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Projects

1st generation graduate students

  

A) Microbial mechanisms of establishment and persistence

Role of key microbial proteins and metabolic functions in persistence

Project

leader(s)

Institution

Doctoral student: Project title

Cooperation partner(s)

D. Bumann

MHH

Somedutta Barat: Molecular mechanisms of persistent Salmonella infection

M. Rhen

O. Pabst/
R. Förster

MHH

Sabrina Voedisch (née Dähne): Exploitation of intact immune functions for Salmonella infection and dissemination

M. Rhen

F. C. Bange

MHH

Sarah Horst: Role of msrA and tpx in resistance of Mycobacterium tuberculosis and Salmonella enterica serovar Typhimurium to oxidative and nitrosative stress

M. Rhen

T. F. Schulz

MHH

Susann Cordes: Role of the LANA1-protein of Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) in latent persistency by controlling the turnover of associated nuclear proteins

M. Masucci

B. Henriques-Normark

KI

Sofia Dahlberg: Characterization of host and microbe interactions affecting the adherence, clearance and systemic spread of S. pneumoniae

M. Gunzer

M. Rhen

KI

Syed Fazle Rouf: Molecular and genetic factors determining persistent Salmonella infection

M. Hornef

Microbial variability and persistence

S. Suerbaum

MHH

Lynn Kennemann (née Schwarzer): Genetic adaption of H. pylori to the host individual

L. Engstrand/ S. Normark

T. Pietschmann

TWINCORE

Dorothea Bankwitz: Role of the hypervariable regions of the hepatitis C virus for immune recognition and viral fitness

M. Sällberg

Biofilm formation and microbial intercellular communication

S. Häußler/

J. Wehland

HZI/
TWINCORE

Matthias Müsken: Intracellular communication in Pseudomonas aeruginosa

U. Römling

B) Host response to infection and microbial modulation of host responses

Host genetic susceptibility

R. Balling/

A. Lengeling

HZI

Meike Küting: Establishment of a new mouse model for Streptococcus pneumoniae infection by humanizing mice for the Polymeric Immunoglobulin Receptor (PIGR) gene

B. Henriques-Normark

Cellular responses to persistent infection

J. Buer/

J. Wehland/

D. Bruder/

R. Geffers

HZI/MHH

Andreas Jeron: Functional characterization of pathogen-induced regulatory T cells in chronic inflammation

H.-G. Ljunggren

C. Josenhans

MHH

Nina Coombs (née Lotzing): Immunomodulatory effects of Helicobacter infection and gastrointestinal colonization by other bacteria: the role of TRAF6 and ubiquitylation

M. Masucci

H. Wedemeyer/
M. P. Manns

MHH

Kerstin Stegmann: The role of TRAIL in interferon alpha-mediated clearance of HCV in patients with acute and chronic hepatitis C

H. G. Ljunggren

C. A. Guzmán

HZI

Peggy Riese: Characterization of immune cells from HCV infected patients to improve vaccine design

H.G. Ljunggren

A. Klos

MHH

Katrin Janik: Effector protein dependent signaling pathways and host responses in chlamydial persistence

M. Rottenberg

M. Hornef

MHH

Claudia Dürr: NOD2-mediated activation of intestinal epithelial cells

B. Henriques Normark

L. Jänsch/

J. Wehland

HZI

Sebastian König: Analysis of signal transduction events induced by pathogenic bacteria upon interaction with host cells: Comparative phosphoproteome analyses of the infected host cell

H.G. Ljunggren

Escape of pathogens from innate and adaptive immunity

M. Gunzer

University Magdeburg

Sabine Stegemann: Analysis of the mechanisms underlying the lethal synergism between viral and bacterial infections - role of Toll like receptors

B. Henriques Normark

2nd generation graduate students

A) Microbial mechanisms of establishment and persistence

 

Project leaders

Project title

A1

O. Pabst (MHH)/

M. Rhen (KI)

Chee Han Lim: Exploitation of intact immune functions for Salmonella infection and disseminaton

A2

F.-C. Bange (MHH)/M. Rhen (KI)

Luisa Denkel: Molecular mechanisms of resistence to oxidative and nitrosative stress in Mycobacterium tuberculosis and Salmonella enterica serovar Typhimurium

A3

T. F. Schulz (MHH)/M. Masucci (KI)

Saumya Gupta: The role of Brd2 and other cellular nuclear kinases in LANA-1 and EBNA-1 mediated episomal replication and latency

A4

T. Pietschmann (TWI)/M. Sällberg (KI)

Anne Frentzen: In vivo and in vitro correlates of the hepatitis C virus replication

A5

S. Suerbaum (MHH)

Juliane Krebes: Mechanisms generating allelic diversity during chronic infection

A6

C. Josenhans (MHH)

Wiebke Behrens: Characterization of mechanisms mediating energy taxis of Helicobacter species

Eugenia Gripp: Determinants of host specificity of Campylobacter species in colonisation and disease

A7

P. Dersch (HZI)/M. Rhen (KI)

Chriselle Mendonca: Environmental control of virulence by members of the SlyA/RovA family

A8

S. Häußler (TWI)/U. Römling (KI)

Andrea Blanka: Impact of environmental and bacterial signals on the establishment and recalcitrance of Pseudomonas aeruginosa biofilms

B) Host response to infection and microbial modulation of host responses

B1

M. Hornef (MHH)/H.-G. Ljunggren (KI)

Natalia Torow: Postnatal maturation dynamics of the enteric mucosal immune system

B2

T. Sparwasser (TWI)/B. Henriques Normark (KI)

Markus Dudek: The role of TLR signalling in dendritic cell and macrophage-mediated host defence against pneumococcal infection

B3

C. Josenhans (MHH)/M. Rhen/M. Masucci (KI)

 

B4

C. Guzmán (HZI)/H.-G. Ljunggren (KI)

Stephanie Trittel: Identification of immune modulators acting on NK and NKT cells which affect hepatocyte infection by the HCV virus

B5

H. Wedemeyer (MHH)/ H.-G. Ljunggren (KI)

Sebastian Lunemann: Effects of type I interferons on human NK cells: Relevance for hepatitis C virus infections

B6

S. Pöhlmann (MHH)/F. Chiodi (KI)

Miriam Kiene: Role of GPR15 in HIV and SIV cell tropism and apoptosis induction

B7

A Klos (MHH)/M. Rhen (KI)

Pavel Dutow: Chlamydial virulence factors related to the complement system and culture conditions

B8

L. Jänsch (HZI)/H.-G. Ljunggren (KI)

Maxi Scheiter: Molecular mechanisms of NK cell cytotoxicity: Analysis of activated receptor signaling

3rd generation graduate students

A) Microbial mechanisms of establishment and persistence

 

Project leaders

Project title

A1

O. Pabst (MHH)/

M. Rhen (KI)

I. Thomsen: Infection triggered adaptions of the intestinal IgA repertoire

A2

F.-C. Bange (MHH)/M. Rhen (KI)

S. Billig: The role of acetate and lactate metabolism in the response of Mycobacterium tuberculosis against host derived stress

A3

T. F. Schulz (MHH)/M. Masucci (KI)

G. Mariggiò: The crosstalk between KSHV associated nuclear antigen (LANA) and the host DNA double-strands breaks (DSBs) repair proteins

A4

T. Pietschmann (TWI)/M. Sällberg (KI)

S. Pfänder: Viral and cellular factors modulating innate HCV immune control

A7

P. Dersch (HZI)/M. Rhen (KI)

M. Rosenheinrich: Modulation of the innate immune response by Yersinia pseudotuberculosis and during different stages of the infection

A8

S. Häußler (TWI)/U. Römling (KI)

A. Lorenz: Identification of fitness determinants in Pseudomonas aeruginosa infection via insertion sequencing

A9

M. Messerle (MHH)/C. Söderberg-Nauclér (KI)

E. Elbasani: Properties and functions of RL11 proteins in cytomegalovirus infection

A10

M. Rhen (KI)/Edmund Loh (KI)

K. Vestö: RNA-modulating enzymes in relation to bacterial virulence and intrinsic antibiotic tolerance

B) Host response to infection and microbial modulation of host responses

B1

M. Hornef (MHH)/B. Henriques-Normark (KI)

T. Ashtalakshmi Selvakumar: Interferon mediated intestinal epithelial gene expression under homeostatic and inducible conditions 

B2

T. Sparwasser (TWI)/M. Rottenberg (KI)

P. Stüve: Novel approaches to control mycobacterial infection

B4

C. Guzmán (HZI)/H.-G. Ljunggren (KI)

N. Vashist: Dissecting innate immune players and their interaction with virus infected cells to improve vaccine design

B5

H. Wedemeyer (MHH)/H.-G. Ljunggren (KI)

J. Hengst: Effects of type I interferons on NK cells: Implications for hepatitis virus infections

B7

A Klos (MHH)/M. Rhen (KI)

M. Bothe: Functions of the cytotoxin CT166 of Chlamydia trachomatis D and homologous potential virulence factors of related chlamydial species

B8

L. Jänsch (HZI)/H.-G. Ljunggren (KI)

J. Voigt: Molecular mechanisms of NK cell cytotoxicity: Analysis of activated receptor signaling

B9

U. Kalinke (TWI)/B. Henriques-Normark (KI)

K. Borst: Analysis of type II interferon responses in anti-viral defense

B10

D. Bruder (HZI)/B. Henriques-Normark (KI)

N. Sharma: Epithelial cell factors influencing the lethal synergism between influenza A virus and Streptococcus pneumoniae