SitemapImpressumDatenschutzerklärungdeutschenglish
MHH Logo

Hannover Medical School

 

 

 

Principal Investigator: Dr. Robert Zweigerdt, TECHNOBEAT Coordinator                    


Principal Investigator: Prof. Ulrich Martin, LEBAO Director

 

Co-principal investigator: Dr. Ruth Olmer


Scientists: Dr. Kristin Schwanke, Post-doctoral Researcher

 

 

 

 

Areas of expertise


- Induction of hiPSCs by somatic cell reprogramming

 

- hiPSCs targeting by homologous recombination using up-to-date technologies such as TALENs and CRISPR/Cas9

 

- hiPSC suspension culture and mass expansion in controlled bioreactors including cardiomyogenic differentiation

 

- Induction, characterisation and mass production of cardiac micro tissues

 

- hiPSC suspension culture and endothelial differentiation

 

 

Main tasks:

 

Work Package 1

 

- Derive transgene-free hiPSC lines via SOP-based protocols


- hiPSC line characterisation


- Reporter line engineering for in situ tracing


- hiPSC line cryopreservation, banking and distribution to network members

 

Work Package 5

 

- Cardiac differentiation in chemically defined medium


- Scale up hiPSC-CM production to 500 – 1,000 ml bioreactor scale


- Develop SOPs for hiPSC-CM


- µ-tissue generation and storage


- hiPSC-CMs / µ-tissues in vitro characterisation including arrhythmogenic and electromechanical properties


- µ-tissues in vivo characterisation; safety and function in rodents

 

Work Package 10

 

- Project coordination and management

 

- Project controlling and contractual management

 

- Resources management

 

- Communication and scientific exchange management

 

- Dissemination

 

Link:

http://www.lebao.eu/ 

http://www.rebirth-hannover.de/