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Prof. Dr. rer. nat. Claudia Grothe

Curriculum Vitae

 

 

Education

1981

Diploma in Biology, Free University of Berlin, Germany

1983

Dr. rer. nat., Free University of Berlin, Germany

1991

Habilitation in Anatomy and Cell Biology at the University of Marburg; Germany

1992

Privatdozent at the Philipps-University of Marburg; Germany

 

 

Academic Appointments:

1983-88

Postdoctorate, Inst. Anatomy & Cell Biology, University of Marburg, Germany

1988-92

Hochschulassistent (C1), Inst. Anatomy & Cell Biology, Marburg, Germany

1993-98

Professor (C3), Institute of Anatomy, University of Freiburg, Germany

since 1998

Professor (C4), Head of the Institute of Neuroanatomy, Hannover Medical School,  Hannover, Germany

 

 

 

Major Research Interests:

Neurotrophic factors

Neural stem cells

Cell and gene therapy

Neurode- and regeneration

Morbus Parkinson; peripheral nerve regeneration

.

 

 

 

Selected publications:

 

Cesnulevicius K, Timmer M, Wesemann M, Thomas T, Barkhausen T, Grothe C. Nucleofection is the most efficient nonviral transfection method for neuronal Stem Cells derived from vetral mesencephali with no changes in cell composition or dopaminergic fate. Stem Cells 2006, 24(12):2776-91.


Timmer M, Cesnulevicius  K, Winkler C, Kolb J, Lipokatic-Takacs E, Jungnickel J, Grothe C. Fibroblast Growth Factor (FGF)-2 and FGF Receptor 3 are required for the development of the substantia nigra and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-Hydroxydopamine lesion. J Neurosci 2007;27(3):459-71.


Haastert K, Mauritz C, Chaturvedi S, Grothe C. Human and rat adult Schwann cell cultures: fast and efficient enrichment and highly effective non-viral transfection protocol. Nature Protocols 2007; 2(1): 99-104.


Bruns AF, Bergeijk JV, Lorbeer C, Nölle A, Jungnickel J, Grothe C, Claus P.: Fibroblast growth factor-2 regulates the stability of nuclear bodies. Proc Natl Acad Sci USA. 2009; 106(31):12747-32.


Haastert-Talini K, Geuna S, Dahlin LB, Meyer C, Stenberg L, Freier T, Heimann C, Barwig C, Pinto LF, Raimondo S, Gambarotta G, Samy SR, Sousa N, Salgado AJ, Ratzka A, Wrobel S, Grothe C. Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 2013;34(38):9886-9904.


Rumpel R, Alam M, Klein A, Özer M, Wesemann M, Jin X, Krauss JK, Schwabe K, Ratzka A, Grothe C. Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats. Neurobiol Dis 2013;59:230-243.


Hohmann M, Rumpel R, Fischer M, Donert M, Ratzka A, Klein A, Wesemann M, Effenberg A, Fahlke C, Grothe C. Electrophysiological characterization of eGFP-labeled intrastriatal dopamine grafts. Cell Transplant 2015;24(8):1451-67.


Meyer C, Stenberg L, Gonzalez-Perez F, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016;76:33-51. 

 

  

 

Contact:

 

Prof. Dr. rer. nat. Claudia Grothe
Institute of Neuroanatomy and Cell Biology, OE 4140

Building I3, Level H, Room 3080
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
Germany
E-mail: grothe.claudiamh-hannover.de
Phone: +49-511-532-2896
Fax: +49-(0)511-532-2880  

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