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Publikationen

selected Publications (since 1999)

 

 

Dhamija, S., Winzen, R., Doerrie, A., Behrens, G., Kuehne, N., Schauerte, C., Neumann, E., Dittrich-Breiholz, O., Kracht, M., and Holtmann, H. (2013). Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1. J Biol Chem 288, 19250-19259.

 

Tiedje, C., Ronkina, N., Tehrani, M., Dhamija, S., Laass, K., Holtmann, H., Kotlyarov, A., and Gaestel, M. (2012). The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS Genet 8, e1002977.

 

Dhamija, S., Kuehne, N., Winzen, R., Doerrie, A., Dittrich-Breiholz, O., Thakur, B.K., Kracht, M., and Holtmann, H. (2011). Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. J Biol Chem 286, 33279-33288.

 

Rzeczkowski, K., Beuerlein, K., Muller, H., Dittrich-Breiholz, O., Schneider, H., Kettner-Buhrow, D., Holtmann, H., and Kracht, M. (2011). c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol 194, 581-596.

 

Dhamija, S., Doerrie, A., Winzen, R., Dittrich-Breiholz, O., Taghipour, A., Kuehne, N., Kracht, M., and Holtmann, H. (2010). IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IkappaBzeta mRNA. J Biol Chem 285, 29165-29178.

 

Otkjaer, K., Holtmann, H., Kragstrup, T.W., Paludan, S.R., Johansen, C., Gaestel, M., Kragballe, K., and Iversen, L. (2010). The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA. PLoS One 5, e8671.

 

Winzen, R., Thakur, B.K., Dittrich-Breiholz, O., Shah, M., Redich, N., Dhamija, S., Kracht, M., and Holtmann, H. (2007). Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets. Mol Cell Biol. 27, 8388-8400. Epub 2007 Oct 8381.

 

Gowrishankar, G., Winzen, R., Bollig, F., Ghebremedhin, B., Redich, N., Ritter, B., Resch, K., Kracht, M., and Holtmann, H. (2005). Inhibition of mRNA deadenylation and degradation by ultraviolet light. Biol. Chem. 386, 1287-1293.

 

Winzen, R., Gowrishankar, G., Bollig, F., Redich, N., Resch, K., and Holtmann, H. (2004). Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR. Mol Cell Biol 24, 4835-4847.

 

Bollig, F., Winzen, R., Gaestel, M., Kostka, S., Resch, K., and Holtmann, H. (2003). Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. Biochem Biophys Res Commun 301, 665-670.

 

Bollig, F., Winzen, R., Kracht, M., Ghebremedhin, B., Ritter, B., Wilhelm, A., Resch, K., and Holtmann, H. (2002). Evidence for general stabilization of mRNAs in response to UV light. Eur J Biochem 269, 5830-5839.

 

Holtmann, H., Enninga, J., Kalble, S., Thiefes, A., Dorrie, A., Broemer, M., Winzen, R., Wilhelm, A., Ninomiya-Tsuji, J., Matsumoto, K., et al. (2001). The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation. J Biol Chem 276, 3508-3516.

 

Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C.Y., Shyu, A.B., Muller, M., Gaestel, M., Resch, K., and Holtmann, H. (1999). The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. Embo J 18, 4969-4980.

 

Holtmann, H., Winzen, R., Holland, P., Eickemeier, S., Hoffmann, E., Wallach, D., Malinin, N.L., Cooper, J.A., Resch, K., and Kracht, M. (1999). Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Mol Cell Biol 19, 6742-6753.

 

 

 


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