Medizinische Hochschule Hannover | Carl-Neuberg-Str.1 | 30625 Hannover | Tel.:(+49) 0511-532-0

Dr. rer. nat. Niko Hensel

 

Curriculum Vitae

 

2004-2010

Diploma Biochemistry, Leibnitz - University Hannover, Germany

2010-2014

PhD studies, Center of Systems Neurosciences, Institut of Neuroanatomy,

Hannover Medical School, Hannover, Germany

2015-2016

Postdoctoral research fellow, Niedersachsen Network on Neuroinfectiology (N-RENNT),

Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany

Since October 2016

Postdoctoral research fellow, SMA Europe, Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany

 

 

 

Publications

 

Hensel, N., Baskal, S., Walter, L. M., Brinkmann, H., Gernert, M., and Claus, P. (2017) ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol Dis 108, 352-361

 

Rademacher, S., Verheijen, B. M., Hensel, N., Peters, M., Bora, G., Brandes, G., Vieira de Sa, R., Heidrich, N., Fischer, S., Brinkmann, H., van der Pol, W. L., Wirth, B., Pasterkamp, R. J., and Claus, P. (2017) Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet 26, 3946-3959

 

Hensel, N., and Claus, P. (2017) The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? Neuroscientist, 1073858417705059

 

Stanslowsky,N., Reinhardt, P., Glass, H., Kalmbach, N., Naujock, M., Hensel, N., Lubben, V., Pal, A., Venneri, A., Lupo, F., De Franceschi, L., Claus, P., Sterneckert, J., Storch, A., Hermann, A., and Wegner, F. (2016) Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci 36, 12027-12043

 

Hensel, N., Schon, A., Konen, T., Lubben, V., Forthmann, B., Baron, O., Grothe, C., Leifheit-Nestler, M., Claus, P., and Haffner, D. (2016) Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density. J Neurochem 137, 756-769

 

Hensel, N., Rademacher, S., and Claus, P. (2015) Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front Neurosci 9, 198

 

Hensel, N., Stockbrügger, I., Rademacher, S., Broughton, N., Brinkmann, H., Grothe, C., and Claus, P. (2014) Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA). Cell Signal 26, 540-548

 

Sun, H., Benardais, K., Stanslowsky, N., Thau-Habermann, N., Hensel, N., Huang, D., Claus, P., Dengler, R., Stangel, M., and Petri, S. (2013) Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One 8, e72926

 

Hensel, N., Ratzka, A., Brinkmann, H., Klimaschewski, L., Grothe, C., and Claus, P. (2012) Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy. PLoS One 7, e31202

 

Nolle, A., Zeug, A., van Bergeijk, J., Tonges, L., Gerhard, R., Brinkmann, H., Al Rayes, S., Hensel, N., Schill, Y., Apkhazava, D., Jablonka, S., O'Mer, J., Srivastav, R. K., Baasner, A., Lingor, P., Wirth, B., Ponimaskin, E., Niedenthal, R., Grothe, C., and Claus, P. (2011) The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Hum Mol Genet 20, 4865-4878 

 

 

 

Contact:


Dr. rer. nat. Niko Hensel
Institute of Neuroanatomy and Cell Biology,
OE 4140
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
Germany
E-mail: hensel.nikomh-hannover.de
Phone: +49-(0)511-532-2932
Fax: +49-(0)511-532-2880