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Anika Großhennig

 

Wissenschaftliche Mitarbeiterin

 

 

Arbeitsschwerpunkte:

- Planung, Durchführung und Auswertung von klinischen Studien
- Biometrische Beratung von Studenten und wissenschaftlichen Mitarbeitern
- Entwicklung von Lehrkonzepten und Durchführung von Lehrveranstaltungen im Fachgebiet Biometrie/ Medizinstatistik
- Betreuung von Bachelor- und Masterarbeiten

 

Forschungsschwerpunkte:

- Validierung von Biomarkerstudien

- Meta-Analysen

- Methodik für seltene Erkrankungen

 

 

 

 

Institut für Biometrie

Medizinische Hochschule Hannover

OE 8410

30625 Hannover

Telefon: (0511) 532 - 65 07

Fax: (0511) 532 - 42 95

E-Mail: Grosshennig.Anikamh-hannover.de

 


Lebenslauf

Berufliche Tätigkeiten
seit 01/2011 Stellvertretende Institutsleiterin am Institut für Biometrie, Medizinische Hochschule Hannover
03/2009 - 12/2010 Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover
12/2004 – 02/2009 Wissenschaftliche Mitarbeiterin in der Medizinischen Klinik II und dem Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck
Hochschulausbildung
12/2004 - 10/2010 Promotionsstudium der Humanbiologie an der Universität zu Lübeck, Abschluss: Dr. rer. hum. biol., Thema der Promotionsschrift: „Genetisch-epidemiologische Methoden zur Analyse komplexer kardiovaskulärer Phänotypen“
10/2000 – 10/2004 Studium mit Fachrichtung Statistik an der Hochschule Magdeburg-Stendal, Abschluss zur Dipl.-Stat. (FH)
Diplomarbeit: „Statistische Analyse zur Prognose von Krebsmortalitäten - Ein Vergleich von Joinpointregressionen und Bayesianischen Alters-Perioden-Kohortenmodellen“

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Bücher

 

Großhennig, A (2011): Genetisch-epidemiologische Methoden zur Analyse kardiovaskulärer Phänotypen, Südwestdeutscher Verlag für Hochschulschriften, Saarbrücken, ISBN: 978-3-8381-2480-3

Hemmelmann C, Ahnert P, Foraita R, Großhennig A, Scherag A, Biebler KE (Ed) (2011): Biometrische Aspekte der Genomanalyse IV – Next Generation Sequencing Data Analysis, Shaker Verlag, Aachen, ISBN: 978-3-8440-0155-6

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Publikationen

 

Heusser K, Tank J, Holz O, May M, Brinkmann J, Engeli S, Diedrich A, Framke T, Koch A, Großhennig A, Jan Danser AH, Sweep FCGJ, Schindler C, Schwarz K, Krug N, Jordan J, Hohlfeld JM. Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans. Sci Rep. 2019 Mar 6;9(1):3641. doi: 10.1038/s41598-019-40343-w.

 

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I (2019): Cholemic nephropathy causes acute kidney injury and is accompanied by loss of aquaporin 2 in collecting ducts. Hepatology. 2019 May;69(5):2107-2119. doi: 10.1002/hep.30499. Epub 2019 Mar 14.

 

Lingner H, Blase L, Großhennig A, Schmiemann G (2018):Manual therapy applied by general practitioners for nonspecific low back pain: results of the ManRück pilot-study. Chiropr Man Therap. 26:39.

 

Lingner H, Buhr-Schinner H, Hummel S, van der Meyden J, Großhennig A, Nowik D, Schultz K (2018): Short-Term Effects of a Multimodal 3-Week Inpatient Pulmonary Rehabilitation Programme for Patients with Sarcoidosis: The ProKaSaRe Study. Respiration. 95(5):343-353.

 

Spineli LM, Jenz E, Großhennig A, Koch A (2017): Critical appraisal of arguments for the delayed-start design proposed as alternative to the parallel-group randomized clinical trial design in the field of rare disease. Orphanet J Rare Dis. 12(1):140.

 

Abbas M, Steffens S, Bellut M, Eggers H, Großhennig A, Becker JU, Wegener G, Schrader AJ, Grünwald V, Ivany P (2016): Intratumoral expression of programmed death ligand 1 (PD-L1) in patients with clear cell renal cell carcinoma (ccRCC). Med Oncol. 33(7):80.

 

Abbas M, Steffens S, Bellut M, Becker JU, Großhennig A, Eggers H, Wegener G, Kuczyk MA, Kreipe HH, Gründwald A, Schrader AJ, Ivany P (2016): Do programmed death 1 (PD-1) and its ligand (PD-L1) play a role in patients with non-clear cell renal cell carcinoma? Med Oncol. 33(6):59.

 

Heusser K, Tank J, Brinkmann J, Schroeder C, May M, Großhennig A, Wenzel D, Diedrich A, Sweep FC, Mehling H, Luft FC, Jordan J (2016): Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping. J Am Heart Assoc. 13;5(1).

 

Volk V, Schneider A, Spineli LM, Großhennig A, Stripecke R (2016): The gender gap: discrepant human T-cell reconstitution after cord blood stem cell transplantation in humanized female and male mice. Bone Marrow Transplant. 51(4): 596–597.


Deterding K, Grüner N, Buggisch P, Galle PR, Spengler U, Hinrichsen H, Berg T, Potthoff A, Großhennig A, Koch A, Diepolder H, Lüth S, Feyerabend S, Jung MC, Rogalska-Taranta M, Schlaphoff V, Cornberg M, Manns MP, Wedemeyer H, Wiegand J, Hep-Net Acute HCV-III Study Group (2016): Symptoms of anxiety and depression are frequent in patients with acute hepatitis C and are not associated with disease severity. Eur J Gastroenterol Hepatol. 28(2):187-92.

 

Schmiemann G, Blase L, Seeber C, Joos S, Steinhäuser J, Ernst S, Großhennig A, Hummers-Pradier E, Lingner H (2015): Manual Therapy by General Medical Practitioners for Nonspecific Low Back Pain in Primary Care: The ManRuck Study Protocol of a Clinical Trial. J.Chiropr Med. 2015; 14(1):39-45


Lingner H, Großhennig A, Flunkert K, Buhr-Schinner H, Heitmann R, Tönnesmann U, van der Meyden J, Schultz K (2015): ProKaSaRe Study Protocol: A prospective multicenter study of pulmonary rehabilitation of patients with sarcoidosis. JMIR Res Protoc. 4(4):e134.

Hong B, Biertz F, Raab P, Scheinichen D, Ertl P, Großhennig A, Nakamura M, Hermann EJ, Lang JM, Lanfermann H, Krauss J (2015): Normobaric hyperoxia for treatment of pneumocephalus after posterior fossa surgery in the semisitting position: a prospective randomized controlled trial. PLoS One. 2015 May 20;10(5):e0125710. doi: 10.1371/journal.pone.0125710. eCollection 2015.

 

Hueper K, Gueler F, Bräsen JH, Gutberlet M, Jang MS, Lehner F, Richter N, Hanke N, Peperhove M, Martirosian P, Tewes S, Vo Chieu VD, Großhennig A, Haller H, Wacker F, Gwinner W, Hartung D (2015): Functional MRI detects perfusion impairment in renal allografts with delayed graft function. Am.J.Physiol.Renal Physiol. 2015; 308(12):F1444-51

 

Gonnermann A, Framke T, Großhennig A and Koch A (2015): No solution yet for combining two independent studies in the presence of heterogeneity, Statistics in Medicine, 34 (16) pp. 2476-2480, DOI: 10.1002/sim.6473.

 

Schober T, Framke T, Großhennig A, Klein C, Kreipe H, Maecker-Kolhoff B (2015): CD30 in pediatric post-transplant lymphoproliferative disease after solid organ transplant: characterization of a new therapeutic target, Leuk Lymphoma 56(3): 832-3.

 

Kreuzer M, Prüfe J, Bethe D, Vogel C, Großhennig A, Koch A, Oldhafer M, Dierks ML, Albrecht UV, Müther S, Brunkhorst R, Pape L (2014): The TRANSNephro-study examining a new transition model for post-kidney transplant adolescents and an analysis of the present health care: study protocol for a randomized controlled trial. Trials 2014, 15:505.  

 

Ahlenstiel-Grunow T, Koch A, Großhennig A, Frömke C, Sester M, Sester U, Schröder C, Pape L (2014): A multicenter, randomized, open-labeled study to steer immunosuppressive and antiviral therapy by measurement of virus (CMV, ADV, HSV)-specific T cells in addition to determination of trough levels of immunosuppressants in pediatric kidney allograft recipients (IVIST01-trial): study protocol for a randomized controlled trial. Trials 2014, 15:324.

 

Calle Serrano B, Großhennig A, Homs M, Heidrich B, Erhardt A, Deterding K, Jaroszewicz J, Bremer B, Koch A, Cornberg M, Manns MP, Buti M, Wedemeyer H (2014): Development and evaluation of a baseline-event-anticipation score for hepatitis delta. J. Viral Hepat., Mar. 2014.

 

Gillmann HJ, Meinders A, Grosshennig A, Larmann J, Bünte C, Calmer S, Sahlmann B, Rustum S, Aper T, Lichtinghagen R, Koch A, Teebken OE, Theilmeier G (2014): Perioperative Levels and Changes of High-Sensitivity Troponin T Are Associated With Cardiovascular Events in Vascular Surgery Patients. Crit. Care Med., Mar. 2014.

Großhennig A, Benda N, Koch A (2013): The relevance of biomarkers for personalised medicine. Bundesgesundheitsblatt. Gesundheitsforschung. Gesundheitsschutz (56), 1480–1488.
 

Deterding K, Grüner N, Buggisch P, Wiegand J, Galle PR, Spengler U, Hinrichsen H, Berg T, Potthoff A, Malek N, Großhennig A, Koch A, Diepolder H, Lüth S, Feyerabend S, Jung MC, Rogalska-Taranta M, Schlaphoff V, Cornberg M, Manns MP, Wedemeyer H, Hep-Net Acute HCV-III Study Group (2013): Delayed versus immediate treatment for patients with acute hepatitis C: a randomised controlled non-inferiority trial. Lancet Infect Dis.: 13(6):497-506.

Schober T, Framke T, Kreipe H, Schulz TF, Großhennig A, Hussein K, Baumann U, Pape L, Schubert S, Wingen AM, Jack T, Koch A, Klein C, Maecker-Kolhoff B (2013): Characteristics of early and late PTLD development in pediatric solid organ transplant recipients. Transplantation.: 95(1):240-6.

Schiffer L, Schiffer M, Merkel S, Schwarz A, Mengel M, Jürgens C, Schroeder C, Zoerner AA, Püllmann K, Bröcker V, Becker JU, Dämmrich ME, Träder J, Großhennig A, Biertz F, Haller H, Koch A, Gwinner W (2012): Rationale and design of the RIACT-study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a randomized controlled trial. Trials.: 13:199.

Ziegler A, Koch A, Krockenberger K, Großhennig A (2012): Personalized medicine using DNA biomarkers: a review.Hum Genet.: 131(10):1627-38.

Mederacke I, Yurdaydin C, Großhennig A, Erhardt A, Cakaloglu Y, Yalcin K, Gurel S, Zeuzem S, Zachou K, Chatzikyrkou C, Bozkaya H, Dalekos GN, Manns MP, Wedemeyer H, Hep-Net/International Delta Hepatitis Study Group (2012): Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection. J Viral Hepat.: 19(6):387-95.

Atschekzei F, Hennenlotter J, Jänisch S, Großhennig A, Tränkenschuh W, Waalkes S, Peters I, Dörk T, Merseburger AS, Stenzl A, Kuczyk MA, Serth J (2012): SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. Epigenetics: 7(5):447-57

Eggers H, Steffens S, Großhennig A, Becker JU, Hennenlotter J, Stenzl A, Merseburger AS, Kuczyk MA, Serth J (2012): Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma. Int J Oncol.: 40(5):1650-8.

Peters I, Eggers H, Atschekzei F, Hennenlotter J, Waalkes S, Tränkenschuh W, Großhennig A, Merseburger AS., Stenzl A, Kuczyk MA, Serth J (2012): GATA5 CpG island methylation in renal cell cancer: a potential biomarker for metastasis and disease progression. BJU Int.: 110(2 Pt 2):E144-5

Javaher P, Stuhrmann M, Wilke C, Frenzel E, Manukjan G, Großhennig A, Dechend F, Schwaab E, Schmidtke J, Schubert S (2012): Should TSPYL1 mutation screening be included in routine diagnostics of male idiopathic infertility? Fertil Steril.: 97(2):402-6.

Großhennig A, Framke T, Koch A (2011): Now: Prediction intervals - was I2 really an advantage? (epup ): Rapid response on Riley, RD et al. (2011): Interpretation of random effects meta-analyses., BMJ.: 342:d549

Kulik U, Framke T, Großhennig A, Ceylan A, Bektas H, Klempnauer J, Lehner F (2011): Liver resection of colorectal liver metastases in elderly patients. World J Surg.: 35(9):2063-72.

Agustian PA, Schiffer M, Gwinner W, Schäfer I, Theophile K, Modde F, Bockmeyer CL, Traeder J, Lehmann U, Großhennig A, Kreipe HH, Bröcker V, Becker JU (2011): Diminished met signaling in podocytes contributes to the development of podocytopenia in transplant glomerulopathy. Am J Pathol.: 178(5):2007-19.

Tank J, Biller H, Heusser K, Holz O, Diedrich A, Framke T, Koch A, Großhennig A, Koch W, Krug N, Jordan J, Hohlfeld JM (2011): Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: a randomized, placebo controlled, crossover study. PLoS One.: 6(4):e18737.

Damm F, Heuser M, Morgan M, Wagner K, Görlich K, Großhennig A, Hamwi I, Thol F, Surdziel E, Fiedler W, Lübbert M, Kanz L, Reuter C, Heil G, Delwel R, Löwenberg B, Valk PJ, Krauter J, Ganser A (2011): Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood.: 117(17):4561-8.

Reichelt A, Zeckey C, Hildebrand F, Großhennig A, Shin HO, Galanski M, Keberle M (2012): Imaging of the brain in polytraumatized patients comparing 64-row spiral CT with incremental (sequential) CT. Eur J Radiol.: 81(4):789-93.

Erdmann J, Willenborg C, Nahrstaedt J, Preuss M, König IR, Baumert J, Linsel-Nitschke P, Gieger C, Tennstedt S, Belcredi P, Aherrahrou Z, Klopp N, Loley C, Stark K, Hengstenberg C, Bruse P, Freyer J, Wagner AK, Medack A, Lieb W, Großhennig A, Sager HB, Reinhardt A, Schäfer A, Schreiber S, El Mokhtari NE, Raaz-Schrauder D, Illig T, Garlichs CD, Ekici AB, Reis A, Schrezenmeir J, Rubin D, Ziegler A, Wichmann HE, Doering A, Meisinger C, Meitinger T, Peters A, Schunkert H (2011): Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J.: 32(2):158-68.

Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Großhennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH Jr, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T (2010): Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol.: 56(19):1552-63

Teupser D, Baber R, Ceglarek U, Scholz M, Illig T, Gieger C, Holdt LM, Leichtle A, Greiser KH, Huster D, Linsel-Nitschke P, Schäfer A, Braund PS, Tiret L, Stark K, Raaz-Schrauder D, Fiedler GM, Wilfert W, Beutner F, Gielen S, Großhennig A, König IR, Lichtner P, Heid IM, Kluttig A, El Mokhtari NE, Rubin D, Ekici AB, Reis A, Garlichs CD, Hall AS, Matthes G, Wittekind C, Hengstenberg C, Cambien F, Schreiber S, Werdan K, Meitinger T, Loeffler M, Samani NJ, Erdmann J, Wichmann HE, Schunkert H, Thiery J (2010): Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet.: 3(4):331-9.

Ivanyi P, Winkler T, Großhennig A, Reuter C, Merseburger AS, Ganser A, Grünwald V (2010): Treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma is associated with drug-induced hyperparathyroidism: a single center experience in 59 patients. World J Urol.: 28(3):311-7.

Damm F*, Heuser M*, Morgan M, Yun H, Großhennig A, Göhring G, Schlegelberger B, Döhner K, Ottmann O, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Döhner H, Heil G, Ganser A, Krauter J (2009): A single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in cytogenetically normal acute myeloid leukemia patients. J Clin Oncol.: 28(4):578-85.

Ramachandran VS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Großhennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, König IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Völker U, Ingelsson E, Kullo I, Haerting J, O’Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM,  Werdan K, Mitchell GF, Rice K, Arnett D, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Völzke H, Bankenberg S (2009): Genetic Variants Associated with Cardiac Structure and function: A meta-analysis of Genome-wide Association data. JAMA.: 302(2):168-78.

Erdmann J, Großhennig A, Braund PS, König IR, Hengstenberg C, Hall AS, Linsel-Nitschke P, Kathiresan S, Wright B, Trégouët DA, Cambien F, Bruse P, Aherrahrou Z, Wagner AK, Stark K, Schwartz SM, Salomaa V, Elosua R, Melander O, Voight BF, O’Donnell CJ, Peltonen L, Siscovick DS, Altshuler D, Merlini PA, Peyvandi F, Bernardinelli L, Ardissino D, Schillert A, Blankenberg S, Zeller T, Wild P, Schwarz DF, Tiret L, Perret C, Schreiber S, El Mokhtari NE, Schäfer A, März W, Renner W, Bugert P, Klüter H, Schrezenmeir J, Rubin D, Ball SG, Balmforth AJ, Wichmann HE, Meitinger T, Fischer M, Meisinger C, Baumert J, Peters A, Ouwehand WH, Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Deloukas P, Thompson JR, Ziegler A, Samani NJ, Schunkert H (2009): New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet., 41(3):280-2.

Trégouët DA, König IR, Erdmann J, Munteanu A, Braund PS, Hall AS, Großhennig A, Linsel-Nitschke P, Perret C, Desuremain M, Meitinger T, Wright BJ, Preuss M, Balmforth AJ, Ball SG, Meisinger C, Germain C, Evans A, Arveiler D, Luc G, Ruidavets JB, Morrison C, van der Harst P, Schreiber S, Neureuther K, Schafer A, Bugert P, El Mokhtari NE, Schrezenmeir J, Stark K, Rubin D, Wichmann HE, Hengstenberg C, Ouwehand W, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Ziegler A, Tiret L, Thompson JR, Cambien F, Schunkert H, Samani NJ (2009): Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet., 41(3):283-5.

Myocardial Infarction Genetics Consortium (2009): Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants. Nat Genet., 41(3):234-41.

Coronary Artery Disease Consortium (2009): Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol., 29(5):774-80.

Linsel-Nitschke P*, Götz A*, Medack A, König IR, Bruse P, Lieb W, Mayer B, Stark K, Hengstenberg C, Fischer M, Baessler A, Ziegler A, Schunkert H, Erdmann J (2008): Genetic variation in the arachidonate 5-lipoxygenaseactivating protein (ALOX5AP) is associated with myocardial infarction in the german population. Clin Sci (Lond): 115(10):309-15.

Samani NJ, Braund PS, Erdmann J, Götz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M, Hengstenberg C, Stark K, Ziegler A, Caulfield M, Burton PR, Schunkert H, Tobin MD (2008): The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med.: 86(11):1233-41.

Lieb W*, Zeller T*, Mangino M*, Götz A, Braund P,Wenzel JJ, Horn C, Proust C, Linsel-Nitschke P, Amouyel P, Bruse P, Arveiler D, König IR, Ferrieres J, Ziegler A, Balmforth AJ, Evans A, Ducimetiere P, Cambien F, Hengstenberg C, Stark K, Hall AS, Schunkert H, Blankenberg S, Samani NJ, Erdmann J, Tiret L (2008): Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. J Mol Med.: 86(10):1163-70

Linsel-Nitschke P, Götz A, Erdmann J, Braenne I, Braund P, Hengstenberg C, Stark K, Fischer M, Schreiber S, El Mokhtari NE, Schaefer A, Schrezenmeier J, Rubin D, Hinney A, Reinehr T, Roth C, Ortlepp J, Hanrath P, Hall AS, Mangino M, Lieb W, Lamina C, Heid IM, Doering A, Gieger C, Peters A, Meitinger T, Wichmann HE, König IR, Ziegler A, Kronenberg F, Samani NJ, Schunkert H, Wellcome Trust Case Control Consortium (WTCCC), Cardiogenics Consortium(2008): Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease - a Mendelian Randomisation study. PLoS ONE.: 3(8):e2986.

Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Linsel-Nitschke P, Cambien F, Hengstenberg C, Stark K, Blankenberg S, Tiret L, Ducimetiere P, Keniry A, Ghori MJ, Schreiber S, El Mokhtari NE, Hall AS, Dixon RJ, Goodall AH, Liptau H, Pollard H, Schwarz DF, Hothorn LA, Wichmann HE, König IR, Fischer M, Meisinger C, Ouwehand W, Deloukas P, Thompson, JR, Erdmann J, Ziegler A, Samani NJ, Cardiogenics Consortium (2008): Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation, 117(13):1675-84.

Lieb W, Mayer B, König IR, Borwitzky I, Götz A, Kain S, Hengstenberg C, Linsel-Nitschke P, Fischer M, Doring A, Wichmann HE, Meitinger T, Kreutz R, Ziegler A, Schunkert H, Erdmann J (2008): Lack of association between the MEF2A gene and myocardial infarction. Circulation, 117(2): 185–91.

Mayer B, Lieb W, Radke PW, Götz A, Fischer M, Bässler A, Doehring LC, Aherrahrou Z, Liptau H, Erdmann J, Holmer S, Hense HW, Hengstenberg C, Schunkert H (2007): Association between arterial pressure and coronary artery calcification. J Hypertens, 25(8): 1731–8.

Aherrahrou Z, Doehring LC, Kaczmarek PM, Liptau H, Ehlers EM, Pomarino A,Wrobel S, Götz A, Mayer B, Erdmann J, Schunkert H (2007): Ultrafine mapping of DYSCALC1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Physiol Genomics, 28(2): 203–12.

Mayer B*, Lieb W*, Götz A, König, IR, Kauschen LF, Linsel-Nitschke P, Pomarino A, Holmer S, Hengstenberg C, Doering A, Loewel H, Hense HW, Ziegler A, Erdmann J, Schunkert H (2006): Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. J Hypertens, 24(10): 1965–70.

Lieb W*, Graf J*, Götz A, König IR, Mayer B, Fischer M, Stritzke J, Hengstenberg C, Holmer SR, Doring A, Lowel H, Schunkert H, Erdmann J (2006): Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. results of the monica Augsburg echocardiographic substudy. J Mol Med, 84(1): 88–96.

Mayer B, Lieb W, Götz A, König, IR, Aherrahrou Z, Thiemig A, Holmer S, Hengstenberg C, Doering A, Loewel H, Hense HW, Schunkert H, Erdmann J (2005): Association of the T8590C polymorphism of CYP4A11 with hypertension in the monica augsburg echocardiographic substudy. Hypertension, 46(4):766–71.


*authors contributed equally

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