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Ausgewählte Publikationen / Selected Publications

 

2018

 

Menon MB, Gaestel M.

MK2-TNF-Signaling Comes Full Circle.

Trends Biochem Sci. 43, 158-167.

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Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3

Natalia Ronkina, Karin Schuster-Gossler, Florian Hansmann, Heike Kunze-Schumacher, Inga Sandrock, Tatiana Yakovleva, Juri Lafera, Wolfgang Baumgärtner, Andreas Krueger, Immo Prinz, Achim Gossler, Alexey Kotlyarov, Matthias Gaestel

 

2017

 

Menon MB*, Gropengießer J*, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M* & Ruckdeschel K* (2017)(* equal contribution)

p38 MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection.

Nat Cell Biol. 19:1248-59.

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2016

 

Ronkina N, Lafera J, Kotlyarov A, Gaestel M. (2016)

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis.

Sci Rep. 6:31219.

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Tiedje C, Diaz-Muñoz MD, Trulley P, Ahlfors H, Laaß K, Blackshear PJ, Turner M, Gaestel M. (2016)

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.

Nucleic Acids Res. 44:7418-40.

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Menon MB, Gaestel M. (2016)

TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation.

Biochem J. 473:2995-9.

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Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. (2016)

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.

Sci Rep. 6:20007.

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2015

 

Tiedje C, Lubas M, Tehrani M, Menon MB, Ronkina N, Rousseau S, Cohen P, Kotlyarov A, Gaestel M (2015)

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex.

RNA. 21:262-78.

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Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A Gaestel, M. (2015)

Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.

PLoS One. 10:e0136138.

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Menon MB, Dhamija S, Kotlyarov A, Gaestel, M (2015)

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.

Autophagy. 11:1425-7.

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Menon MB, Gaestel, M (2015)

Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis.

J Cell Sci. 128:1877-86.

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2014

 

Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K, Galla M, Schambach A, Gossler A, Förster R, Heuser M, Kotlyarov A, Kinoshita M, Gaestel M. (2014)

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.

PLoS Genet. 10:e1004558.

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Tiedje C, Holtmann H, Gaestel M. (2014)

The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation.

J Interferon Cytokine Res. 34:220-32.

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2013

 

Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M. (2013)

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production.

Biochem J. 456:163-72.

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Gaestel M. (2013)

What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition.

Biol. Chem. 394:1301-15.

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Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ (2013)

Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.

Mol. Cell. Biol. 33:2586-602.

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McGuire VA, Gray A, Monk CE, Santos SG, Lee K, Aubareda A, Crowe J, Ronkina N, Schwermann J, Batty IH, Leslie NR, Dean JL, O'Keefe SJ, Boothby M, Gaestel M, Arthur JS (2013)

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.

Mol Cell Biol. 33:4152-65.

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Köpper F, Bierwirth C, Schön M, Kunze M, Elvers I, Kranz D, Saini P, Menon MB, Walter D, Sørensen CS, Gaestel M, Helleday T, Schön MP, Dobbelstein M (2013)

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.

Proc Natl Acad Sci U S A. 110:16856-61.

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2012

 

Tiedje, C, N Ronkina, M Tehrani, S Dhamija, K Laass, H Holtmann, A Kotlyarov, M Gaestel (2012).

The p38/MK2-Driven Exchange between Tristetraprolin and HuR regulates AU-rich Element-Dependent Translation.

PLoS Genetics 8, e1002977

 

Brand, F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A. (2012).

The ERK3 (MAPK6) - MAPKAP kinase 5 signalling complex regulates septin function and dendrite morphology.

Mol. Cell. Biol. 32, 2467-78.

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2011

 

Menon, M.B., Kotlyarov, A., and Gaestel, M. (2011).

SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition.

PLoS One 6, e23054.

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Ronkina, N., Menon, M.B., Schwermann, J., Arthur, J.S., Legault, H., Telliez, J.B., Kayyali, U.S., Nebreda, A.R., Kotlyarov, A., and Gaestel, M. (2011)

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes.

Nucleic Acids Res 39, 2503-2518.

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Kress, T.R., Cannell, I.G., Brenkman, A.B., Samans, B., Gaestel, M., Roepman, P., Burgering, B.M., Bushell, M., Rosenwald, A., and Eilers, M. (2011).

The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis.

Mol Cell 41, 445-457.

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2010

 

Menon, M.B., Schwermann, J., Singh, A.K., Franz-Wachtel, M., Pabst, O., Seidler, U., Omary, M.B., Kotlyarov, A., and Gaestel, M. (2010).

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

J Biol Chem 285, 33242-33251.

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Ronkina, N., Menon, M.B., Schwermann, J., Tiedje, C., Hitti, E., Kotlyarov, A., and Gaestel, M. (2010).

MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.

Biochem Pharmacol 80, 1915-1920.

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Tiedje, C., Kotlyarov, A., and Gaestel, M. (2010).

Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins.

Biochem Soc Trans 38, 1632-1637.

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2009

 

Gaestel M, Kotlyarov A, Kracht M (2009)

Targeting innate immunity protein kinase signaling in inflammation

Nat Rev Drug Discov 8, 480-499.

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Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C and Gaestel M. (2009)

MAPKAP kinase MK2 maintains self-renewal capacity of hematopoietic stem cells.

Embo J 28, 1392-1406.

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2008

 

Ronkina N, Kotlyarov A, Gaestel M (2008)

MK2 and MK3--a pair of isoenzymes?

Front. Bioscience 13, 5511-5521.

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Kotlyarov A, Gaestel M (2008)

Protein kinases as substrates for stress-activated protein kinases

Topics in Curr. Genetics 20, 243-260.

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Gaestel M

Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo

Front. Bioscience 13, 6050-6059.

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Thomas T, Timmer M, Cesnulevicius K, Hitti E, Kotlyarov A, Gaestel M. (2008)

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease

J Neurochem 105, 2039-2052.

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2007

 

Zaru R, Ronkina N, Gaestel M, Arthur JS, Watts C. (2007)

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

Nature Immunol. 8, 1227-1235.

PDF and News and Views

 

Gaestel M, Mengel A, Bothe U, Asadullah K. (2007)

Protein kinases as small molecule inhibitor targets in inflammation

Curr. Med. Chem. 14, 2214-2234.

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N. Ronkina, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. (2007)

The MAPKAP kinases MK2 and MK3 cooperate in stimulation of TNF biosynthesis and stabilization of p38 MAPK.

Mol. Cell. Biol. 27, 170-181.

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Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. (2007)

MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation

J. Exp. Med. 204, 1637-1652.

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2006

 

M. Gaestel (2006) MAPKAP kinases - MKs - Two's company, three's a crowd.

Nature Rev. Mol. Cell Biol. 7, 120-130.

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Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M.(2006) Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.

J. Biol. Chem. 281, 35511-9.

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Vertii A, Hakim C, Kotlyarov A, Gaestel M. (2006)

Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress.

J. Biol. Chem. 281, 26966-75.

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M. Hegen, M. Gaestel, C.L. Nickerson-Nutter, L.-L. Lin, and J.-B. Telliez (2006) MAPKAP kinase 2-deficient Mice are Resistant to Collagen-Induced Arthritis.

J. Immunol. 177, 1913-1917.

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E. Hitti, Iakovleva, T., Brook, M., Deppenmeier, S., Gruber, A.D., Radzioch, D., Clark, A., Blackshear, P.J., Kotlyarov, A. and Gaestel, M. (2006)

MAPK-activated protein kinase 2 (MK2) regulates TNF-mRNA stability and translation mainly by altering tristetraprolin (TTP) expression, stability and binding to adenine/uridine-rich element.

Mol. Cell. Biol. 26, 2399-2407.

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2005

 

H.O. Weber, R.L. Ludwig, D. Morrison, A. Kotlyarov, M. Gaestel and K.H. Vousden (2005) HDM2 phosphorylation by MAPKAP kinase 2.

Oncogene 24, 1965-1972.

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2004

 

S. Schumacher, K. Laaß, S. Kant, Y. Shi, A. Visel, A.D. Gruber, A. Kotlyarov and M. Gaestel (2004) Scaffolding by ERK3 regulates MK5 in development.

EMBO-J. 23, 4770-4779.

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2003

 

Y. Shi, A. Kotlyarov, K. Laaß, A. D. Gruber, E. Butt, K. Marcus, H.E. Meyer, A. Friedrich,  H.-D. Volk and M. Gaestel (2003) Elimination of  Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination.

Mol. Cell. Biol. 23, 7732-7741.

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2002

 

A. Kotlyarov, Y. Yannoni, S. Fritz, K. Laaß, J.-B. Telliez, D. Pitman, L.-L. Lin, and M. Gaestel (2002) Distinct cellular functions of MK2.

Mol. Cell. Biol.  22 , 4827-4835.

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A. Neininger, D. Kontoyiannis, A. Kotlyarov, R. Winzen, R. Eckert, H.-D. Volk, H. Holtmann, G. Kollias and M. Gaestel (2002) MK2 targets AU-rich elements and regulates biosynthesis of TNF and IL-6 independently at different levels.

J. Biol. Chem. 277, 3065-3068.

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2001

 

A. Neininger, H. Thielemann and M. Gaestel (2001) FRET-based detection of two conformations of MK2.

EMBO Rep. 2, 703-708.

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1999

 

A. Kotlyarov, A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H.-D. Volk and M. Gaestel (1999) MAPKAP kinase 2 is essential for LPS-induced TNFa biosynthesis.

Nature Cell Biol. 1, 94-97.

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Th. Rogalla, M. Ehrnsperger, X. Preville, A. Kotlyarov, G. Lutsch, C. Ducasse, C. Paul, M. Wieske, A.-P. Arrigo, J. Buchner and M. Gaestel (1999) Regulation of Hsp27 oligomerization, chaperone function and protective activity against oxidative stress/TNFa by phosphorylation.

J. Biol. Chem. 274, 18947-18956.

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1998

 

K. Engel, A. Kotlyarov and M. Gaestel (1998) Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.

EMBO-J. 17, 3363-3371.

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