Workshop Title: The Beta Cell in Health, Disease and after Therapy
Organizers: Prof. Sigurd Lenzen & Prof. Anne Jörns
Steigenberger Hotel Sanssouci
Allee nach Sanssouci 1
+49 331 9091-0
Situated between the Park Sanssouci (3 min. walk) in the city center, the hotel boasts an ideal position. Lovers of art and culture are just three minute walk away from the Church of Peace.
“In each of the 137 rooms and suites you will feel thoroughly at home. The warm-colored interiors with extra comforts such as ceiling fan, soundproofed windows, minibar, a bottle of water per booking, flat-screen TV and radio will guarantee a friendly experience.”
“Unwind in the tranquil wellness area at the Steigenberger Hotel Sanssouci with its Finnish sauna and in-house steam bath. Come and enjoy one of our professional massages or take advantage of attractive offers for invigorating activities in the great outdoors. Our wellness offerings make the hotel a cozy haven of peace where you can breathe deep in every sense.”
Prof. Sigurd Lenzen, MD
Institute of Experimental Diabetes Research
Hannover Medical School
30625 Hannover / Germany
Tel. : +49 511 532 6525
Prof. Anne Jörns, MD
The special focus of this year's workshop will be the mechanisms of Beta Cell dysfunction and death in the T1DM autoimmune disease scenario and in the gluco-/lipotoxicity mediated T2DM scenario with the aim to provide a concise understanding of the underlying molecular pathomechanisms and the resulting therapeutic perspectives with special references to curative therapies.
Start of the workshop: Friday, 5 October 2018, 3 p.m.
End of the workshop: Sunday, 7 October 2018, 1 p.m.
Welcome and Introduction: Sigurd Lenzen (Hannover)
Why has translation of basic understanding of beta cell pathology into new therapies not been very successful during the last decades?
Keynote Lecture 1: David Ron (Cambridge)
Regulation of ER stress
The role of ER stress in proinflammatory cytokine and lipotoxicity mediated beta cell toxicity in T1DM and T2DM
Keynote Lecture 2: Decio Eizirik (Brussels)
The role of ER stress in beta cell dysfunction and death in diabetes
Lipotoxicity and gluco-/lipotoxicity in beta cells
Keynote Lecture 3: Anette Schürmann (Potsdam)
In vivo studies on the impact of gluco-lipotoxicity on islet function in diabetes-susceptible and diabetes-resistant mouse models
Comparison between primary human beta cells and the EndoC-βH1 beta-cell line
Keynote Lecture 4: Raphael Scharfmann (Paris)
Human pancreatic beta cell lines: What for?
Differential pathology of beta cell dysfunction and death in human diabetes and therapeutic perspectives
Keynote Lecture 5: Anne Jörns (Hannover)
Differential pathology of beta cell dysfunction and death in human T1DM, LADA and T2DM
Beta cell regeneration
Keynote Lecture 6: Heiko Lickert (Munich)
Beta cell regeneration and its potential for beta cell renewal in regenerative therapies
Role of G-protein receptors and ligants in T2DM
Keynote Lecture 7: Aine McKillop (Coleraine)
Mechanisms of GPR-mediated effects through GLP-1 and related peptides on beta cell regeneration with particular emphasis on the T2DM situation
Short consensus discussion:
Upon the issues addressed in the scientific sections
Further topics will be among others:
a) Second messengers in non-ATP-dependent incident glucose-induced insulin secretion.
b) Mediators of gluco-/lipotoxicity.
c) Inflammatory mediators in T1DM and T2DM islets.
d) A novelty and surprise: A new mouse model of human T1DM,
specially suited for therapy translation studies.
Further short oral presentations will be selected from the submitted abstracts.
Potsdam is a city of UNESCO World Heritage and the one thousand year old royal capital of Prussia. Nowadays the capital of the Federal State of Brandenburg. The city is in close vicinity to Berlin located in a lake area with many historical and cultural attractions, amongst them the famous castle Sanssouci with its beautiful park, the historical city centre with different monuments and museums, the famous Dutch quarter and the Babelsberg Film Center.
Further information can be found under https://en.potsdam.de/content/discover-potsdam
The castle was the summer residence of Frederick the Great, King of Prussia. It is located in the eastern part of the Park. The name Sanssouci (French sans souci “without care”) should be understood as both the primary wish and “leitmotif” of the king, because this was the place where he preferred to retreat in the company of his dogs. “The location of the palace beside its well-known vineyard terraces and the originally preserved 18th century interior decoration allow visitors to delve into the world of the “philosopher of Sanssouci.” The interiors are characterized by their elegance and stylish displays of grandeur. They are also a clear expression of the king’s love of beautiful surroundings – his “Prussian Arcadia.”
The magnificent Picture Gallery and the New Chambers palace also belong to the ensemble that forms Sanssouci Palace. It is of note that the king wished to be buried in a crypt on the uppermost terrace of the vineyard. Even in death, he wanted to be near his beloved Sanssouci. His wish was granted, although not until his reburial there in 1991. Frederick the Great’s grave is located on the highest terrace.”
The social program will include a guided tour of the Sanssouci Castle and the Art Galleries.
You may need a visa to enter Germany. Citizens from EU countries need no visa.
An Overview of visa requirements and exemptions can be found under: http://www.auswaertiges-amt.de/EN/EinreiseUndAufenthalt/03_Visabestimmungen/StaatenlisteVisumpflicht_node.html
(German Federal Foreign Office)
Submit your visa application and the required supporting documentation to the German Consulate/Embassy relevant to your country of residence.
If you need support with visa issues please contact:lenzen.sigurdmh-hannover.de
The language of the conference is English.
Climate and Clothing
Dress code during the conference is business casual and casual on the excursion. In early October, the average temperature is around 12 – 15 °C (54 – 59 °F).
Fees on the Registration and Accommodation Form are listed and charged in Euro (€) and will apply to payments received by the indicated deadlines.
Early-bird Registration until 30th June 2018
After 30th June 2018
*please provide a documentation of Student status
Meeting Fees include:
For registration please contact: lenzen.sigurdmh-hannover.de
You will get then detailed information for payment and registration forms
for participation and hotel accomodation by email
Berlin is easily accessible from everywhere (by plane, train and car)
Local Public Transport (30 min. ride to Potsdam)
Take the S-Bahn train (S3 to Erkner), enter at station: Berlin Messe-Süd (venue of the 2018 EASD Congress) and after one station change the train at: Berlin Westkreuz. Then take the S7 to Potsdam and leave train at station: Potsdam HbF (Central Station).
Connection: every 10 min.
Price: 2-3 €
From there you can walk (around 2 km, 26 min.)
to the workshop venue at:
Steigenberger Hotel Sanssouci
Allee nach Sanssouci
or take a taxi.
Deadline for Submission of Abstracts: July 15th 2018
Successful presenters will be notified by July 25th 2018.
For writing the abstract (1 page maximally) please follow the EASD rules for abstracts.
Please mail the abstract file as an attachment to the oraganizer Sigurd Lenzen.
Notification of cancellation should be sent in writing to: lenzen.sigurdmh-hannover.de
Refunds of registration fees will be made as follows:
We have allocated 20 minutes (20+5) for the lectures of invited speakers and 15 minutes (10+5) for short oral presentations.
Please provide your presentation either as .ppt, .pptx or .pdf file on an USB stick/pendrive, and make sure that it runs on both, MAC and PC.
The screen format will be a wide screen (16:9).
Please provide your file latest two hours before your session to the staff in the conference room.
Poster printing services are not provided. You will have to bring the poster to the conference venue.
Poster board: (w 120 cm; h 150 cm).
We will not send posters back to participants after the workshop.
Poster Presentation Dates, and Times:
Posters will be exhibited from Friday 4 pm until Sunday 12 am.
The poster should be self-explanatory and must cover the same material as reported in the abstract.
Materials to fix the poster on the poster wall will be provided on site.