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Dr. rer. nat. Niko Hensel


Curriculum Vitae



Diploma Biochemistry, Leibnitz - University Hannover, Germany


PhD studies, Center of Systems Neurosciences, Institut of Neuroanatomy,

Hannover Medical School, Hannover, Germany


Postdoctoral research fellow, Niedersachsen Network on Neuroinfectiology (N-RENNT),

Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany

2016- 2018

Postdoctoral research fellow, SMA Europe, Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany

Since March 2018

Senior Researcher, Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany






Uhde A.K., Ciurkiewicz M., Herder V., Khan M.A., Hensel N., Claus P., Beckstette M., Teich R., Floess S., Baumgärtner W., Jung K., Huehn J., Beineke A. (2018) Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Sci Rep., 8(1)



Hensel, N., Baskal, S., Walter, L. M., Brinkmann, H., Gernert, M., and Claus, P. (2017) ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol Dis 108, 352-361


Rademacher, S., Verheijen, B. M., Hensel, N., Peters, M., Bora, G., Brandes, G., Vieira de Sa, R., Heidrich, N., Fischer, S., Brinkmann, H., van der Pol, W. L., Wirth, B., Pasterkamp, R. J., and Claus, P. (2017) Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet 26, 3946-3959


Hensel, N., and Claus, P. (2017) The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? Neuroscientist, 1073858417705059


Stanslowsky,N., Reinhardt, P., Glass, H., Kalmbach, N., Naujock, M., Hensel, N., Lubben, V., Pal, A., Venneri, A., Lupo, F., De Franceschi, L., Claus, P., Sterneckert, J., Storch, A., Hermann, A., and Wegner, F. (2016) Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci 36, 12027-12043


Hensel, N., Schon, A., Konen, T., Lubben, V., Forthmann, B., Baron, O., Grothe, C., Leifheit-Nestler, M., Claus, P., and Haffner, D. (2016) Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density. J Neurochem 137, 756-769


Hensel, N., Rademacher, S., and Claus, P. (2015) Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front Neurosci 9, 198


Hensel, N., Stockbrügger, I., Rademacher, S., Broughton, N., Brinkmann, H., Grothe, C., and Claus, P. (2014) Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA). Cell Signal 26, 540-548


Sun, H., Benardais, K., Stanslowsky, N., Thau-Habermann, N., Hensel, N., Huang, D., Claus, P., Dengler, R., Stangel, M., and Petri, S. (2013) Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One 8, e72926


Hensel, N., Ratzka, A., Brinkmann, H., Klimaschewski, L., Grothe, C., and Claus, P. (2012) Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy. PLoS One 7, e31202


Nolle, A., Zeug, A., van Bergeijk, J., Tonges, L., Gerhard, R., Brinkmann, H., Al Rayes, S., Hensel, N., Schill, Y., Apkhazava, D., Jablonka, S., O'Mer, J., Srivastav, R. K., Baasner, A., Lingor, P., Wirth, B., Ponimaskin, E., Niedenthal, R., Grothe, C., and Claus, P. (2011) The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Hum Mol Genet 20, 4865-4878 





Dr. rer. nat. Niko Hensel
Institute of Neuroanatomy and Cell Biology,
OE 4140
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
Phone: +49-(0)511-532-2932
Fax: +49-(0)511-532-2880