Department of Gastroenterology, Hepatology & Endocrinology, Working Group Immune Tolerance
Tolerance, regulatory T cells, FOXP3, diabetes, transplantation, adoptive cell therapy, chimeric antigen receptor
We aim in inducing an immunological tolerance for therapy of autoimmune diseases and after solid organ transplantation. We are developing new therapeutic interventions by use of monoclonal antibodies and cell therapies. We try to induce organ-specific immune tolerance without interfering with the general immunocompetence of the patient by generating new chimeric antigen receptors (CARs).