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Peer Reviewed Publications

 

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Wollenberg, R. D. *, Taft, M. H.*, Giese, S , Thiel, C., Balázs, Z., Giese, H., Manstein, D. J., Sondergaard, T. E. (2018) Phenamacril is a reversible and non-competitive inhibitor of Fusarium class I myosin. J Biol Chem. pii: jbc.RA118.005408. doi: 10.1074/jbc.RA118.005408. *equal contribution

 

Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D. J., and Di Donato, N. (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9(1):4250, DOI: 10.1038/s41467-018-06713-0

 

Meiring, J. C. M., Bryce, N. S., Wang, Y., Taft, M. H., Manstein, D. J., Liu Lau, S., Stear, J., Hardeman, E. C. and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053.

 

Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruehwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Sarnow, K., Gruetzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Knoefler, R., Manstein, D. J., and Di Donato, N. (2018). Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations. bioRxiv. DOI: 10.1101/303909.

 

Pathan-Chhatbar, S.*, Taft, M. H.*, Reindl, T., Hundt, N., Latham, S. L., and Manstein, D. J. (2018) Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous beta-actin in vitro. J. Biol. Chem. pii: jbc.M117.806521. doi: 10.1074/jbc.M117.806521. *equal contribution

 

Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D. J., Lieske, J., Oberthuer, D., Fischetti, R. F., and Chapman, H. N. (2017) Pink-beam serial crystallography. Nat. Commun. 8, 1281; doi: 10.1038/s41467-017-01417-3.

 

Zattelman, L., Regev, R., Ušaj, M., Reinke, P. Y. A., Giese, S., Samson, A. O., Taft, M. H., Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii: jbc.M117.794008. doi: 10.1074/jbc.M117.794008.

 

Behrens, V. A., Münnich, S., Adler-Gunzelmann, G., Thiel, C., Henn, A., Latham, S. L., and Taft, M. H. (2017) The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2., Sci. Rep. 7, 7650; doi:10.1038/s41598-017-07933-y

 

Schuster-Gossler, K., Cordes, R., Müller, J., Geffers, I., Delany-Heiken, P., Taft, M. H., Preller, M., and Gossler, A. (2016) Context-dependent sensitivity to mutations disrupting the structural integrity of individual EGF repeats in the mouse Notch ligand DLL1., Genetics 202, 1119-33.

Hundt, N., Steffen, W., Pathan-Chhatbar, W., Taft, M. H., and Manstein, D. J. (2016) Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2., Sci. Rep. 6, 20554; doi: 10.1038/srep20554

Abbey, M., Hakim, C., Anand, R., Lafera, J., Schambach, A., Kispert, A., Taft, M. H., Kaever, V., Kotlyarov, A., Gaestel, M., and Menon, M. (2015) GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis., Sci. Rep. 6, 20007, doi:10.1038/srep20007

Münnich, S., Taft, M. H., and Manstein, D. J. (2014) Crystal Structure of Human Myosin 1c-The Motor in GLUT4 Exocytosis: Implications for Ca(2+) Regulation and 14-3-3 Binding., J. Mol. Biol. 426, 2070-81.

Radke, M. B.*, Taft, M. H.*, Stapel, B., Hilfiker-Kleiner, D., Preller, M., and Manstein, D. J. (2014) Small molecule-mediated refolding and activation of myosin motor function., eLife 3, e01603. *equal contribution

Taft, M. H.#, Behrmann, E., Munske-Weidemann, L.-C., Thiel, C., Raunser, S., and Manstein, D. J. (2013) Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3., J. Biol. Chem. 288, 30029-41. #corresponding author

Müller, M., Diensthuber, R. P., Chizhov, I., Claus, P., Heissler, S. M., Preller, M., Taft, M. H., and Manstein, D. J. (2013) Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins., PLoS ONE 8, e70636.

Rump, A., Scholz, T., Thiel, C., Hartmann, F. K., Uta, P., Hinrichs, M. H., Taft, M. H., and Tsiavaliaris, G. (2011) Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division., J. Cell. Sci. 124, 2521-8.

Chinthalapudi, K., Taft, M. H., Martin, R., Heissler, S. M., Preller, M., Hartmann, F. K., Brandstaetter, H., Kendrick-Jones, J., Tsiavaliaris, G., Gutzeit, H. O., Fedorov, R., Buss, F., Knölker, H.-J., Coluccio, L. M., and Manstein, D. J. (2011) Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity., J. Biol. Chem. 286, 29700-8.

Diensthuber, R. P., Müller, M., Heissler, S. M., Taft, M. H., Chizhov, I., and Manstein, D. J. (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin., FEBS Lett. 585, 767-71.

Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F. K., Taft, M. H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H. O., and Manstein, D. J. (2009) The mechanism of pentabromopseudilin inhibition of myosin motor activity., Nat. Struct. Mol. Biol. 16, 80-8.

Taft, M. H., Hartmann, F. K., Rump, A., Keller, H., Chizhov, I., Manstein, D. J., and Tsiavaliaris, G. (2008) Dictyostelium myosin-5b is a conditional processive motor., J. Biol. Chem. 283, 26902-10.