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Publications

Journal Articles

 

2019

Amrute-Nayak, M., Nayak, A., Steffen, W., Tsiavaliaris, G., Scholz, T., and Brenner, B. (2019)
Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor.
Small, 15, 1804313. DOI: 10.1002/smll.201804313.

2017

Topf., A., Franz, P., and Tsiavaliaris, G. (2017).
MicroScale Thermophoresis (MST) for studying actin polymerization kinetics.
BioTechniques. 63 (4), 187-190.

Vallotton, P., van Oijen, A.M., Whitchurch, C.B., Gelfand, V., Yeo, L., Tsiavaliaris, G., Heinrich, S., Dultz, E., Weis, K., and Grünwald, D. (2017).
Diatrack particle tracking software: review of applications and performance evaluation.
Traffic, 18(12), 840-852 (Review).

 

2016

Arias-Hidalgo, M, Hegermann, J., Tsiavaliaris, G., Carta, F., Supuran, C.T., Gros, G., Endeward, V. (2016)
CO2 and HCO3 Permeability of the Rat Liver Mitochondrial Membrane.
Cell. Physiol. Biochem., 39(5):2014-2024.

Awah, C.U., Tamm, S., Hedtfeld, S, Steinemann, D., Tümmler, B., Tsiavaliaris, G., Stanke, F.
Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP.
Biochim. Biophys. Acta, 1859, 1411-1428.

2015

Arndt, T., Wedekind, D., Jörns, A., Tsiavaliaris, G., Cuppen, E., Hedrich, H.-J., and Lenzen, S.
A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes
Diabetologia, in press.

Månsson, A., Dilson, R., and Tsiavaliaris, G. (2015).
Poorly understood aspects of striated muscle contraction.
Review
BioMed Research International, epub ahead of print.

Tsiavaliaris,G., Itel, F., Hedfalk, K., Al-Samir, S., Meier, W., Gros, G., and Endeward, V. (2015)
Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy.
FASEB J., epub ahead of print.

Diensthuber, R.P., Tominaga, M., Preller, M., Hartmann, F.K., Orii, H., Chizhov, I., Oiwa, K., and Tsiavaliaris, G. (2015).
Kinetic mechanism of Nicotiana tabacum myosin-11 defines a new type of a processive motor.
FASEB J., 29, 81-94.

2014

Janssen, S., Gudi, V., Prajeeth, C.K., Singh, V., Stahl, K., Heckers, S., Skripuletz, T., Pul, R., Trebst, C., Tsiavaliaris, G., and Stangel, M. (2014).
A pivotal role of nonmuscle myosin-2 during microglial activation.
Exp. Neurol., 261, 666-676.

Amrute-Nayaka, M., Lambecka,K.-A., Huhnt, H., Scholz, T., Radocaja, A., Tsiavaliaris, G., Walter, W.J., and Brenner, B. (2014).
Individual molecule ATP-turnover assay hints at two conformers of the myosin active site.
PNAS U.S.A., 111 (7), 2536-2541.

 

2013

Pfaender, S., Heyden, J., Friesland, M., Ciesek, S., Ejaz, A., Steinmann, J., Steinmann, J., Malarski, A., Stoiber, H., Tsiavaliaris, G., Bader, W., Jahreis, G., Pietschmann, T., Steinmann, E. (2013).
Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk.
J. Infect. Dis., 208 (12), 1943-1952.

Chizhov, I., Hartmann, F.K., Hundt, N., and Tsiavaliaris, G. (2013).
Global fit analysis of myosin-5b motility reveals thermodynamics of magnesium-sensitive acto-myosin-ADP states.
PLoS One, 8(5):e64797. doi: 10.1371/journal.pone.0064797.

2011

Rump, A., Scholz, T., Thiel, C., Hartmann, F. K., Uta, P., Hinrichs, M. H., Taft, M.H. and Tsiavaliaris, G. (2011).
Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division.
J. Cell Sci., 124, 2521-2528.

Chinthalapudi, K., Taft, M. H., Martin, R., Heissler, S. M., Preller, M., Hartmann, F. K., Brandstaetter, H., Kendrick-Jones, J., Tsiavaliaris, G., Gutzeit, H. O., Fedorov, R., Buss, F., Knolker, H. J., Coluccio, L. M., and Manstein, D. J. (2011).
Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
J. Biol. Chem., 286, 29700-29708.

2010

Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B., and Tsiavaliaris, G. (2010).
Targeted optimization of a protein nanomachine for operation in biohybrid devices.
Angew. Chem. Int. Ed. Engl., 49, 312-316.

Forke, R., Gruner, K. K., Knott, K. E., Auschill, S., Agarwal, S., Martin, R., Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D. J., Gutzeit, H. O., Knölker, H.-J. (2010).
Total Synthesis of Biologically Active Alkaloids Using Transition Metals.
Pure Appl. Chem., 82. No. 11, 1975-1991.

Martin, R., Agarwal, S., Jäger, A., Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D. J., Gutzeit, H. O., Knölker, H.-J. (2010)
Specific Inhibitors of Myosin ATPase via Silver-Catalyzed Synthesis of Pyrroles. The Chemistry and Biological Activity of Synthetic and Natural Compounds – Modern Aspects of Chemistry of Heterocycles.
Book chapter

V. G. Kartsev, Ed.; ICSPF Press, Moscow; Vol. 1, 110-117.

Dieckmann, R., von Heyden, Y., Kistler, C., Gopaldass, N., Hausherr, S., Crawley, S.W., Schwarz, E.C., Diensthuber, R.P., Côté; G.P., Tsiavaliaris, G., and Soldati T., (2010).
A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency.
Mol. Biol. Cell, 21, 1505-1518.

2009

Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F.K., Taft, M.H., Baruch, P., Brenner, B., Martin, R., Knölker, H.J., Gutzeit, H.O., and Manstein, D.J. (2009).
The mechanism of pentabromopseudilin inhibition of myosin motor activity.
Nat. Struct. Mol. Biol., 16, 80 - 87.

Furch, M., Manstein, D.J., and Tsiavaliaris, G. (2009).
Myosine - Molekulare Motoren als moderne Werkzeuge und Ziele in der humanen Wirkstoffentwicklung.
Labor&More, Jahr 2009, Heft 4.

2008

Taft, M.H., Hartmann, F.K., Rump, A., Keller H., Chizhov, I., Manstein, D.J., and Tsiavaliaris, G. (2008).
Dictyostelium myosin-5b is a conditional processive motor.
J. Biol. Chem., 283, 26902-26910.

Tsiavaliaris, G., Fujita-Becker, S., Dürrwang, U., Diensthuber, R.P., Geeves, M.A., and Manstein D.J. (2008).
Mechanism, regulation, and functional properties of Dictyostelium myosin-1B.
J. Biol. Chem., 283, 4520-4527.

2006

Fujita-Becker, S., Tsiavaliaris, G., Ohkura, R., Shimada, T., Manstein, D.J., and Sutoh, K., (2006).
Functional characterization of the N-terminal region of myosin-2.
J. Biol. Chem., 281, 36102-36109.

Dürrwang, U., Fujita-Becker, S., Erent, M., Kull, F.J., Tsiavaliaris, G., Geeves, M.A., and Manstein, D.J. (2006).
Dictyostelium myosin-1E is a fast molecular motor involved in phagocytosis
J. Cell Sci., 119, 550-558.

2004

Tsiavaliaris, G., Fujita-Becker, S., and Manstein, D.J. (2004).
Molecular engineering of a backwards moving myosin motor.
Nature, 427, 558-561.

2003

Knetsch, M.L.W., Tsiavaliaris, G., Zimmermann, S., Rühl U., and Manstein, D.J. (2003).
Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum
J. Muscle Res. Cell Mot., 605-611.

Tsiavaliaris, G. and Manstein, D.J. (2003).
TIRF-Mikroskopie und ihre Anwendung in der Biologie.
Biospektrum, 596-600.

2002

Tsiavaliaris, G., Fujita-Becker, S., Batra, R., Levitsky, D.I., Kull, F.J., Geeves, M.A., and Manstein, D.J. (2002).
Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium.
EMBO Reports, 3, 1099-1105.

2001

Tsiavaliaris, G., Haubrich, S., Merckle, C., and Blümel, J. (2001).
New bifunctional chelating phosphine ligands for immobilization of metal complexes on oxidic supports.
Synlett, 391-394.


Patents

Dietmar J. Manstein, Roman Fedorov, Georgios Tsiavaliaris, Hans-Joachim Knölker, René Martin, Juliane Kirst, Herwig O. Gutzeit, Markus Böhl, Marcus Furch.
Means for treating myosin-related diseases.
(WO/2009/065600), International Application No.: PCT/EP2008/009891; Publication Date: 28.05.2008; International Filling Date: 21.11. 2008.

Selected Conference Abstracts

Schirmer, B., Rajendraprasad, G., Tsiavaliaris, G.; Rehmann, H, Seifert, R (2015) Exotoxin Y of Pseudomonas aeruginosa inhibits actin polymerization.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY  Volume: 388   Supplement: 1   Pages: S43-S43.   

Ralph P. Diensthuber, Falk K. Hartmann, Daniela Kathmann, Katharina Stahl, Manuel H. Taft, Georgios Tsiavaliaris (2013)
Mechanisms of mechanochemical coupling in low and high duty ratio myosins.
Biophysical Journal 01/2013; 104(2):3a–4a. DOI:10.1016/j.bpj.2012.11.040.

Hartmann, F.K., Hundt, N., Diensthuber, R.P., Chizhov, I., and Tsiavaliaris, G. (2012)
Control of transport in myosin-based nanodevices by divalent cations.
J Muscle Res Cell Motil (2012) 33:235–289; DOI 10.1007/s10974-012-9313-x

Scholz, T., Rump, A., Uta, P., Hinrichs, M., Thiel, C., Tsiavaliaris, G. (2010)
Myosin-1 function extends to microtubule-dependent processes.
Biophysical Journal 01/2010; 98(3). DOI:10.1016/j.bpj.2009.12.3040

Kathmann, D.,  Diensthuber, R.P., Hartmann, F.K., Fedorov, R., Manstein, D.J., and Tsiavaliaris, G. (2010)
Switch-2 dependent modulation of the myosin power stroke.
Biophysical Journal 01/2010; 98(3-3, Supplement 1):143a-144a. DOI:10.1016/j.bpj.2009.12.773 ·

Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B., and Tsiavaliaris, G. (2010)
Targeted optimization of a molecular motor for controlling movement in biohybrid devices.
Biophysical Journal 01/2010; 98(3-3, Supplement 1):606a. DOI:10.1016/j.bpj.2009.12.3301 ·

Martin, R., Agarwal, S., Jäger, A., Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D. J., Gutzeit, H. O., Knölker, H.-J. (2010).
Specific inhibitors of myosin ATPase via silver-catalyzed synthesis of pyrroles. The chemistry and biological activity of synthetic and natural compounds – modern aspects of chemistry of heterocycles.
V. G. Kartsev, Ed.; ICSPF Press, Moscow; Vol. 1, 110-117.