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Prof. Immo Prinz

 

Institute of Immunology

 

E-Mail:

Prinz.Immo@mh-hannover.de

 

gamma-delta T cells, high throughput sequencing of TCR repertoires, regulatory T cells, innate lymphocytes, interleukin-17

 

Homepage (link):

www.mh-hannover.de/index.php

 

Synopsis

We are exploring the development, homeostasis, and function of innate lymphocytes such as NK cells and γδ T cells. These cells likely play an important role in immediate immune responses against invading pathogens. The focus of our group is clearly the investigation of γδ T cells, in particular of the mechanisms that lead to their differentiation into interferon-γ or interleukin-17 producing effector cells. Thereby, we are very interested in the role of the γδ TCR and the relation of TCR specificity and γδ T cell function. To this end, we established protocols for high-throughput TCR sequencing. Furthermore, we investigate dynamic immune responses of γδ T cells using two-photon laser scanning microscopy.