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Publikationen

  • 2017

    Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment.
    Kröger N, Panagiota V, Roesner LM, Kienlin P, Begemann G, Dittrich-Breiholz O, Werfel T.
    J Allergy Clin Immunol. 2017 Oct;140(4):1184-1187.e8.
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    TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD.
    Bikker R, Christmann M, Preuß K, Welz B, Friesenhagen J, Dittrich-Breiholz O, Huber R, Brand K.
    Cell Signal. 2017 Sep;37:123-135.
    Publisher's page

    Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation.
    Kröger N, Panagiota V, Badbaran A, Zabelina T, Triviai I, Araujo Cruz MM, Shahswar R, Ayuk F, Gehlhaar M, Wolschke C, Bollin R, Walter C, Dugas M, Wiehlmann L, Lehmann U, Koenecke C, Chaturvedi A, Alchalby H, Stadler M, Eder M, Christopeit M, Göhring G, Koenigsmann M, Schlegelberger B, Kreipe HH, Ganser A,Stocking C, Fehse B, Thol F, Heuser M.
    Biol Blood Marrow Transplant. 2017 Jul; 23(7): 1095-1101.
    Publisher's page

    Impact of sample processing on human airways microbial metagenomes.
    Wiehlmann L, Pienkowska K, Hedtfeld S, Dorda M, Tümmler B.
    J Biotechnol. 2017 May 20;250:51-55.
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    Multilocus amplicon sequencing of Pseudomonas aeruginosa cystic fibrosis airways isolates collected prior to and after early antipseudomonal chemotherapy.
    Fischer S, Greipel L, Klockgether J, Dorda M, Wiehlmann L, Cramer N, Tümmler B.
    J Cyst Fibros. 2017 May;16(3):346-352.
    Publisher's page

    Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.
    Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A.
    Dev Biol. 2017 Mar 15;423(2):170-188.
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  • 2016

    Filtration and Normalization of Sequencing Read Data in Whole-Metagenome Shotgun Samples.
    Chouvarine P, Wiehlmann L, Moran Losada P, DeLuca DS, Tümmler B.
    PLoS One. 2016 Oct 19;11(10):e0165015.
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    The cystic fibrosis lower airways microbial metagenome.
    Moran Losada P, Chouvarine P, Dorda M, Hedtfeld S, Mielke S, Schulz A, Wiehlmann L, Tümmler B.
    ERJ Open Res. 2016 May 9;2(2). pii: 00096-2015.
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    Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients.
    Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, Cramer N, Tümmler B.
    Antimicrob Agents Chemother. 2016 Oct 21;60(11):6726-6734.
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    Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14.
    Fischer S, Klockgether J, Morán Losada P, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Dorda M, Goesmann A, Hilker R, Mielke S, Schönfelder T, Suerbaum S, Türk O, Woltemate S, Wiehlmann L, Tümmler B.
    Environ Microbiol Rep. 2016 Apr;8(2):227-34.
    Publisher's page

  • 2015

    C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages.
    Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R.
    Biochimica et Biophysica Acta. 2015; 1849(8):966-78.
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    Transcriptional profiling of intestinal CD4+ T cells in the neonatal and adult mice.
    Torow N, Dittrich-Breiholz O, Hornef MW.
    Genomics Data. 2015; 5: 371–374.
    Publisher's page

    The Histamine H4 Receptor Regulates Chemokine Production in Human Natural Killer Cells.
    Mommert S, Dittrich-Breiholz O, Stark H, Gutzmer R, Werfel T.
    International Archives of Allergy and Immunology. 2015; 166:225-230.
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    The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.
    Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.
    Cell Reports. 2015; pii: S2211-1247(15)00002-9.
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    Habitat-associated skew of clone abundance in the Pseudomonas aeruginosa population.
    Wiehlmann L, Cramer N, Tümmler B.
    Environ Microbiol Rep. 2015 Dec;7(6):955-60.
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    Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment.
    Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B.
    Environ Microbiol. 2015 Jan;17(1):29-46.
    Publisher's page

  • 2014

    Stromal cells as trend-setters for cells migrating into the lymph node.
    Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U.
    Mucosal Immunology. 2014; 10.1038/mi.2014.97.
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    THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
    Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.
    Nucleic Acids Research. 2014; 42(19):12249-60.
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    DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
    Zmora P, Blazejewska P, Moldenhauer AS, Welsch K, Nehlmeier I, Wu Q, Schneider H, Pöhlmann S, Bertram S.
    Journal of Virology. 2014; 88(20):12087-97.
    Publisher's page

    Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing.
    López ML, Bruges G, Crespo G, Salazar V, Deglesne PA, Schneider H, Cabrera-Fuentes H, Schmitz ML, Preissner KT.
    Thrombosis and Haemostasis. 2014; 112(5):992-1001.
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    Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer.
    Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.
    Gastroenterology. 2014; S0016-5085(14)00461-2.
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    Identification of Two Forms of TNF Tolerance in Human Monocytes: Differential Inhibition of NF-κB/AP-1- and PP1-Associated Signaling.
    Günther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K.
    The Journal of Immunology. 2014; 192(7):3143-55.
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    THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
    Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.
    Nucleic Acids Res. 2014 Oct 29;42(19):12249-60.
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    Genetic characterization of acquired aplastic anemia by targeted sequencing.
    Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brümmendorf TH, Dugas M, Ganser A, Thol F.
    Haematologica. 2014 Sep;99(9):e165-7.
    Publisher's page

    In vivo imaging of bioluminescent Pseudomonas aeruginosa in an acute murine airway infection model.
    Munder A, Wölbeling F, Klockgether J, Wiehlmann L, Tümmler B.
    Pathog Dis. 2014 Oct;72(1):74-7.
    Publisher's page

    Advances in understanding Pseudomonas.
    Tümmler B, Wiehlmann L, Klockgether J, Cramer N.
    F1000Prime Rep. 2014 Feb 3;6:9.
    Publisher's page

    Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.
    Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, Kirchner A, Huang L, Chaturvedi A, Wichmann M, Wiehlmann L, Shahswar R, Damm F, Göhring G, Schlegelberger B, Schlenk R, Döhner K, Döhner H, Krauter J, Ganser A, Heuser M.
    Blood. 2014 Feb 6;123(6):914-20.
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  • 2013

    Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression.
    Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.
    Molecular Cell. 2013; 10.1016/j.molcel.2013.12.002.
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    The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells.
    Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF.
    PLOS Pathogens. 2013; 10.1371/journal.ppat.1003737.
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    Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.
    Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.
    Cell Death & Disease. 2013; 4:e879.
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    Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
    Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ.
    Molecular and Cellular Biology. 2013; 33(13):2586-602.
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    Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1.
    Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H.
    The Journal of Biological Chemistry. 2013; 288(26):19250-9.
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    THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
    Saran S, Tran DD, Klebba-Färber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R, Tamura T.
    BMC Cell Biol. 2013 Nov 22;14:51. doi: 10.1186/1471-2121-14-51.
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    EU FP7 funded COST Action BM1003 "Cell surface virulence determinants of cystic fibrosis pathogens". Developing an international Pseudomonas aeruginosa reference panel.
    De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JE, Burns JL, Sá-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tümmler B, McClean S, Winstanley C.
    Microbiology open. 2013 Dec;2(6):1010-23.
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    Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence.
    Klockgether J, Miethke N, Kubesch P, Bohn YS, Brockhausen I, Cramer N, Eberl L, Greipel J, Herrmann C, Herrmann S, Horatzek S, Lingner M, Luciano L, Salunkhe P, Schomburg D, Wehsling M, Wiehlmann L, Davenport CF, Tümmler B.
    Environ Microbiol. 2013 Jan;15(1):191-210.
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  • 2012

    The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.
    Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.
    Nucleic Acids Research. 2012; 1–20.
    Publisher's page

    Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor.
    Hansen B, Dittrich-Breiholz O, Kracht M, Windheim M.
    Cellular Signalling. 2012; 25(1):214-228.
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    Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCγ1 and Activating NFAT1-dependent RCAN1 Expression.
    Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Hävemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF.
    PLoS Pathogens. 2012; 8(9):e1002927.
    Publisher's page

    Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling.
    Rehren F, Ritter B, Dittrich-Breiholz O, Henke A, Lam E, Kati S, Kracht M, Heim A.
    Medical Microbiology and Immunology. 2012;
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    Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages.
    Zeitvogel J, Dalpke A, Eiz-Vesper B, Kracht M, Dittrich-Breiholz O, Werfel T, Wittmann M.
    The Journal of Biological Chemistry. 2012;
    Publisher's page

    Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo.
    Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E, Förster R.
    European Journal of Immunology. 2012; 42(1):48-57.
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    Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal a-toxin.
    Kasraie S, Niebuhr M, Kopfnagel V, Dittrich-Breiholz O, Kracht M, Werfel T.
    Allergy. 2012; 67(1):41-49.
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    Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis.
    Cramer N, Wiehlmann L, Ciofu O, Tamm S, Høiby N, Tümmler B.
    PLoS One. 2012;7(11):e50731.
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    Molecular typing and epidemiological investigation of clinical populations of Pseudomonas aeruginosa using an oligonucleotide-microarray.
    Ballarini A, Scalet G, Kos M, Cramer N, Wiehlmann L, Jousson O.
    BMC Microbiol. 2012 Jul 27;12:152.
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    Genotypic analysis of UK keratitis-associated Pseudomonas aeruginosa suggests adaptation to environmental water as a key component in the development of eye infections.
    Shankar J, Sueke H, Wiehlmann L, Horsburgh MJ, Tuft S, Neal TJ, Kaye SB, Winstanley C.
    FEMS Microbiol Lett. 2012 Sep;334(2):79-86.
    Publisher's page

    Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure.
    Selezska K, Kazmierczak M, Müsken M, Garbe J, Schobert M, Häussler S, Wiehlmann L, Rohde C, Sikorski J.
    Environ Microbiol. 2012 Aug;14(8):1952-67.
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    Effective prevention of Pseudomonas aeruginosa cross-infection at a cystic fibrosis centre - results of a 10-year prospective study.
    Wiehlmann L, Cramer N, Ulrich J, Hedtfeld S, Weissbrodt H, Tümmler B.
    Int J Med Microbiol. 2012 Mar;302(2):69-77.
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  • 2011

    Intranodal Interaction with Dendritic Cells Dynamically Regulates Surface Expression of the Co-stimulatory Receptor CD226 Protein on Murine T Cells.
    Seth S, Qiu Q, Danisch S, Maier MK, Braun A, Ravens I, Czeloth N, Hyde R, Dittrich-Breiholz O, Förster R, Bernhardt G.
    The Journal of Biological Chemistry. 2011; 286(45):39153-63.
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    Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells.
    Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF.
    Journal of Virology. 2011; 85(19):10375-10388.
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    Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism.
    Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H.
    The Journal of Biological Chemistry. 2011; 286(38):33279-33288.
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    Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.
    Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, Tamura T.
    BMC Genomics. 2011; 12196.
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    Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.
    Gerhard R, Queisser S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
    Naunyn Schmiedeberg's Archives of Pharmacology. 2011; 383(3):285-295.
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    Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines.
    Gregorovic G, Bosshard R, Karstegl CE, White RE, Pattle S, Chiang AK, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
    Journal of Virology. 2011; 85(7):3535-45.
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    Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.
    Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E.
    Oncogene. 2011;
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    c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.
    Rzeczkowski K, Beuerlein K, Müller H, Dittrich-Breiholz O, Schneider H, Kettner-Buhrow D, Holtmann H, Kracht M.
    The Journal of Cell Biology. 2011; 194(4):581-596.
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    Pseudomonas aeruginosa Genomic Structure and Diversity.
    Klockgether J, Cramer N, Wiehlmann L, Davenport CF, Tümmler B.
    Front Microbiol. 2011 Jul 13;2:150.
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    Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections.
    Stewart RM, Wiehlmann L, Ashelford KE, Preston SJ, Frimmersdorf E, Campbell BJ, Neal TJ, Hall N, Tuft S, Kaye SB, Winstanley C.
    J Clin Microbiol. 2011 Mar;49(3):993-1003.
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    Genotypic and phenotypic characterization of Pseudomonas aeruginosa isolates from urinary tract infections.
    Tielen P, Narten M, Rosin N, Biegler I, Haddad I, Hogardt M, Neubauer R, Schobert M, Wiehlmann L, Jahn D.
    Int J Med Microbiol. 2011 Apr;301(4):282-92.
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  • 2010

    IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA.
    Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H.
    The Journal of Biological Chemistry. 2010; 285(38):29165-78.
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    Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
    Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H.
    Cell Death and Differentiation. 2010; 17(9):1435-47.
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    Role of the Kaposi's Sarcoma-Associated Herpesvirus K15 SH3 Binding Site in Inflammatory Signaling and B-Cell Activation.
    Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.
    Journal of Virology. 2010; 84(16):8231-40.
    Publisher's page

    Clonal epidemiology of Pseudomonas aeruginosa in cystic fibrosis.
    Cramer N, Wiehlmann L, Tümmler B.
    Int J Med Microbiol. 2010 Dec;300(8):526-33.
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    Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains.
    Klockgether J, Munder A, Neugebauer J, Davenport CF, Stanke F, Larbig KD, Heeb S, Schöck U, Pohl TM, Wiehlmann L, Tümmler B.
    J Bacteriol. 2010 Feb;192(4):1113-21.
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  • 2009

    Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways.
    Berg D, Stühmer T, Siegmund D, Müller N, Giner T, Dittrich-Breiholz O, Kracht M, Bargou R, Wajant H.
    FEBS Journal. 2009; 276(23):6912-27.
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    Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
    Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML.
    EMBO reports. 2009; 10(4):381-86.
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    Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.
    Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A.
    Inflammatory Bowel Diseases. 2009; 15(12):1812-23.
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    Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
    Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D.
    The Journal of Experimental Medicine. 2009; 206(10):2161-77.
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    Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner.
    Mosa A, Trumstedt C, Eriksson E, Soehnlein O, Heuts F, Janik K, Klos A, Dittrich-Breiholz O, Kracht M, Hidmark Å, Wigzell H, Rottenberg ME.
    Infection and Immunity. 2009; 77(7):2908-2918.
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    Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus.
    Wang L, Pietrek M, Brinkmann MM, Havemeier A, Fischer I, Hillenbrand B, Dittrich-Breiholz O, Kracht M, Chanas S, Blackbourn DJ, Schulz TF.
    Journal of General Virology. 2009; 90(Pt 5):1190-1201.
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    Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease.
    Rakhimova E, Wiehlmann L, Brauer AL, Sethi S, Murphy TF, Tümmler B.
    J Infect Dis. 2009 Dec 15;200(12):1928-35.
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    Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis.
    Mainz JG, Naehrlich L, Schien M, Käding M, Schiller I, Mayr S, Schneider G, Wiedemann B, Wiehlmann L, Cramer N, Pfister W, Kahl BC, Beck JF, Tümmler B.
    Thorax. 2009 Jun;64(6):535-40.
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    Visualization of Pseudomonas genomic structure by abundant 8-14mer oligonucleotides.
    Davenport CF, Wiehlmann L, Reva ON, Tümmler B.
    Environ Microbiol. 2009 May;11(5):1092-104. doi: 10.1111/j.1462-2920.2008.01839.x. Epub 2009 Jan 21.
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  • 2008

    CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties.
    del Rio ML, Rodriguez-Barbosa JI, Bölter J, Ballmaier M, Dittrich-Breiholz O, Kracht M, Jung S, Förster R.
    The Journal of Immunology. 2008; 181(9):6178-88.
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    Transcriptional Regulation of EGR-1 by the Interleukin-1-JNK-MKK7-c-Jun Pathway.
    Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M.
    The Journal of Biological Chemistry. 2008; 283(18):12120-28.
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    Differential Gene Regulation by Epstein-Barr Virus Type 1 and Type 2 EBNA2.
    Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
    Journal of Virology. 2008; 82(15):7456-66.
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    c-Jun Controls Histone Modifications, NF-κB Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene.
    Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M.
    Molecular and Cellular Biology. 2008; 28(13):4407-4423.
    Publisher's page

    Transcript profiling of the Pseudomonas aeruginosa genomic islands PAGI-2 and pKLC102.
    Klockgether J, Würdemann D, Wiehlmann L, Tümmler B.
    Microbiology. 2008 Jun;154(Pt 6):1599-604.
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    The neglected intrinsic resistome of bacterial pathogens.
    Fajardo A, Martínez-Martín N, Mercadillo M, Galán JC, Ghysels B, Matthijs S, Cornelis P, Wiehlmann L, Tümmler B, Baquero F, Martínez JL.
    PLoS One. 2008 Feb 20;3(2):e1619.
    Publisher's page

  • 2007

    The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK.
    Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.
    Molecular and Cellular Biology. 2007; 27(1):170-81.
    Publisher's page

    Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus.
    Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF.
    Journal of Virology. 2007; 81(1):42-58.
    Publisher's page

    Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.
    Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF.
    Journal of General Virology. 2007; 88(Pt 6):1698-707.
    Publisher's page

    Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets.
    Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H.
    Molecular and Cellular Biology. 2007; 27(23):8388-8400.
    Publisher's page

    Functional genomics of Pseudomonas aeruginosa to identify habitat-specific determinants of pathogenicity.
    Wiehlmann L, Munder A, Adams T, Juhas M, Kolmar H, Salunkhe P, Tümmler B.
    Int J Med Microbiol. 2007 Nov;297(7-8):615-23.
    Publisher's page

    Population structure of Pseudomonas aeruginosa.
    Wiehlmann L, Wagner G, Cramer N, Siebert B, Gudowius P, Morales G, Köhler T, van Delden C, Weinel C, Slickers P, Tümmler B.
    Proc Natl Acad Sci U S A. 2007 May 8;104(19):8101-6.
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    Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa.
    Klockgether J, Würdemann D, Reva O, Wiehlmann L, Tümmler B.
    J Bacteriol. 2007 Mar;189(6):2443-59.
    Publisher's page

  • 2006

    Identification of Mouse Genes With Highly Specific Expression Patterns in Differentiated Intestinal Epithelium.
    Schröder N, Sekhar A, Geffers I, Müller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A.
    Gastroenterology. 2006; 130(3):902-7.
    Publisher's page

    Inhibition of mRNA deadenylation and degradation by different types of cell stress.
    Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H.
    Biological Chemistry. 2006; 387(3):323-7.
    Publisher's page

    Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NF?B-MAPK signaling pathways.
    Kettner-Buhrow D, Dittrich-Breiholz O, Schneider H, Wolter S, Resch K, Kracht M.
    Biochemical and Biophysical Research Communications. 2006; 347(3):566-73.
    Publisher's page

    Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions.
    Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzmer R, Werfel T.
    The Journal of Immunology. 2006; 177(7):4444-50.
    Publisher's page

    Cell target genes of Epstein–Barr virus transcription factor EBNA-2: induction of the p55a regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
    Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ.
    Journal of General Virology. 2006; 87(Pt 10):2859-67.
    Publisher's page

    Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals.
    Ansari AW, Bhatnagar N, Dittrich-Breiholz O, Kracht M, Schmidt RE, Heiken H.
    International Immunology. 2006; 18(10):1443-51.
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    Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
    Bragonzi A, Wiehlmann L, Klockgether J, Cramer N, Worlitzsch D, Döring G, Tümmler B.
    Microbiology. 2006 Nov;152(Pt11):3261-9.
    Publisher's page

  • 2005

    GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB.
    Juhas M, Wiehlmann L, Salunkhe P, Lauber J, Buer J, Tümmler B.
    FEMS Microbiol Lett. 2005 Jan 15;242(2):287-95.
    Publisher's page

    Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
    Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
    Clinical & Experimental Allergy. 2005; 35(8):1088-95.
    Publisher's page

    MEK1-dependent Delayed Expression of Fos-related Antigen-1 Counteracts c-Fos and p65 NF-?B-mediated Interleukin-8 Transcription in Response to Cytokines or Growth Factors.
    Hoffmann E, Thiefes A, Buhrow D, Dittrich-Breiholz O, Schneider H, Resch K, Kracht M.
    The Journal of Biological Chemistry. 2005; 280(10):9706-18.
    Publisher's page

    Simultaneous Blockade of NF?B, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes.
    Thiefes A, Wolter S, Mushinski JF. Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M.
    The Journal of Biological Chemistry. 2005; 280(30):27728-41.
    Publisher's page

    Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing.
    Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H.
    Molecular and Cellular Biology. 2005; 25(15):6363-79.
    Publisher's page

    Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
    Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
    Clinical & Experimental Allergy. 2005; 35(8):1088-95.
    Publisher's page

  • 2004

    Structure of Pseudomonas aeruginosa populations analyzed by single nucleotide polymorphism and pulsed-field gel electrophoresis genotyping.
    Morales G, Wiehlmann L, Gudowius P, van Delden C, Tümmler B, Martínez JL, Rojo F.
    J Bacteriol. 2004 Jul;186(13):4228-37.
    Publisher's page

    Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.
    Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML.
    Blood. 2004; 104(10):3302-4.
    Publisher's page

    NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.
    Kreuz S, Siegmund D, Rumpf J, Samel D, Leverkus M, Janssen O, Häcker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H.
    The Journal of Cell Biology. 2004; 166(3):369-80.
    Publisher's page

  • 2003

    Entwicklung und Evaluierung eines DNA Mikroarrays für entzündungsrelevante Gene.
    Dittrich-Breiholz O, Schneider H, Wehmeier L, Resch K, Kracht M.
    Biospektrum. 2003; 1/03:88-92.
    Publisher's page

    Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess.
    Wehmeier L, Dittrich-Breiholz O, Kracht M.
    Managment und Krankenhaus. 2003;
    Publisher's page

    Disruption of the c-JUN-JNK Complex by a Cell-permeable Peptide Containing the c-JUN δ Domain Induces Apoptosis and Affects a Distinct Set of Interleukin-1-induced Inflammatory Genes.
    Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M.
    The Journal of Biological Chemistry. 2003; 278(41):40213-23.
    Publisher's page

  • 2002

    Multiple control of interleukin-8 gene expression.
    Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M.
    Journal of Leukocyte Biology. 2002; 72(5):847-855.
    Publisher's page