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2006

   1.  Agrawal R, Marx A, HallerH. Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension.J Hypertens. 2006 Jan;24(1):185-92
   2. Fliser D, Kielstein JT. Technology Insight: treatment of renal failure in the intensive care unit with extended dialysis. Nat Clin Pract Nephrol. 2006 Jan;2(1):32-9. Review. (PDF)
      Fliser D, Kielstein JT, Menne J. Insulin resistance and renal disease. Contrib Nephrol. 2006;151:203-11. Review. (PDF)
   3. Gwinner W, Scheuer H, Haller H, Brandes RP, Groene HJ. Pivotal role of xanthine oxidase in the initiation of tubulointerstitial renal injury in rats with hyperlipidemia.Kidney Int. 2006 Feb;69(3):481-7.
   4. Woywodt A, de Groot K, Bahte S, Schwarz A, Haller H, Haubitz M. Severe relapse of Wegener's granulomatosis during the early postpartum period. Ann Rheum Dis. 2006 Jan;65(1):137.
   5. Haller H, Viberti GC, Mimran A, Remuzzi G, Rabelink AJ, Ritz E, Rump LC, Ruilope,LM, Katayama S, Ito S, Izzo JL Jr, Januszewicz A. Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study.J Hypertens. 2006 Feb;24(2):403-8.
      Kielstein JT, Tsikas D, Fliser D. Effects of asymmetric dimethylarginine (ADMA) infusion in humans. Eur J Clin Pharmacol. 2006 Feb;62 Suppl 1:39
   6. Haubitz M, Peest D. Myeloma--new approaches to combined nephrological-haematological management. Nephrol Dial Transplant. 2006 Mar;21(3):582-90.
      Haller H, Bahlmann F, Fliser D. [Regeneration of renal tissue -- therapy of the future?] Dtsch Med Wochenschr. 2006 Apr 21;131(16):896-8. German.
   7. Menne J, Park JK, Agrawal R, Lindschau C, Kielstein JT, Kirsch T, Marx A, Muller D, Bahlmann FH, Meier M, Bode-Boger SM, Haller H, Fliser D. Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers.FASEB J. 2006 May;20(7):994-6. Epub 2006 Apr 5.
   8. Merkel S, Mogilevskaja N, Mengel M, Haller H, Schwarz A. effects of sirolimus. Transplant Proc. 2006 Apr;38(3):714-5.
   9. Woywodt A, Blann A. D, Kirsch T, Erdbruegger U, Banzet N, Haubitz M, Dignat-George F. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb. Haemost. 2006 (4): 671-677.
      Woywodt A, Haubitz M, Haller H, Matteson EL.:Wegener’s granulomatosis.Lancet.2006 April, 22; 367(9519):1362.
  10. Erdbruegger U, Haubitz M, Woywodt A. endothelial cells: A novel marker of endothelial damage.Clin Chim Acta. 2006 Nov;373(1-2):17-26. May 16.
      Woywodt A, Erdbruegger U, Haubitz M. Circulating endothelial cells and endothelial progenitor cells after angioplasty: news from the endothelial rescue squad.J Thromb
  11. Haemost. 2006 May;4(5):976-8.
      Haller H, Park JK, Lindschau C, Meyer M, Menne J; Renin Academy. Spotlight on renin: intrarenal renin-angiotensin system--important player of the local milieu. J Renin
  12. Angiotensin Aldosterone Syst. 2006 Jun;7(2):122-5.
      Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J, Scalera F, Cooke JP, Fliser D, Bode-Boger SM. ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Stroke. 2006 Aug;37(8):2024-9. Epub 2006 Jun 29. (PDF)
  13. Kielstein JT, Salpeter SR, Bode-Boeger SM, Cooke JP, Fliser D. Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis. Nephrol Dial Transplant. 2006 Sep;21(9):2446-51. Epub 2006 Jun 9. (PDF)
  14. Menne J, Fliser D, Haller H. Kidney and Hypertension. Herz. 2006 Jun;31(4):317-321
      Peters I, Tossidou I, Achenbach J, Woroniecki R, Mengel M, Park JK, Paschy M, de Groot K, Haller H, Schiffer M. IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. J. Am Soc Nephrol. 2006 Jun;17(6):1644-56. Epub 2006 May 3.
      J. T. Kielstein · C. Hafer „Extended dialysis“ auf der Intensivstation. Die Kolff-Dialyse wird wieder entdeckt. Nephrologe 2006 · 1:97–102. (PDF)
  15. Schiffer M, Haller H. [Focal segmental glomerulosclerosis (FSGS). Molecular defects and clinical relevance] Dtsch Med Wochenschr. 2006 Jul 7;131(27):1541-5. Review. German.
  16. Woywodt A, Kirsch T, Haubitz M. Immunomagnetic isolation and FACS--competing techniques for the enumeration of circulating endothelial cells. Thromb Haemost. 2006 Jul;96(1):1-2.
  17. J.T.Kielstein und D. Fliser. Diuretikatherapie bei niereninsuffizienten Patienten. Nephrologe 2006 (PDF)
  18. Ziegler E, Gueler F, Rong S, Mengel M, Witzke O, Kribben A, Haller H, Kunzendorf U, Krautwald S. CCL19-IgG Prevents Allograft Rejection by Impairment of Immune Cell Trafficking. J Am Soc Nephrol. 2006 Aug 9
  19. Fliser D, Bahlmann FH, Haller H. EPO: renoprotection beyond anemia correction. Pediatr Nephrol. 2006 Sep 7; [Epub ahead of print]
  20. Kumpers P, Herrmann A, Lotz J, Mengel M, Schwarz A. A blue kidney--chronic renal failure as a consequence of siderosis in paroxysmal nocturnal hemoglobinuria? Clin Nephrol. 2006 Sep;66(3):210-3.
  21. Kumpers P, Wiesemann E, Becker H, Haubitz B, Dengler R, Zermann DH. [Sacral nerve root cysts--a rare cause of bladder dysfunction. Case report and review of the literature] Aktuelle Urol. 2006 Sep;37(5):372-5. German.
  22. Meier M, Beigel A, Schiffer L, Lotz J, Hiss M, Mengel M, Haller H, Schwarz A. Magnetic resonance (MR) imaging in a patient with chronic lithium nephropathy. Nephrol Dial Transplant. 2006 Sep 20; [Epub ahead of print]
  23. Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, Ociepka R, Leitges M. Rinta-Valkama J, Holthofer H, Haller H. Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. Kidney Int. 2006 Sep 6; [Epub ahead of print]
  24. Erdbruegger U, Woywodt A, Kirsch T, Haller H, Haubitz M. Circulating endothelial cells as a prognostic marker in thrombotic microangiopathy. Am J Kidney Dis. 2006 Oct;48(4):564-70.
  25. Fliser D, Bahlmann FH, deGroot K, Haller H. Mechanisms of disease: erythropoietin--an old hormone with a new mission? Nat Clin Pract Cardiovasc Med. 2006 Oct;3(10):563-72.
  26. Kielstein JT, Donnerstag F, Gasper S, Menne J, Fliser D, Kielstein A, Martens-Lobenhoffer J, Scalera F, Bode-Boger SM, Cooke J. Response to Letter by Tsuda. Stroke. 2006 Oct 12
      Rifai K, Hafer C, Rosenau J, Athmann C, Haller H, Peter Manns M, Fliser D. Treatment of severe refractory pruritus with fractionated plasma separation and adsorption (Prometheus(R)). Scand J Gastroenterol. 2006 Oct;41(10):1212-7.
      Schwarz A, Rustien G, Merkel S, Radermacher J, Haller H. Decreased renal transplant function after parathyroidectomy. Nephrol Dial Transplant. 2006 Oct 11; [Epub ahead of
  27. print]
      Kirsch T, Woywodt A, Beese M, Wyss K, Park JK, Erdbruegger U, Hertel B, Haller H, Haubitz M. Engulfment of apoptotic cells by microvascular endothelial cells induces proinflammatory responses. /Blood/ 2006 Nov 21; [Epub ahead of print]
  28. Habicht A, Clarkson MR, Yang J, Henderson J, Brinkmann V, Fernandes S, Jurewicz M, Yuan X, Sayegh MH. Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection. J Immunol. 2006 Jan 1;176(1):36-42.
  29. Kielstein JT, Czock D, Schopke T, Hafer C, Bode-Boger SM, Kuse E, Keller F, Fliser Pharmacokinetics and total elimination of meropenem and vancomycin in intensive care unit patients undergoing extended daily dialysis. Crit Care Med. 2006 Jan;34(1):51-6. (PDF)
  30. Müller, S., Disse , J., Schöttler, M., Schön, S., Prante, C., Brinkmann, T., Kuhn, J., Kleesiek, K., Götting,C. Humann xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme. Biochem. J 394,163-171, 2006
  31. Sanchez-Fueyo A, Sandner S, Habicht A, Mariat C, Kenny J, Degauque N, Zheng XX, Strom TB, Turka LA, Sayegh MH. Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol. 2006 Jan 1;176(1):329-34
  32. Susztak K, Raff AC, Schiffer M, Bottinger EP. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 2006 Jan;55(1):225-33
  33. Bode-Boger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M, Reinecke H. Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol. 2006 Apr;17(4):1128-34. Epub 2006 Feb 15. (PDF)
  34. Campbell S, Burkly LC, Gao HX, Berman JW, Su L, Browning B, Zheng T, Schiffer L, Michaelson JS, Putterman C. Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol. 2006 Feb 1;176(3):1889-98.
  35. Dechend R, Homuth V, Wallukat G, Muller DN, Krause M, Dudenhausen J, Haller H, Luft FC. Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia.J Soc Gynecol Investig. 2006 Feb;13(2):79-86. Review.
  36. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17;21(4):467-80.
      Ramanujam M, Wang X, Huang W, Liu Z, Schiffer L, Tao H, Frank D, Rice J, Diamond B, Yu KO, Porcelli S, Davidson A. Similarities and differences between selective and nonselective BAFF blockade in murine SLE. J Clin Invest. 2006 Mar;116(3):724-34. Epub 2006 Feb 16.
  37. Rifai K, Ernst T, Kretschmer U, Haller H, Manns MP, Fliser D. Removal selectivity of Prometheus: a new extracorporeal liver support device. World J Gastroenterol. 2006 Feb 14;12(6):940-4.
  38. Lessmann E, Leitges M, Huber. A redundant role for PKC-{epsilon} in mast cell signaling and effector function. Int Immunol. 2006 May;18(5):767-73. Epub 2006 Mar 28.
  39. Natascha Hermann-Kleiter, Nikolaus Thuille, Christa Pfeifhofer, Thomas Gruber, Michaela Schäfer, Christof Zitt, Armin Hatzelmann, Christian Schudt, Michael Leitges and Gottfried Baier. PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocyte Blood 2006 Mar 2.
  40. Neipp M, Jackobs S, Jaeger M, Schwarz A, Lueck R, Gwinner W, Becker T, Klempnauer J. Living kidney donors >60 years of age: is it acceptable for the donor and the recipient? Transpl Int. 2006 Mar;19(3):213-7.
  41. Schön, S., Huep, G., Prante, C., Möller, S., Christ, R., Hagena, F.W., Kuhn, J. Kleesiek, K., Götting, C. Mutational and functional analyses of xylosyltransferases exclud their implication in hypermetabolic repair response in osteoarthritis. Osteoarthritis Cartilage 14, 442-448.
  42. Wittkop U, Krausse-Opatz B, Gust TC, Kirsch T, Hollweg G, Kohler L, Zenke M, Gerard HC, Hudson AP, Zeidler H, Wagner AD. Fate of Chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting infection.Microb Pathog. 2006 Mar;40(3):101-9.
  43. Woroniecki RP, Schiffer M, Shaw AS, Kaskel FJ, Bottinger EP. Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein. Pediatr Nephrol. 2006 Mar;21(3):333-8. Epub 2005 Dec 31.
  44. Yao LJ, Leitges M, Vallon V. Mice Lacking Protein Kinase C Beta Present Modest Increases in Systolic Blood Pressure and NH(4)Cl-Induced Metabolic Acidosis. Kidney Blood Press Res. 2006 Mar 2;29(1):36-42.
  45. Schön, S., Prante, C., Bahr, C., Kleesiek, K., Götting, C. Cloning and recombinant expression of active full-lenght xylosyltransferases I (XT-I) and characterization of subcellular localization of XT-I and XT-II. J. Biol. Chem. 281, 14224-14231 (2006).
  46. Wagner AD. [Giant cell arteritis (temporal arteritis). Pathophysiology, immunology] Ophthalmologe. 2006 Apr;103(4):302-7. Review. German.
  47. Flossmann O, Bacon PA, de Groot K, Jayne DR, Rasmussen N, Seo P, Westman K, Luqmani RA. Development of comprehensive disease assessment in systemic vasculitis. Ann Rheum Dis. 2006 May 25
  48. Holschermann H, Stadlbauer TH, Wagner AH, Fingerhuth H, Muth H, Rong S, Guler F, Tillmanns H, Hecker M. STAT-1 and AP-1 decoy oligonucleotide therapy delays acute rejection and prolongs cardiac allograft survival. Cardiovasc Res. 2006 Aug 1;71(3):527-36. Epub 2006 May 27.
  49. Pfeifhofer C., Gruber T., Letschka T., Thuille N., Lutz-Nicoladoni C., Hermann-Kleiter N., Braun U., Leitges M.* and Baier G.* Defective IgG2a/2b class switching in PKC alpha -/- mice. * equally contributed; J Immunol. 2006 May 15;176(10):6004-1.
  50. Schmid FX, Floerchinger B, Vudattu NK, Eissner G, Haubitz M, Holler E, Andreesen R, Birnbaum DE. Direct evidence of endothelial injury during cardiopulmonary bypass by demonstration of circulating endothelial cells. Perfusion. 2006 May;21(3):133-7.
  51. Schön, S., Schulz, V., Prante, C., Hendig, D., Szliska, C., Kuhn, J., Kleesiek, K., G?tting, C. Polamorphisms in the xylosyltransferase genes couse higher serum XT-I activties in patients with pseudoxanthoma elasticum (PXE) and are involves in a severe disease course. J. Med. Genet. 43, 745-749, 2006.
  52. Zoccali C, Kielstein JT. Asymmetric dimethylarginine: a new player in the pathogenesis of renal disease? Curr Opin Nephrol Hypertens. 2006 May;15(3):314-20. (PDF)
  53. Abraham D., Oster H. and Leitges M. The expression pattern of three Mast cell specific proteases during mouse development. Mol Immunol. 2006 Jun 12; [Epub ahead of print]
  54. LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M., Dorner AJ, Morris EA, Majumdar MK, Arai M. Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23
  55. von Essen M, Nielsen MW, Bonefeld CM, Boding L, Larsen JM, Leitges M., Baier G, Odum N, Geisler C. Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation. J Immunol. 2006 Jun 15;176(12):7502-10.
  56. Bahr, C., Schön, S., Kuhn, J., Groop, P.-H., Parkkonen, M., Wessmann, M., Kleesiek, K., Götting, C. Novel sequence variations in the human xylosyltransferase I gene and their role in diabetic nephropathy. Diabet. Med. 23, 681-684, 2006.
  57. Kovac J., Oster H. and Leitges M. Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis. Gene Expr Patterns. 2006 Jul 15; [Epub ahead of print]
  58. Lessmann E, Ngo M, Leitges M. Minguet S, Ridgway ND, Huber M. Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.Cell Signal. 2006 Jul 25; [Epub ahead of print]
  59. Oster H. and Leitges M. Protein Kinase Ca (PKCa) but not PKCz Suppresses Intestinal Tumor Formation in ApcMin/+ Mice. Cancer Res. 2006 Jul 15;66(14):6955-63.
  60. Grote K, Ortmann M, Salguero G, Doerries C, Landmesser U, Luchtefeld M, Brandes RP, Gwinner W, Tschernig T, Brabant EG, Klos A, Schaefer A, Drexler H, Schieffer B. Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation.
  61. Cardiovasc Res. 2006 Aug 1;71(3):596-605. Epub 2006 May 26.
      Kalousova M, Kielstein JT, Hodkova M, Zima T, Dusilova-Sulkova S, Martens-Lobenhoffer J, Bode-Boger SM. No Benefit of Hemodiafiltration over Hemodialysis in Lowering Elevated Levels of Asymmetric Dimethylarginine in ESRD Patients. Blood Purif. 2006 Aug 25;24(5):439-444. (PDF)
  62. Pape H, Orth K, Heese A, Heyll A, Kobbe G, Schmitt G, Niederbichler AD, Peiper M, Schwarz A, Boelke E. G-CSF during large field radiotherapy reduces bone marrow recovery capacity. Eur J Med Res. 2006 Aug 30;11(8):322-8
  63. Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006 Oct;116(10):2682-94.
  64. David Czock, Cordula Husig-Linde, Anita Langhoff, Timo Schopke, Carsten Hafer, Kirsten de Groot, Stefanie Swoboda, Ernst Kuse, Hermann Haller, Danilo Fliser, Frieder Keller and Jan T. Kielstein Pharmacokinetics of Moxifloxacin and Levofloxacin in Intensive Care Unit Patients Who Have Acute Renal Failure and Undergo Extended Daily Dialysis. Clin J Am Soc Nephrol 1: 1263 -1268, 2006. (PDF)
  65. Prante, C., Bieback, K., Funke, C., Schön, S., Kern, S., Kuhn, J., Gastens, J., Kleesiek, K., Götting, C. The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I Stem Cells (2006)
  66. Bolke E, Gripp S, Peiper M, Budach W, Schwarz A, Orth K, Reinecke P, van de Nes JA. Multifocal epithelioid hemangioendothelioma: case report of a clinical chamaeleon. Eur J Med Res. 2006 Nov 30;11(11):462-6.
  67. Demetriou D, Habicht A, Schillinger M, Horl WH, Vychytil A. Adequacy of automated peritoneal dialysis with and without manual daytime exchange: A randomized controlled trial. Kidney Int. 2006 Nov;70(9):1649-55.
  68. Helfrich I, Schmitz A, Zigrino P, Michels C, Haase I, Bivic AL, Leitges M, Niessen CM. Role of aPKC Isoforms and Their Binding Partners Par3 and Par6 in Epidermal Barrier Formation. J Invest Dermatol. 2006 Nov 16
  69. Lessmann E, Grochowy G, Weingarten L, Giesemann T, Aktories K, Leitges M, Krystal G, Huber M. Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. Exp Hematol. 2006 Nov;34(11):1532-41.
  70. Masek KS, Fiore J, Leitges M, Yan SF, Freedman BD, Hunter CA. Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii. J Cell Sci. 2006 Nov 1;119(Pt 21):4565-73.
  71. Pracht C, Minguet S, Leitges M, Reth M, Huber M. Association of protein kinase C-delta with the B cell antigen receptor complex. Cell Signal. 2006 Nov 13; [Epub ahead of print]
  72. Steinbach G, Bolke E, Schulte Am Esch J, Peiper M, Zant R, Schwarz A, Spiess B, van Griensven M, Orth K. Comparison of whole blood interleukin-8 and plasma interleukin-8 as a predictor for sepsis in postoperative patients. Clin Chim Acta. 2006 Nov 28.
  73. Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, Tkachuk S, Dumler I, Haller H, Schiffer M. CD2AP/CIN85 balance determines RTK-signaling response in podocytes. J Biol Chem. 2007 Jan 9.