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Dr. Timm Fiebig

 

Diplom-Biochemiker

Wissenschaftlicher Mitarbeiter (PostDoc)

 

  

Gebäude J3, Ebene 04, Raum 2261 oder 1240

Tel.: +49(0)511/532-5210 oder -9805

FAX: +49(0)511/532-8801

 

E-Mail: Fiebig.Timm(at)mh-hannover.de

 

 

Research interests

 

-         Biochemical and structural characterisation of bacterial capsule polymerases

 

-         In vitro production of bacterial capsular polysaccharides

 

-         Vaccine development


 

 

Publications

 

 

Litschko C., Oldrini D., Budde I., Berger M., Meens J., Gerardy-Schahn R., Berti F., Schubert M., Fiebig T. (2018) A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers in Gram-Negative Pathogens. MBio. 9, e00641-18

 

Oldrini D., Fiebig T., Romano M. R., Proietti D., Berger M., Tontini M., De Ricco R., Santini L., Morelli L., Lay L., Gerardy-Schahn R., Berti F., Adamo R. (2018) Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens. ACS Chem. Biol. 13, 984–994

 

Fiebig T., Litschko C., Freiberger F., Bethe A., Berger M., Gerardy-Schahn R. (2017). Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production. J Biol Chem, e-pub ahead of print: Nov 29, 2017, doi: 10.1074/jbc.RA117.000488.

 

Fiebig T., Romano M.R., Oldrini D., Adamo R., Tontini M., Brogioni B., Santini L., Berger M., Costantino P., Berti F., Gerardy-Schahn R. (2016). An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate. npj Vaccines 1: B71-B77

 

Litschko C., Romano M.R., Pinto V., Claus H., Vogel U., Berti F.,Gerardy-Schahn R., Fiebig T. (2015). The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyzes the Synthesis of a Complex Trimeric Repeating Unit Comprising Glycosidic and Phosphodiester Linkages. J Biol Chem 290: 24355-24366

 

Fiebig T., Berti F., Freiberger F., Pinto V., Claus H., Romano M.R., Proietti D., Brogioni B., Stummeyer K., Berger M., Vogel U., Costantino P., Gerardy-Schahn R. (2014). Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: a new perspective for vaccine development. Glycobiology 24: 150-158

 

Fiebig T., Freiberger F., Pinto V., Romano M.R., Black A., Litschko C., Bethe A., Yashunsky D., Adamo R., Nikolaev A., Berti F., Gerardy-Schahn R. (2014) Molecular cloning and functional characterisation of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: towards in vitro vaccine production. J Biol Chem 289: 19395-19407

 

Haselhorst T., Fiebig T., Dyason J. C., Fleming F. E., Blanchard H., Coulson B.S., and von Itzstein M. (2011) Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles. Angew. Chem. Int. Ed. 50: 1055-1058.