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Research Profile

 1

R E S E A R C H   P R O F I L E  

The Clinic of Pneumology has five main Research Projects, maintains a separate Department of Experimental Pneumology and participates in the German Center for Pulmonary Research (DZL):

 

• Department of Experimental Pneumology

 
• DZL/BREATH


• Molecular pneumology


• Fibrotic lung diseases 


• Respiratory diseases (bronchial asthma, COPD, allergic rhinitis)


• Cardiopulmonary interactions (pulmonary hypertension)


• Lung transplantation

In the following section, we would like to report on the work of the research Groups:

  • MOLECULAR PNEUMOLOGY WITH FOCUS ON PROTEASE/ANTI-PROTEASE-SYSTEMS

     

    The lack of α1-Antitrypsin is a crucial reason for especially serious and early onset form of chronic obstructive bronchitis (COPD) and of emphysema.  In the group Molecular Pneumology of Prof. Dr. med. Sabina-Marija Janciaskiene acute and chronic inflammatory reactions will be investigated with focus on the role of protease/anti-protease-systems in the regulation of defence mechanisms in the innate immune system.

  • FIBROTIC LUNG DISEASES

     

    The pathogenesis of fibrotic lung diseases is a focus in cooperation between MHH and Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM, Prof. Dr. Antje Prasse, staff member from both departments). 

     

    The objective of the research group is to identify and test new diagnostic methods and biomarkers for the disease and response to therapy. A further focus is to test new therapeutic strategies for idiopathic pulmonary fibrosis as part of clinical studies. 

    Within the project supported by Federal Ministry of Education and Research, the development of idiopathic pulmonary fibrosis is examined with special emphasis on development of acute exacerbations.

     

     

  • RESPIRATORY DISEASES (BRONCHIAL ASTHMA, COPD, ALLERGIC RHINITIS)

     

    The pathophysiology of respiratory diseases, especially allergic disorders, is one focus of the cooperation between MHH and Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM, Prof. Hohlfeld, staff member from both departments). 

    For clinical research of phases I and II, the ITEM has elaborated diagnostic methods (gas analysis, Respiratory particle analysis, sputum diagnostics) and different provocation models (pollen room, ‎bronchoscopic segmental provocation, ozone provocation, rhino virus provocation). 

    The technical equipment  for fundamental and clinical research  complement  each other and enable joint projects by German center for pulmonary research and Clinical Research Center Hannover (www.crc-hannover.de). 

    The clinic of pneumology carries out research studies for  testing new diagnostic methods ans therapies in the field of  asthma and COPD. Besides clinical studies, we mainly explore bronchoscopical interventions on patients with severe obstructive airways diseases. 

    In the course of several projects funded by the Federal Ministry of Education and Research, we investigate long term developments in asthma and COPD.

     

     

  • CARDIOPULMONARY INTERACTIONS (PULMONARY HYPERTENSION)


    Prof. Dr. med Marius Hoeper is leading the pulmonary hypertension unit. 

    This working group currently includes Dr. med. Katrin Meyer and PD Dr. med. Karen Olsson. The more important thematic focus point over the last years was and is the development of new therapies to all types of pulmonary hypertension.

     

    >> HERE you will find detailed information about our outpatient clinic for pulmonary hypertonie.

     

    >> HERE you will find detailed information about pulmonary hypertonie.

  • LUNG TRANSPLANTATION

     

    The lung transplantation program is carried on by the Clinic of Pneumology and Clinic Heart, Thoracic, and Transplant Surgery. Research expertise of the transplants department include early recognition of risk factors and the treatment of chronic transplant failure, treatment of respiratory complications, research into the infections after transplantation and new methods of patient training.

     

    The department is financed from national funds and incorporated into the integrated research and treatment center transplantation (IFB) and into the German center for pulmonary research (DZL). 

     

    Aside from numerous clinical projects there are  connections to basic research.   

     

    You can find the current List of publications >> HERE .