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Publications

Selected publications

 

Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction.

Piccoli MT, Gupta SK, Viereck J, Foinquinos A, Samolovac S, Kramer FL, Garg A, Remke J, Zimmer K, Batkai S, Thum T.

Circ Res. 2017 Aug 18;121(5):575-583. doi: 10.1161/CIRCRESAHA.117.310624. Epub 2017 Jun 19.

 

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes V, Thum T.

Sci Rep. 2016 Nov 22;6:37354. doi: 10.1038/srep37354.

 

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy.

Bär C, Chatterjee S, Thum T.

Circulation. 2016 Nov 8; 134(19):1484-1499.

 

MicroRNA-based Therapy of Gata2-deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Oct 25. pii: CIRCULATIONAHA.116.022478. [Epub ahead of print]

 

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.

Beermann J, Piccoli MT, Viereck J, Thum T.

Physiol Rev. 2016 Oct; 96(4):1297-325. doi: 10.1152/physrev.00041.2015.

 

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.

Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T.

J Am Coll Cardiol. 2016 Oct 4;68(14):1557-71. doi: 10.1016/j.jacc.2016.07.739.

 

Identification of miR-126 as a new regulator of skin aging.

Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M.

Exp Dermatol. 2016 Aug 30. doi: 10.1111/exd.13173. [Epub ahead of print]

 

Long noncoding RNA Chast promotes cardiac remodeling.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.

Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

 

Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J.

Chem Commun (Camb). 2015 Jun 2;51(48):9821-4.

 

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

Lorenzen JM, Schauerte C, Hübner A, Kölling M, Martino F, Scherf K, Batkai S, Zimmer K, Foinquinos A, Kaucsar T, Fiedler J, Kumarswamy R, Bang C, Hartmann D, Gupta SK, Kielstein J, Jungmann A, Katus HA, Weidemann F, Müller OJ, Haller H, Thum T.

Eur Heart J. 2015 Apr 21. pii: ehv109.

 

Long noncoding RNAs in cardiac development and ageing.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.

Nat Rev Cardiol. 2015 Apr 7. doi: 10.1038/nrcardio.2015.55

 

Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.

Dangwal S, Stratmann B, Bang C, Lorenzen JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T, Tschoepe D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1480-8.

 

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.

Watson CJ, Gupta SK, O'Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T.

Eur J Heart Fail. 2015 Apr;17(4):405-15.

 

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology.

Thum T, Condorelli G.

Circ Res. 2015 Feb 13;116(4):751-62.

 

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T

J Clin Invest. 2014;124:2136-2146.

 

Functional MicroRNA library screening identifies the HypoxaMiR MiR-24 as a potent regulator of smooth muscle cell proliferation and vascularization.

Fiedler J, Stohr A, Gupta SK, Hartmann D, Holzmann A, Just A, Hansen A, Hilfiker-Kleiner D, Eschenhagen T, Thum T

Antioxid Redox Signal. 2014;21:1167-1176.

 

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T

Circ Res. 2014;114:1569-1575.

 

MicroRNA-24 antagonism prevents renal ischemia reperfusion injury.

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T.

 J Am Soc Nephrol. 2014.

 

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.

Jazbutyte V, Fiedler J, Kneitz S, Galuppo P, Just A, Holzmann A, Bauersachs J, Thum T

Age (Dordr). 2013;35:747-762.

 

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T

Nat Commun. 2012;3:1078.

 

MicroRNA-24 regulates vascularity after myocardial infarction.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T

Circulation. 2011;124:720-730.

 

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T

EMBO Rep. 2011;12:1153-1159.

 

Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.

Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S. 

J Clin Invest. 2011;121:461-2; author reply 462-3.

 

Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.

Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J.

Eur Heart J. 2011;32:1275-1286.

 

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.

Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K.

Nat Genet. 2010;42:1101-1108.

 

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008;456:980-984.

 

MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure.

Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J.

Circulation. 2007;116:258-267.

 

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007;100:434-443.

 

 

For a complete list of publications please go to PubMed.