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AG HPV-induzierte Neoplasien

 

Klinik für Frauenheilkunde und Geburtshilfe

Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover

 

  

Wissenschaftliche Schwerpunkte:

 

- Evaluation verschiedener Testmethoden zur Diagnostik der genitalen HPV-Infektion

- Photodynamische Diagnostik und Therapie HPV-assoziierter Dysplasien der Zervix und Vulva

- Prävention der HPV-Infektion durch Impfung

- Gesundheitsökonomische Untersuchungen zu HPV-assoziierten Dysplasien / Karzinomen

 

 

Ort:

 

Klinik für Frauenheilkunde und Geburtshilfe, Gebäude K11, Ebene SO,

Frauenklinik im Forschungszentrum, Gebäude I11, Ebene S0. 

 

 

Kontakt: 

 

Prof. Dr. med. Peter Hillemanns

Tel.: 0511-532-6144

Fax.: 0511-532-6145 

 

 

Ständige Mitarbeiterinnen und Mitarbeiter:

 

Dr. med. Philipp Soergel

Dr. med. Matthias Jentschke

 

unter Mitwirkung von:

Prof. Dr. rer. nat. Ralf Hass

Dr. rer. nat. Thilo Dörk-Bousset

 

 

Laufende Forschungsprojekte:

 

- HPV-Impfstudien   [HPV 070]

- Selbstuntersuchungsmethoden auf HPV

- Genetische Disposition für Dysplasien und Karzinome der Cervix (Zervigen)

- Vergleich verschiedener HPV-Testsysteme

- Photodynamische Therapie der CIN 1 – 3    [Cervira]

- HPV-Nachweis aus Urin

 

 

Drittmittel der letzten fünf Jahre:

 

Deutsche Krebsgesellschaft

Bruno und Helene Jöster Stiftung

Novartis Institute of Biomedical Research

Abbott

GSK

 

 

Wissenschaftliche Publikationen der letzten fünf Jahre:

 

Jentschke M, Soergel P, Hillemanns P (2013) Evaluation of a multiplex real time PCR assay for the detection of human papillomavirus infections on self-collected cervico-vaginal lavage samples. J Virol Methods 193:131-134.

 

Jentschke M, Lange V, Soergel P, Hillemanns P (2013) Enzyme-linked immunosorbent assay for p16(INK4a) - a new triage test for the detection of cervical intraepithelial neoplasia? Acta Obstet Gynecol Scand 92(2):160-164.

 

Jentschke M, Soergel P, Lange V, Kocjan B, Dörk T, Luyten A, Petry KU, Poljak M, Hillemanns P (2012) Evaluation of a new multiplex real-time polymerase chain reaction assay for the detection of human papillomavirus infections in a referral population. Int J Gynecol Cancer 22:1050-1056.

 

Soergel P, Dahl GF, Onsrud M, Hillemanns P (2012) Photodynamic therapy of cervical intraepithelial neoplasia 1-3 and human papilloma virus (HMV) infection with methylaminolevulinate and hexaminolevulinate--a double-blind, dose-finding study. Lasers Surg Med 44(6):468-474.

 

Soergel P, Makowski L, Schippert C, Staboulidou I, Hille U, Hillemanns P (2012) The cost efficiency of HPV vaccines is significantly underestimated due to omission of conisation-associated prematurity with neonatal mortality and morbidity. Hum Vaccin Immunother 8:243-251.

 

Soergel P, Makowski L, Makowski E, Schippert C, Hertel H, Hillemanns P (2011) Treatment of high grade cervical intraepithelial neoplasia by photodynamic therapy using hexylaminolevulinate may be costeffective compared to conisation procedures due to decreased pregnancy-related morbidity. Lasers Surg Med 43:713-720.

 

Sroczynski G, Schnell-Inderst P, Mühlberger N, Lang K, Aidelsburger P, Wasem J, Mittendorf T, Engel J, Hillemanns P, Petry KU, Krämer A, Siebert U. Decision-analytic modeling to evaluate the long-term effectiveness and cost-effectiveness of HPV-DNA testing in primary cervical cancer screening in Germany. GMS Health Technol Assess. 2010 Apr 27;6:Doc05.

 

Soergel P, Loehr-Schulz R, Hillemanns M, Landwehr S, Makowski L, Hillemanns P. Effects of photodynamic therapy using topical applied hexylaminolevulinate and methylaminolevulinate upon the integrity of cervical epithelium. Lasers Surg Med. 2010 Nov;42(9):624-30.

 

Gross G, Gissmann L, Hillemanns P, Ikenberg H, Kaufmann AM, Petry KU, Pfister H, Schneede P, Schneider A, Smola S; für das HPV-Management Forum. [Prevention of HPV-associated neoplasias by vaccination - short version of the German S3 (level 3) guideline]. Dtsch Med Wochenschr. 2010 May;135(21):1083-6.

 

Gallwas J, Ditsch N, Hillemanns P, Friese K, Thaler C, Dannecker C. The significance of HPV in the follow-up period after treatment for CIN. Eur J Gynaecol Oncol. 2010;31(1):27-30.

 

Soergel P, Hillemanns P. Photodynamic therapy for intraepithelial neoplasia of the lower genital tract. Photodiagnosis Photodyn Ther. 2010 Mar;7(1):10-4. Epub 2010 Jan 12. Review.

 

Garcia-Sicilia J, Schwarz TF, Carmona A, Peters K, Malkin JE, Tran PM, Behre U, Iturbe EB, Catteau G, Thomas F, Dobbelaere K, Descamps D, Dubin G; HPV Vaccine Adolescent Study Investigators Network. Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women. J Adolesc Health. 2010 Feb;46(2):142-51.

 

Kuemper C, Burges A, Hillemanns P, Mueller-Egloff S, Lenhard M, Ditsch N, Strauss A. Supraclavicular lymph node metastases of unknown origin: HPV-typing identifies the primary tumour. Eur J Cancer Care (Engl). 2009 Nov;18(6):606-11.

 

Pathirana D, Hillemanns P, Petry KU, Becker N, Brockmeyer NH, Erdmann R, Gissmann L, Grundhewer H, Ikenberg H, Kaufmann AM, Klusmann J, Kopp I, Pfister H, Rzany B, Schneede P, Schneider A, Smola S, Winter-Koch N, Wutzler P, Gross G. Short version of the German evidence-based Guidelines for prophylactic vaccination against HPV-associated neoplasia. Vaccine. 2009 Jul 23;27(34):4551-9. Review.

 

Soergel P, Löning M, Staboulidou I, Schippert C, Hillemanns P. Photodynamic diagnosis and therapy in gynecology. J Environ Pathol Toxicol Oncol. 2008;27(4):307-20. Review.

 

Hollwitz B, Rinnau F, Holm S, Petry KU, Hillemanns P. [HPV-associated anogenital neoplasia in HIV]. MMW Fortschr Med. 2008 Apr 28;150, 34.

 

Wang XL, Wang HW, Hillemanns P, Hamblin MR. Distinctive features of foreskin condylomata acuminata associated with diabetes mellitus. Acta Derm Venereol. 2008;88(6):578-83.

 

Soergel P, Wang X, Stepp H, Hertel H, Hillemanns P. Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate. Lasers Surg Med. 2008 Nov;40(9):611-5.

 

Hampl M, Hantschmann P, Michels W, Hillemanns P; German Multicenter Study Group. Validation of the accuracy of the sentinel lymph node procedure in patients with vulvar cancer: results of a multicenter study in Germany. Gynecol Oncol. 2008 Nov;111(2):282-8.

 

Petry KU, Breugelmans JG, Bénard S, Lamure E, Littlewood KJ, Hillemanns P. Cost of screening and treatment of cervical dyskaryosis in Germany. Eur J Gynaecol Oncol. 2008;29(4):345-9.

 

Hillemanns P, Breugelmans JG, Gieseking F, Bénard S, Lamure E, Littlewood KJ, Petry KU. Estimation of the incidence of genital warts and the cost of illness in Germany: a cross-sectional study. BMC Infect Dis. 2008 Jun 2;8:76.

 

Kieckbusch H, Coldewey SM, Hollenhorst J, Haeseler G, Hillemanns P, Hertel H.Patent blue sentinel node mapping in cervical cancer patients may lead to decreased pulse oximeter readings and positive methaemoglobin results. Eur J Anaesthesiol. 2008 May;25(5):365-8.

 

Hillemanns P, Wang X, Hertel H, Andikyan V, Hillemanns M, Stepp H, Soergel P. Pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate in patients with cervical intraepithelial neoplasia. Am J Obstet Gynecol. 2008 Mar;198(3):300.e1-7.

 

 

 

Letzte Aktualisierung: 30.09.2013