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2013

Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, Schröder A, Venturini L, Blair HJ, Vormoor J, Ottmann O, Ganser A, Pich A, Hilfiker-Kleiner D, Heidenreich O, Eder M.

Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia.

Leukemia 2014;28(3);554-565

Abstract

 

Andruszkow H, Lefering R, Frink M, Mommsen P, Zeckey C, Rahe K, Krettek C, Hildebrand F.

Survival benefit of helicopter emergency medical services compared to ground emergency medical services in traumatized patients.

Crit Care 2013;17(3);R124

Abstract

 

Bagramyan K, Kaplan BE, Cheng LW, Strotmeier J, Rummel A, Kalkum M.

Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples.

Anal Chem 2013;85(11);5569-5576

Actract

 

Balletta A, Lorenz D, Rummel A, Gerhard R, Bigalke H, Wegner F.

Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPgammaS containing intracellular solution.

Eur J Pharmacol 2013;720(1-3);227-236

Abstract

 

Bigalke H.

Botulinum toxin: application, safety, and limitations.

Curr Top Microbiol Immunol 2013;364;307-317

Abstract

 

Chatterji B, Pich A.

MALDI imaging mass spectrometry and analysis of endogenous peptides.

Expert Rev Proteomics 2013;10(4);381-388

Abstract

 

Gerhard R, Frenzel E, Goy S, Olling A.

Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain.

J Med Microbiol 2013;62(9);1414-1422

Abstract

 

Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.

Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.

Toxicon 2013;75C;108-121

Abstract

 

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H.

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Int J Biochem Cell Biol 2013;45(8);1767-1775

Abtract

 

Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R.

Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity.

PLoS Pathog 2013;9(10);e1003690

Abstract

 

Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T.

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Biochem J 2013;453(1);37-47

Abstract

 

May M, Wang T, Müller M, Genth H.

Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470.

Toxins (Basel) 2013;5(1):106-119

Abstract

 

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

FEBS Lett 2013;587(23):3831-3836

Abstract

 

Rangrez AY, Bernt A, Poyanmehr R, Harazin V, Boomgaarden I, Kuhn C, Rohrbeck A, Frank D, Frey N.

Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy.

J Cell Biol 2013;203(4):643-656

Abstract

 

Rummel A.

Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.

Curr Top Microbiol Immunol 2013;364;61-90

Abstract


Schweer J, Kulkarni D, Kochut A, Pezoldt J, Pisano F, Pils MC, Genth H, Huehn J, Dersch P.

The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases.

PLoS Pathog 2013;9(11);e1003746

Abstract

 

Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Holleboom JM, Schur F, Small JV, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K.

Rac function is critical for cell migration but not required for spreading and focal adhesion formation.

J Cell Sci 2013;126(Pt.20);4572-4588

Abstract

 

Stevens GB, Silver DA, Zgaga-Griesz A, Bessler WG, Vashist SK, Patel P, Achazi K, Strotmeier J, Worbs S, Dorner MB, Dorner BG, Pauly D, Rummel A, Urban GA, Krueger M.

Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity.

Analyst 2013;138(20);6154-6162

Abstract
 

Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

Biochemistry 2013;52(22);3930-3938

Abstract

 

Zeiser J, Gerhard R, Just I, Pich A.

Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques.

J Proteome Res 2013;12(4);1604-1618

Abstract