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Publications

 

2019

 

Schadzek, P., Stahl, Y., Preller, M., Ngezahayo, A., Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation. FEBS Open Bio. epub (2019).  DOI: 10.1002/2211-5463-12624.

 

2018

 

Roberts, S., Seeger, M., Jiang, Y., Mishra, A., Sigmund, F., Stelzl, A., Lauri, A., Symvoulidis, P., Rolbieski, H., Preller, M., Deán-Ben, X.L., Razansky, D., Orschmann, T., Desbordes, S.C., Vetschera, P., Bach, T., Ntziachristos, V., Westmeyer, G.G.,

Calcium Sensor for Photoacoustic Imaging.
J. Am. Chem. Soc., 140, 2718-2721 (2018). doi.org/10.1021/jacs.7b03064

 

2017


Beyer, U., Brand, F., Martens, H., Weder, J., Christians, A., Elyan, N., Hentschel, B., Westphal, M., Schackert, G., Pietsch, T., Hong, B., Krauss, J.K., Samii, A., Raab, P., Das, A., Dumitru, C.A., Sandalcioglu, I.E., Hakenberg, O.W., Erbersdobler, A., Lehmann, U., Reifenberger, G., Weller, M., Reijns, M.A.M., Preller, M., Wiese, B., Hartmann, C., Weber, R.G., Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.
Acta Neuropathol. 134, 905-922 (2017). doi.org/10.1007/s00401-017-1774-y


Chinthalapudi, K., Heissler, S.M., Preller, M., Sellers, J.R., and Manstein, D.J.,
Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Elife 6, 10.7554/eLife.32742 (2017). doi.org/10.7554/eLife.32742.002


Mohammadi-Ostad-Kalayeh, S., Hrupins, V., Helmsen, S., Ahlbrecht, C., Stahl, F., Scheper, T., Preller, M., Surup, F., Stadler, M., Kirschning, A., and Zeilinger, C.,
Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors.
Bioorg. Med. Chem. 25, 6345-6352 (2017). doi.org/10.1016/j.bmc.2017.10.003


Osmanovic, A., Rangnau, I., Kosfeld, A., Abdulla, S., Janssen, C., Auber, B., Raab, P., Preller, M., Petri, S., and Weber, R.G. 
FIG4 variants in central European patients with amyotrophic lateral sclerosis: a whole-exome and targeted sequencing study.
Eur. J. Hum. Genet. 25, 324-331 (2017). doi.org/10.1038/ejhg.2016.186

Preller, M. and Manstein, D.J.
Myosin Motors: Structural Aspects and Functionality.
Reference Module in Life Sciences (2017), Elsevier.  dx.doi.org/10.1016/B978-0-12-809633-8.08058-4

 

2016

Schadzek, P., Schlingmann, B., Schaarschmidt, F., Lindner, J., Koval, M., Heisterkamp, A., Ngezahayo, A., and Preller, M.,
Data of the Molecular Dynamics Simulations of Mutations in the Human Connexin46 Docking Interface.
Data Brief 7, 93-99 (2016). dx.doi.org/10.1016/j.dib.2016.01.067

Schadzek, P., Schlingmann, B., Schaarschmidt, F., Lindner, J., Koval, M., Heisterkamp, A., Preller, M., and Ngezahayo, A.,
The Cataract Related Mutation N188T in Human Connexin46 (hCx46) Revealed a Critical Role for Residue N188 in the Docking Process of Gap Junction Channels.
Biochim. Biophys. Acta 1858, 57-66 (2016). dx.doi.org/10.1016/j.bbamem.2015.10.001

Schuster-Gossler, K., Cordes, R., Muller, J., Geffers, I., Delany-Heiken, P., Taft, M., Preller, M., and Gossler, A.,
Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.
Genetics 202, 1119-1133 (2016). dx.doi.org/10.1534/genetics.115.184515

2015

 

Diensthuber, R.P.; Tominaga, M.; Preller, M.; Hartmann, F.K.; Orii, H.; Chizhov, I.; Oiwa, K.; Tsiavaliaris, G.,
Kinetic Mechanism of Nicotiana Tabacum Myosin-11 Defines a New Type of Processive Motor.
FASEB J.,
doi: 10.1096/fj.14-254763

 

2014

Hundt, N., Preller, M., Swolski, O., Ang, A.M., Mannherz, H.G., Manstein, D.J., and Müller, M.,
Molecular Mechanisms of Disease-Related Human Beta-Actin Mutations p.R183W and p.E364K.
FEBS J. 281, 5279-5291 (2014). dx.doi.org/10.1111/febs.13068

 

Martin, R.; Risacher, C.; Barthel, A.; Jäger, A.; Schmidt, A.W.; Richter, S.; Böhl, M.; Preller, M.; Chinthalapudi, K.; Manstein, D.J.; Gutzeit, H.O.; Knölker, H.-J.,
Silver(I)-Catalyzed Route to Pyrroles: Synthesis of Halogentated Pseudilins as Allosteric Inhibitors of Myosin ATPase and X-ray Crystal Structures of the Protein-Inhibitor Complexes.

Eur. J. Org. Chem., dx.doi.org/10.1002/ejoc.201402177

 

Radke, M.B.; Taft, M.H.; Stapel, B.; Hilfiker-Kleiner, D.; Preller, M.; Manstein, D.J.,
Small-Molecule-Mediated Refolding and Activation of Myosin Motor Function.
eLife,
doi: 10.7554/eLife.01603.001

 

2013

 

Preller, M., and D. J. Manstein (2013)
Myosin structure, allostery, and mechano-chemistry
Structure, doi: 10.1016/j.str.2013.09.015

 

Chaturvedi, A.; Araujo Cruz, M.M.; Jyotsana, N.; Sharma, A.; Yun, H.; Görlich, K.; Wichmann, M.; Schwarzer, A.; Preller, M.; Thol, F.; Meyer, J.; Haemmerle, R.; Struys, E.A.; Jansen, E.E., Modlich, U.; Li, Z.; Sly, L.M.; Geffers, R.; Lindner, R.; Manstein, D.J.; Lehmann, U.; Krauter, J.; Ganser, A.; Heuser, M.

Mutant IDH1 Promotes Leukemogenesis In Vivo and Can Be Specifically Targeted in Human AML.
Blood, doi: 10.1182/blood-2013-03-491571

Preller, M. and Holmes, K.C.,
The Myosin Start-of-Power Stroke State and How Actin Binding Drives the Power Stroke.
Cytoskeleton, doi: 10.1002/cm.21125

Müller, M.; Diensthuber, R.P.; Chizhov, I.; Claus, P.; Heissler, S.M.; Preller, M.; Taft, M.H.; Manstein, D.J.,
Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins.
PLoS One, doi: 10.1371/journal.pone.0070636

 

2012

Preller, M. and Manstein, D. J., Comprehensive Biophysics. Vol. 04.
Myosin Motors: Structural Aspects and Functionality
Academic Press, doi: 10.1016/B978-0-12-374920-8.00410-0

 

2011

Preller, M.; Chinthalapudi, K.; Martin, R.; Knölker, H.-J.; Manstein, D. J.,
Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study
.
J. Med. Chem., doi: 10.1021/jm200259f

Preller, M.; Bauer, S.; Adamek, N.; Fujita-Becker, S.; Fedorov, R.; Geeves, M. A.; Manstein, D. J.,
Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J. Biol. Chem.
, doi: 10.1074/jbc.M111.265298

 

Chinthalapudi, K.; Taft, M. H.; Martin, R.; Heissler, S. M.; Preller, M.; Hartmann, F. K.; Brandstaetter, H.; Kendrick-Jones, J.; Tsiavaliaris, G.; Gutzeit, H. O.; Fedorov, R.; Buss, F.; Knölker, H.-J.; Coluccio, L. M.; Manstein, D. J.,
Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J. Biol. Chem.,
doi: 10.1074/jbc.M111.239210

 

Preller, M.; Grunenberg, J.; Bulychev, V. P.; Bulanin, M. O.,
Calculation of the Structure, Potential Energy Surface, Vibrational Dynamics, and Electric Dipole Properties for the Xe:HI van der Waals Complex.
J. Chem. Phys., doi: 10.1063/1.3583817

 

Patents

Heuser, M., Chaturvedi, A., Preller, M.,
Means and Methods for Treating Cancer,
EP 2996692 A2 (2016).

Preller, M.; Kalesse, M.; Manstein D. J.,
Novel Means and Methods for Treating Malaria and Other Parasitic Disorders,
EP 2727911 B1 (2016).

Preller, M., Furch, M., Díaz-Gómez, N., Kalesse, M., Manstein D. J.,
Biphenyl Compounds For Use In Treating Malaria and Other Parasitic Disorders,
US 9499471 B2 (2016).