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Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Jang M, Mengel M, Wacker F, Rong S*, Gueler F*. Kidney transplantation – Multiparametric functional MRI for assessment of renal allograft pathophysiology in mice.*contributed equally as last authors

Invest Radiol 2016;51(1):58-65. 


Gueler F, Shushakova N, Megnel M, Hueper K, Chen R, Liu X, Park J, Haller H, Wensvoort G, Rong S. A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice.

PLoS one. 2015;10(1):e0115709


Happle C, Lachmann N, Škuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. 

Sci Transl Med. 2014 Aug 20;6(250):250ra113. doi:10.1126/scitranslmed.3009750.


Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F,. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathology and Renal Function

Radiology 2014 Jan; 270(1):117-24


Hueper K*, Peperhove M*, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F#T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice.

Eur Radiol 2014;24(9):2252-60. *contributed equally as first authors, #contributed equally as last authors


Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F. Renal PKC epsilon deficiency attenuates acute kidney injury and ischemic allograft injury via TNF alpha dependent inhibition of apoptosis and inflammation.

Am J Physiol-Renal 2014;307(6):F718-26.


Tudorache I, Calistru A, Cebotari S, Baraki H,  Meyer T, Höffler K, Sarikouch S, Bara C, Görler A,  Hartung D, Hilfiker A, Haverich A. Orthotopic replacement of aortic heart valves with tissue engineered Grafts.

Tissue Engineering 2013 in press


Meyer BC, Brost A, Kraitchman DL, Gilson WD, Strobel N, Hornegger J, Lewin JS, Wacker FK. Percutaneous Punctures with MR Imaging Guidance: Comparison between MR Imaging-enhanced Fluoroscopic Guidance and Real-time MR Imaging Guidance.

Radiology 2013, 266: 912-919


Joshi R, Feldmann V, Koestner W, Detje C, Gottschalk S, Mayer HA, Sauer MG, Engelmann J. Multifunctional silica nanoparticles for optical and magnetic resonance imaging.

Biol Chem 2013, 394: 125-135


Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. T2 Relaxation Time and Apparent Diffusion Coefficient for Non-invasive Assessment of Renal Pathology Following Acute Kidney Injury in Mice – Comparison with Histopathology.

Invest Radiol 2013;48(12):834-42.


Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Assessment of Impaired Vascular Reactivity in a Rat Model of Diabetic Nephropathy - Effect of Nitric Oxide Synthesis Inhibition on Intrarenal Diffusion and Oxygenation Measured by Magnetic Resonance Imaging.

Am J Physiol-Renal 2013; 305(10): F1428-35.


Bauer M, Hassel T, Biskup C, Hartung D, Schilling T, Weidling M, Wriggers P, Wacker F, Bach FW, Haverich A. Geometric adaption of resorbable myocardial stabilizing structures based on the magnesium alloys LA63 and ZEK100 for the support of myocardial grafts on the left ventricle.

Biomed Tech (Berl) 2012, DOI: 10.1515/bmt-2012-4214. [Epub ahead of print]


Rodt T, Luepke M, Boehm C, Hueper K, Halter R, Glage S, Hoy L, Wacker F, Borlak J, von Falck C. Combined micro-PET/micro-CT imaging of lung tumours in SPC-raf and SPC-myc transgenic mice.

PLoS One 2012, 7:e44427


Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Magnetic resonance diffusion tensor imaging for evaluation of histopathological changes in a rat model of diabetic nephropathy.

Invest Radiol 2012, 47: 430-437


Rodt T, von Falck C, Dettmer S, Hueper K, Halter R, Hoy L, Luepke M, Borlak J, Wacker F. Lung tumour growth kinetics in SPC-c-Raf-1-BB transgenic mice assessed by longitudinal in-vivo micro-CT quantification.

J Exp Clin Cancer Res 2012, 31: 15


Hueper K, Elalfy M, Laenger F, Halter R, Rodt T, Galanski M, Borlak J. PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay. 

PLoS One 2012, 7: e30432


Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald DM, Brasch RC, Raatschen HJ. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF).

Eur J Radiol 2012, 81: 891-896

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Frericks BB, Kühl AA, Loddenkemper C, Stroux A, Valdeig S, Hotz B, Misselwitz B, Hoffmann JC, Wacker FK. Gadofluorine M-enhanced magnetic resonance imaging of inflammatory bowel disease: quantitative analysis and histologic correlation in a rat model.

Invest Radiol 2011, 46: 478-485


Rodt T, Luepke M, Boehm C, von Falck C, Stamm G, Borlak J, Seifert H, Galanski M. Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice.

Acta Radiol 2011, 52: 75-80


Rodt T, von Falck C, Dettmer S, Halter R, Maus R, Ask K, Kolb M, Gauldie J, L‰nger F, Hoy L, Welte T, Galanski M, Maus UA, Borlak J. Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-fl1.

Respir Res 2010, 11: 181


Raatschen HJ, Fu Y, Rogut V, Simon GH, Sennino B, Wolf KJ, Brasch RC. [Effects of MRI-assayed microvascular permeability on the accumulation of vinorelbine in xenograft tumors].

Rofo 2010, 182: 133-139



von Falck C, Rodt T, Halter R, Spanel R, Galanski M, Borlak J. Combined microPET/CT for imaging of hepatocellular carcinoma in mice.

Front Biosci 2009, 14: 2193-2202


Frericks BB, Wacker F, Loddenkemper C, Valdeig S, Hotz B, Wolf KJ, Misselwitz B, K¸hl A, Hoffmann JC. Magnetic resonance imaging of experimental inflammatory bowel disease: quantitative and qualitative analyses with histopathologic correlation in a rat model using the ultrasmall iron oxide SHU 555 C.

Invest Radiol 2009, 44: 23-30


Rodt T, von Falck C, Halter R, Ringe K, Shin H-O, Galanski M, Borlak J. In-vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice.

Front Biosci 2009, 14: 1939-1944


Sennino B, Raatschen HJ, Wendland MF, Fu Y, You WK, Shames DM, McDonald DM, Brasch RC. Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice.

Magn Reson Med 2009, 62: 616-625



Raatschen HJ, Fu Y, Brasch RC, Pietsch H, Shames DM, Yeh BM. In vivo monitoring of angiogenesis inhibitory treatment effects by dynamic contrast-enhanced computed tomography in a xenograft tumor model.

Invest Radiol 2009, 44: 265-270

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Raatschen HJ, Simon GH, Fu Y, Sennino B, Shames DM, Wendland MF, McDonald DM, Brasch RC. Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats.

Radiology 2008, 247: 391-399


Cyran CC, Fu Y, Raatschen HJ, Rogut V, Chaopathomkul B, Shames DM, Wendland MF, Yeh BM, Brasch RC. New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues.

J Magn Reson Imaging 2008, 27: 581-589


Vogel-Claussen J, Gimi B, Artemov D, Bhujwalla ZM. Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126.

Cancer Biol Ther 2007, 6: 1469-1475


Saborowski O, Simon GH, Raatschen HJ, Wendland MF, Fu Y, Henning T, Baehner R, Corot C, Chen MH, Daldrup-Link HE. MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent.

Contrast Media Mol Imaging 2007, 2: 72-81


Hillenbrand CM, Jesberger JA, Wong EY, Zhang S, Chang DT, Wacker FK, Lewin JS, Duerk JL. Toward rapid high resolution in vivo intravascular MRI: evaluation of vessel wall conspicuity in a porcine model using multiple imaging protocols.

J Magn Reson Imaging 2006, 23: 135-144.


Maes RM, Lewin JS, Duerk JL, Misselwitz B, Kiewiet CJ, Wacker FK. A new type of susceptibility-artefact-based magnetic resonance angiography: intra-arterial injection of superparamagnetic iron oxide particles (SPIO) A Resovist in combination with TrueFisp imaging: a feasibility study.

Contrast Media Mol Imaging 2006, 1: 189-195


Maes RM, Morrison WB, Lewin JS, Duerk JL, Kiewiet CJ, Wacker FK. Use of intra-articular carbon dioxide and air for MR arthrography: a feasibility study.

Contrast Media Mol Imaging 2006, 1: 147-152


Zhang S, Rafie S, Chen Y, Hillenbrand CM, Wacker FK, Duerk JL, Lewin JS. In vivo cardiovascular catheterization under real-time MRI guidance.  

J Magn Reson Imaging 2006, 24: 914-917


Wacker FK, Vogt S, Khamene A, Jesberger JA, Nour SG, Elgort DR, Sauer F, Duerk JL, Lewin JS. An augmented reality system for MR image-guided needle biopsy: initial results in a swine model.

Radiology 2006, 238: 497-504


Raatschen HJ, Swain R, Shames DM, Fu Y, Boyd Z, Zierhut ML, Wendland MF, Misselwitz B, Weinmann HJ, Wolf KJ, Brasch RC. MRI tumor characterization using Gd-GlyMe-DOTA-perfluorooctyl-mannose-conjugate (Gadofluorine M), a protein-avid contrast agent.

Contrast Media Mol Imaging 2006, 1: 113-120


Raatschen HJ, Fu Y, Shames DM, Wendland MF, Brasch RC. Magnetic resonance imaging enhancement of normal tissues and tumors using macromolecular Gd-based cascade polymer contrast agents: preclinical evaluations.

Invest Radiol 2006, 41: 860-867


Fu Y, Nitecki DE, Maltby D, Simon GH, Berejnoi K, Raatschen HJ, Yeh BM, Shames DM, Brasch RC. Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization.

Bioconjug Chem 2006, 17: 1043-1056


Wacker FK, Hillenbrand C, Elgort DR, Zhang S, Duerk JL, Lewin JS. MR imaging-guided percutaneous angioplasty and stent placement in a swine model comparison of open- and closed-bore scanners.

Acad Radiol. 2005, 12: 1085-1088


Maes RM, Lewin JS, Duerk JL, Wacker FK. Combined use of the intravascular blood-pool agent, gadomer, and carbon dioxide: a novel type of double-contrast magnetic resonance angiography (MRA).

J Magn Reson Imaging. 2005, 21: 645-649


Simon GH, Raatschen HJ, Wendland MF, von Vopelius-Feldt J, Fu Y, Chen MH, Daldrup-Link HE. Ultrasmall superparamagnetic iron-oxide-enhanced MR imaging of normal bone marrow in rodents: original research original research.

Acad Radiol 2005, 12: 1190-1197

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