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Publikationen - Veröffentlichungen des Instituts

Publikationen 2017



Engeli S, Stinkens R, Heise T, May M, Goossens GH, Blaak EE, Havekes B, Jax T, Albrecht D, Pal P, Tegtbur U, Haufe S, Langenickel TH, Jordan J. Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension. Hypertension 2017, Epub 2017 Nov 27


Haufe S, Engeli S, Kaminski J, Witt H, Rein D, Kamlage B, Utz W, Fuhrmann JC, Haas V, Mähler A, Schulz-Menger J, Luft FC, Boschmann M, Jordan J. Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals. Nutr Metab Cardiovasc Dis 2017; 27: 858-864


Engeli S, May M, Nussberger J, Danser AHJ, Dole WP, Prescott MF, Dahlke M, Stitah S, Pal P, Boschmann M, Jordan J. Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension. J Am Soc Hypertens 2017; 11: 488-497

Haufe S, Wiechmann K, Stein L, Kück M, Smith A, Meineke S, Zirkelbach Y, Rodriguez Duarte S, Drupp M, Tegtbur U. Low-dose, non-supervised, health insurance initiated exercise for the treatment and prevention of chronic low back pain in employees. Results from a randomized controlled trial. PLoS One 2017 Jun 29;12(6):e0178585.

Herold C, Engeli S, Beckmann B, Vogt PM, Rennekampff HO. Adipokine concentrations in lipoaspirates may have a role in wound healing. Indian J Plast Surg 2017; 50: 56-63


Jordan J, Tank J, Heusser K, Heise T, Wanner C, Heer M, Macha S, Mattheus M, Lund SS, Woerle HJ, Broedl UC. The effect of empagliflozin on muscle sympathetic nerve activity in patients with type II diabetes mellitus. J Am Soc Hypertens 2017; 11: 604-612


Buck A, Kayacelebi AA, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das AM, Tsikas D, Lücke T. Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth. Amino Acids 2017; 49: 783-794

O'Callaghan EL, Hart EC, Sims-Williams H, Javed S, Burchell AE, Papouchado M, Tank J, Heusser K, Jordan J, Menne J, Haller H, Nightingale AK, Paton JF, Patel NK. Chronic Deep Brain Stimulation Decreases Blood Pressure and Sympathetic Nerve Activity in a Drug- and Device-Resistant Hypertensive Patient. Hypertension 2017; 69: 522-528

Haarmann H, Folle J, Nguyen XP, Herrmann P, Heusser K, Hasenfuß G, Andreas S, Raupach T. Impact of Non-Invasive Ventilation on Sympathetic Nerve Activity in Chronic Obstructive Pulmonary Disease. Lung 2017; 195: 69-75

Haufe S, Bara C, Eigendorf J, Chobanyan-Jürgens K, Rojas SV, Schmitto J, Tegtbur U, Jordan J, Tank J. Physical Activity Guided by Pulse Pressure in Patients With Continuous Flow Left Ventricular Assist Devices: A Pilot Study. Circulation 2017; 135: 1567-1569

Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flögel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T. Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure. Eur Heart J 2017; 38: 362-372

Tsikas D, Kayacelebi AA, Hanff E, Mitschke A, Beckmann B, Tillmann HC, Gutzki FM, Müller M, Bernasconi C. GC-MS and GC-MS/MS measurement of ibuprofen in 10-μL aliquots of human plasma and mice serum using [α-methylo-2H3]ibuprofen after ethyl acetate extraction and pentafluorobenzyl bromide derivatization: Discovery of a collision energy-dependent H/D isotope effect and pharmacokinetic application to inhaled ibuprofen-arginine in mice. J Chromatogr B Analyt Technol Biomed Life Sci 2017; 1043: 158-166

von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Döcke S, Murahovschi V, Kriebel J, de Las Heras Gala T, Grallert H, Rudovich N, Stockmann M, Spranger J, Jahreis G, Bornstein SR, Lau G, Xu A, Schulz-Menger J, Exner L, Haufe S, Jordan J, Engeli S, Birkenfeld AL. ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Horm Metab Res 2017; 49: 343-349

Tsikas D, Rothmann S, Schneider JY, Gutzki FM, Beckmann B, Frölich JC. Simultaneous GC-MS/MS measurement of malondialdehyde and 4-hydroxy-2-nonenal in human plasma: Effects of long-term L-arginine administration. Anal Biochem 2017; 524: 31-44

Jordan J, Stinkens R, Jax T, Engeli S, Blaak EE, May M, Havekes B, Schindler C, Albrecht D, Pal P, Heise T, Goossens GH, Langenickel TH. Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension. Clin Pharmacol Ther 2017; 101: 254-263

Kayacelebi AA, Schauerte C, Kling K, Herbers J, Beckmann B, Engeli S, Jordan J, Zoerner AA, Tsikas D. Cross-validated stable-isotope dilution GC-MS and LC-MS/MS assays for monoacylglycerol lipase (MAGL) activity by measuring arachidonic acid released from the endocannabinoid 2-arachidonoyl glycerol. J Chromatogr B Analyt Technol Biomed Life Sci 2017; 1047: 151-159

Publikationen 2016



Jordan J, El-Armouche A, Hanefeld M, Bornstein SR, Birkenfeld AL. Comment on Ferrannini et al. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care 2016;39:1108-1114. Diabetes Care 2016; 39: e224-e225


Heise T, Jordan J, Wanner C, Heer M, Macha S, Mattheus M, Lund SS, Woerle HJ, Broedl UC. Pharmacodynamic Effects of Single and Multiple Doses of Empagliflozin in Patients With Type 2 Diabetes. Clin Ther 2016; 38: 2265-76


Jordan J, Diedrich A, Grassi G, Tank J. Living with severe orthostatic hypotension. J Hypertens 2016; 34: 1942-4


Haarmann H, Folle J, Nguyen XP, Herrmann P, Heusser K, Hasenfuß G, Andreas S, Raupach T. Sympathetic Activation is Associated with Exercise Limitation in COPD. COPD 2016; 13: 589-94


Jordan J, Albrecht UV. Applications might be subject to medical device regulation. J Hypertens 2016; 34: 1882


Jordan J, Toplak H, Grassi G, Yumuk V, Kotsis V, Engeli S, Cuspidi C, Nilsson PM, Finer N, Doehner W. Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and heart failure. J Hypertens 2016; 34: 1678-88


Haufe S, Witt H, Engeli S, Kaminski J, Utz W, Fuhrmann JC, Rein D, Schulz-Menger J, Luft FC, Boschmann M, Jordan J. Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects. Nutr Metab Cardiovasc Dis 2016; 26: 637-42


Jordan J, Grassi G, Tank J. Device-based treatments in hypertension: think physiology. J Hypertens 2016; 34: 1502-4


Heise T, Jordan J, Wanner C, Heer M, Macha S, Mattheus M, Lund SS, Woerle HJ, Broedl UC. Acute Pharmacodynamic Effects of Empagliflozin With and Without Diuretic Agents in Patients With Type 2 Diabetes Mellitus. Clin Ther 2016; 38: 2248-64.


Gabrielsen AM, Omland T, Brokner M, Fredheim JM, Jordan J, Lehmann S, Lund MB, Hjelmesæth J, Hofsø D. The effect of surgical and non-surgical weight loss on N-terminal pro-B-type natriuretic peptide and its relation to obstructive sleep apnea and pulmonary function. BMC Res Notes 2016; 9: 440.


Heusser K, Brinkmann J, Topalidis W, Menne J, Haller H, Berliner D, Luft FC, Tank J, Jordan J. Physiology Unmasks Hypertension. Hypertension 2016; 68: 252-6


Heusser K, Tank J, Brinkmann J, Menne J, Kaufeld J, Linnenweber-Held S, Beige J, Wilhelmi M, Diedrich A, Haller H, Jordan J. Acute Response to Unilateral Unipolar Electrical Carotid Sinus Stimulation in Patients With Resistant Arterial Hypertension. Hypertension 2016; 67: 585-91


Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S. Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue. Arch Physiol Biochem 2016; 122: 47-53


Heusser K, Tank J, Brinkmann J, Schroeder C, May M, Großhennig A, Wenzel D, Diedrich A, Sweep FC, Mehling H, Luft FC, Jordan J. Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping. J Am Heart Assoc 2016; 5(1). pii: e002674


Jordan J, Grassi G. Precision medicine should become more 'sympathetic' in managing hypertension. J Hypertens 2016; 34: 629-31


Chobanyan-Jürgens K, Jordan J. Mind the Vein. Hypertension 2016; 68: 310-1


Bolten WW, Krüger K, Reiter-Niesert S, Stichtenoth DO; Kommission Pharmakotherapie der DGRh. DGRh-Empfehlungen zur Implementierung aktueller Sicherheitsaspekte in die NSAR-Therapie muskuloskelettaler Schmerzen. Z Rheumatol 2016; 75: 103-16


Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D. Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells. J Chromatogr B Analyt Technol Biomed Life Sci 2016; 1019: 72-82


Jordan J, Birkenfeld AL. Cardiometabolic crosstalk in obesity-associated arterial hypertension. Rev Endocr Metab Disord 2016; 17: 19-28


Hanff E, Böhmer A, Zinke M, Gambaryan S, Schwarz A, Supuran CT, Tsikas D. Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets. Amino Acids 2016; 48: 1695-706


Tsikas D, Böhmer A, Gros G, Endeward V. Evidence of the chemical reaction of (18)O-labelled nitrite with CO2 in aqueous buffer of neutral pH and the formation of (18)OCO by isotope ratio mass spectrometry. Nitric Oxide 2016; 55-56: 25-35


Calvier L, Legchenko E, Grimm L, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy S, Hansmann G. Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. Heart 2016; 102: 390-6


Tsikas D, Rothmann S, Schneider JY, Suchy MT, Trettin A, Modun D, Stuke N, Maassen N, Frölich JC. Development, validation and biomedical applications of stable-isotope dilution GC-MS and GC-MS/MS techniques for circulating malondialdehyde (MDA) after pentafluorobenzyl bromide derivatization: MDA as a biomarker of oxidative stress and its relation to 15(S)-8-iso-prostaglandin F2α and nitric oxide (NO). J Chromatogr B Analyt Technol Biomed Life Sci 2016; 1019: 95-111


Icken D, Feller S, Engeli S, Mayr A, Müller A, Hilbert A, de Zwaan M. Caffeine intake is related to successful weight loss maintenance. Eur J Clin Nutr 2016; 70: 532-4


Tsikas D, Hanff E, Kayacelebi AA, Böhmer A. Gas chromatographic-mass spectrometric analysis of the tripeptide glutathione in the electron-capture negative-ion chemical ionization mode. Amino Acids 2016; 48: 593-8


Zinke M, Hanff E, Böhmer A, Supuran CT, Tsikas D. Discovery and microassay of a nitrite-dependent carbonic anhydrase activity by stable-isotope dilution gas chromatography-mass spectrometry. Amino Acids 2016; 48: 245-55