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Department of Experimental Pneumology

 

D E P A R T M E N T   O F   E X P E R I M E N T A L   P N E U M O L O G Y

 

Warm welcome to Department of Experimental Pneumology in our Clinic!


Here you will find all information on our projects, staff members, job offers and much more!

 

 

  • C O N T A C T I N F O R M A T I O N

     


    Contact Person  

     

    Univ.-Prof. Dr. rer. nat. Ulrich A. Maus


    Position


    Department Head

    Principal Investigator des Deutschen Zentrums für Lungenforschung (DZL)


    Administration


    Monica Angyal

    Tel. 0511 / 532 9617

    Fax. 0511 / 532 9699


    Address


    Medizinische Hochschule Hannover

    Abteilung für Experimentelle Pneumologie

    Feodor-Lynen-Strasse 21 + 23

    30625 Hannover

  • O V E R V I E W


    The Department of Experimental Pneumology mainly deals with basic research of pathobiology pulmonary bacterial and mycobacterial infections.  

    One focus of our activities lays in characterization of the immune response mechanisms of the lung against inhaled bacterial pathogens and in the development and testing of new interventions for improving the pulmonary immune response.

    Basic principles of our infectious biology research are animal models of pulmonary infections and of chronic lung disease.

  • P R O J E C T S

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    S E L E C T E D   T H I R D - P A R T Y   F U N D E D   R E S E A R C H   P R O J E C T S :

     

    •  Characterization of the pulmonary infection defence mechanisms of chronic pulmonary diseases. 

       (Sub-Project  A12 of  SFB 587)

        Funding:  DFG 


    •  Mechanisms of the immune paralysis  for trauma/ haemorrhage and consecutive pneumococcal pneumonia. 

        Funding:  DFG. 
     


    •  Function of mononuclear phagocytes in the early stages of pulmonary mycobacterial infections. 

        Funding: Lower Saxony's society to fight tuberculosis e.V.

     


    •  Susceptibility through infections: Functional significance of the heightened cholesterol biosynthesis by

        pneumococcal pneumonia or by pneumogenic sepsis (PROGRESS II , Sub-Project).

        Funding: BMBF.


    •  The evaluation of therapeutical efficiency of neautral  serine protease  for pulmonary defence against infection

        of mycobacterial infections in the mouse (CG/NE).

        Funding: BMBF.

     

    • Characterization of the pathobiology of the acute lung damage after bacterial infections within the framework

       of DZL (German Center for Lung Research), location BREATH Hannover.

       Funding: BMBF.

     

  • P R O G R A M S

     

    P R O G R A M S   A I M E D   A T   P R O M O T I N G   A   N E W   G E N E R A T I O N   

    O F   S C I E N T I F I C  / M E D I C A L   T A L E N T

     

     

    O U R   D E P A R T M E N T   I S   I N V O L V E D   I N  

     

    •  MD/PhD - Program  "Molecular Medicine" of the MHH


    •  PhD - Program "Infection Biology" of the Centre for Infectionbiology (ZIB) of the MHH


    •  StrucMed - Program oft he MHH aimed at promoting a new generation of medical and scientific talents


    •  "Biomedicine" - Program of the MHH 

  • P U B L I C A T I O N S

     

    S E L E C T E D   P U B L I C A T I O N S   F R O M   2 0 0 7  

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    Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tort Tarres M, Hoymann HG, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA. Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax. 70:636-646, 2015.

     

    Knippenberg S, Brumshagen C, Aschenbrenner F, Welte T, Maus UA. Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. Eur J Immunol. 45:1716-1726, 2015.

    Bischof A, Brumshagen C, Ding N, Kirchhof G, Briles DE, Gessner JE, Welte T, Mack M, Maus UA. Basophil expansion protects against invasive pneumococcal disease in mice. J Infect Dis 210:14-24, 2014.

     
    Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Mägel L, Welte T, Yamasaki S, Maus UA. Macrophage-inducible C-type lectin Mincle expressing dendritic cells contribute to control splenic Mycobacterium bovis BCG infection in mice. Infect Immun. 2014 IAI.02500-14. [Epub ahead of print]

     

    Steinwede K*, Henken S*, Bohling J, Maus R, Ueberberg B, Brumshagen C, Brincks EL, Griffith TS, Welte T, Maus UA. TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice. J Exp Med 209: 1937 - 1952, 2012 (*shared first authorship).

     

    Brumshagen C, Maus R, Bischof A, Ueberberg B, Bohling J, Osterholzer JJ, Ogunniyi AD, Paton JC, Welte T, Maus UA. FMS-like tyrosine kinase-3 ligand (Flt3L) treatment of mice aggravates acute lung injury in response to S. pneumoniae: role of pneumolysin. Infect Immun 80: 4281 - 4290, 2012.

     

    Ding N, Dahlke K, Janze AK, Mailer PC, Maus R, Bohling J, Welte T, Bauer M, Riedemann NC, Maus UA. Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice. J Trauma Acute Care Surg 73: 861 - 868, 2012.

     

    Behler F, Steinwede K, Balboa L, Ueberberg B, Maus R, Kirchhof G, Yamasaki S, Welte T, Maus UA. Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice. J Immunol 189: 3121 - 3129, 2012.

     

    Steinwede K, Maus R, Bohling J, Voedisch S, Braun A, Ochs M, Schmiedl A, Länger F, Gauthier F, Roes J, Welte T, Bange FC, Niederweis M, Bühling F, Maus UA. Cathepsin G and Neutrophil Elastase Contribute to Lung-Protective Immunity against Mycobacterial Infections in Mice. J Immunol 188: 4476 - 4487, 2012.

     

    Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA *, Bauer M *. Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 26: 2424 - 2436, 2012. (* shared senior authorship).

     

    Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott EW, Christman JW. Functional PU.1 in macrophages has a pivotal role in NF-kB activation and neutrophilic lung inflammation during endotoxemia. Blood 118: 5255 - 5266, 2011.

     

    Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Länger F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA. Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. J Immunol 187: 5346 - 5356, 2011.

     

    Hahn I, Klaus A, Janze AK, Steinwede K, Ding N, Bohling J, Brumshagen C, Serrano H, Gauthier F, Paton JC, Welte T, Maus UA. Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun 79: 4893 - 4901, 2011.

     

    Hahn I, Klaus A, Maus R, Christman JW, Welte T, Maus UA. Dendritic Cell Depletion and Repopulation in the Lung after Irradiation and Bone Marrow Transplantation in Mice. Am J Respir Cell Mol Biol 45: 534 - 541, 2011.

     

    Jonigk D, Golpon H, Bockmeyer CL, Maegel L, Hoeper MM, Gottlieb J, Nickel N, Hussein K, Maus U, Lehmann U, Janciauskiene S, Welte T, Haverich A, Rische J, Kreipe H, Laenger F. Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment.  Am J Pathol 179: 167 - 179, 2011.

     

    Henken S, Bohling J, Martens-Lobenhoffer J, Paton JC, Ogunniyi AD, Briles DE, Salisbury VC, Wedekind D, Bode-Böger SM, Welsh T, Bange FC, Welte T, Maus UA. Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 54: 707 - 717, 2010.

     

    Herbold W, Maus R, Hahn I, Ding N, Srivastava M, Christman JW, Mack M, Reutershan J, Briles DE, Paton JC, Winter C, Welte T, Maus UA. Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect Immun 78: 2620 - 2630, 2010.

     

    Henken S, Bohling J, Ogunniyi AD, Paton JC, Salisbury VC, Welte T, Maus UA. Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumoniae serotypes. Antimicrob Agents Chemother 54: 3155 - 3160, 2010.

     

    Winter C, Herbold W, Maus R, Länger F, Briles DE, Paton JC, Welte T, Maus UA. Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae.  J Immunol 182: 4931 - 4937, 2009. 

     

    Denzel A, Maus UA, Gomez MR, Moll C, Niedermeier M, Winter C, Maus R, Hollingshead S, Briles DE, Kunz-Schughart LA, Talke Y, Mack M. Basophils enhance immunological memory responses. Nat Immunol 9: 733 - 742, 2008.

     

    Taut K, Winter C, Briles DE, Paton JC, Christman JW, Maus R, Baumann R, Welte T, Maus U. Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae. Am J Respir Cell Mol Biol 38: 105 - 113, 2008.

     

    Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. Mice That Overexpress CC Chemokine Ligand 2 in Their Lungs Show Increased Protective Immunity to Infection with Mycobacterium bovis Bacille Calmette-Guérin. J Infect Dis 198: 1044 - 1054, 2008.

     

    Winter C, Taut K, Maus R, Länger, F, Srivastava M, Briles DE, Paton JC, Welte T, Maus U. FMS-Like Tyrosine Kinase 3 Ligang Aggravates the Lung Inflammatory Response to Streptococcus pneumoniae Infection in Mice: Role of Dendritic Cells. J Immunol 179: 3099 - 3108, 2007.

     

    Wulffen Wv, Steinmüller M, Herold S, Marsh LM, Bulau P, Seeger W, Welte T, Lohmeyer J, Maus U. Lung Dendritic Cells Elicited by Fms-like Tyrosin 3-Kinase Ligand Amplify the Lung Inflammatory Response to Lipopolysaccaride. Am J Respir Crit Care Med 176: 892 - 901, 2007.

     

    Maus U, Backi M, Winter C, Srivastava M, Rückle T, Schwarz MK, Paton JC, Briles D, Mack M, Welte T, Maus R, Bohle R, Seeger W, Rommel C, Hirsch E, Lohmeyer J, Preissner KT. Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection. Am J Respir Crit Care Med 175: 958 - 966, 2007.

     

    Winter C, Taut K, Srivastava M, Länger F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus U. Lung-Specific Overexpression of CC Chemokine Ligand (CCL) 2 Enhances the Host Defense to Streptococcus pneumoniae Infection in Mice: Role of the CCL2-CCR2 Axis. J Immunol 178: 5828 - 5838, 2007.

     

    Srivastava M, Meinders A, Steinwede K, Maus R, Lucke N, Bühling F, Ehlers S, Welte T, Maus U. Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobaterial infections in the lungs of mice. Cell Microbiol 9: 738 - 752, 2007.

  • J O B O F F E R S

     

    J O B   O F F E R S


    If you are interested in the position as a research assistant or as MTA/BTA, do not hesitate to contact us directly.

     

     

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    I N T E R N S H I P S 

     

    Internships for pupils are  arranged by Hannover Biomedical Research School (HBRS) at the MHH.

     

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    S T U D E N T   I N T E R N S H I P S,   D I P L O M A   T H E S E S,   M A S T E R   T H E S E S

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    If you are interested in a student intership or in diploma/masterthesis as part of your biomedicine/biotechnology studies or similar specialty, please contact us directly. We gladly inform you about the current possibilities.   

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  • S T A F F M E M B E R S



    P O S T D O C S / R E S E A R C H   A S S O C I A T E 

     

    Dr. rer. nat. Nadine Ding 

    Ding.Nadinemh-hannover.de

    Dr. rer. nat. Sarah Knippenberg 

    Knippenberg.Sarahmh-hannover.de

     

     

    D O C T O R A L   C A N D I D A T E 

     

    Tina Bormann

    Bormann.Tinamh-hannover.de

    Anne Dommaschk 

    Dommaschk.Annemh-hannover.de

    Hannah Makait 

    Makait.Hannahmh-hannover.de

    Steffi Moye

    Moye.Steffimh-hannover.de

    Robert Neßlage 

    Nesslage.Robertmh-hannover.de

    Katrin Schmidt

    Schmidt.Katrinmh-hannover.de

    Alena Singpiel 

    Singpiel.Alenamh-hannover.de

    Ole Tempelhof 

    Tempelhof.Olemh-hannover.de

    Meritxell Tort Tarrés 

    TortTarres.Meritxellmh-hannover.de



    M E D I C A L - T E C H N I C A L   E M P L O Y E E S 

     

    Franziska Aschenbrenner 

    Aschenbrenner.Franziskamh-hannover.de

    Petra Aue 

    Aue.Petramh-hannover.de

    Lara Friederike Bittersohl 

    Bittersohl.Laramh-hannover.de

    Jennifer Bohling 

    Bohling.Jennifermh-hannover.de

    Gabriele Kirchhof 

    Kirchhof.Gabrielemh-hannover.de

    Julia Kramer

    Kramer.Juliamh-hannover.de

    Regina Maus 

    Maus.Reginamh-hannover.de

    Julia Schneider 

    Schneider.Julia.PNEmh-hannover.de

     

     

  • D I R E C T I O N S
    Feodor-Lynen-Str. 21, 30655 Hannover

     

    A R R I V A L   B Y   P U B L I C   T R A N S P O R T  A T I O N :

     

    Underground No. U3 / U7 / U9 
                          Direction: Altwarmbüchen / Fasanenkrug 
    Station: Noltemeyerbrücke or Spannhagengarten 
                  change to a bus No. 123 or 137 

    Station:  Neue-Land-Straße

     

     

     

    A R R I V A L   B Y   C A R :

     

    Coming from the direction of Kassel: from the A7 exit at junction Hannover Süd, then take the A37 to Hannover. The A37 merges with the fast track to the trade fair grounds. 

     

    Coming from the direction of Hamburg: take the A7 until you reach the motorway intersection Hannover-Kirchhorst, then take the A37 to Hannover.

      

    Coming from the direction of Dortmund or Berlin: take the A2 until you reach the motorway intersection Hannover-Buchholz, then take the A37 to Hannover. On A37 (‘Messeschnellweg’), exit at ‘Weidetorkreisel’ round-about and turn onto ‘Karl-Wiechert-Allee’ (see diagram). Go straight on and in a few minutes you will arrive at MHH. Turn right into the Rudolf-Pichlmayr-Straße .  At the T-crossroads (Feodor-Lynen-Straße)  you will find us in the second building on the right.