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Ausgewählte Literatur seit 2005




Hildebrand F, Mommsen P, Frink M, van Griensven M, Krettek C.

Genetic Predisposition for Development of Complications in Multiple Trauma Patients

Shock. 2011, [Epub ahead of print]

Zeckey C, Hildebrand F, Frink M, Krettek C.

Heterotopic ossifications following implant surgery-epidemiology, therapeutical approaches and current concepts

Semin Immunopathol. 2011  [Epub ahead of print]

Mommsen P, Barkhausen T, Hildebrand F, Zeckey C, Krettek C, van Griensven M.

Regulation of L-selectin expression by trauma-relevant cytokines

Pathol Res Pract. 2011 [Epub ahead of print]




Mommsen P, Barkhausen T, Frink M, Zeckey C, Probst C, Krettek C, Hildebrand, F

Productive capacity of alveolar macrophages and pulmonary organ damage after femoral fracture and hemorrhage in IL-6 knockout mice

Cytokine. 2011 Jan;53(1):60-5.

Zeckey C, Dannecker S, Hildebrand F, Mommsen P, Scherer R, Probst C, Krettek C, Frink M

Alcohol and multiple trauma-is there an influence on the outcome?

Alcohol. 2010 [Epub ahead of print]

Gosemann JH, van Griensven M, Barkhausen T, Kobbe P, Thobe BM, Haasper C, Pape HC, Krettek C, Hildebrand F, Frink M

TLR4 influences the humoral and cellular immune response during polymicrobial sepsis

Injury. 2010. [Epub ahead of print]

Probst C, Zelle B, Panzica M, Lohse R, Sitarro NA, Krettek C, Pape HC

examination 10 or more years after polytrauma: is there a gender related clinical re-examination 10 or more years after polytrauma: is there a gender related difference?

J Trauma. 2010 Mar;68(3):706-11

Zeckey C, Hildebrand F, Hoevel P, Müller K, Krettek C, Barkhausen T, van Griensven M 

Activity of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment in IL-6 knockout mice

J Innate Immun. 2010;2(5):469-77

Zeckey C, Tschernig T, Hildebrand F, Frink M, Frömke C, Dorsch M, Krettek C, Barkhausen T.

Macrophage-activating lipopeptide-2 exerts protective effects in a murine sepsis model

Shock. 2010 Jun;33:614-9

Probst C, Richter M, Lefering R, Frink M, Gaulke R, Krettek C, Hildebrand F

Incidence and significance of injuries to the foot and ankle in polytrauma patients--an analysis of the Trauma Registry of DGU

Injury. 2010 Feb;41 (2):210-5




Hildebrand F, Kalmbach M, Kaapke A, Krettek C, Stuhrmann M

No association between CALCA polymorphisms and clinical outcome or serum procalcitonin levels in German polytrauma patients

Cytokine. 2009 Jul;47(1):30-6

Hildebrand F, Lill H, Partenheimer A, Frink M, Probst C, Mommsen P, Krettek C

Requirements of trauma networks in Lower Saxony

Unfallchirurg. 2009 Feb;112(2):211-6

Probst C, Zelle BA, Sittaro NA, Lohse R, Krettek C, Pape HC

Late death after multiple severe trauma: when does it occur and what are the causes?

J Trauma. 2009 Apr;66(4):1212-7

Barkhausen T, Probst C, Hildebrand F, Pape HC, Krettek C, van Griensven M

Insulin therapy induces changes in the inflammatory response in a murine 2-hit model

Injury. 2009 Aug;40(8):806-14

Mommsen P, Frink M, Pape HC, van Griensven M, Probst C, Gaulke R, Krettek C, Hildebrand F

Elevated systemic IL-18 and neopterin levels are associated with posttraumatic complications among patients with multiple injuries: a prospective cohort study

Injury. 2009 May;40(5):528-34




Giannoudis PV, van Griensven M, Hildebrand F, Krettek C, Pape HC

Femoral nailing-related coagulopathy determined by first-hit magnitude: an animal study

Clin Orthop Relat Res. 2008 Feb;466(2):473-80

Probst C, Hildebrand F, Frink M, Mommsen P, Krettek C

Prehospital treatment of severely injured patients in the field: an update

Chirurg. 2008 Oct;78(10):875-84




Wrann CD, Winter SW, Barkhausen T, Hildebrand F, Krettek C, Riedemann N

Distinct involvement of p38-, ERK1/2 and PKC signaling pathways in C5a-mediated priming of oxidative burst in phagocytic cells

Cell Immunol. 2007 Feb;245(2):63-9

Sittaro NA, Lohse R, Panzica M, Probst C, Pape HC, Krettek C

Hannover-polytrauma-long-term-study HPLS (II)

2007 Jun 1;59(2):81-7

Sittaro NA, Lohse R, Panzica M, Probst C, Pape HC, Krettek C

Hannover-Polytrauma-Longterm-Study HPLS

Versicherungsmedizin. 2007 Mar 1;59(1):20-5

Probst C, Probst T, Gaensslen A, Krettek C, Pape HC

Polytrauma Study Group of the German Trauma Society Timing and duration of the initial pelvic stabilization after multiple trauma in patients from the German trauma registry: is there an influence on outcome?

J. Trauma. 2007 Feb;62(2):370-7

Hildebrand F, Stuhrmann M, van Griensven M, Meier S, Hasenkamp S, Krettek C, Pape HC

Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma

Cytokine. 2007 Mar;37(3):192-9

Frink M, Hsieh YC, Hu S, Hsieh CH, Pape HC, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH

Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis

Ann Surg. 2007 Nov;246(5):836-43 

Frink M, Klaus AK, Kuther G, Probst C, Gosling T, Kobbe P, Hildebrand F, Richter M, Giannoudis PV, Krettek C, Pape HC

Long term results of compartment syndrome of the lower limb in polytraumatised patients

Injury. 2007 May;38(5):607-13

Frink M, Pape HC, van Griensven M, Krettek C, Chaudry IH, Hildebrand F

Influence of sex and age on mods and cytokines after multiple injuries

Shock. 2007 Feb;27(2):151-6

Frink M, Lu A, Thobe BM, Hsieh YC, Choudhry MA, Schwacha MG, Kunkel SL, Chaudry IH

Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production

Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292 (3):R1110-6




Hildebrand F, Hubbard WJ, Choudhry MA, Frink M, Pape HC, Kunkel SL, Chaudry IH

Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage

Am J Pathol. 2006 Sep;169(3):784-94

Hildebrand F, Hubbard WJ, Choudhry MA, Thobe BM, Pape HC, Chaudry IH

Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?

J Leukoc Biol. 2006 Jun;79(6):1173-80

Hildebrand F, Hubbard WJ, Choudhry MA, Thobe BM, Pape HC, Chaudry IH

Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females

J Leukoc Biol. 2006 Oct;80(4):759-65




Pape HC, Zelle B, Hildebrand F, Giannoudis PV, Krettek C, van Griensven M

Reamed femoral nailing in sheep: does irrigation and aspiration of intramedullary contents alter the systemic response?

J Bone Joint Surg Am. 2005 Nov;87(11):2515-22

Hildebrand F, Pape HC, Krettek C

The importance of cytokines in the posttraumatic inflammatory reaction

Unfallchirurg. 2005 Oct;108(10):793-4, 796-803

Hildebrand F, van Griensven M, Giannoudis P, Luerig A, Harwood P, Harms O, Fehr M, Krettek C, Pape HC

Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma

Cytokine. 2005 Sep 7;31(5):382-93

Hildebrand F, Pape HC, Harwood P, Müller K, Hoevel P, Pütz C, Siemann A, Krettek C, van Griensven M

Role of adhesion molecule ICAM in the pathogenesis of polymicrobial sepsis

Exp Toxicol Pathol. 2005 Mar;56(4-5):281-90

Hildebrand F, Giannoudis P, van Griensven M, Chawda M, Probst C, Harms O, Harwood P, Otto K, Fehr M, Krettek C, Pape HC

Secondary effects of femoral instrumentation on pulmonary physiology in a standardised sheep model: what is the effect of lung contusion and reaming?

Injury. 2005 Apr;36(4):544-55

Hildebrand F, Giannoudis PV, Griensven M, Zelle B, Ulmer B, Krettek C, Bellamy MC, Pape HC

Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries

Injury. 2005 Feb;36(2):293-302

Hildebrand F, Pape HC, van Griensven M, Meier S, Hasenkamp S, Krettek C, Stuhrmann M

Genetic predisposition for a compromised immune system after multiple trauma

Shock. 2005 Dec;24(6):518-22