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German Center for infection Research (DZIF)

 

Although antibiotics and vaccines have been used successfully for decades, infections remain responsible for worldwide an immense number of illnesses and deaths. Among the major challenges are in addition to chronic and poverty-related infectious diseases in particular emerging, microbial and viral infections, which spread quickly globally via modern ways of transportation. The rapid emergence of resistance against on the market anti-infectives is another serious threat. There are also infections in immunocompromised patients, which paves the way by the modern high-performance medicine in particular in the field of transplantation and oncology.

To combat the pathogens and the associated threats to the health new, integrative and interdisciplinary approaches are needed in which experts work closely together in the fields of translational basic science, epidemiology and clinic. In 2011 the Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung ) has established the German Centre for Infection Research, in which universities, university hospitals, Leibniz and Max Planck Institutes and the Helmholtz Centres and federal research facilities combined with a distinctive profile in the field of infectious diseases to the infectiological main challenges with an integrated approach to counter.

 

About Mission

DZIF aims to coordinate the translational infection research and strategic direction to develop new diagnostic, preventive and therapeutic methods in the treatment of infectious diseases.

For this purpose the DZIF has divided the research into thematic translational units (Thematic Units Translational, TTUs). Within these units, scientists devote targeted a specific pathogen or an infectious disease.

Experts in the fields of basic research, epidemiology and clinic should be specific topics merged and cross-linked in the coming years to ensure the strongest synergies.

 

 

DZIF Biobanking Platform

 

Access to a comprehensive biobanking infrastructure is mandatory for multi-site infectious disease research and its translation into practical application.

 

Biomaterials of interest to DZIF include culture collections of infectious pathogens and microbial producers, liquid biological samples such as serum, plasma and urine, and characterized tissue samples from infected patients.

 

A biobank coordination and technology platform will be established within this project. The Heidelberg site supports the development of a DZIF infectious diseases tissue bank. The German Collection of Microorganisms and Cell Cultures (DSMZ) provides suitable standards and protocols for the deposition, maintenance, authentication and quality control of microbial pathogens and natural compound producers. The Munich site facilitates, coordinates and advances DZIF liquid biobanking with specific emphasis on an interactive platform as well as high level preanalytical and storage quality.

 

Aims of the DZIF biobanking platform
The DZIF biobanking platform has the aim to provide safe and high quality, authentified and standardized biomaterial and their derivates to the DZIF-Projects and partners.

Aims in detail:

  • Setup and coordination of a DZIF bio resource platform
  • Establishment and characterization of collections of  microbial pathogens and compound producer as well as human biomaterial and their derivates (DNA, RNA, meta data, cell lines) for DZIF and other partners on the DZIF partner sites
  • Setup of a method platform for the generation of  derivates and improved analysis
  • Setup of a data base, a "virtual bio resource center", in which the corresponding meta data of the samples becomes available for the DZIF partner.
  • Development of structured ELSI, QM und IT solutions for DZIF biobanks and partners.

 

Link:

http://www.dzif.de/

 

 

DZIF partner site Hannover / Braunschweig:

 

 

Partner site speaker:

Sebastian Suerbaum (Hannover Medical School)

 

Mark Brönstrup (Helmholtz Center for Infection Research)

 

Partner site manager:

Silke Hartmann (Hannover Medical School)

 

 

Involved researcher at partner site Hannover-Braunschweig:

 

TTU "Hepatitis":

Michael P. Manns, Sandra Ciesek, Markus Cornberg, Thomas von Hahn, Hansjörg Hauser, Gérard Krause, Thomas Pietschmann, Heiner Wedemeyer, Karsten Wursthorn

 

TTU "Gastrointestinal Infektions":

Sebastian Suerbaum, Oliver Bachmann, Thomas F. Schulz, Petra Dersch, Christine Josenhans, Oliver Pabst, Florenz Sasse, Ursula Bilitewski, Philipp Solbach

 

TTU "Tubeculosis":

Franz-Christoph Bange, Ulrich A. Maus

 

TTU "HIV":

Reinhold E. Schmidt, Georg Behrens

 

TTU "Novel Infections":

Paul Becher

 

TTU "Infections of the immunocompromised Host":

Thomas F. Schulz, Christine S. Falk, Martin Messerle, Luka Cicin-Sain, Beate Sodeik, Eva Mischak-Weissinger, Reinhold E. Schmidt, Arnold Ganser, Hermann Haller, Tobias Welte, Gérard Krause, Thomas Illig

 

TTU "Healthcare-associate und antibiotic-resistant bacterial infections":

Tobias Welte

 

Infrastructure:

 

Natural Compound Library:

Rolf Müller, Jörg Overmann, Marc Stadler, Florenz Sasse, Ursula Bilitewski, Rolf Hartman, Mark Brönstrup

 

Biobanking Platform:

Jörg Overmann, Birte Abt, Thomas Illig, Inga Bernemann

 

Bioinformatics Platform:

Alice McHardy, Hansjörg Hauser, Robert Geffers, Dieter Jahn, Burkhard Tümmler

 

Clinical Trial Unit:

Tobias Welte

 

 

 

DZIF biobanking platform

 

Access to a comprehensive biobanking infrastructure is mandatory for multi-site infectious disease research and its translation into practical application.

 

Biomaterials of interest to DZIF include culture collections of infectious pathogens and microbial producers, liquid biological samples such as serum, plasma and urine, and characterized tissue samples from infected patients.

 

A biobank coordination and technology platform will be established within this project. The Heidelberg site supports the development of a DZIF infectious diseases tissue bank. The German Collection of Microorganisms and Cell Cultures (DSMZ) provides suitable standards and protocols for the deposition, maintenance, authentication and quality control of microbial pathogens and natural compound producers. The Munich site facilitates, coordinates and advances DZIF liquid biobanking with specific emphasis on an interactive platform as well as high level preanalytical and storage quality.

 

The biobanking platform cooperates with the national (TMF) und international (BBMRI, EMbaRC, GBRCN) actors in the field of biobanking and use their generic concepts.

 

Aims in detail:

  • Setup and coordination of a DZIF bioresource platform
  • Establishment and characterization of collections of microbial pathogens and compound producer as well as human biomaterial and their derivates (DNA, RNA, meta data, cell lines) for DZIF and other partners at the DZIF partner sites
  • Setup of a method platform for the generation of  derivates and improved analysis
  • Setup of a database, a "virtual bio resource center", in which the corresponding meta data of the samples becomes available for the DZIF partner.
  • Development of structured ELSI-, QM- und IT solutions for DZIF biobanks und Partner

 

Link:

http://www.dzif.de/infrastruktur/biobanken/

 

Contact DZIF biobanking platform:

Coordinator

Peter Schirmacher, University Heidelberg

 

Co-Coordinators

H.-Erich Wichmann, Helmholtz Zentrum München

Jörg Overmann, Leibniz Institute DSMZ

 

Project Management

Lotte Schmidt, University Heidelberg

 

Contact Biobanking partner site Hannover:

Thomas Illig, head of HUB

Inga Bernemann, project management