MHH Logo




Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P.

The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.

EMBO J. 2000 Dec 1;19(23):6361-70.



Busch C, Schömig K, Hofmann F, Aktories K.

Characterization of the catalytic domain of Clostridium novyi alpha-toxin.

Infect Immun. 2000 Nov;68(11):6378-83.



Dressler D, Zettl U, Benecke R, Bigalke H.

Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure?

Mov Disord. 2000 Nov;15(6):1279-81.



Lehnardt S, Ahnert-Hilger G, Bigalke H, Jons T.

Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin.

Histochem Cell Biol. 2000 Nov;114(5):387-91.



Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M.

Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.

Blood. 2000 Oct 1;96(7):2592-8.



Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W.

Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.

J Neurosci. 2000 Sep 15;20(18):6743-51.



Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I.

Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin.

J Mol Biol. 2000 Sep 1;301(5):1091-5.



Dressler D, Dimberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD.

Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay.

Mov Disord. 2000 Sep;15(5):973-6.



Dressler D, Bigalke H, Rothwell JC.

The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans.

J Neurol. 2000 Aug;247(8):630-2.



Wilde C, Genth H, Aktories K, Just I.

Recognition of RhoA by Clostridium botulinum C3 exoenzyme.

J Biol Chem. 2000 Jun 2;275(22):16478-83.



Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H.

Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study.



Busch C, Hofmann F, Gerhard R, Aktories K.

Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.

J Biol Chem. 2000 May 5;275(18):13228-34.



Linseman DA, Hofmann F, Fisher SK.

A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase.

J Neurochem. 2000 May;74(5):2010-20.



Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I.

New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.

Infect Immun. 2000 Mar;68(3):1094-101.



Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M.

Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.

Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.



Bigalke H.

Neuromuskuläre Verbindung – Präsynaptisches Terminal.

Klin. Neurophysiol 2000;31;115-121


Just I, Hofmann F, Aktories K

Molecular mode of action of the large clostridial cytotoxins.

Curr Top Microbiol Immunol 2000;250;55-83


Just I, Boquet P

Large clostridial cytotoxins as tools in cell biology.

Curr Top Microbiol Immunol 2000;250;97-107