Institute of Immunology
Chemokines, T cells, dendritic cells, immune response, lymphoid organs
Lymphoid organs such as lymph node and spleen, but also ectopic lymphoid tissue, such as bronchus-associated lymphoid tissue (BALT), play an important role in initiating protective as well as regulatory immune responses. Using molecular as well as imaging approaches, including 2-photon microscopy we aim to better understand the dynamics of how the different immune cells present in lymphoid organs interact with each other and how effector cells such as NK cells or cytotoxic T lymphocytes mediate their function in vivo. Furthermore we aim to decipher the molecules and mechanisms that allow homing of immune cells arriving at lymph nodes via afferent lymphatics.