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D D H Tran*, C Kessler*, S E Niehus, M Mahnkopf, A Koch and T Tamura. Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs. Oncogene. 2017 Sep 4. doi: 10.1038/onc.2017.312



Doan Duy Hai Tran*, Alexandra Koch*, Aldrige Allister, Shashank Saran, Florian Ewald, Martina Koch, Björn Nashan, and Teruko Tamura. Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP). Cellular Signalling 2016 Sep 10;28(12):1872-1880. doi: 10.1016/j.cellsig.2016.09.002.


Doan Duy Hai Tran, Shashank Saran, Alexandra Koch, Marcel Armbrecht, Florian Ewald, Martina Koch, Tom Wahlicht, Dagmar Wirth, Armin Braun, Björn Nashan, Matthias Gaestel and Teruko Tamura. Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture. Cellular Signalling 2016, doi:10.1016/j.cellsig.2016.02.007.


Doan Duy Hai Tran, Shashank Saran, Alexandra Koch, Teruko Tamura. mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy. Cancer Letters 2016, Jan 28. pii: S0304-3835(16)30017-9. doi: 10.1016/j.canlet.2016.01.045.



Shashank Saran*, Doan Duy Hai Tran*, Florian Ewald, Alexandra Koch, Andrea  Hoffmann, Martina Koch  , Björn Nashan  , Teruko Tamura. Depletion of three combined THOC5, mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. Oncogene 2015, accepted (*equal contribution).



Alexandra Koch*, Shashank Saran*, Doan Duy Hai TranSabine Klebba-Färber, Hauke Thiesler, Katherina Sewald, Susann Schindler, Armin Braun, Robert Klopfleisch, Teruko Tamura. Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell Communication and Signaling, 2014 Nov 7;12:73. (* equal contribution).


Doan Duy Hai Tran , Shashank Saran, Andrew JK Williamson, Andrew Pierce, Oliver Dittrich-Breiholz, Lutz Wiehlmann, Alexandra Koch, Anthony D Whetton, and Teruko Tamura. THOC5 controls 3´end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100). Nucleic Acids Res. 2014 Oct 1. pii: gku911.


Doan D Tran, Alexandra Koch and Teruko Tamura. THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation. Cell Communication and Signaling 2014, 12:3



Doan Duy Hai Tran, Saran Shashank, O Dittrich-Breiholz, Sabine Klebba-Färber , Alexandra Koch, Michael Kracht, Teruko Tamura. M-CSF induced macrophage differentiation is regulated by THOC5, a member of the mRNA export complex that plays a key role in the mRNA processing of a subset of immediate-early genes. Cell Death and Disease (2013) 4, e879;


Shashank Saran*, Doan Duy Hai Tran*, Sabine Klebba-Färber, Patricia M Losada, Lutz Wiehlmann, Alexandra Koch, Himpriya Chopra, Oliver Pabst, Andrea Hoffmann, Robert Klopfleisch, Teruko Tamura. THOC5, a member of the mRNA export complex, plays a crucial role in processing of a subset of Wnt target mRNAs in mice, thereby leading to severe pathological alterations of the gastrointestinal tract. BMC Cell Biol. 2013 Nov 22;14:51.(*equal contribution)


Griaud, F., Pierce, A., Gonzalez Sanchez, M.B., Scott, M., Abraham, S.A., Holyoake, T.L., Tran, D.D., Tamura, T., and Whetton, A.D. (2013). A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia 27, 932-940.



Ramachandran S., Tran DD., Klebba-Faerber S., Kardinal C., Whetton AD., Tamura T. An ataxia-teleaniectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA 17(11):1957-66, 2011


Dutta P.*, Koch A.*, Breyer B., Schneider H., Dittrich-Breiholz O., Kracht M., Tamura T. Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis, BMC Genomics 12:196, 2011.


Guria A.*, Tran D.D.H*,Ramachandran S.*,Koch A.,Bounkari O.,Dutta P,Hauser H,Tamura  T. Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts, RNA, 2011 17:00-00.(*equal contribution)



Mancini,  A.*,  Niemann-Seyde, S*. C., Pankow, R.*,  El Bounkari, O., Klebba-Färber, S., Koch, A., EJaworska, E., Spooncer, E., Gruber, A. D. , Whetton, A. D., Tamura, T. (2010) THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biology 8, 1.



Carney, L., Pierce, A., Rjinen, M., Gonzalez-Sachez M. B., Hamzah, H. G., Zhang, L., Tamura, T., and Whetton, A. D. (2009) THOC5 couples M-CSF receptor signalling to transcription factor expression. Cell. Signalling, 21: 209-316.

 El Bounkari, O., Guria, A.,  Klebba-Faerber, S., Claußen, M., Pieler, T., Griffiths, J.R., Whetton, A. D., Koch, A., and Tamura.T. (2009) Nuclear localization of the pre-mRNA associating protein, THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). FEBS Letter, 583, 13-18.

Tossidou I, Dangers M, Koch A, Brandt DT, Schiffer M, and Kardinal C. (2008) Tyrosine phosphatase SHP-2 is a regulator of p27Kip1 tyrosine phosphorylation. Cell Cycle 7, 3858-3868.

Koch A, Scherr M, Breyer B, Mancini A, Kardinal C, Battmer K, Eder M, Tamura T. Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover. Oncogene 2008;27(34):4678-89.

Pierce, A., Carney L., Hamza HG, Griffiths JR, Zhang L., Whetton BA, Belen M., Sanchez G., Tamura, T., Sternberg D., and Whetton AD. (2008) Thoc5 splicesome protein: a target for leukaegenic tyrosine kinases that affects inositol lipid turnover. Br. J. Hematol. 141, 641-650.

Mancini, A., El Bounkari, O., Norrenbrock, A-F., Scherr, M., Schaefer, D., Eder M., Banham, A. H., Pulford, K., Lyne, L., Whetton A. D., and Tamura, T. (2007) FMIP controls the adipocyte lineage commitment of C2C12 cells by down-modulation of C/EBPalpha. Oncogene 26, 1020-1027.

Kardinal C., Dangers M., Kardinal A., Brandt D.T., Koch A., Tamura T., and Welte K. (2005) Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelotic leukemia cell line NB4. Blood<//span>. 2006 Feb 1;107(3):1133-40.  

Koch A., Mancini A., El Bounkari O., and Tamura T. (2005) The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. Oncogene, 24, 3436-47.

Mancini A., Koch A., Whetton A.D., and Tamura T. (2004)The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation and thereby potentiates M-CSF-mediated differentiation. Oncogene, 23, 6581-9.

Ohrt, Th., Mancini, A., Tamura, T. and Niedenthal, R. (2004) c-Cbl binds to tyrosine- phosphorylated neurotrophin receptor p75 and induces its ubiquitination. Cellular Signaling, 16, 1291-1298.








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