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AG Witte


Arbeitsgruppenleiter: Prof. Dr. Torsten Witte

AG Witte


Arbeitsgruppenleiter:      
Prof Dr. med. Torsten Witte

                                               W3-Professor für Rheumatologie

 

 

Mitarbeiter:

Hui Zhi Low, PhD-Studentin

Dareen Ahmed, PhD

Dr. med. Gerrit Ahrenstorf

Dr. med. Niklas Baerlecken

Dr. med. Sören Nothdorft

Dr. med. Panagiota Xanthouli

MTA Katja Kniesch

 

Schwerpunkte: Genetische Ursachen, Pathophysiologie und neue Biomarker von Autoimmunerkrankungen

 

Laufende Projekte

 

1. Assoziationsstudien von Allelen des ILT6 und weiterer Immunoglobulin-like Transcripts mit Autoimmunerkrankungen

 

2. Funktionelle Analyse von rekombinantem ILT6
 

3. Identifizierung neuer Biomarker von Autoimmunerkrankungen mit Hilfe von Protein Arrays
 

4. Untersuchung der Sensitivität und Spezifität dieser neuen Biomarker mit ELISAs
 

 

Als experimentelle Promotionsarbeiten für Medizinstudenten (sowohl im StrucMed-Programm als auch nach konventioneller Art) sind die Projekte unter 1. und 4. geeignet. Der Zeitaufwand der experimentellen Arbeiten liegt bei ca 1 Jahr.

 

Kontakt: witte.torstenmh-hannover.de

 

 

Publikationen 2011:

  1. Alonso-Perez E, Suarez-Gestal M, Calaza M, Witte T, Papasteriades C, Marchini M, Migliaresi S, Kovacs A, Ordi-Ros J, Bijl M, Santos MJ, Ruzickova S, Pullmann R, Carreira P, Skopouli FN, D'Alfonso S, Sebastiani GD, Suarez A, Blanco FJ, Gomez-Reino JJ, Gonzalez A; and for the European Consortium of SLE DNA Collections. Association of systemic lupus erythematosus clinical features with European population genetic substructure.
  2. Alonso-Perez E, Suarez-Gestal M, Calaza M, Witte T, Papasteriades C, Marchini M, Migliaresi S, Kovacs A, Ordi-Ros J, Bijl M, Santos MJ, Ruzickova S, Pullmann R, Carreira P, Skopouli FN, D'Alfonso S, Sebastiani GD, Suarez A, Blanco FJ, Gomez-Reino JJ, Gonzalez A; and for the European Consortium of SLE DNA Collections. PLoS One. 2011;6(12):e29033. Epub 2011 Dec 14.
  3. Delforge M, Farber CM, Spath P, Kaveri S, Witte T, Misbah SA, Hübner R, Haerynck F, Latinne D, Muylle L, Toungouz M, Deneys V. Recommended indications for the administration of polyclonal immunoglobulin preparations. Acta Clin Belg. 2011 Sep-Oct;66(5):346-60.
  4. Schwemmle C, Kreipe HH, Witte T, Ptok M. Bamboo nodes associated with mixed connective tissue disease as a cause of hoarseness. Rheumatol Int. 2011 Nov 16. [Epub ahead of print]
  5. Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeón CP, Beretta L, Vonk MC, Luis Callejas J, Castellví I, Carreira P, José García-Hernández F, Fernández Castro M; the Spanish Scleroderma Group, Coenen MJ, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Koeleman BP, Voskuyl AE, Schuerwegh AJ, Palm O, Hesselstrand R, Nordin A, Airó P, Lunardi C, Scorza R, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Tan FK, Arnett FC, Agarwal SK, Assassi S, Fonseca C, Mayes MD, Radstake TR, Martin J. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum Mol Genet. 2011 Nov 29. [Epub ahead of print]
  6. Thomas R, Low HZ, Kniesch K, Jacobs R, Schmidt RE, Witte T. NKG2C DELETION IS A RISK FACTOR OF HIV INFECTION. AIDS Res Hum Retroviruses. 2011 Nov 10. [Epub ahead of print]
  7. Aringer M, Burkhardt H, Burmester GR, Fischer-Betz R, Fleck M, Graninger W, Hiepe F, Jacobi AM, Kötter I, Lakomek HJ, Lorenz HM, Manger B, Schett G, Schmidt RE, Schneider M, Schulze-Koops H, Smolen JS, Specker C, Stoll T, Strangfeld A, Tony HP, Villiger PM, Voll R, Witte T, Dörner T. Current state of evidence on "off label" therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria, and Switzerland - a consensus report. Lupus. 2011 Nov 9. [Epub ahead of print]
  8. Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol. 2012 Jan;73(1):107-10.
  9. Farmand S, Baumann U, von Bernuth H, Borte M, Foerster-Waldl E, Franke K, Habermehl P, Kapaun P, Klock G, Liese J, Marks R, Müller R, Nebe T, Niehues T, Schuster V, Warnatz K, Witte T, Ehl S, Schulze I. [Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency]. Klin Padiatr. 2011 Nov;223(6):378-85.
  10. Martin JE, Carmona FD, Broen JC, Simeón CP, Vonk MC, Carreira P, Ríos-Fernández R, Espinosa G, Vicente-Rabaneda E, Tolosa C, García-Hernández FJ, Castellví I, Fonollosa V, González-Gay MA, Sáez-Comet L, Portales RG, de la Peña PG, Fernández-Castro M, Díaz B, Martínez-Estupiñán L, Coenen M, Voskuyl AE, Schuerwegh AJ, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm O, Chee MM, van Laar JM, Denton C, Herrick A, Worthington J, Koeleman BP, Radstake TR, Fonseca C, Martín J. The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes Immun. 2011 Oct 20. doi: 10.1038/gene.2011.72. [Epub ahead of print]
  11. Castillejo-López C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sánchez E, Pöllmann D, López-Egido JR, Fineschi S, Domínguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegård J, Pons-Estel BA, D'Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcón-Riquelme ME. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis. 2012 Jan;71(1):136-42.
  12.  Bossini-Castillo L, Simeon CP, Beretta L, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Camps MT, Rodríguez-Rodríguez L, Rodríguez-Carballeira M, García-Hernández FJ, López-Longo FJ, Hernández-Hernández V, Sáez-Comet L, Egurbide MV, Hesselstrand R, Nordin A, Hoffmann-Vold AM, Vanthuyne M, Smith V, De Langhe E, Kreuter A, Riemekasten G, Witte T, Hunzelmann N, Voskuyl AE, Schuerwegh AJ, Lunardi C, Airó P, Scorza R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Koeleman BP, Rueda B, Radstake TR, Martin J; Spanish Scleroderma Group. Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology (Oxford). 2011 Nov;50(11):1976-81.
  13. Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, González-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, García de la Peña P, Carreira P; Spanish Scleroderma Group, Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TR, Mayes MD, Martin J. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet. 2011 Jul;7(7):e1002178.
  14. Low HZ, Witte T. Aspects of innate immunity in Sjögren's syndrome. Arthritis Res Ther. 2011 May 27;13:218.
  15. Carmona FD, Simeon CP, Beretta L, Carreira P, Vonk MC, Ríos-Fernández R, Espinosa G, Navarrete N, Vicente-Rabaneda E, Rodríguez-Rodríguez L, Tolosa C, García-Hernández FJ, Castellví I, Egurbide MV, Fonollosa V, González-Gay MA, Rodríguez-Carballeira M, Díaz-Gónzalez F, Sáez-Comet L, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Shiels P, Fonseca C, Denton C, Nordin A, Palm Ø, Hoffmann-Vold AM, Airó P, Scorza R, Lunardi C, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Koeleman BP, Radstake TR, Martín J. Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Ann Rheum Dis. 2011 Nov;70(11):2050-2.
  16. Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martín J, Brown EE, Vilá LM, Alarcón GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcón-Riquelme ME; BIOLUPUS Network, Nath SK, Harley JB, Sawalha AH. Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum. 2011 Jun;63(6):1689-97.
  17. Meyer-Olson D, Witte T. Immunology: Prevention of infections in patients with autoimmune diseases. Nat Rev Rheumatol. 2011 Apr;7(4):198-200.
  18. Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum. 2011 Feb;63(2):365-72.
  19. Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, Camps MT, Navarrete N, González-Escribano MF, Vicente-Rabaneda E, Rodríguez L, Tolosa C, Román-Ivorra JA, Gómez-Gracia I, García-Hernández FJ, Castellví I, Gallego M, Fernández-Nebro A, García-Portales R, Egurbide MV, Fonollosa V, de la Peña PG, Pros A, González-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Coenen MJ, Koeleman BP, Houssiau F, Smith V, de Keyser F, Westhovens R, De Langhe E, Voskuyl AE, Schuerwegh AJ, Chee MM, Madhok R, Shiels P, Fonseca C, Denton C, Claes K, Padykov L, Nordin A, Palm O, Lie BA, Airó P, Scorza R, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Radstake TR, Martín J, Rueda B.A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Ann Rheum Dis. 2011 Apr;70(4):638-41.
  20. Broen JC, Coenen MJ, Rueda B, Witte T, Padyukov L, Klareskog L, Hesselstrand R, Wuttge DM, Simeon C, Ortego-Centeno N, González-Gay MA, Pros A, Hunzelman N, Riemekasten G, Kreuter A, Vonk M, Scorza R, Beretta L, Airò P, van Riel PL, Kimberly R, Martin J, Edberg J, Radstake TR. The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility. J Rheumatol. 2011 Mar;38(3):446-9.
  21. Mederacke I, Witte T, Wedemeyer H, Meyer-Olson D. Successful clearance of hepatitis C virus with pegylated interferon α-2a and ribavirin in an etanercept-treated patient with psoriatic arthritis, hepatitis B virus coinfection and latent tuberculosis. Ann Rheum Dis. 2011 Jul;70(7):1343-4.
  22. Diaz-Gallo LM, Gourh P, Broen J, Simeon C, Fonollosa V, Ortego-Centeno N, Agarwal S, Vonk MC, Coenen M, Riemekasten G, Hunzelmann N, Hesselstrand R, Tan FK, Reveille JD, Assassi S, García-Hernandez FJ, Carreira P, Camps MT, Fernandez-Nebro A, de la Peña PG, Nearney T, Hilda D, González-Gay MA, Airo P, Beretta L, Scorza R, Herrick A, Worthington J, Pros A, Gómez-Gracia I, Trapiella L, Espinosa G, Castellvi I, Witte T, de Keyser F, Vanthuyne M, Mayes MD, Radstake TR, Arnett FC, Martin J, Rueda B. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Ann Rheum Dis. 2011 Mar;70(3):454-62.
  23. Schiffer L, Kielstein JT, Haubitz M, Lührs H, Witte T, Haller H, Kümpers P, Schiffer M. Elevation of serum CXCL13 in SLE as well as in sepsis. Lupus. 2011 Apr;20(5):507-11.
  24. Varadé J, Palomino-Morales R, Ortego-Centeno N, Díaz-Rubio M, Fernández-Gutiérrez B, González-Gay MÁ, Pascual-Salcedo D, Balsa A, Iglesias A, Gómez-García M, Witte T, Radstake TR, Coenen MJ, Urcelay E, Martín J. Analysis of the REL polymorphism rs13031237 in autoimmune diseases. Ann Rheum Dis. 2011 Apr;70(4):711-2.