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Publications

 

2018

  • Dürre K, Keber FC, Bleicher P, Brauns F, Cyron CJ, Faix J, Bausch AR.
    Capping protein-controlled actin polymerization shapes lipid membranes.
    Nat Commun. 9, 1630.

  • Litschko C, Damiano-Guercio J, Brühmann S, Faix J.
    Analysis of Random Migration of Dictyostelium Amoeba in Confined and Unconfined Environments.
    Methods Mol Biol. 1749, 341-350.

2017

  • Rottner K, Faix J, Bogdan S, Linder S, Kerkhoff E.
    Actin assembly mechanisms at a glance.
    J Cell Sci. 130, 3427-3435.

  • Reboll MR, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schönfeld HJ, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen HW, Pich A, Bauersachs J, Gogos JA, Wang Y, Wollert KC.
    EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.
    Circulation. 136, 1809-1823.

  • Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.
    Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
    J Cell Biol. 216, 3785-3798.

  • Dräger NM, Nachman E, Winterhoff M, Brühmann S, Shah P, Katsinelos T, Boulant S, Teleman AA, Faix J, Jahn TR.
    Bin1 directly remodels actin dynamics through its BAR domain

  • EMBO Rep. 18, 2051-2066.

  • Litschko C, Linkner J, Brühmann S, Stradal TEB, Reinl T, Jänsch L, Rottner K, Faix J.
    Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes.
    Eur J Cell Biol. 96:715-727.

  • Brühmann S, Ushakov DS, Winterhoff M, Dickinson RB, Curth U, Faix J.
    Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays.
    Proc Natl Acad Sci U S A. 114, E5815-E5824.

  • Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K.
    FMNL formins boost lamellipodial force generation.
    Nat Commun. 8:14832.

  • Dang I, Linkner J, Yan J, Irimia D, Faix J, Gautreau A.
    The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis.
    Biol Cell. 109, 162-166.


2016

  • Junemann A, Filić V, Winterhoff M, Nordholz B, Litschko C, Schwellenbach H, Stephan T, Weber I, Faix J.
    A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis.
    Proc Natl Acad Sci U S A. 113, E7464-E7473.

  • Winterhoff M, Brühmann S, Franke C, Breitsprecher D, Faix J.
    Visualization of Actin Assembly and Filament Turnover by In Vitro Multicolor TIRF Microscopy.
    Methods Mol Biol. 1407, 287-306

  • Brinkmann K, Winterhoff M, Önel SF, Schultz J, Faix J, Bogdan S.
    WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development.
    J Cell Sci. 16. pii: jcs.179325.


2015

  • Ramalingam N, Franke C, Jaschinski E, Winterhoff M, Lu Y, Brühmann S, Junemann A, Meier H, Noegel AA, Weber I, Zhao H, Merkel R, Schleicher M, Faix J.
    A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement.
    Nat Commun. 6, 8496.

  • Swaminathan K, Stumpf M, Müller R, Horn AC, Schmidbauer J, Eichinger L, Müller-Taubenberger A, Faix J, Noegel AA.
    Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.
    Sci Rep. 5, 14437.

  • Platonova E, Winterflood CM, Junemann A, Albrecht D, Faix J, Ewers H.
    Single-molecule microscopy of molecules tagged with GFP or RFP derivatives in mammalian cells using nanobody binders.
    Methods. 88, 89-97.

  • Winterhoff M, Faix J.
    Actin-filament disassembly: it takes two to shrink them fast.
    Curr Biol. 25, R450-452.

 

2014

  • Filić V, Marinović M, Faix J, Weber I.
    The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.
    Cell Mol Life Sci. 71, 2775-2785.

  • Linkner J, Witte G, Zhao H, Junemann A, Nordholz B, Runge-Wollmann P, Lappalainen P, Faix J.
    The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis.
    J Cell Sci. 127, 1279-1292.

  • Swaminathan K, Müller-Taubenberger A, Faix J, Rivero F, Noegel AA.
    A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.
    Proc Natl Acad Sci U S A. 111, E25-33.

  • Pleiser S, Banchaabouchi MA, Samol-Wolf A, Farley D, Welz T, Wellbourne-Wood J, Gehring I, Linkner J, Faix J, Riemenschneider MJ, Dietrich S, Kerkhoff E.
    Enhanced fear expression in Spir-1 actin organizer mutant mice.
    Eur J Cell Biol. 93, 225-237.

  • Winterhoff M, Junemann A, Nordholz B, Linkner J, Schleicher M, Faix J.
    The Diaphanous-related formin dDia1 is required for highly directional phototaxis and formation of properly sized fruiting bodies in Dictyostelium.
    Eur J Cell Biol. 93, 212-224.


2013

  • Dang I, Gorelik R, Sousa-Blin C, Derivery E, Guérin C, Linkner J, Nemethova M, Dumortier JG, Giger FA, Chipysheva TA, Ermilova VD, Vacher S, Campanacci V, Herrada I, Planson AG, Fetics S, Henriot V, David V, Oguievetskaia K, Lakisic G, Pierre F, Steffen A, Boyreau A, Peyriéras N, Rottner K, Zinn-Justin S, Cherfils J, Bièche I, Alexandrova AY, David NB, Small JV, Faix J, Blanchoin L, Gautreau A.
    Inhibitory signalling to the Arp2/3 complex steers cell migration.
    Nature. 503, 281-284.

  • Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G.
    CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.
    EMBO J. 32, 2735-2750.

  • Chacón-Martínez CA, Kiessling N, Winterhoff M, Faix J, Müller-Reichert T, Jessberger R.
    The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.
    J Biol Chem. 288, 28687-28703.

  • Junemann A, Winterhoff M, Nordholz B, Rottner K, Eichinger L, Gräf R, Faix J.
    ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells.
    Eur J Cell Biol. 92, 201-212.

  • Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Margit Holleboom J, Schur F, Victor Small J, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K.
    Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.
    J Cell Sci. 126, 4572-4588.

  • Koestler SA, Steffen A, Nemethova M, Winterhoff M, Luo N, Holleboom JM, Krupp J, Jacob S, Vinzenz M, Schur F, Schlüter K, Gunning PW, Winkler C, Schmeiser C, Faix J, Stradal TE, Small JV, Rottner K.
    Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.
    Mol Biol Cell. 24, 2861-2875.

  • Faix J, Weber I.
    A dual role model for active Rac1 in cell migration.
    Small GTPases. 4, 110-115.

  • Faix J, Linkner J, Nordholz B, Platt JL, Liao XH, Kimmel AR.
    The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci.
    Methods Mol Biol. 983, 249-267.

  • Yan S, Lv Z, Winterhoff M, Wenzl C, Zobel T, Faix J, Bogdan S, Grosshans J.
    The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
    J Cell Sci. 126, 1796-1805.


2012

  • Arhzaouy K, Strucksberg KH, Tung SM, Tangavelou K, Stumpf M, Faix J, Schröder R, Clemen CS, Eichinger L.
    Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains.
    PLoS One. 7, e46879.

  • Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K.
    FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
    Curr Biol. 22, 1005-1012.
  • Filic V, Marinovic M, Faix J, Weber I.
    A dual role for Rac1 GTPases in the regulation of cell motility.
    J Cell Sci.
    125, 387-398.
  • Linkner J, Nordholz B, Junemann A, Winterhoff M, Faix J.
    Highly effective removal of floxed Blasticidin S resistance cassettes from Dictyostelium discoideum mutants by extrachromosomal expression of Cre.
    Eur J Cell Biol. 91, 156-160.

2011

  • Breitsprecher D, Koestler SA, Chizhov I, Nemethova M, Mueller J, Goode BL, Small JV, Rottner K, Faix J.
    Cofilin cooperates with fascin to disassemble filopodial actin filaments.
    J Cell Sci. 2011 124, 3305-3318

  • de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE.
    Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.
    Structure. 19, 1294-1306

  • Dames SA, Junemann A, Sass HJ, Schönichen A, Stopschinski BE, Grzesiek S, Faix J, Geyer M.
    Structure, dynamics, lipid binding, and physiological relevance of the putative GTPase-binding domain of Dictyostelium formin C.
    J Biol Chem. 286, 36907-36920.

  • Linkner J, Witte G, Stradal T, Curth U, Faix J.
    High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.
    PLoS One. 6, e21327

  • Fenn S, Breitsprecher D, Gerhold CB, Witte G, Faix J, Hopfner KP.
    Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.
    EMBO J. 30, 2153-2166.

  • Breitsprecher D, Kiesewetter AK, Linkner J, Vinzenz M, Stradal TE, Small JV, Curth U, Dickinson RB, Faix J.
    Molecular mechanism of Ena/VASP-mediated actin-filament elongation.
    EMBO J. 30, 456-467.

  • Mondal S, Burgute B, Rieger D, Müller R, Rivero F, Faix J, Schleicher M, Noegel AA.
    Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I.
    PLoS One. 5, e15440.

2010

  • Mondal S, Burgute B, Rieger D, Müller R, Rivero F, Faix J, Schleicher M, Noegel AA.
    Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I.
    PLoS One. 2010 Nov 10.
  • Ramalingam N, Zhao H, Breitsprecher D, Lappalainen P, Faix J, Schleicher M.
    Phospholipids regulate localization and activity of mDia1 formin.
    Eur J Cell Biol. 89, 723-733

  • Wiesner C, Faix J, Himmel M, Bentzien F, Linder S.
    KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding and extracellular matrix degradation in primary macrophages.
    Blood. 116, 1559-1569

  • Breitsprecher D, Faix J.
    The inverted Formin INF2 sorts it out.
    Dev Cell. 18, 689-690.
     

2009

  • Breitsprecher D, Kiesewetter AK, Linkner J, Faix J.
    Analysis of actin assembly by in vitro TIRF microscopy.
    Methods Mol Biol. 571, 401-415

  • Lai FP, Szczodrak M, Oelkers JM, Ladwein M, Acconcia F, Benesch S, Auinger S, Faix J, Small JV, Polo S, Stradal TE, Rottner K.
    Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.
    Mol Biol Cell. 20, 3209-3223

  • Faix J, Breitsprecher D, Stradal TE, Rottner K.
    Filopodia: Complex models for simple rods.
    Int J Biochem Cell Biol. 4, 1656-1664.

  • Hotulainen P, Llano O, Smirnov S, Tanhuanpää K, Faix J, Rivera C, Lappalainen P.
    Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis.
    J Cell Biol. 185, 323-339.

2008

  • Breitsprecher D, Kiesewetter AK, Linkner J, Urbanke C, Resch GP, Small JV, Faix J.
    Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.
    EMBO J. 27, 2943-2954.

  • Block J, Stradal TE, Hänisch J, Geffers R, Köstler SA, Urban E, Small JV, Rottner K, Faix J.
    Filopodia formation induced by active mDia2/Drf3.
    J Microsc. 231, 506-517.

  • Lai FP, Szczodrak M, Block J, Faix J, Breitsprecher D, Mannherz HG, Stradal TE, Dunn GA, Small JV, Rottner K.
    Arp2/3 complex interactions and actin network turnover in lamellipodia.
    EMBO J. 27, 982-92.

2007

  • Arasada R, Gloss A, Tunggal B, Joseph JM, Rieger D, Mondal S, Faix J, Schleicher M, Noegel AA.
    Profilin isoforms in Dictyostelium discoideum.
    Biochim Biophys Acta. 1773, 631-41.


2006

  • Kimmel, A., Faix, J.
    Generation of multiple knock outs mutants using the cre-loxP system.
    In: Methods in Molecular Biology: Dictyostelium discoideum Protocols.
    Eds. L. Eichinger & F. Rivero. Humana Press, 346, 187-209.

  • Kimmel AR, Faix J.
    Generation of multiple knockout mutants using the Cre-loxP system.
    Methods Mol Biol. 346, 187-199

  • Strehle A, Schleicher M, Faix J.
    Trix, a novel Rac guanine-nucleotide exchange factor from Dictyostelium discoideum is an actin-binding protein and accumulates at endosomes.
    Eur J Cell Biol. 85, 1035-1045.

  • Faix, J.
    Formine und Aktinzytoskelett.
    Biospektrum 1, 19-21

  • Faix J., Grosse R.
    Staying in shape with formins.
    Dev Cell. 10, 693-706.

  • Schirenbeck A, Arasada R, Bretschneider T, Stradal TE, Schleicher M, Faix J.
    The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation.
    Proc Natl Acad Sci U S A. 103, 7694-7699.

  • Steffen A, Faix J, Resch GP, Linkner J, Wehland J, Small JV, Rottner K, Stradal TE.
    Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes.
    Mol Biol Cell. 17, 2581-2591.

2005

  • Faix J, Rottner K.
    The making of filopodia.
    Curr Opin Cell Biol. 18, 18-25.

  • Schirenbeck, A., Arasada, R., Bretschneider, T., Schleicher, M. & Faix, J.
    Formins and VASPs may co-operate in the formation of filopodia.
    Biochem. Soc. Trans. 33, 1256-1259.

  • Schirenbeck, A., Bretschneider, T., Arasada, R., Schleicher, M., and Faix, J. (2005).
    The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.
    Nature Cell Biol. 6, 619-625.

  • Rehberg, M., Kleylein-Sohn J., Faix, J., Ho, T.-H., Schulz, I., and Gräf, R. (2005).
    Dictyostelium LIS1 is a centrosomal and microtubule-associated protein required for microtubule Interactions with the cell cortex and actin dynamics.
    Mol. Cell Biol. 16, 2759-2771

2004

  • Faix, J. Kreppel, L., Shaulsky, G., Schleicher, M., and Kimmel, A.R.
    A rapid and efficient method to generate multiple gene disruptions in Dictyostelium using a single selectable marker and the Cre-loxP system.
    Nuc. Acids. Res. 32, e143.

  • Gerisch, G., Faix, J., Köhler, J., and Müller-Taubenberger, A. (2004).
    Actin-binding proteins required for reliable chromosome segregation in mitosis.
    Cell Motil. Cytoskeleton. 57, 18-25.
     

2003
  

  • Schneider, N., Weber, I., Faix J., Prassler, J., Müller-Taubenberger, A., Köhler, J., Burghardt, E., Gerisch, G., and Marriott, G. (2003).
    A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle.
    Cell Motil. Cytoskeleton. 56, 130-139.

 
2002
  

  • Faix, J. (2002).
    The actin-bundling protein cortexillin is the downstream target of a Rac1 signaling pathway required for cytokinesis in Dictyostelium.
    J. Mus. Res. Cell Mot. 23, 765-772.

  • Müller-Taubenberger, A., Bretschneider, T., Faix, J., Konzok, A., Simmeth, E., and Weber. I. (2002).
    Differential localization of the Dictyostelium PAKa kinase during cytokinesis and cell migration.
    J. Mus. Res. Cell Mot. 23, 751-763.

2001

  • Faix, J., Weber, I., Mintert, U., Köhler, J., Lottspeich, F., and Marriott, G. (2001).
    Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins.
    EMBO J. 20, 3705-3715.

2000
  

  • Dumontier, M., Höcht, P., Mintert, U., and Faix, J. (2000).
    Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium.
    J. Cell Sci. 113, 2253-2265.

  • Weber, I., Neujahr, R., Du, A., Köhler, J., Faix, J., and Gerisch, G. (2000).
    Two-step positioning of a cleavage furrow by cortexillin and myosin II.
    Cur. Biol. 10, 501-506.

Before 2000

  • Faix, J. (1999).
    Contact site A (csA).
    In: The guidebook to the extracellular matrix and adhesion proteins. Ed. T. Kreis und R. Vale. Oxford University Press, pp. 177-179.

  • Kloboucek, A., Behrisch, A., Faix, J., and Sackmann, E. (1999).
    Adhesion-induced receptor segregation and adhesion plaque formation: A model membrane study.
    Biophys J. 4, 2311-2328.

  • Faix, J. (1999).
    The Cortexillins.
    In: The guidebook to the cytoskeletal and motor proteins. Ed. T. Kreis und R. Vale. Oxford University Press, pp. 70-72.

  • Weber, I., Niewöhner, J., and Faix, J. (1999).
    Cytoskeletal protein mutations and cell motility in Dictyostelium.
    In: Cell Behaviour: Control and Mechanism of Motility. Ed. J.M. Lackie, G.A. Dunn und G.E. Jones. Biochem. Soc. Symp.,  pp245-265.

  • Stock, A., Steinmetz, M.O., Janmey, P., Aebi, U., Gerisch, G., Kammerer, R.A., Weber, I., and Faix, J. (1999).
    Domain analysis of cortexillin I: actin-bundling, PIP2-binding and the rescue of cytokinesis.
    EMBO J. 18, 5274-5284.

  • Weber, I., Gerisch, G., Heizer, C., Murphy, J., Badelt, K., Stock, A., Schwartz, J.M., and Faix, J. (1999).
    Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow.
    EMBO J. 18, 586-594.

  • Faix, J., Clougherty, C., Konzok, A., Mintert, U., Murphy, J., Albrecht, R., Mühlbauer, B., and Kuhlmann, J. (1998).
    The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.
    J. Cell Sci. 111, 3059-3071.

  • Ponte, E., Bracco, E., Faix, J., and Bozzaro, S. (1998).
    Detection of subtle phenotypes: the case of the cell adhesion molecule csA in Dictyostelium.
    Proc. Natl. Acad. Sci. USA 95, 9360-9365

  • Steinmetz, M.O., Stock, A., Schulthess, T., Landwehr, R., Lustig, A., Faix, J., Gerisch, G., Aebi, U., and Kammerer, R.A. (1998).
    A distinct 14-residue site triggers coiled-coil formation in cortexillin I.
    EMBO J. 17, 1883-1891.

  • Prassler, J., Murr, A., Stocker, S., Faix, J., Murphy, J., and Marriott, G. (1998).
    DdLim is a cytoskeleton associated protein involved in the protrusion of lamellipodia in Dictyostelium.
    Mol. Biol. Cell 9, 545-559.

  • Simson, R., Wallraff, E., Faix, J., Niewöhner, J., Gerisch, G., and Sackmann, E. (1998).
    Membrane bending modulus and adhesion energy of wild-type and mutant cells of Dictyostelium lacking talin or cortexillins.
    Biophys. J. 74, 514-522

  • Faix, J., and Dittrich, W. (1996).
    DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum.
    FEBS Lett. 394, 251-257.

  • Faix, J., Steinmetz, M., Boves, H., Kammerer, R.A., Lottspeich, F., Mintert, U., Murphy, J., Stock, A., Aebi, U., and Gerisch. G. (1996).
    Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail.
    Cell 86, 631-642.

  • Faix, J., Dittrich, W., Prassler, J., Westphal M., and Gerisch, G. (1995).
    The pDcsA vectors for strict developmentally regulated protein synthesis during early development of Dictyostelium discoideum.
    Plasmid 34, 148-151.

  • Faix, J., Gerisch, G., and Noegel, A.A. (1992).
    Overexpression of the csA cell adhesion molecule under its own cAMP-regulated promoter impairs morphogenesis in Dictyostelium.
    J. Cell Sci. 102, 203-214.

  • Faix, J., Gerisch, G., and Noegel, A.A. (1990).
    Constitutive overexpression of the contact site A glycoprotein enables growth-phase cells of Dictyostelium discoideum to aggregate.
    EMBO J. 9, 2709-2716.

  • Schleicher, M., Noegel, A., Schwarz, T., Wallraff, E., Brink, M., Faix, J., Gerisch, G., and Isenberg, G. (1988).
    A Dictyostelium mutant with severe defects in a-actinin: its characterisation using cDNA probes and monoclonal antibodies.
    J. Cell. Sci. 90, 59-71.