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Ausgewählte Publikationen


Plege A, Borns K, Baars W, Schwinzer R.
Suppression of human T-cell activation and expansion of regulatory T cells by pig cells overexpressing PD-ligands.
Transplantation. 2009 Apr 15;87(7):975-82.


Wallemacq P, Goffinet JS, O'Morchoe S, Rosiere T, Maine GT, Labalette M, Aimo G, Dickson D, Schmidt E, Schwinzer R, Schmid RW.
Multi-site analytical evaluation of the Abbott ARCHITECT tacrolimus assay.
Ther Drug Monit. 2009 Apr;31(2):198-204.


Weiss EH, Lilienfeld BG, Müller S, Müller E, Herbach N, Kessler B, Wanke R, Schwinzer R, Seebach JD, Wolf E, Brem G.
HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity.
Transplantation. 2009 Jan 15;87(1):35-43.


Meyer D, Seth S, Albrecht J, Maier MK, du Pasquier L, Ravens I, Dreyer L, Burger R, Gramatzki M, Schwinzer R, Kremmer E, Foerster R, Bernhardt G. 
CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. 
J Biol Chem. 2009 Jan 23;284(4):2235-44.


Windhagen A, Sonmez D, Hornig-Do HT, Kalinowsky A, Schwinzer R.

Altered CD45 isoform expression in C77G carriers influences cytokine responsiveness and adhesion properties of T cells.

Clin Exp Immunol. 2007 Sep 28; [Epub ahead of print]


Tchilian EZ, Gil J, Navarro ML, Fernandez-Cruz E, Chapel H, Misbah S, Ferry B, Renz H, Schwinzer R, Beverley PC.

Unusual case presentations associated with the CD45 C77G polymorphism.

Clin Exp Immunol. 2006 Dec;146(3):448-54


Kues WA, Schwinzer R, Wirth D, Verhoeyen E, Lemme E, Herrmann D, Barg-Kues B, Hauser H, Wonigeit K, Niemann H.

Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs.

FASEB J. 2006 May 9; [Epub ahead of print]


Do HT, Baars W, Borns K, Windhagen A, Schwinzer R.

The 77C->G mutation in the human CD45 (PTPRC) gene leads to increased intensity of TCR signaling in T cell lines from healthy individuals and patients with multiple sclerosis.

J Immunol. 2006 Jan 15;176(2):931-8


Karacsonyi C, Bedke T, Hinrichsen N, Schwinzer R, Lindner R.

MHC II molecules and invariant chain reside in membranes distinct from conventional lipid rafts.

J Leukoc Biol. 2005 Nov;78(5):1097-105


Klose R, Kemter E, Bedke T, Bittmann I, Kelsser B, Endres R, Pfeffer K, Schwinzer R, Wolf E.

Expression of biologically active human TRAIL in transgenic pigs.

Transplantation. 2005 Jul 27;80(2):222-30


Do HT, Baars W, Schwinzer R.

Functional significance of the 77C --> G polymorphism in the human CD45 gene: enhanced T-cell reactivity by variantly expressed CD45RA isoforms.

Transplant Proc. 2005 Jan-Feb;37(1):51-2


Bedke T, Baars W, Schwinzer R.

Modulation of human anti-pig T cell responses by monoclonal antibodies directed to porcine CD45 molecules.

Ann Transplant. 2003;8(3):35-8


Schwinzer R, Witte T, Hundrieser J, Ehlers S, Momot T, Hunzelmann N, Krieg T, Schmidt RE, Wonigeit K.

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.

Genes Immun. 2003 Mar;4(2):168-9.


Lehner F, Becker T, Sybrecht L, Luck R, Schwinzer R, Slateva K, Blasczyk R, Hertenstein B, Klempnauer J, Nashan B.

Successful outcome of acute graft-versus-host disease in a liver allograft recipient by withdrawal of immunosuppression.

Transplantation 2002 Jan 27;73(2):307-10.


Niemann H, Verhoeyen E, Wonigeit K, Lorenz R, Hecker J, Schwinzer R, Hauser H, Kues WA, Halter R, Lemme E, Herrmann D, Winkler M, Wirth D, Paul D.

Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection.

Transplantation 2001 Dec 27;72(12):1898-906.


Dulat HJ, von Grumbkow C, Baars W, Schroder N, Wonigeit K, Schwinzer R.

Down-regulation of human alloimmune responses by genetically engineered expression of CD95 ligand on stimulatory and target cells.

Eur J Immunol 2001 Juli;31(7):2217-26.


Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, Wonigeit K, Lindert RB, Kantarci O, Schaefer-Klein J, Schipper HI, Oertel WH, Heidenreich F, Weinshenker BG, Sommer N, Hemmer B.

A point mutation in PTPRC is associated with the development of multiple sclerosis.

Nature Genet 2000 Dec;26(4):495-9


Siefken R, Klein-Hessling S, Serfling E, Kurrle R, Schwinzer R.

A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.

J Immunol. 1998 Aug 15;161(4):1645-51.


Szamel M, Appel A, Schwinzer R, Resch K.

Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR.

J Immunol. 1998 Mar 1;160(5):2207-14.


Reinke P, Schwinzer R, Hoflich C, Ode-Hakim C, Docke WD, Frei U, Volk HD.

Selective in vivo deletion of alloactivated TH1 cells by OKT3 monoclonal antibody in acute rejection.

Immunol Lett. 1997 Jun 1;57(1-3):151-3.


Siefken R, Kurrle R, Schwinzer R.

CD28-mediated activation of resting human T cells without costimulation of the CD3/TCR complex.

Cell Immunol. 1997 Feb 25;176(1):59-65.


Schwinzer R, Siefken R.

CD45RA+ and CD45RO+ T cells differ in susceptibility to cyclosporin A mediated inhibition of interleukin-2 production.

Transpl Immunol. 1996 Mar;4(1):61-3.


Nashan B, Schlitt HJ, Schwinzer R, Ringe B, Kuse E, Tusch G, Wonigeit K, Pichlmayr R.

Immunoprophylaxis with a monoclonal anti-IL-2 receptor antibody in liver transplant patients.

Transplantation. 1996 Feb 27;61(4):546-54.


Thude H, Hundrieser J, Wonigeit K, Schwinzer R.

A point mutation in the human CD45 gene associated with defective splicing of exon A.

Eur J Immunol. 19995 Jul;25(7):2101-6


Nashan B, Schwinzer R, Schlitt HJ, Wonigeit K, Pichlmayr R.

Immunological effects of the anti-IL-2 receptor monoclonal antibody BT 563 in liver allografted patients.

Transpl Immunol. 1995 Sep;3(3):203-11


Schwinzer R, Siefken R, Franklin RA, Saloga J, Wonigeit K, Gelfand EW.

Human CD45RA+ and CD45R0+ T cells exhibit similar CD3/T cell receptor-mediated transmembrane signaling capacities but differ in response to co-stimulatory signals.

Eur J Immunol. 1994 Jun;24(6):1391-5.


Schwinzer R, Schlitt HJ, Wonigeit K.

Monoclonal antibodies to common epitopes of the human alpha/beta T-cell receptor preferentially activate CD45RA+ T-cells.

Cell Immunol. 1992 Mar;140(1):31-41


Schwinzer R, Franklin RA, Domenico J, Renz H, Gelfand EW.

Monoclonal antibodies directed to different epitopes in the CD3-TCR complex induce different states of competence in resting human T cells.

J Immunol. 1992 Mar 1;148(5):1322-8.


Schwinzer R, Schraven B, Kyas U, Meuer SC, Wonigeit K.

Phenotypical and biochemical characterization of a variant CD45R expression pattern in human leukocytes.

Eur J Immunol. 1992 Apr;22(4):1095-8.


Schwinzer R, Sommermeyer H, Schlitt HJ, Schmidt RE, Wonigeit K.

Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals.

Cell Immunol. 1991 Sep;136(2):318-28


Schwinzer R, Wonigeit K.

Genetically determined lack of CD45R- T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression.

J Exp Med. 1990 May 1;171(5):1803-8