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Projects

 

1.) Prevention of allergic inflammation and asthma by the synthetic TLR2/6 Agonist MALP-2

Dr. Armin Braun, Immunologie und Allergologie, Nikolai-Fuchs-Str 1, 30625 Hannover, Tel: 0511 5350 263, FAX: 0511 5350 250, e-mail: braunitem.fraunhofer.de

 

Aim of the Project: Development of methods to prevent the development of allergic inflammation and asthma

 

2.) Role of lung collectins surfactant protein A and D in Toll-Like-Receptor agonist modulated allergic inflammation

Principal Investigator: Prof. Dr. med. Jens M. Hohlfeld. Abteilung Klinische Allergie-, Asthma- und Inhalationsforschung, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Nikolai-Fuchs-Strasse 1a, 30625 Hannover, Tel: 0511-5350-604, Fax: -620 und Abteilung Pneumologie, Medizinische Hochschule Hannover, email: hohlfelditem.fraunhofer.de

Co-Investigator: Dr. med. Veit J. Erpenbeck, Ph.D. Abteilung Pneumologie, Medizinische Hochschule Hannover und Klinische Allergie-, Asthma- und Inhalationsforschung, Fraunhofer-Institut für Toxikolgie und Experimentelle Medizin, Nikolai-Fuchs-Strasse 1a, 30625 Hannover, Tel: 0511-5350-644, Fax: -620, email: erpenbeckitem.fraunhofer.de

 

Aim of the Project: This project investigates the interaction of surfactant proteins with TLR-agonists and the subsequent influence on allergic airway inflammation.

 

3.) Role of the costimulatory molecule CD27 in allergic asthma

Prof. Dr. Gesine Hansen, ab 01.11.05: Abteilung für Pädiatrische Pneumologie und Neonatologie, Carl-Neuberg-Str. 1, 30625 Hannover, Tel. 0511-532-9138, e-mail: hansen.gesinemh-hannover.de

 

Aim of the Project: The aim of the project is to analyze the role of the costimulatory molecule CD27, a member of the TNFR family, in the immunologic response of allergic asthma.

 

4.) Expression and function of proline specific peptidases in allergic asthma

Principle Investigator: Prof. Dr. med. Stephan von Hörsten, Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, e-mail: Hoersten.stephan.vonmh-hannover.de

Co-Investigator: Dr. med. Michael Stephan, Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Tel: 05115322866, Fax: 05115328868, e-mail: Stephan.michaelmh-hannover.de

 

Aim of the Project: Characterization of expression and function of DPIV-like praline specific peptidases (DP8, DP9, DP10, FAP, Attractin) in asthma

 

5.) Functional role of lysosomal proteinases in allergic airway inflammation

Principle Investigator: Prof. Dr. Tobias Welte, Department of Respiratory Diseases, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover , Tel.: 0511-532-3530, FAX: 0511-532– 3353, E-Mail: welte.tobiasmh-hannover.de

Co-Investigator: PD Dr. David Groneberg, Department of Respiratory Diseases, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover , Tel.: 0511-532-3530, FAX: 0511-532– 3353, E-Mail: groneberg.davidmh-hannover.de

 

Aim of the Project: Functional characterization of the role of lysosomal proteinases as mediators of airway inflammation in a murine model of allergic asthma

 

6.) Role of keratinocytes for the development and chronification of allergic eczematous skin diseases

Juniorprofessorin Dr. med. Miriam Wittmann, Klinik und Poliklinik für Dermatologie und Venerologie der Medizinischen Hochschule Hannover, Ricklinger Str. 5, 30449 Hannover, Tel: ++49 (0)511 9246 278, Fax: ++49 (0)511 9246 440, email: wittmann.miriammhhannover.de

 

Aim of the Project: It is the aim of this study to further elucidate the contribution of keratinocyte T-cell cross-talk to the onset and maintenance of atopic dermatitis.

 

7.) Autoallergic T-cell responses in atopic dermatitis

Principle Investigator: Prof. Dr. med. Thomas Werfel, Klinik und Poliklinik für Dermatologie und Venerologie, Medizinische Hochschule Hannover, Ricklinger Str. 5, 30449 Hannover, Tel: ++49 (0)511 9246 278, Fax: ++49 (0)511 9246 440, email: werfel.thomasmh-hannover.de

Co-Investigator: Dr. med. Margarete Lisewski, Klinik und Poliklinik für Dermatologie und Venerologie (address: see above), email: lisewski.magaretemh-hannover.de

 

Aim of the Project: Investigation of the regulation and effects of autoallergens (both “atopy associated intracellular autoantigens” and autoallergens which crossreact to defined allergens) on T-cells and on antigen presenting cells and activated keratinocytes in atopic dermatitis