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Dr. Christa Litschko

 

Dr. rer. nat. biochemistry

Post-Doc

Email: Litschko.Christamh-hannover.de

Phone: +49(0)511/532-8303 or -9805

Building J03, Level 04, Room 1300 or 1240

 

 

 

 

 

Research Interests:

 

  • Functional and biochemical characterization of bacterial capsule polymerases
  • Bacterial capsule synthesis
  • Vaccine development and production
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PUBLICATIONS

 

Litschko C., Oldrini D., Budde I., Berger M., Meens J., Gerardy-Schahn R., Berti F., Schubert M., Fiebig T. (2018) A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers in Gram-Negative Pathogens. MBio. 9, e00641-18

Fiebig T., Litschko C., Freiberger F., Bethe A., Berger M., Gerardy-Schahn R. (2017) Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production. J Biol Chem, e-pub ahead of print: Nov 29, 2017, doi: 10.1074/jbc.RA117.000488.

Sikorra S, Litschko C., Müller C., Thiel N., Galli T., Eichner T., Binz T. (2016) Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for Human SNAP-23. J Mol Biol 428 372-8

Litschko C., Romano M. R., Pinto V., Claus H., Vogel U., Berti F., Gerardy-Schahn R., Fiebig T. (2015) The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyzes the Synthesis of a Complex Trimeric Repeating Unit Comprising Glycosidic and Phosphodiester Linkages. J Biol Chem 290: 24355-24366

Fiebig T., Freiberger F., Pinto V., Romano M. R., Black A., Litschko C., Bethe A., Yashunsky D., Adamo R., Nikolaev A., Berti F., Gerardy-Schahn R. (2014) Molecular cloning and functional characterisation of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: towards in vitro vaccine production. J Biol Chem 289: 19395-19407