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Publications + Presentations

Papers

 

Allodi, I., Udina, E., Navarro, X.(2012): Specificity of peripheral nerve regeneration: Interactions at the axon level; Progress in Neurobiology 98 (2012) 16-37

 

Allodi I., Casals-Díaz L., Santos-Nogueira E., Gonzalez-Perez F., Navarro X., Udina E. FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons. Mol Neurobiol 2013, 47:770-781.

 

Allodi I., Mecollari V., González-Pérez F., Eggers R., Hoyng S., Verhaagen J., Navarro X., Udina E. Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury. Glia 2014, 62:1736-46.

 

Assunção-Silva R., Costa-Oliveira C., Ziv-Polat O., Gomes E.D., Shahar A., Sousa N., Silva N.A., Salgado A.J. Induction of Neurite Outgrowth in 3D Hydrogel-Based Environments. Biomedical Materials, 2015 Oct 20; 10(5):051001.

 

Arbat-Plana A., Torres-Espín A., Navarro X., Udina E. Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury. Exp Neurol 2015 Jan;263:293-305. doi: 10.1016/j.expneurol.2014.10.009. Epub 2014 Oct 23.

 

Buskbjerg Jager S, Ronchi G., Bjerggaard Vaegter C, Geuna S. The mouse median nerve experimental model in regenerative research. Biomed Res Int. 2014;2014:701682.

 

Chemnitz A., Dahlin LB., Carlsson IK. Consequences and adaptation in daily life - patients' experiences three decades after a nerve injury sustained in adolescence. BMC Muscoloskel Dis 2013, 22(14):252.

 

Cobianchi S., de Cruz J., Navarro X. Assessment of sensory thresholds and nociceptive fiber growth after sciatic nerve injury reveal the differential contribution of collateral reinnervation and nerve regeneration to neuropathic pain. Exp Neurol 2014, 255:1-11.

 

Gambarotta G., Ronchi G., Geuna S., Perroteau I. Neuregulin 1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration. Neural Regen Res. 2014 15;9(12):1183-5.

 

Gambarotta G., Ronchi G., Friard O, Galletta P, Perroteau I., Geuna S. Identification and validation of suitable housekeeping genes for normalizing quantitative real-time PCR assays in injured peripheral nerves. PLoS One. 2014 Aug 21;9(8):e105601.

 

Gambarotta G., Pascal D., Ronchi G., Morano M., Jager S.B., Moimas S., Zentilin L., Giacca M., Perroteau I., Tos P., Geuna S., Raimondo S. Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fibre maturation. Gene Ther. 2015 May 4

 

Geuna S., Raimondo S., Fregnan F., Haastert-Talini K., Grothe C. In vitro models for peripheral nerve regeneration. Eur J Neurosci. 2015 Aug 26

 

Geuna S., Herrera-Rincon C. Update on stereology for light microscopy. Cell Tissue Res. 2015 Apr;360(1):5-12.


Geuna S. The sciatic nerve injury model in pre-clinical research. J Neurosci Methods. 2015 Mar 30;243:39-46. doi:

 

Gnavi S., Fornasari B.E., Tonda-Turo C., Laurano R., Zanetti M., Ciardelli G., Geuna S. The Effect of Electrospun Gelatin Fibres Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design. Int J Mol Sci. 2015 Jun 8;16(6):12925-42

 

Gonzalez-Perez F., Cobianchi S., Geuna S., Barwig C., Freier T., Udina E., Navarro X. Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat. Microsurgery 2015 May;35(4):300-8.

 

Gonzalez-Perez F., Alé A., Santos D., Barwig C., Freier T., Navarro X., Udina E. Substratum preferences of motor and sensory axons in postnatal and adult rats. Eur J Neurosci 2015 Aug 31

 

López-Álvarez V.M., Modol L., Navarro X., Cobianchi S. Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury. Pain 2015 Sep;156(9):1812-25

 

Haastert-Talini, K., Geuna, S., Dahlin, L. B., Meyer, C., StenbergL., Freier, T, Heimann, C., Barwig, C.,  Pinto, L. F.V., Raimondo, S., Gambarotta, G., Samy, S. R., Sousa, N., Salgado, A. J., Ratzka, A., Wrobel, S., Grothe, C. (2013): Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34 (2013), pp. 9886-9904

 

Hallgren A., Björkman A., Chemnitz A., Dahlin L.B.. Subjective outcome related to donor site morbidity after sural nerve graft harvesting: a survey in 41 patients. BMC Surg. 2013, 13:39.

 

Meyer, C.,Wrobel, S., Raimondo, S., Rochkind, S., Heimann, C., Shahar, A., Ziv-Polat, O., Geuna, S., Grothe, C., Haastert-Talini, K. Peripheral nerve regeneration through hydrogel enriched chitosan tubes containing engineered Schwann cells for drug delivery. Cell Transplantation, April 2015, in press 

 

Meyer C., Wrobel S., Raimondo S., Rochkind S., Heimann C., Shahar A., Ziv-Polat O., Geuna S., Grothe C., Haastert-Talini K. Peripheral nerve regeneration through hydrogel enriched chitosan conduits containing engineered Schwann cells for drug delivery. Cell Transplant. 2015 Apr 14.

 

Meyer C., Stenberg L., Gonzalez-Perez F., Wrobel S., Ronchi G., Udina E., Suganuma S., Geuna S., Navarro X., Dahlin L.B., Grothe C. , Haastert-Talini K. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2015 Oct 21;76:33-51.


Morano M., Wrobel S., Fregnan F., Ziv-Polat O., Shahar A., Geuna S., Grothe C., Haastert-Talini K.
Nanotechnology versus stem cell engineering - In vitro-comparison of neurite inductive potentials. Int J Nanomedicine 9(1):5289-5306

 

Oliveira N.G., Sirgado T., Reis L., Pinto L.F.V., da Silva C.L., Ferreira F.C., Rodrigues A. In vitro assessment of three dimensional dense chitosan-based structures to be used as bioabsorbable implants, Journal of the Mechanical Behavior of Biomedical Materials 40 2014, 413–425.


Oliveira N.G., Rodrigues A., Reis L., Pinto L.F.V. Trends in Bioabsorbable Osteosynthesis Devices: Introduction to a Novel Production Process of Chitosan-Based Implants, J. Chitin Chitosan Sci. 2013, Vol. 1, No. 3, 1-11.

 

Oliveira N.G., Pinto L.F.V., Reis L., Rodrigues A.  Competitiveness of chitosan-based implants. Ciência & Tecnologia dos Materiais, 26, 77–88, July-December 2014

 

Ronchi G., Raimondo S., Geuna S., Gambarotta G. New insights on the standardization of peripheral nerve regeneration quantitative analysis. Neural Regen Res. 2015 May;10(5):707-9

 

Ronchi G., Haastert-Talini K., Fornasari B.E., Perroteau I., Geuna S., Gambarotta G. The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Eur J Neurosci. 2015 Jun 8

 

Shapira, Y., Tolmasov, M., Nissan, M., Reider, E., Koren, A., Biron, T., Bitan, Y., Geuna, S., Rochkind, S. Comparison of results between chitosan hollow tube and autologous nerve graft in reconstruction of peripheral nerve defect: An experimental study. Microsurgery, April 2015. DOI: 10.1002/micr.22418

 

Silva R., Oliveira C, Polat O., Gomes E.D., Sahar  A., Sousa N., Silva  N.A., Salgado A.J. Induction of Neurite Outgrowth in 3D Hydrogel-Based Environments. Biomed Mater. 2015 Oct 20;10(5):051001

 

Stenberg, L., Kanje, M., Dolezal, K., Dahlin, L.B.(2012): Expression of activationg transcription Factor 3 (ATF 3) and caspase Schwann cells and axonal outgrowth after sciatic nerve repair in diabetic BB rats; Neuroscience letters 515 (2012) 34-38

 

Stenberg L., Dahlin L.B.. Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats. BMC Neurosci. 2014, 15:107.

 

Stenberg L., Kodama A., Lindwall- Blom C., Dahlin L.B. Nerve regeneration in chitosan conduits and in autologous nerve grafts in healthy and in type 2 diabetic Goto-Kakizaki rats. Eur J Neurosci. 2015 Sep 10.

 

Wrobel S., Serra S.C., Ribeiro-Samy S., Sousa N., Heimann C., Barwig C., Grothe C., Salgado A.J., Haastert-Talini K. (2014): In Vitro Evaluation of Cell-Seeded Chitosan Films for Peripheral Nerve Tissue Engineering. Tissue Engineering Part A

 

Ziv-Polat O, Shahar A, Levy I, Skaat H, Neuman S, Fregnan F, Geuna S, Grothe C, Haastert-Talini K, Margel S. (2014):  The role of neurotrophic factors conjugated to iron oxide nanoparticles in peripheral nerve regeneration - in vitro studies. BioMed Research International, Vol 2014 (2014)

 

Ziv-Polat O., Margel S., Shahar A. Application of iron oxide nanoparticles in neuronal tissue engineering. Neural Regen Res. 2015 Feb;10(2):189-91

 

Letter to the Editor: "BIOHYBRID-Biohybrid templates for peripheral nerve regeneration", Grothe et al. , Journal of the Peripheral Nervous System 17:220–222 (2012)

Book Chapters

 

 

Geuna S, Haastert-Talini K, Navarro X. (2013): The nerve trunk in injury and during regeneration. In Dahlin L, Ada S, Leblebicioğlu G (eds): Current treatment of nerve injuries and disorders. Federation of European Societies for the Surgery of the Hand. Palme Publications

 

Gnavi S, Barwig C, Freier T, Haastert-Talini K, Grothe C, Geuna S              
Chapter 1: The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System
In: Int Rev Neurobiol. 2013;109C:1-62.

 

Shahar A., Ziv-Polat O., Margel S., Freier T. Developing a Customized Tissue-Engineered Implant for Peripheral Nerve Reconstruction: Role of Nanoparticles. Book Chapter no. 14, pp: 361-380 in "Medical Nanobiotechnology", Vol. 5, Bhupinder Singh, Sanjeev Puri, Swaranjit Singh Cameotra (Editors), ISBN No. 1-62699-055-7, "Nanobiomedicine” Book Series, Studium Press LLC, USA, Book Series- ISBN No. 1-62699-050-6 (2015

 

 

 

 

Review articles

 

Geuna S., Raimondo S., Fregnan F., Haastert-Talini K., Grothe C. (2015) In vitro models for peripheral nerve regeneration. Eur J Neurosci. 2015 Aug 26. doi: 10.1111/ejn.13054. [Epub ahead of print] review

 


Navarro X. Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models. A critical overview. Eur J Neurosci 2015 Jul 30. doi: 10.1111/ejn.13033. [Epub ahead of print]

 

 

 

Published abstracts

 

Haastert-Talini, K., Geuna, S., Dahlin, L.B., Salgado, A.S., Shahar, A.,Freier, T., Grothe, C., and the BIOHYBRID consortium. New chitosan-based scaffolds for peripheral nerve regeneration – pre clinical studies. 3rd International
Conference on Tissue Science & Regenerative Medicine, September 24th-26th, Valencia, Spain, J Tissue Sci Eng 2014; 5(3):35


Wrobel, S., Morano, M., Meyer, C., Shahar, A., Ziv, O., Haastert-Talini, K., Geuna, S., Grothe, C. Development of cell-enhanced chitosan scaffolds to overcome long gaps after peripheral nerve injury. Cytotherapy 2014, Vol. 16, Issue 4, Supplement, Page S102

 

Figueiredo L., Moura C., Pinto L.F.V., Ferreira F.C., Rodrigues A.  Processing and characterization of 3D dense chitosan pieces, for orthopedic applications, by adding plasticizers.  Procedia Engineering, 110, 175 – 182, 2015. 4th International Conference on Tissue Engineering, ICTE2015, An ECCOMAS Thematic Conference. doi:10.1016/j.proeng.2015.06.182

 

 

 

 

In preparation

 

 

Fregnan F., Ziv-Polat O., Morano M., Mandelbaum-Livnat M., Nissan M., Koren A., Biran T., Bitan Y., Reider E., Viano N.,  Rochkind S., Geuna S., Shahar A. Effect of local delivery of GDNF conjugated iron oxide nanoparticles on nerve regeneration along long chitosan nerve guides.

Gonzalez-Perez F, Cobianchi C, Heimann C, Phillips JB, Udina E, Navarro X. Stabilization, rolling and addition of other ECM proteins to collagen hydrogels improves regeneration in chitosan guides for long peripheral nerve gaps in rats. Submitted.


Rochkind S., Mandelbaum-Livnat M., Morano M., Raimondo S., Nissan M., Koren A., Biran T., Yifat Bitan, Reider E.,  Ziv-Polat O., Shahar A., Geuna S. Peripheral Nerve Reconstruction using Different Acetylation Chitosan Conduits Filled with NVR-Gel and Magnetic Fibrin Hydrogel.   


Serra S.C. et al., Effects of ACS Influence of Cell Passage Number Adipose Stem Cells Secretome and Its effect on CNS/PNS derived cells. Expected submission date: December 2015


Stenberg L, Hazer B., Suganuma S., Mårtensson L., Lindvall-Blom C., Dahlin L.B. Expression of HSP27 in Schwann cells and sensory neurons after nerve injury and repair.

 

 

 

Conference contributions

 

 

Assunção-Silva R. C., Costa-Oliveira C., Ziv-Polat O., Gomes E.D., Shahar A., Sousa N., Silva N.A., Salgado A.J. Inducing Axonal Growth in 3D ECM-like Environments. SPN 2015; Póvoa de Varzim, Portugal (4- 5th June, 2015)  

Cobianchi S, Modol L, Lopez VM, Navarro X. Early increasing-intensity treadmill exercise (InTR) reduces neuropathic pain by restoring NKCC1 and KCC2 cation-chloride cotransporters homeostasis after peripheral nerve injury. 5th International Congress on Neuropathic Pain (NeuPSIG 2015); Nice, France (14- 17th May, 2015) 

Dahlin L.B., Enander J., Hazer B., Lindwall-Blom C., Stenberg L. Expression of Heat Shock Protein 27 (HSP27) and axonal outgrowth after nerve injury and repair.  Neuroscience, Washington DC, November 15-19, 2014.  

Geuna S. Tissue engineering for enhancing peripheral nerve repair and regeneration. Frontier Research Academy for Young Researchers, Kyushu Institute of Technology; Fukuoka, Japan, (9- 14th February, 2015) 

Geuna S. Ingegneria tissuale e rigenerazione del nervo periferico. ASNP-2015 (9- 11th April, 2015) Turin, Italy 

Geuna S. Nerve regeneration. 7th European Plastic Surgery Research Council; Hamburg, Germany (27- 30th August, 2015)  


Geuna S., Haastert-Talini K., Dahlin L.B., Rochkind S., Navarro X., Salgado A.J., Freier T., Shahar A., Grothe C. Bioartificial guides for peripheral nerve repair: Developments and findings from the EU-Collaborative project BIOHYBRID. 2015 PNS Biennial Meeting; Quebec City, Quebec, Canada (28th June- 2nd July, 2015)  


Geuna S., Haastert-Talini K., Freier T. Chitosan-based bioartificial conduits for peripheral nerve repair-developments and findings from the EU-Collaborative Project BIOHYBRID. 37th GAM Meeting; Strasbourg, France (15- 16th May, 2015)  


Geuna S., Raimondo S., Fregnan F., Ronchi G. and Giacobini- Robecchi M.G. Conduit enrichment strategies for severe peripheral nerve injuries. S.I.A.I. 69° National Congress; Ferrara, Italy (17- 19th September, 2015)

 

Geuna S., Raimondo S., Battiston B., Tos P. Innovative Bio-engineered scaffolds for peripheral nerve reconstruction. X. National Congress of the Romanian Society of Hand Surgery (2- 4th April, 2015) Cluj Napoca, Romania  


Geuna S., Ronchi G., Raimondo S., Viano N., Gambarotta G. Methodological pitfalls in peripheral nerve regeneration research.. XXIV. Convegno Nazionale Gruppo Italiano Per Lo Studio Della Neuromorfologia (28-29th November, 2014) Bologna, Italy  


Gnavi S., Fornasari B.E., Tonda-Turo C., Laurano R., Zanetti M., Ciardelli G., Geuna S. The influence of electrospun fibre alignment on Schwann Cell Behaviour and axonal outgrowth. The neuregulin1/ERBB system, a potential tool to improve peripheral nerve regeneration. ASNP-2015; Turin, Italy (9- 11th April, 2015)  


Haastert-Talini K. (German, 10.10.2014) Chitosan-Nervenleitschienen: prä-klinische Studien zur unterstützenden Wirkung auf die peripheren Nervenregeneration. 55.Kongress der Deutschen Gesellschaft der Handchirurgie, Baden-Baden, Germany


Haastert-Talini K. Bioartifizielle Nervenimplantate auf Chitosanbasis – Entwicklungen des EU-Konsortiums BIOHYBRID. (German, 20.02.2015) Wissenschaftliches NervClub-Symposium 2015, Hamburg, Germany


Haastert-Talini K., Geuna S., Shahar A., Freier T., Grothe C. and the BIOHYBRID consortium (2014): BIOHYBRID nerve transplants - development of chitosan-based nerve grafts.  48th DGBMT Annual Conference, October 8th-10th 2014, Hannover, Germany; Biomed Tech 2014; 59 (s1) DOI 10.1515/bmt-2014-4343  


MEDOVENT 55. Kongress der DGH (9 – 11th October, 2014) Baden-Baden, Germany   Congress Booth

 

MEDOVENT DGH Workshop (6- 7th February, 2015) Bonn, Germany   Congress Booth

MEDOVENT DGU (25th April, 2015) Düsseldorf, Germany   Congress Booth
           

MEDOVENT 56. DAH Symposium (7− 9th May, 2015) Aarau, Switzerland   Congress Booth

       
MEDOVENT 3. Lübecker Trainingsprogramm der Mikrochirurgie (8− 9th May, 2015) Lübeck, Germany   Congress Booth and TRAINING WORKSHOP

MEDOVENT 35. Handchirurgischer Operationskurs (16− 18th September, 2015) Gießen, Germany   Congress Booth
           

MEDOVENT Nerve in Hands; (19th September, 2015) Ludwigshafen, Germany   Congress Booth

MEDOVENT 56. DGH Kongress (24−26th September, 2015) Ludwigsburg, Germany   Congress Booth

MEDOVENT Nervenrekonstruktion mit dem Biopolymer Chitosan – Die erste CE-zertifizierte Nervenleitschiene Made in Germany. with Prof. Haastert-Talini, Dr. Siemers and Dr. Freier – scientific symposium 55. Kongress der DGH; Baden-Baden, Germany (9 – 11th October, 2014) 

Oliveira M., Carvalho C. Chitosan Films with Low Degrees of Acetylation for Peripheral Nerve Regeneration. FBPS 2015 (8- 11th July, 2015) Riva Del Garda, Italy  

 

Oliveira E., Assunção Silva R.C., Ziv-Polat O., Gomes E.D., Shahar A., Sousa N., Silva N., Salgado A.J. Hydrogels for Nerve Regeneration. SPN 2015; Póvoa de Varzim, Portugal (4- 5th June, 2015)  

 

Pascal D., Tos P., Ronchi G., Raimondo S., Gambarotta G., Gnavi S.  and Geuna S. The Neuregulin 1/ERBB System, a potential tool to improve peripheral nerve regeneration. ASNP-2015; Turin, Italy 9- 11th April, 2015 

Pascal D., Tos P., Ronchi G., Raimondo S., Gambarotta G., Gnavi S., Geuna S. Chitosan-based bioartificial conduits for peripheral nerve repair – developments and findings from the EU-Collaborative project BIOYHBRID. ASNP-2015, Turin, April 9-11, 2015 


Ronchi G., Haastert-Talini K., Fornasari B.E., Viano N., Perroteau I., Geuna S., and Gambarotta G. Selective regulation of the Neuregulin1/ERBB system after peripheral nerve injury. 2015 PNS Biennial Meeting; Quebec City, Quebec, Canada (28th June- 2nd July, 2015)  


Ronchi G., Viano N., Ceccopieri S.., Perroteau I.1, Geuna S., Gambarotta G.
NRG1/ERBB System regulation after peripheral nerve injury. ASNP-2015 (9- 11th April, 2015) Turin, Italy  

 

Salgado A.J. BioHybrid: A Case of Success. Internal event at University of Minho, Braga, Portugal  


Serra S.C., Costa J., Teixeira F.G., Silva N.A., Anjo S.I., Manadas B., Gimble J., Sousa N., Salgado A.J. Influence of cell passage number on the effect of adipose stem cells secretome on neuronal cells. SPN 2015; Póvoa de Varzim, Portugal (4- 5th June, 2015)  


Stenberg, Lena: Half-time seminar presentation and approval of the PhD thesis at Lund University in November 2014 (tentative thesis spring 2016).  

 

The BIOHYBRID Consortium presented extensive insights into the ongoing research at the 3rd international Symposium on Peripheral Nerve Regeneration (ISPNR), Sept. 24-25th, 2015 in Hannover, Germany 

Arbat-Plana A., Cobianchi S., Navarro X., Udina E. Role of TrkB and noradrenergic descendent projections in the modulatory effects induced by treadmill exercise on the spinal changes that motoneurons suffer after peripheral nerve injury in rats.

 

Assunção-Silva R. C., Costa-Oliveira C., Ziv-Polat O., Gomes E.D., Shahar A., Sousa N., Silva N.A., Salgado A.J. Using Stem Cells and Nanoparticles as Tools to Modulate Axonal Growth in 3D ECM-like Environments.

 

Barwig C. Regulatory requierements for nerve guides in europe

 

de la Oliva N., del Valle J., Mueller M., Stieglitz T., Navarro X. Biocompatibility of parylene c and polyimide as substrates for intraneural interfaces and its effect on peripheral nerves

 

del Valle J., Santos D., Righi M., Bossi S., Micera S., Navarro X. Development and evaluation of a new planar regenerative electrode.

 

Gambarotta G., Ronchi G., Haastert-Talini K., Fornasari B.E., Crosio A., Pugliese P., El Souri M., Perroteau I., Geuna S. The regulation of the Neuregulin1/ErBB system in the degenerating and regenerating nerve.

 

Geuna S., Ronchi G., Raimondo S., Gambarotta G. Standardization of morphological and biomolecular methods for peripheral nerve research.

 

Gnavi S., Tonda Turo C., Morano M., Fornasari B., Riccobono C., Zanetti M., G Ciardelli G., Perroteau I. and Geuna S. Electrospun gelatin fibres features modulate Schwann Cell and DRG Neuron behaviour

 

Gonzalez-Perez F., Cobianchi S., Hernández J., Barwig C., Freier T., Phillips J.B., Udina E., Navarro X. Functionalization of artificial nerve guides to promote peripheral nerve regeneration.

 

Grothe C., Geuna S., Raimondo S., Fregnan F., Haastert-Talini K. In vitro models for peripheral nerve regeneration.


Haastert- Talini K. The BIOHYBRID Conclusion: outcome and prospects from pre- clinical evaluation of chitosan hollow and composite artificial nerve grafts.


López-Álvarez V.M., Navarro X., Cobianchi S. Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injur

 

MEDOVENT 3rd International Symposium ISPNR (congress Booth9

 

Navarro X. Functional and electrophysiological evaluation of peripheral nerve regeneration and target reinnervation.

 

Raimondo S., Wrobel S., Ziv-Polat O., Fregnan F., Morano M., Rochkind S., Shahar A., Grothe C., Geuna S. Neurotrophic factors conjugated to Iron Oxide Nanoparticles: Effects on peripheral nerve regeneration.

 

Rochkind S., Shainberg A. Muscle response to complete peripheral nerve injury: Dynamic changes of Acetylcholine receptors (AChR) and Creatine Kinase (CK) activity over time

 

Santos D., Wieringa P., Moroni L., Micera S., del Valle J., Navarro X. Polyactive nerve guides enhance regeneration in long gap defects

 

Stenberg L., Suganuma, S., Meyer C., Haastert-Talini K., Dahlin L.B. Nerve regeneration in hollow and membrane containing chitosan conduits bridging a 15 mm rat sciatic nerve defect in healthy and diabetic rats.

 

Stößel M., Meyer C., Grothe C., Ronchi G., Geuna S., Haastert- Talini K. Peripheral nerve regeneration after delayed repair of long gap defects in the rat sciatic nerve using two types of chitosan nerve guides. (Poster)

 

Tos P.L., Geuna S., Crosio A., Gambarotta G., Raimondo S., Perroteau I., Battiston B: Muscle-vein-combined graft: technique and experimental applications.

Udina E. Modulation of the stretch reflex arc to improve functional recovery after nerve
injury.

 

Carvalho C.R., Goncalves J.P., Reis R.L., Oliveira J.M., TermStem 2014, 23-24 October 2014, Porto, Portugal. Application of keratin/chitosan conduits for peripheral nerve regeneration.

 

Freier, T., 18th DGH Fortbildungsseminar, 05. – 06. September 2014 Berlin, Germany. Presentation of Reaxon® Nerve Guide (Congress booth)

 

Arbat-Plana A., Macias-Gómez A., Navarro X., Udina E., 9th FENS Forum of Neuroscience, July 2014, Milan, Italy. Time course characterization and effects of NT3/BDNF application on the synaptic stripping suffered by rat motoneurons after sciatic nerve injury. 

 

Gonzalez-Perez F., Alé A., Navarro X., Udina E., 9th FENS Forum of Neuroscience, July 2014, Milan, Italy. In vitro comparison of motor and sensory neuron outgrowth in different extracellular matrix (ECM) enriched matrices.

 

Morano, M., Fregnan, F., Wesemann, M., Ziv-Polat, O., Shahar, A., Grothe, C., Haastert-Talini, K., Geuna S., 9th FENS Forum of Neuroscience, July 2014, Milan, Italy. In vitro analysis on NVR-gel combined with iron oxide-conjugated factors for peripheral nerve engineering.

 

Dahlin L.B., 5th Regenerative Medicine Symposium “Regeneration of Nerves and Epithelia: Current Progress & Future Therapies”June 26th-27th 2014, Lübeck, Germany. Clinical challenges in nerve reconstruction.

 

Grothe, C., 5th Regenerative Medicine Symposium “Regeneration of Nerves and Epithelia:  Current Progress & Future Therapies”, June 26th-27th 2014, Lübeck, Germany. Biohybrid nerve devices

 

Meyer C., Haastert-Talini K., Wrobel S., Grothe C., 5th Regenerative Medicine Symposium “Regeneration of Nerves and Epithelia: Current Progress & Future Therapies”, June 26th-27th 2014, Lübeck, Germany. Addressing the long gap: Reaxon nerve guides supplemented with genetically modified Schwann cells over- expressing GDNF or FGF-218kDa in NVR-Gel.

 

Stenberg L., Geuna S., Grothe C., Freier T., Dahlin L.B., 5th Regenerative Medicine Symposium “Regeneration of Nerves and Epithelia: Current Progress & Future Therapies”, June 26th-27th 2014, Lübeck, Germany, Reconstruction of sciatic nerve defect in healthy and diabetic GK rats with hollow chitosan tubes (BIOHYBRID) and autologous nerve grafts – short time perspectives.

 

Carvalho C.R., Pedro J., Ng K.W., Neves N., Reis R.L., Oliveira J.M., TERMIS-EU 2014 Chapter Meeting, 10-13 June 2014, Genova, Italy. Keratin/chitosan as novel grafts for peripheral nerve regeneration.

 

Geuna, S., Haastert-Talini, K., Freier, T., Grothe, C., and the BIOHYBRID Consortium TERMIS-EU 2014 Chapter Meeting, 10-13 June 2014, Genova, Italy. Different acetylation of chitosan conduits for the peripheral nerve repair.

 

Wrobel S., Morano M., Meyer C., Shahar A., Ziv-Polat O., Haastert-Talini K., Geuna S., Grothe C., 20th ISCT Annual Meeting, April 23rd-26th 2014, Paris, France; Cytotherapy, 16 (4), Supplement, April 2014 Development of cell-enhanced chitosan scaffolds to overcome long gaps after peripheral nerve injury.

 

K. Haastert-Talini and BIOHYBRID consortium, 5th Vienna Symposium on Surgery of Peripheral Nerves, March 21.-23., 2014, Vienna, Austria. BIOHYBRID - development of new chitosan based nerve graft - first pre-clinical results.”

 

Stenberg L., Kodama A., Freier T., Geuna S., Dahlin L.B., 5th Vienna Symposium on Surgery of Peripheral Nerves, March 21.-23., 2014, Vienna, Austria. Nerve regeneration after nerve repair or after nerve reconstruction with hollow chitosan conduits (BIOHYBRID) or with autologous nerve grafts bridging a sciatic nerve defect in healthy and diabetic Goto-Kakizaki (GK) rats.

 

The BIOHYBRID Consortium presented extensive insights into the ongoing research at the 2nd international Symposium on Peripheral Nerve Regeneration (ISPNR), Jan. 23-25th, 2014 in Turin, Italy.

 

Carvalho, C.R., Silva-Correia, J., Martins, A.,  Neves, N.M., Oliveira, J.M., Reis, R.L.,  Chitosan nanofibers for guided peripheral nerve regeneration

 

Cobianchi S., Navarro X. Advantages and pitfalls of algesimetry tests for functional evaluation after nerve injuries.

 

Gonzalez-Perez, F., Cobianchi. S., Barwig, C., Freier, T., Udina E., Navarr, X.,  Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat

 

Haastert-Talini, K., Grothe C., Geuna, S., Dahlin, L.B., Salgado, A., Freier, T. The BIOHYBRID project:  pre-clinical evaluation of chitosan-based artificial nerve grafts.

 

Iannello A., Ronchi G. , Pascal D., Crosio A., Friard O., Geuna S., Gambarotta G. Expression analysis of Neuregulin 1 isoforms and ErbB receptors in two experimental models : end-to-end repair and crush injury.

 

Meyer, C., Haastert-Talini, K., Wrobel, S., Ratzka, A., Grothe, C., Inflamatory and physiological tissue responses following nerve reconstruction with chitosan tubes of different degrees of acetylation  (Poster)

 

Morano, M., Fregnan, F., Wesemann, M., Ziv-Polat, O., Shahar, A., Grothe, C., Haastert-Talini, K., Geuna, S.,  In vitro evaluation of NVR-gel enriched with neurotrophic factors conjugated to iron oxide nanoparticles for peripheral nerve repair (Poster)

 

Navarro X. Electrophysiological and functional tests: what is meaningful for functional recovery.

 

Shapira, Y., Tolmasov, M., Shchetinkov, L., Nissan, M., Reider, E., Koren, A., Biron, T., Bitan, Y., Ronchi, G., Geuna, S.,  Rochkind, S., Peripheral nerve reconstruction of sciatic nerve in rats using chitosan hollow tubes versus standard care with nerve graft

 

Silva N.A., Gomes E.D., Silva R.C., Serra, S.C., Wrobel, S., Grothe, C., Haastert-Talini, K., Sousa, N., Salgado, A.J., Peptide grafted gellan gum based hydrogels and mesenchymal stem cells in peripheral nerve regeneration

 

Stenberg, L., Kodam, A., Freier, T., Geuna, S., Dahlin L.B. Nerve regeneration in hollow chitosan tubes (BIOHBYBRID) and in autologous nerve grafts bridging a sciatic nerve defect in healthy and diabetic GK rats.

Wrobel, S., Wesemann, M., Grothe, C., Heimann, C., Shahar, A., Ziv-Polat, O., Salgado, A., Haastert-Talini, K., In vitro evaluation of cell-seeded chitosan tubes for peripheral nerve tissue engineering (Poster)

 

Ziv-Polat, O., Geuna, S., Grothe, C., Margel, S., Shahar, A., Role of nerve growth factors conjugated to iron oxide nanaoparticles in the reconstruction of severed perheral nerve- in vitro studies

 

Freier, T.  Presentation of Reaxon® Nerve Guide. (Congress booth)

 

Raimondo S., Geuna S., Haastert-Talini K., Freier T., Grothe C., and the BIOHYBRID Consortium, 15th International Symposium on Neural Regeneration, December 2013, Pacific Grove, California, USA. A new chitosan scaffold for peripheral nerve repair.

 


Stenberg L., Geuna S., Grothe C., Freier T., Dahlin L.B. Neuroscience, November 2013, San Diego USA Nerve regeneration in hollow chitosan tube (BIOHYBRID) and in autologous nerve grafts bridging a sciatic nerve defect in healthy and diabetic rats.

 

Geuna, S., Haastert-Talini, K., Freier, T., Grothe, C., and the BIOHYBRID Consortium 2013 annual meeting of the Asia Pacific Chapter of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), October 23rd – 26th 2013, Shanghai, China. Pre-clinical assessment of chitosan scaffolds of varying degrees of acetylation for repairing peripheral nerve lesions with substance loss. 

 

Carvalho CR, Silva-Correia J, Martins A, Oliveira JM, Reis RL. TermStem 2013, 10-12 October 2013, Porto, Portugal. Chitosan nanofibers as scaffolds for peripheral nerve regeneration.  

 

Reider E., Rochkind S., 15th World Congress of Neurosurgery (WFNS), 8-13 September, 2013, Seoul, Korea. Monitoring of rat sciatic nerve and chitosan tube following complete nerve injury.

 

González-Pérez F., Allodi I., Navarro X., Udina E.  15 Congreso Nacional de la  Sociedad Española de Neurociencia, 25-27 September 2013, Oviedo, Spain. Schwann cells transfected with a lentiviral vector overexpressing  FGF-2: in vitro and in vivo effects on to preferentially promote motorneuron regeneration.


Stenberg L., Dahlin L.B. FENS, Prague, 11-14 September, 2013. Nerve regeneration is different in male and female in healthy and diabetic rats after nerve repair.

 

Pinto, L.V.F, Prata S., Espiga A., Oliveira, N.G., Pires E. EUCHIS 2013 – 11th International Conference of the European Chitin Society, 5th-8th May, Porto, Portugal, 2013. From medical grade chitosan production to medical devices manufacture and commercialization.

 

Stenberg L., Kanje M., Dahlin L.B. FESSH, May 29 – June 1, 2013, Antalya, Turkey. Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and diabetic rats.

 

K. Haastert-Talini and BIOHYBRID consortium German Society for Neurosurgery (DGNC) section "peripheral nerves”, Feb 11th 2012, Hannover, Germany,EU-FP7-HEALTH-2011-278612 Biohybrid templates for peripheral nerve regeneration”

 

S. Geuna and BIOHYBRID consortium 11th Congress of the European Federation of Societies of Microsurgery (E.F.S.M), April 5th – 7th 2012, in Paris, France.Biohybrid templates for peripheral nerve regeneration” 

 

S. Geuna, Lars B. Dahlin11th Congress of the European Federation of Societies of Microsurgery (E.F.S.M), April 5th – 7th 2012, in Paris, France. “Current concepts in Experimental Microsurgery” –  Advances in peripheral nerve tissue engineering”.

 

Haastert-Talini K., Grothe C., BIOHYBRID Consortium (2012) 8th FENS Forum of Neuroscience, Jul 14th – 18th 2012, Barcelona, Spain. FENS Abstract, Volume 6, p012.35, 2012 Biohybrid Templates To Increase Peripheral Nerve Regeneration. 

 

K. Haastert-Talini, Collaborators and BIOHYBRID consortium 3rd TERMIS World Congress 2012, Sept 5th – 8th 2012, Vienna, Austria. “Keynote: New molecules and biohybrid templates to increase peripheral nerve regeneration”. (J Tissue Eng Reg Med 2012; 6 (Suppl.1): 83)

 

K. Haastert-Talini, C. Grothe 46th DGBMT Annual Meeting, BMT 2012, Sept 16th – 19th 2012, Jena, Germany. “Best Practice: Coordination of EU-Project: Biohybrid Templates for Peripheral Nerve Regeneration”. 

 

Cobianchi S, Casals-Diaz L, Udina E, Jaramillo J, Navarro X 8th FENS Forum of Neuroscience, Jul 14th – 18th 2012, Barcelona, Spain. “Effects of early treadmill exercise, electrical stimulation and their combination on neuropathic pain and neurotrophins expression after peripheral nerve injury”

 

Allodi I, Mecollari V, González-Pérez F, Eggers R, Hoyng S, Casas C, Navarro X, Verhaagen J, Udina E 8th FENS Forum of Neuroscience, Jul 14th – 18th 2012, Barcelona, Spain. “In vitro and in vivo characterization of lentiviral vector overexpressing FGF-2 – a promising tool to promote peripheral nerve regeneration”.

 

Talk by UNITO: S. Geuna and the BIOHYBRID Consortium CEITEC International Conference – Cell Interaction with Surfaces, October 22-23, 2012, Brno, Czech Republic. "Biohybrid templates for enhancing peripheral nerve repair and regeneration",

 

Udina E, Allodi I, Casals L, Hernández J, Roet KCD, Navarro X. Society for Neuroscience 2011, Nov 12th-16th 2011, Washington DC, USA. “Role of cell-axon interaction in specific motor and sensory regeneration”. 

 

Allodi I, Casals-Díaz L, Mason M, Van Kesteren R, Verhaagen J, Navarro X, Udina E Society for Neuroscience 2011, Nov 12th-16th 2011, Washington DC, USA. “FGF-2 (low molecular weight - 18 kDa) specifically promotes neuritogenesis in motor neurons in vitro”.