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Gruppenmitglied - Prof. Dr. Christian Stock

Curriculum vitae

Studies of biology and chemistry at the Universities of Oldenburg, Bonn and Osnabrück. Holding a diploma in plant cell biology and a PhD in animal physiology. Postdoc positions at the Universities of Heidelberg (1998), Hawai'i (1998-2002), Würzburg (2002-2003) and Münster (2003-2008). In 2008 Habilitation and Venia legendi for Physiology, and in 2014 "Außerplanmäßiger Professor", both awarded by the Medical Faculty of the University of Münster. At the Department of Gastroenterology, Hepatology and Endocrinology since September 2014. I am interested in how ion transport processes across cellular membranes are involved in osmoregulation, cell motility (migration and invasion) and cell differentiation, and how they may create typical, locally limited microenvironments in the cytosol and at the cell surface that regulate cell/cell and cell/matrix interactions.

 

Publications

 

1. Stock, C., Krüppel, T., and Lueken, W. (1997). Kinesis in Euplotes vannus - ethological and electrophysiological characteristics of chemosensory behavior. J. Euk. Microbiol. 44, 427-433.

2.    Stock, C., Krüppel, T., Lueken, W., and Key, G. (1998). Congruence of electrical properties in two Antarctic and two middle-latitude marine species of Euplotes (Ciliata, Hypotrichida). Polar Biol 20, 127-133.

3.       Stock, C., Krüppel, T., Key, G., and Lueken, W. (1999). Sexual behaviour in Euplotes raikovi is accompanied by pheromone-induced modifications of ionic currents. J. Exp. Biol. 202, 475-483.

4.       Stock, C., Allen, R. D., and Naitoh, Y. (2001). How the external osmolarity affects the activity of the contractile vacuole complex, the cytosolic osmolarity and the water permeability of the plasma membrane in Paramecium multimicronucleatum. J. Exp. Biol. 204, 291-304.

5.       Stock, C., Grønlien, H.K., Allen, R.D., and Naitoh, Y. (2002). Osmoregulation in Paramecium: in situ ion gradients permit water to cascade through the cytosol to the contractile vacuole. J. Cell Sci. 115, 2339-2348.

6.       Grønlien, H.K., Stock, C., Aihara, M.S. , Allen, R.D. and Naitoh, Y. (2002). Relationship between the membrane potential of the contractile vacuole complex and its osmoregulatory activity in Paramecium multimicronucleatum. J. Exp. Biol. 205, 3261-3270.

7.    Stock, C., Grønlien, H.K., and Allen, R.D. (2002). The ionic composition of the contractile vacuole fluid of Paramecium mirrors ion transport across the plasma membrane. Eur. J. Cell Biol. 81, 505-512. 

8.       Schilling, T., Stock, C., Schwab, A., and Eder, C. (2004). Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration. Eur. J. Neurosci. 19, 1469-1474.

9. Shahin,V., Albermann, L., Schillers,H., Kastrup, L., Ludwig, Y., Schäfer, C., Stock, C., Oberleithner, H. (2005). Steroids dilate nuclear pores imaged with atomic force microscopy. J. Cell. Physiol. 202, 591-601.

10. Dreval, V., Dieterich, P., Stock, C., Schwab, A. (2005). The role of Ca2+ transport across the plasma membrane for cell migration. Cell. Physiol. Biochem. 16, 119-126.

11. Stock, C., Gassner, B., Hauck, C.R., Arnold, H., Mally, S., Dieterich, P., and Schwab, A. (2005). Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J. Physiol. 567, 225-238.

12. Schwab, A., Rossmann, H., Klein, M., Dieterich, P., Gassner, Neff, B.C., Stock, C., and Seidler, U. (2005). Functional role of Na+-HCO3- cotransport in migration of transformed renal epithelial cells. J. Physiol. 568, 445-458.

13. Schwab, A., Wulf, A., Schulz, C., Kessler, W., Nechyporuk-Zloy, V., Römer M., Reinhardt J., Weinhold, D., Dieterich ,P., Stock, C., and Hebert,  S.C. (2006). Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells. J. Cell. Physiol. 206, 86-94.

14. Hillebrand, U., Hausberg, M., Stock, C., Shahin, V., Nikova, D., Riethmüller, C., Kliche, K., Ludwig, T., Schillers, H., Schneider, S.W., and Oberleithner H. (2006). 17β-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange. Cardiovasc. Res. 69, 916-924.

15. Oberleithner, H., Riethmüller, C., Ludwig, T., Shahin, V., Stock, C., Schwab, A., Hausberg, M., Kusche, K., Schillers, H. (2006). Differential action of steroid hormones on human endothelium. J. Cell Sci. 119, 1926-1932.

16. Nechyporuk-Zloy, V., Stock, C., Schillers H., Oberleithner, H. and Schwab A. (2006). Single plasma membrane potassium channel detection by using dual-colour quantum dot labeling. Am. J. Physiol. 291, C266-C269.

17.  Kliche, K., Kuhn, M., Hillebrand, U., Ludwig, Y., Stock, C. and Oberleithner, H. (2006). Direct aldosterone action on mouse cardiomyocytes detected with atomic force microscopy. Cell. Physiol. Biochem. 18, 265-274.

18.   Stock, C., Schilling, T., Schwab, A., and Eder, C. (2006). Lysophosphatidylcholine stimulates IL-1β release from microglia via a P2X7 receptor-independent mechanism induced by lysophosphatidylcholine. J. Immunol. 177, 8560-8568.

19.   Hillebrand, U., Schillers, H., Riethmüller, C., Stock, C., Wilhelmi, M., Oberleithner, H. and Hausberg, M. (2007).  Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone. J. Hypertens. 25, 639-647. 

20. Stock, C., Mueller, M., Kraehling, H., Mally, S., Noël, J., Eder, C., Schwab, A. (2007). pH nanoenvironment at the surface of single melanoma cells. Cell. Physiol. Biochem. 20, 679-686.

21. Stüwe, L., Müller, M., Fabian, A., Waning, J., Mally, S., Noël, J., Schwab, A., Stock, C. (2007). pH dependence of melanoma cell migration: Protons extruded by NHE1 dominate protons of the bulk solution. J. Physiol. 585, 351-360.

22. Schneider, L., Klausen, T., Stock, C., Mally, S., Christensen, S., Pedersen, S., Hoffmann, E., Schwab, A. (2008). H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts. Eur. J. Physiol. 455, 1055-1062.

23. Nechyporuk-Zloy, V., Dieterich, P., Oberleithner, H., Stock, C., Schwab, A. (2008). Dynamics of single potassium channel proteins in the plasma membrane of migrating cells.<tt> </tt>Am. J. Physiol. 294, C1096-1102. (PMID 18287336)

24. Hillebrand, U., Lang, D., Telgmann, R.G., Hagedorn, C., Reuter, S., Kliche, K., Stock, C., Oberleithner, H., Pavenstädt, H., Büssemaker, E., Hausberg, M. (2009). Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study. J. Hypertens. 27, 517-526. (PMID 19330906)

25. Schneider, L., Stock, C., Dieterich, P., Satir, P., Schwab, A., Christensen, S.T. (2009). The Na+/H+ exchanger NHE1 plays a central role in directional migration stimulated via PDGFRαα in the primary cilium. J. Cell Biol. 185, 163-176. (PMID 19349585)

26. <tt>Callies, C., Schön, P., Liashkovich, I., Stock, C., Kusche-Vihrog, K., Fels, J., Sträter, A.S., Oberleithner, H. (2009). </tt><tt>Simultaneous mechanical stiffness and electrical potential measurements of living vascular endothelial cells using combined atomic force and epifluorescence microscopy. </tt><tt>Nanotechnology</tt><tt> 20, 175104.</tt> (PMID 19420584)

27. Krähling ,H., Mally, S., Eble, J.A., Noël, J., Schwab, A., Stock, C. (2009). The glycocalyx maintains a cell surface pH nanoenvironment crucial for integrin-mediated migration of human melanoma cells. Eur. J. Physiol. 458, 1069-1083. (PMID 19562366)

28. </tt><//tt><tt>Schneider, L., Cammer, M., Lehman, J., Nielsen, S.K., Guerra, C.F., Veland, I.R., Stock, C., Hoffmann, E.K., Yoder, B.K., Schwab, A., Satir, P., Christensen, S.T. (2010). </tt><tt>Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. </tt>Cell. Physiol. Biochem.<tt> 25, 279-292.</tt> (PMID 20110689)

29. Götte, M., Mohr, C., Koo, C.-Y., Stock, C., Vaske, A.-K., Viola, M., Ibrahim, S.A., Peddibhotla, S., Teng, Y. H.-F., Low, J.-Y., Ebnet, K., Kiesel, L., Yip, G.W. (2010). miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene 29, 6569-6580. (PMID 20818426)

30. Martin, C., Pedersen, S.F., Schwab, A., Stock, C. (2011). Intracellular pH gradients in migrating cells. </tt><//tt><tt>Am. J. Physiol.</tt><tt> 300, C490-C495. </tt>(PMID 21148407)

31. Stock, C., Jungmann, O.,  Seidler, D.G. (2011). Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification. J. Cell. Physiol. 226, 2641-2650. (PMID 21792923)

32. Stock, C., Riethmüller, C. (2011). Endothelial activation drives lateral migration and diapedesis of leukocytes. Cell. Immunol. 271, 180-183. (PMID 21764046)

33. Schwab, A., Nechyporuk-Zloy, V., Gassner, B., Schulz, C., Kessler, W., Mally, S., Römer, M., Stock, C. (2012).  Dynamic redistribution of calcium sensitive potassium channels (hKCa3.1) in migrating cells. J Cell. Physiol. 227, 686-696. (PMID 21465474)

34. Lauritzen, G., Stock, C., Lemaire, J., Lund,  S.F., Jensen, M.F., Damsgaard, B., Petersen, K.S., Wiwel, M., Rønnov-Jessen, L., Schwab A., Pedersen, S.F. (2012). </tt><//tt><tt>The Na+/H+ exchanger NHE1, but not the Na+,HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. </tt><tt>Cancer Letters</tt><tt> 317, 172-183.</tt>  (PMID 22120673)

<tt>35. Ibrahim, S.A., Yip, G.W., Stock, C., Pan, J.-W., Neubauer, C., Poeter, M., Pupjalis, D., Koo, C.Y., Kelsch, R., Schüle, R., Rescher, U., Kiesel, L., Götte, M. (2012). </tt>Targeting of  Syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism<tt>. </tt><tt>Int. J. Cancer </tt><tt>131</tt><tt>, E884-E896. </tt>(PMID 22573479)

36.  Jungmann, O., Nikolovska, K., Stock, C., Schulz, J.-N., Eckes, B., Riethmüller, C., Owens, R.T., Iozzo, R.V., Seidler, D.G. (2012).  The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system in a collagen-rich matrix. PLoS ONE 7, e50809. (PMID 23226541)

37. Ludwig, F.T., Schwab, A., Stock, C. (2013).  The Na+/H+ exchanger (NHE1) generates pH nanodmomains at focal adhesions. </tt><//tt><tt>J. Cell. Physiol.</tt><tt> 228, 1351-1358. </tt>(PMID 23184727)

38. Di Marco, G.S., König, M., Stock. C., Wiesinger, A., Hillebrand, U., Reiermann, S., Reuter, S., Amler, S., Köhler, G., Buck, F., Fobker, M., Kümpers, P., Oberleithner, H., Hausberg, M., Lang, D., Pavenstädt, H., Brand, M. (2013). High phosphate directly affects endothelial function by downregulating annexin II. Kidney Int. 83, 213-222. (PMID 22913982)

39. Clement, D. L., Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen S.F., Christensen, S.T. (2013). PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. J. Cell Sci. 126, 953-965. (PMID 23264740)

40. Van Horssen, R., Willemse, M., Haeger, A., Attanasio, F., Günen, T., Schwab, A., Stock, C., Buccione, R., Fransen, J.A.M., Wieringa, B. (2013). Intracellular NAD(H) levels control motility and invasion of glioma cells. Cell Mol. Life Sci. 70, 2175-2190. (PMID 23307072)

41. Vahle, A.-K., Domikowsky, B., Schwöppe, C., Krähling, H., Mally, S., Schäfers,  M., Hermann, S., Shahin, V., Haier, J., Schwab, A., Stock, C. (2014). Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility. Int. J. Oncol. 44, 78-90. ( PMID 24173371)

42. Riemann, A., Schneider, B., Gündel, D., Stock, C., Thews, O., Gekle, M. (2014). Acidic priming enhances metastatic potential of cancer cells. Eur. J. Physiol. 466, 2127-2138. (PMID 24531759)

43. Kumar, A.V., Salem Gassar, E., Spillmann, D., Stock, C., Sen, Y.P., Zhang, T., Van Kuppevelt, T.H., Hülsewig, C., Koszlowski, E., Pavao, M.S., Ibrahim, S.A., Poeter, M., Rescher, U., Kiesel, L., Koduru, S., Yip, G.W., Götte, M. (2014). HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression. Int. J. Cancer 135, 2579-2592 (PMID 24752740).

44. Linder, K., Borchardt, C., Schöpp, M., Bürgers, A., Stock, C., Hussey, D.J., Haier, J., Hummel, R. (2014). Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer. J. Exp. Clin. Cancer Res. 33, 73 (PMID: 25175076).

45. Frontzek, F., Nitzlaff, S., Horstmann, M., Schwab, A., Stock, C. (2014). Functional interdependence of NHE1 and merlin in human melanoma cells. Biochem. Cell Biol., in press.

 

     Reviews

1. Stock, C. and Schwab, A. (2006). The role of the Na+/H+ exchanger NHE1 in cell migration. Acta Physiol. 187, 149-157. 

2. Schwab, A., Nechyporuk-Zloy, V., Fabian, A. and Stock, C. (2007). Cells move when ions and water flow. Eur. J. Physiol. 453, 421-432.

3. Hillebrand, U., Hausberg, M., Lang, D., Stock, C., Riethmüller, C., Callies, C., Büssemaker, E. (2008). How steroid hormones act on the endothelium-insights by atomic force microscopy. Eur. J. Physiol 456, 51-60.

4. Stock, C., Cardone, R.A., Busco, G., Krähling, H., Schwab, A., Reshkin, S.J. (2008). Protons extruded by NHE1: Digestive or glue? Eur. J. Cell Biol. 87, 591-599. (PMID 18328592)

5. Schwab, A., Hanley, P., Fabian, A., Stock, C. (2008). Potassium channels keep mobile cells on the go. Physiology 23, 212-220. (PMID 18697995)

6. Stock, C. and Schwab, A. (2009). Protons make tumor cells move like clockwork. Eur. J. Physiol. 458, 981-992. (PMID 19437033)

7. Stock, C., Ludwig, F.T., Schwab, A. (2012). Is the multifunctional Na+/H+ exchanger isoform 1 a potential therapeutic target in cancer? Curr. Med. Chem. 19, 647-660. (PMID 22204338)   

8.  Schwab, A., Fabian, A., Hanley, P.J., Stock, C. (2012). Role of ion channels and transporters in cell migration. Physiol. Rev. 92, 1865-1913. (PMID 23073633)

9.  Stock, C., Ludwig, F.T., Hanley, P.J., Schwab, A. (2013). Roles of ion transport in cell motility. Compr. Physiol. 3, 59-119. (PMID 23720281)

10. Schwab, A. and Stock, C. (2014). Ion channels and transporters in tumour cell migration and invasion. Philosophical Transactions of the Royal Society B, 369, 1638. (PMID 24493750) 

11.  Spugnigni, E., Sonveaux, P., Stock, C., Perez-Sayans, M., De Milito, A., Avnet, S., Garcìa Garcìa,  A., Harguindey, S., Fais, S. (2014).  Implication of proton channels and exchangers in cancer. Biochim. Biophys. Acta, in press.

12.  Stock, C., Schwab, A. (2014). Ion channels and transporters in metastastis. Biochim. Biophys. Acta, in press.

 

Meeting Report 

      1. Pedersen S.F. and Stock C. (2013). Ion channels and transporters in cancer: pathophysiology, regulation and clinical potential. Meeting Report. Cancer Res. 73, 1-4. (PMID 23302229)

 

      Popular Scientific Articles

 1. Stock, C. and Schwab, A. (2006). How ion channels and transporters affect metastasis. PN (Physiology News, Quarterly Newsletter of the Physiological Society, UK), spring edition, number 62, 19-20.

Klinik für Gastroenterologie, Hepatologie und Endokrinologie
 
Zentrum für Innere Medizin
Medizinische Hochschule Hannover
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