SitemapImpressumDatenschutzerklärungdeutschenglish
MHH Logo

Publikationen

Publikationsliste des Konsiliarlabors (2003 - 2015, nach Themen geordnet):

 

Diagnostik & klinische Virologie

1.

Engelmann I, Coiteux V, Heim A, Magro L, Dewilde A, Dulery R, et al. Adenovirus infection followed by septicaemia: relevance of co-infections in allogeneic hematopoietic stem cell transplantation. Infect Disord Drug Targets. 2015.

2.

Mynarek M, Ganzenmueller T, Mueller-Heine A, Mielke C, Gonnermann A, Beier R, et al. Patient, virus, and treatment-related risk factors in pediatric adenovirus infection after stem cell transplantation: results of a routine monitoring program. Biol Blood Marrow Transplant. 2014;20(2):250-6.

3.

Henke-Gendo C, Ganzenmueller T, Kluba J, Harste G, Raggub L, Heim A. Improved quantitative PCR protocols for adenovirus and CMV with an internal inhibition control system and automated nucleic acid isolation. J Med Virol. 2012;84(6):890-6.

4.

Ganzenmueller T, Heim A. Adenoviral load diagnostics by quantitative polymerase chain reaction: techniques and application. Rev Med Virol. 2012;22(3):194-208.

5.

Ganzenmueller T, Buchholz S, Harste G, Dammann E, Trenschel R, Heim A. High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load. J Clin Virol. 2011;52(1):55-9.

6.

Heim A. Advances in the management of disseminated adenovirus disease in stem cell transplant recipients: impact of adenovirus load (DNAemia) testing. Expert Rev Anti Infect Ther. 2011;9(11):943-5.

7.

Gaspert A, Luthi B, Mueller NJ, Bossart W, Heim A, Wuthrich RP, et al. Subacute allograft failure with dysuria and hematuria in a kidney transplant recipient. Am J Kidney Dis. 2009;54(1):154-8.

8.

Mattner F, Sykora KW, Meissner B, Heim A. An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies. Pediatr Infect Dis J. 2008;27(5):419-24.

9.

Forstmeyer D, Henke-Gendo C, Brocker V, Wildner O, Heim A. Quantitative temporal and spatial distribution of adenovirus type 2 correlates with disease manifestations and organ failure during disseminated infection. J Med Virol. 2008;80(2):294-7.

10.

Madisch I, Wolfel R, Harste G, Pommer H, Heim A. Molecular identification of adenovirus sequences: a rapid scheme for early typing of human adenoviruses in diagnostic samples of immunocompetent and immunodeficient patients. J Med Virol. 2006;78(9):1210-7.

11.

Seidemann K, Heim A, Pfister ED, Koditz H, Beilken A, Sander A, et al. Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature. Am J Transplant. 2004;4(12):2102-8.

12.

Heim A, Ebnet C, Harste G, Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol. 2003;70(2):228-39.

13.

Friedrichs N, Eis-Hubinger AM, Heim A, Platen E, Zhou H, Buettner R. Acute adenoviral infection of a graft by serotype 35 following renal transplantation. Pathol Res Pract. 2003;199(8):565-70.

 

 

Modellsysteme für Adenovirusinfektionen, Virulenz von Adenoviren

14.

Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, et al. Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 2015;10(7):e0131201.

15.

Markel D, Lam E, Harste G, Darr S, Ramke M, Heim A. Type dependent patterns of human adenovirus persistence in human T-lymphocyte cell lines. J Med Virol. 2014;86(5):785-94.

16.

Ramke M, Lam E, Meyer M, Knipper A, Heim A. Porcine corneal cell culture models for studying epidemic keratoconjunctivitis. Mol Vis. 2013;19:614-22.

17.

Lam E, Ramke M, Groos S, Warnecke G, Heim A. A differentiated porcine bronchial epithelial cell culture model for studying human adenovirus tropism and virulence. J Virol Methods. 2011;178(1-2):117-23.

 

 

 

Evolution von humanen Adenoviren, neue Adenovirustypen („emerging viruses“)

18.

Hage E, Gerd Liebert U, Bergs S, Ganzenmueller T, Heim A. Human mastadenovirus type 70: a novel, multiple recombinant species D mastadenovirus isolated from diarrhoeal faeces of a haematopoietic stem cell transplantation recipient. J Gen Virol. 2015;96(9):2734-42.

19.

Hage E, Huzly D, Ganzenmueller T, Beck R, Schulz TF, Heim A. A human adenovirus species B subtype 21a associated with severe pneumonia. J Infect. 2014;69(5):490-9.

20.

Hofmayer S, Madisch I, Darr S, Rehren F, Heim A. Unique sequence features of the Human adenovirus 31 complete genomic sequence are conserved in clinical isolates. BMC Genomics. 2009;10:557.

21.

Madisch I, Hofmayer S, Moritz C, Grintzalis A, Hainmueller J, Pring-Akerblom P, et al. Phylogenetic analysis and structural predictions of human adenovirus penton proteins as a basis for tissue-specific adenovirus vector design. J Virol. 2007;81(15):8270-81.

22.

Madisch I, Heim A. Extent of circulation of incorrectly labeled adenovirus 50 and 51 prototype preparations. J Clin Microbiol. 2007;45(6):2092; discussion

23.

Walsh MP, Chintakuntlawar A, Robinson CM, Madisch I, Harrach B, Hudson NR, et al. Evidence of molecular evolution driven by recombination events influencing tropism in a novel human adenovirus that causes epidemic keratoconjunctivitis. PLoS One. 2009;4(6):e5635.

24.

Darr S, Madisch I, Hofmayer S, Rehren F, Heim A. Phylogeny and primary structure analysis of fiber shafts of all human adenovirus types for rational design of adenoviral gene-therapy vectors. J Gen Virol. 2009;90(Pt 12):2849-54.

25.

Engelmann I, Madisch I, Pommer H, Heim A. An outbreak of epidemic keratoconjunctivitis caused by a new intermediate adenovirus 22/H8 identified by molecular typing. Clin Infect Dis. 2006;43(7):e64-6.

26.

Madisch I, Harste G, Pommer H, Heim A. Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy. J Virol. 2005;79(24):15265-76.

 

 

 

Antivirale Therapie & Desinfektion

27.

Sukdolak C, Tischer S, Dieks D, Figueiredo C, Goudeva L, Heuft HG, et al. CMV-, EBV- and ADV-specific T cell immunity: screening and monitoring of potential third-party donors to improve post-transplantation outcome. Biol Blood Marrow Transplant. 2013;19(10):1480-92.

28.

Darr S, Madisch I, Heim A. Antiviral activity of cidofovir and ribavirin against the new human adenovirus subtype 14a that is associated with severe pneumonia. Clin Infect Dis. 2008;47(5):731-2.

29.

Engelmann G, Heim A, Greil J, Schmitt CP, Flechtenmacher C, Daum E, et al. Adenovirus infection and treatment with cidofovir in children after liver transplantation. Pediatr Transplant. 2009;13(4):421-8.

30.

Stock R, Harste G, Madisch I, Heim A. A rapid quantitative PCR-based assay for testing antiviral agents against human adenoviruses demonstrates type specific differences in ribavirin activity. Antiviral Res. 2006;72(1):34-41.

31.

Sauerbrei A, Sehr K, Brandstadt A, Heim A, Reimer K, Wutzler P. Sensitivity of human adenoviruses to different groups of chemical biocides. J Hosp Infect. 2004;57(1):59-66.

 

 

Wasserqualität & Adenoviren

32.

van Heerden J, Ehlers MM, Heim A, Grabow WO. Prevalence, quantification and typing of adenoviruses detected in river and treated drinking water in South Africa. J Appl Microbiol. 2005;99(2):234-42.

 

 

Gentherapievektoren

33.

Kallenbach K, Salcher R, Heim A, Karck M, Mignatti P, Haverich A. Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3. J Vasc Surg. 2009;49(3):750-8.

34.

Hoffmann D, Bayer W, Heim A, Potthoff A, Nettelbeck DM, Wildner O. Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma. J Invest Dermatol. 2008;128(4):988-98.

35.

Hoffmann D, Heim A, Nettelbeck DM, Steinstraesser L, Wildner O. Evaluation of twenty human adenoviral types and one infectivity-enhanced adenovirus for the therapy of soft tissue sarcoma. Hum Gene Ther. 2007;18(1):51-62.

 

 

 

Ältere  Publikationen des Konsiliarlabors (bis 2002)

36.

Arnberg N., Kidd AH, Edlund K., Nilsson J., Pring-Åkerblom P., Wadell G. "Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction." Virology. 2002 Oct 10;302(1):33-43.

37.

Arnberg N., Pring-Åkerblom P., Wadell G. "Adenovirus type 37 uses sialic acid as a cellular receptor on Chang C cells." J Virol. 2002 Sep;76(1 7):8834-41.

38.

Blusch JH, Deryckere F., Windheim M., Ruzsics Z., Arnberg N., Adrian T., Burgert HG. "The novel early region 3 protein E3/49K is specifically expressed by adenoviruses of subgenus D: implications for epidemic keratoconjunctivitis and adenovirus evolution." Virology. 2002 Apr 25;296(1):94-106.

39.

Cichon G., Boeckh-Herwig S., Schmidt HH., Wehnes E., Muller T., Pring-Åkerblom P., Burger R. "Complement activation by recombinant adenoviruses." Gene Ther. 2001 Dec;8(23):1794-800.

40.

Pring-Åkerblom P., Trijssenaar FE., Adrian T., Hoyer H. "Multiplex polymerase chain reaction for subgenus-specific detection of human adenoviruses in clinical samples." J Med Virol. 1999 May;58(1):87-92.

41.

Grumbach IM, Heim A., Pring-Åkerblom P., Vonhof S., Hein WJ, Muller G., Figulla HR. "Adenoviruses and enteroviruses as pathogens in myocarditis and dilated cardiomyopathy." Acta Cardiol. 1999 Apr;54(2):83-8.

42.

Liebermann H., Mentel R., Bauer U., Pring-Åkerblom P., Dolling R., Modrow S., Seidel W. ."Receptor binding sites and antigenic epitopes on the fiber knob of human adenovirus serotype 3." J Virol. 1998 Nov;72(11):9121-30.

43.

Pring-Åkerblom P., Heim A., Trijssenaar FE. "Molecular characterization of hemagglutination domains on the fibers of subgenus D adenoviruses." J Virol. 1998 Mar;72(3):2297-304.

44.

Eiz B., Pring-Åkerblom P. "Molecular characterization of the type-specific gamma-determinant located on the adenovirus fiber." J Virol. 1997 Sep;71(9):6576-81.

45.

Pring-Åkerblom P., Blazek K., Schramlova J., Kunstyr I. "Polymerase chain reaction for detection of guinea pig adenovirus." J Vet Diagn Invest. 1997 Jul;9(3):232-6.

46.

Pring-Åkerblom P., Adrian T., Kostler T. "PCR-based detection and typing of human adenoviruses in clinical samples." Res Virol. 1997 May-Jun;148(3):225-31.

47.

Pring-Åkerblom P., Heim A., Trijssenaar FE. "Conserved sequences in the fibers of epidemic keratoconjunctivitis associated human adenoviruses." Arch Virol. 1997;142(1):205-11.

48.

Eiz B., Adrian T., Pring-Åkerblom P. "Recombinant fibre proteins of human adenoviruses Ad9, Ad15 and Ad19: localization of the haemagglutination properties and the type-specific determinant." Res Virol. 1997 Jan-Feb;148(1):5-10.

49.

Adrian T. "Genome polymorphism of human adenoviruses of subgenus C." Arch Virol. 1996;141(6):1021-31.

50.

Eiz B., Adrian T., Pring-Åkerblom P. "Immunological adenovirus variant strains of subgenus D: comparison of the hexon and fiber sequences." Virology. 1995 Nov 10;213(2):313-20.

51.

Pring-Åkerblom P., Trijssenaar FE., Adrian T.. "Hexon sequence of adenovirus type 7 and comparison with other serotypes of subgenus B." Res Virol. 1995 Nov-Dec;146(6):383-388.

52.

Pring-Åkerblom P., Trijssenaar FE., Adrian T. "Sequence characterization and comparison of human adenovirus subgenus B and E hexons." Virology. 1995 Sep 10;212(1):232-6.

53.

Pring-Åkerblom P., Adrian T. "Sequence characterization of the adenovirus 31 fibre and comparison with serotypes of subgenera A to F." Res Virol. 1995 Sep-Oct;146(5):343-54.

54.

Pring-Åkerblom P., Adrian T. "Characterization of adenovirus subgenus D fiber genes." Virology. 1995 Jan 10;206(1):564-71.

55.

Pring-Åkerblom P., Adrian T. "Type- and group-specific polymerase chain reaction for adenovirus detection." Res Virol. 1994 Jan-Feb;145(1):25-35.

56.

Pring-Åkerblom P., Adrian T. "The hexon genes of adenoviruses of subgenus C: comparison of the variable regions." Res Virol. 1993 Mar-Apr;144(2):117-27.

57.

Adrian T., Brunnemann H., Wigand R. "Adenovirus isolations from patients with conjunctivitis in Thuringia." Zentralbl Bakteriol. 1993 Feb;278(1):127-31.

58.

Adrian T. "Genome type analysis of adenovirus type 4." Intervirology. 1992;34(4):180-3.

59.

Adrian T., Wigand R. "Restriction site mapping of subgenus D adenoviruses, prototypes 42-47, intermediate and atypical strains." Zentralbl Bakteriol. 1991 Dec;276(1):107-19.

60.

Wigand R., Adrian T. "A rational system for classifying and denominating adenovirus genome types." Res Virol. 1991 Jan-Feb;142(1):47-56.

61.

Adrian T., Wolf U., Lauer HJ., Wigand R. "Restriction site mapping of adenovirus type 8 genome types." Res Virol. 1990 Nov-Dec;141(6):611-24.

62.

Adrian T., Sassinek J., Wigand R. "Genome type analysis of 480 isolates of adenovirus types 1, 2, and 5." Arch Virol. 1990;112(3-4):235-48.

63.

Wigand R., Adrian T. "Restriction site mapping of adenovirus prototypes of subgenus D." Med Microbiol Immunol (Berl). 1990;179(2):67-75.

64.

Adrian T., Wolf U. "Adenovirus 6 genome types: mapping of restriction site alterations on the genome." Res Virol. 1989 Nov-Dec;140(6):545-50.

65.

Adrian T., Schlipkoter U., Roggendorf M., Wigand R. "Nosocomial and endemic infections with a genome type of adenovirus type 5." Zentralbl Bakteriol. 1989 Sep;271(3):339-44. PMID: 2553041 [PubMed - indexed for MEDLINE]

66.

Adrian T, Best B, Hierholzer JC, Wigand R. "Molecular epidemiology and restriction site mapping of adenovirus type 3 genome types." J Clin Microbiol. 1989 Jun;27(6):1329-34.

67.

Adrian T., Wigand R. "Genome type analysis of certain adenovirus serotypes of subgenus D." Zentralbl Bakteriol Mikrobiol Hyg [A]. 1989 Mar;270(4):527-33.

68.

Adrian T., Wigand R., Knocke KW., Schafer G., Grundmann M. "Genome type analysis of adenoviruses: isolates from one year from the Hannover area." Arch Virol. 1989;105(1-2):89-101.

69.

Adrian T., Becker M., Hierholzer JC., Wigand R. "Molecular epidemiology and restriction site mapping of adenovirus 7 genome types." Arch Virol. 1989;106(1-2):73-84.

70.

Adrian T., Bastian B., Wagner V. "Restriction site mapping of adenovirus types 9 and 15 and genome types of intermediate adenovirus. "15/H9. Intervirology. 1989;30(3):169-76.

71.

Wigand R, Adrian T. "Intermediate adenovirus strains of subgenus D occur in extensive variety." Med Microbiol Immunol (Berl). 1989;178(1):37-44.