gerardy-Schahn R., Hildebrandt H. (2014) A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex. Development. 141(15): 3022-3032. (* equally contributing)

 

Schiff M., Röckle I., Burkhardt H., Weinhold B., Hildebrandt H. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J Neurosci. 31(4):1302-12.

 

Nacher J., Guirado R., Varea E., Alonso-Llosa G., Röckle I., Hildebrandt H. (2010) Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex. Neuroscience. 167(3):825-37.

 

Hildebrandt H., Mühlenhoff M., Oltmann-Norden I., Röckle I., Burkhardt H., Weinhold B., Gerardy-Schahn R. (2009) Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain. 132(Pt 10):2831-8.

 

Röckle I., Seidenfaden R., Weinhold B., Mühlenhoff M., Gerardy-Schahn R., Hildebrandt H. (2008) Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol. 68(9):1170-84.

 

Weinhold B., Seidenfaden R., Röckle I., Mühlenhoff M., Schertzinger F., Conzelmann S., Marth J.D., Gerardy-Schahn R., Hildebrandt H. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem. 280(52):42971-7.