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Regenerative Medicine

Further publications:   Gene Therapy     Vectorology / Biosafety     Hematopoiesis

2016

Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M.

Stem Cells Transl Med. 2016 May;5(5):591-601. doi: 10.5966/sctm.2015-0176.

 

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N.

Stem Cell Reports. 2016 Aug 9;7(2):292-305. doi: 10.1016/j.stemcr.2016.06.011.

 

Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG).

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weiβmann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Körner C, Schambach A, Rapp E, Buettner FF.

Mol Cell Proteomics. 2016 Apr;15(4):1435-52. doi: 10.1074/mcp.M115.054122.

 

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Dec 13;134(24):1973-1990.

 

Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells.

Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T.

Cell Biol Int. 2016 May;40(5):534-48. doi: 10.1002/cbin.10590.

 

Lung surfactant metabolism: early in life, early in disease and target in cell therapy.

Lopez-Rodriguez E, Gay-Jordi G, Mucci A, Lachmann N, Serrano-Mollar A.

Cell Tissue Res. 2016 Oct 25. [Epub ahead of print] Review.

 

Long noncoding RNA Chast promotes cardiac remodeling.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.

Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

 

Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD.

Cell Stem Cell. 2016 Jun 2;18(6):797-808. doi: 10.1016/j.stem.2016.01.010.

 

Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase.

Eggenschwiler R, Moslem M, Fráguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T.

Sci Rep. 2016 Dec 2;6:38198. doi: 10.1038/srep38198.

 

Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor.

Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E.

Am J Transplant. 2016 Dec 20. doi: 10.1111/ajt.14175. [Epub ahead of print]

 

Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions.

Börger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C.

Mol Med. 2016 May 16;22. doi: 10.2119/molmed.2015.00235. [Epub ahead of print]

2015

Production of mature healthy hematopoietic cells from induced pluripotent stem cells derived from an AML diagnostic sample containing the t(8;21) translocation.

Hoffmann D, Göhring G, Heuser M, Ganser A, Schambach A, Morgan MA.

Stem Cells. 2015 Sep 21. doi: 10.1002/stem.2207. [Epub ahead of print]

 

Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Lüttge D, Buchegger T, Kühnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T.

Stem Cell Reports. 2015 Feb 10;4(2):282-96. doi: 10.1016/j.stemcr.2015.01.005.

2014

FAS-based cell depletion facilitates the selective isolation of mouse induced pluripotent stem cells.

Warlich E, Schambach A, Lock D, Wedekind D, Glage S, Eckardt D, Bosio A, Knöbel S.

PLoS One. 2014 Jul 16;9(7):e102171. doi: 10.1371/journal.pone.0102171. eCollection 2014.

 

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.

Felgentreff K, Du L, Weinacht KG, Dobbs K, Bartish M, Giliani S, Schlaeger T, DeVine A, Schambach A, Woodbine LJ, Davies G, Baxi SN, van der Burg M, Bleesing J, Gennery A, Manis J, Pan-Hammarström Q, Notarangelo LD.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8889-94. doi: 10.1073/pnas.1323649111. Epub 2014 Jun 2.

 

Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Göhring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T.

Biomaterials. 2014 Feb;35(5):1531-42. doi: 10.1016/j.biomaterials.2013.11.024. Epub 2013 Nov 26.

2013

Toward position-independent retroviral vector expression in pluripotent stem cells.

Schambach A, Moritz T.

Mol Ther. 2013 Aug;21(8):1474-7. doi: 10.1038/mt.2013.161. No abstract available.

 

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T.

Stem Cells. 2013 Mar;31(3):488-99. doi: 10.1002/stem.1316.

2012

Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Araúzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T.

Stem Cells Dev. 2012 Mar 20;21(5):689-701. doi: 10.1089/scd.2011.0010. Epub 2011 Aug 24.

2011

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T.

EMBO Rep. 2011 Oct 28;12(11):1153-9. doi: 10.1038/embor.2011.176.

 

Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells.

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Schöler HR, Schambach A, Cantz T.

Cytometry A. 2011 Jun;79(6):426-35. doi: 10.1002/cyto.a.21072. Epub 2011 May 4.

 

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, Schambach A.

Mol Ther. 2011 Apr;19(4):782-9. doi: 10.1038/mt.2010.314. Epub 2011 Feb 1.

2007 - 2010

Generation and genetic modification of induced pluripotent stem cells.

Schambach A, Cantz T, Baum C, Cathomen T.

Expert Opin Biol Ther. 2010 Jul;10(7):1089-103. doi: 10.1517/14712598.2010.496775. Review.

 

Zinc-finger nucleases meet iPS cells: Zinc positive: tailored genome engineering meets reprogramming.

Cathomen T, Schambach A.

Gene Ther. 2010 Jan;17(1):1-3. doi: 10.1038/gt.2009.151. Epub 2009 Nov 12. No abstract available.

 

HOXB4's road map to stem cell expansion.

Schiedlmeier B, Santos AC, Ribeiro A, Moncaut N, Lesinski D, Auer H, Kornacker K, Ostertag W, Baum C, Mallo M, Klump H.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16952-7. Epub 2007 Oct 16.