Institute of Immunology
gamma-delta T cells, high throughput sequencing of TCR repertoires, regulatory T cells, innate lymphocytes, interleukin-17
We are exploring the development, homeostasis, and function of innate lymphocytes such as NK cells and γδ T cells. These cells likely play an important role in immediate immune responses against invading pathogens. The focus of our group is clearly the investigation of γδ T cells, in particular of the mechanisms that lead to their differentiation into interferon-γ or interleukin-17 producing effector cells. Thereby, we are very interested in the role of the γδ TCR and the relation of TCR specificity and γδ T cell function. To this end, we established protocols for high-throughput TCR sequencing. Furthermore, we investigate dynamic immune responses of γδ T cells using two-photon laser scanning microscopy.