The Institute "Molecular and Translational Therapeutic Strategies" was founded in 2009 at the Hannover Medical School under the umbrella of the Integrated Research Center Transplantation (IFB-Tx). A main group’s focus is the development of microRNA-based therapeutic strategies in cardiovascular and transplantation medicine. Currently we particularly focus on the regeneration and treatment of injured organs by use of genetic microRNA manipulation (Circulation, 2007; Nature, 2008; Circ Res, 2010).
MicroRNAs (miRNA) are endogenous small ribonucleotides that orchestrate development, growth, function and stress response of probably all cells by regulating target messenger RNA translation. The uncovering of miRNAs as important regulators not only for single genes but whole gene networks has enormous therapeutic implications. MiRNAs also regulate differentiation of embryonic stem cells (Nat Genet, 2008), induced pluripotent stem (iPS) cells (Nat Biotechnol, 2009) and many other stem/progenitor cell types putting miRNAs at the forefront as key players in regenerative medicine. We develop oligonucleotide- and stem/progenitor-cell based therapeutic strategies in the fields of cardiovascular medicine and transplantation research. Many high-throughput technologies such as miRNA profiling, transfection of global miRNA libraries or ribonucleoprotein immunoprecipitation–microarray (RIP-Chip) techniques to identify regulated miRNA targets have been implemented to develop innovative miRNA-based treatment strategies for future clinical trials.