Institute of Pharmacology
Histamine, T cells, Dendritic Cells, Mucosal Immunology
Histamine is a mediator of a large series of physiological and pathological processes. So far, four receptor subtypes selective for histamine are known, referred to as histamine H1-receptor (H1R), H2R, H3R and H4R. The H4R, identified in 2001, is expressed manly on cells of hematopoietic origin and provides a potential target for new anti-inflammatory therapeutic strategies. This role of the H4R in models of inflammatory diseases is investigated in our group.