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Neuroglycobiochemistry

 

Prof. Dr. Herbert Hildebrandt

Phone:  +49(0)511/532-9808

Fax:     +49(0)511/532-8801

e-mail:  hildebrandt.herbertmh-hannover.de

 

 

Mailing Address:

Medizinische Hochschule Hannover, MHH

Institut für Klinische Biochemie, OE 4340

(formerly: Institut für Zelluläre Chemie)

Carl-Neuberg-Strasse 1

30625 Hannover

 

Campus Address:

Building J03, Level 04, Room 1320 (Office), Room 1040 (Lab)

 

 

RESEARCH

 

The focus of our research is on the role of glycoconjugates in brain and tumor development with a particular emphasis on polysialic acid as a posttranslational modification of the neural cell adhesion molecule NCAM. We also study the role of other, newly identified protein carriers of polysialic acid such as SynCAM 1 in NG2 cells or neuropilin-2 and E-selectin ligand 1 in microglia and macrophages. Another interest is to explore the possible links between altered polysialic acid synthesis and neurodevelopmental predisposition to schizophrenia and other mental disorders. Experimental approaches include neuroanatomical, cellular and molecular analyses of mouse models deficient for polysialic acid biosynthesis as well as organotypic and cell culture systems.

 

Team

 

Publications

 

Open positions:

Currently no open position.

Inquiries for Master's or Bachelor's theses can be filed at any time.

 

 

LINKS ZUR LEHRE

 

Neuroentwicklung
(Vorlesung und Kursteil im Modul Neurobiologie für B.Sc. Biologie, fächerübergreifender Bachelor Major Biologie, B.Sc. Biochemie)

Ausgewählte Aspekte der Zoologie
(Vorlesung im Modul 'Biologie und Grundlagen der Biochemie' für B.Sc. Biochemie)

Neurodegenerative Erkrankungen
(Beitrag zur Vorlesung im Modul 'Molekulare Mechanismen der Pathobiochemie' für M.Sc. Biochemie)

Molekulare Ursachen gestörter Gehirnentwicklung als Risikofaktoren für Schizophrenie (Beitrag zur Vorlesung im Modul 'Neurobiochemistry in Health and Disease', M.Sc. Biochemie)

 

         

 

last update: 03/2019