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Publications

Original Articles

  • Manstein, D. J., Meiring, J. C. M., Hardeman, E. C., et al. (2019). Actin–tropomyosin distribution in non‑muscle cells. J Muscle Res Cell Motil. DOI 10.1007/s10974-019-09514-0
  • Wollenberg, R.D., Taft, M.H., Giese, S., Thiel, C., Balazs, Z., Giese, H., Manstein, D.J., and Sondergaard, T.E. (2019). Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. J Biol Chem; 294, 1328-1337. DOI: 10.1074/jbc.RA118.005408

  • Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D. J., and Di Donato, N. (2018)
    Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat Commun.;9(1):4250, DOI: 10.1038/s41467-018-06713-0

  • Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, et al. (2018)
    Treatments targeting inotropy. Eur Heart J., DOI: 10.1093/eurheartj/ehy600

  • Meiring, J.C.M., Bryce, N., Wang, Y., Taft, M.F., Manstein, D.J., Lau, S.L., Stear, J., Hardeman, E.C., and Gunning, P.W. (2018). Co-polymers of actin and tropomyosin account for a major fraction of the human actin cytoskeleton. Current Biology. DOI: 10.1016/j.cub.2018.05.053
  • Latham, S.L., Ehmke, N., Reinke, P.Y.A., Taft, M.H., Lyons, M.J., Friez, M.J., Lee, J.A., Hecker, R., Fruehwald, M.C., Becker, K., Neuhann, T.M., Horn, D., Schrock, E., Sarnow, K., Gruetzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Knoefler, R., Manstein, D.J., and Di Donato, N. (2018). Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations. bioRxiv. DOI: 10.1101/303909.
  • Pathan-Chhatbar, S., Taft, M.H., Reindl, T., Hundt, N., Latham, S.L., and Manstein, D.J. (2018)
    Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous beta-actin in vitro.
    J Biol Chem, jbc.M117.806521 DOI: 10.1074/jbc.M117.806521
  • Chinthalapudi, K., Heissler, S.M., Preller, M., Sellers, J.R., and Manstein, D.J. (2017)
    Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C.
    Elife 6, DOI: 10.7554/eLife.32742

  • Zattelman, L., Regev, R., Usaj, M., Reinke, P. Y. A., Giese, S., Samson, A. O., Taft, M. H., Manstein, D. J. and Henn, A. (2017)
    N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.

    J Biol Chem, 292, 17804-17818, DOI: 10.1074/jbc.M117.794008

  • Shevchenko, V., Mager, T., Kovalev, K., Polovinkin, V., Alekseev, A., Juettner, J., Chizhov, I., Bamann, C., Vavourakis, C., Ghai, R., Gushchin, I., Borshchevskiy, V., Rogachev, A., Melnikov, I., Popov, A., Balandin, T., Rodriguez-Valera, F., Manstein, D. J., Bueldt, G., Bamberg, E. and Gordeliy, V. (2017)
    Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach.

    Sci Adv. 3, DOI: 10.1126/sciadv.1603187

  • Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D. J., Lieske, J., Oberthuer, D., Fischetti, R. F. and Chapman, H. N. (2017)
    Pink-beam serial crystallography.
    Nat Commun. 8, 1281, DOI: 10.1038/s41467-017-01417-3

  • Hirschmann, F., Krause, F., Baruch, P., Chizhov, I., Mueller, J. W., Manstein, D. J., Papenbrock, J. and Fedorov, R. (2017)
    Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism.

    Sci Rep. 7, 4160, DOI: 10.1038/s41598-017-04539-2

  • Chinthalapudi, K., Heissler, S. M., Preller, M., Sellers, J. R. and Manstein, D. J. (2017) Mechanistic Insights Into The Active Site And Allosteric Communication Pathways In Human Nonmuscle Myosin-2C.
    bioRxiv, DOI: 10.1101/138891

  • Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, l., Gunning, P.W., Manstein, D.J., Michelot, A., and Lappalainen, P. (2017)
    Tropomyosin isoforms specify functionally distinct actin filament populations.
    Current Biology. DOI: 10.1016/j.cub.2017.01.018

  • von der Ecken, J.,  Heissler, S. M., Pathan-Chhatbar, S., Manstein, D. J., and Raunser, S. (2016)
    Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.
    Nature 534, 724-728. http://rdcu.be/mD0X

  • Hundt,  N., Steffen, W., Pathan-Chhatbar, S., Taft, M. H., and Manstein, D. J. (2016)
    Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.
    Sci Rep 6, 20554, doi: 10.1038/srep20554

  • Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noe, F., Haucke, V., Daumke, O., and Eschenburg, S. (2015)
    Crystal structure of the dynamin tetramer.
    Nature 525, 404, rdcu.be/mD09, doi: 10.1038/nature14880

  • Lohöfener,J., Steinke,N., Kay-Fedorov,P., Baruch,P., Nikulin,A., Tishchenko,S., Manstein,D.J., and Fedorov,R. (2015)
    The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
    Structure, doi: 10.1016/j.str.2015.03.012

  • von der Ecken, J., Müller, M., Lehman, W., Manstein, D.J., Penczek, P.A., and Raunser, S. (2015)
    Structure of the F-actin–tropomyosin complex.
    Nature 519, 114, rdcu.be/mD01 , doi: 10.1038/nature14033

  • Brandstaetter, H., Kishi-Itakura, C., Tumbarello, D.A., Manstein, D.J., and Buss, F. (2014)
    Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.
    Autophagy, doi: 10.4161/15548627.2014.984272

  • Münnich, S., Pathan-Chhatbar, S., and Manstein, D.J. (2014)
    Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.
    FEBS Lett, doi: 10.1016/j.febslet.2014.1011.1007

  • Hundt, N., Preller, M., Swolski, O., Ang, A.M., Mannherz, H.G., Manstein, D.J., and Muller, M. (2014)
    Molecular mechanisms of disease-related human beta-actin mutations p.R183W and p.E364K.
    Febs J,
    doi: 10.1111/febs.13068

  • Martin R, Risacher C, Barthel A, Jäger A, Schmidt AW, Richter S, Böhl M, Preller M, Chinthalapudi K, Manstein DJ, Gutzeit HO, Knölker H-J (2014)
    Silver(I)-Catalyzed Route to Pyrroles: Synthesis of Halogenated Pseudilins as Allosteric Inhibitors for Myosin ATPase and X-ray Crystal Structures of the Protein–Inhibitor Complexes.
    Eur J Org Chem, doi: 10.1002/ejoc.201402177

  • Stefan Münnich, Manuel H. Taft and Dietmar J. Manstein (2014)
    Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca2+-Regulation and 14-3-3 binding.
    J Mol Biol, doi: 10.1016/j.jmb.2014.03.004

  • Rai, A., R. Fedorov, and D. J. Manstein (2014)
    Expression, purification and crystallization of a dye-decolourizing peroxidase from Dictyostelium discoideum
    Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S2053230X14000545  (reprint, pdf)

  • Radke, M. B., M. H. Taft, B. Stapel, D. Hilfiker-Kleiner, M. Preller, and D. J. Manstein (2014)
    Small molecule-mediated Refolding and Activation of Myosin Motor Function
    eLife, doi: 10.7554/eLife.01603

  • Preller, M., and D. J. Manstein (2013)
    Myosin structure, allostery, and mechano-chemistry
    Structure, doi: 10.1016/j.str.2013.09.015

  • Chizhov, I., B. Zorn, D. J. Manstein, and W. Gartner (2013)
    Kinetic and Thermodynamic Analysis of the Light-induced Processes in Plant and Cyanobacterial Phytochromes
    Biophys J, doi: 10.1016/j.bpj.2013.09.033

  • Chaturvedi, A., Araujo Cruz, M.M., Jyotsana, N., Sharma, A., Yun, H., Gorlich, K., Wichmann, M., Schwarzer, A., Preller, M., Thol, F., Meyer, J., Haemmerle, R., Struys, E.A., Jansen, E.E., Modlich, U., Li, Z., Sly, L.M., Geffers, R., Lindner, R., Manstein, D.J., Lehmann, U., Krauter, J., Ganser, A., and Heuser, M. (2013)
    Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
    Blood, doi: 10.1182/blood-2013-03-491571

  • Heissler, S.M., and Manstein, D.J. (2013)
    Nonmuscle myosin-2: mix and match
    Cell Mol Life Sci., doi: 10.1007/s00018-012-1002-9

  • Müller, M., Diensthuber, R.P., Chizhov, I., Claus, P., Heissler, S.M., Preller, M., Taft, M.H., and Manstein, D.J. (2013)
    Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins
    PLoS One, doi: 10.1371/journal.pone.0070636

  • Münnich, S., and Manstein, D.J. (2013)
    Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human myosin 1c in complex with calmodulin
    Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S1744309113020988

  • Rai A, Tzvetkov N, and Manstein DJ (2013)
    Functional Dissection of the Dictyostelium discoideum Dynamin B Mitochondrial Targeting Sequence
    PloS one, doi: 10.1371/journal.pone.0056975

  • Taft, M.H., Behrmann, E., Munske-Weidemann, L.C., Thiel, C., Raunser, S., and Manstein, D.J. (2013)
    Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3
    J Biol Chem., doi: 10.1074/jbc.M113.497180

  • Müller, M., Mazur, A.J., Behrmann, E., Diensthuber, R.P., Radke, M.B., Qu, Z., Littwitz, C., Raunser, S., Schoenenberger, C.A., Manstein, D.J., Mannherz, H.G. (2012)
    Functional characterization of the human alpha-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy.
    Cell Mol Life Sci 69:3457–3479, rdcu.be/mD3P, doi: 10.1007/s00018-012-1030-5

  • Heissler, S.M., Selvadurai, J., Bond, L.M., Fedorov, R., Kendrick-Jones, J., Buss, F. and Manstein, D.J. (2012)
    Kinetic properties and small-molecule inhibition of human myosin-6. 
    FEBS Lett., doi: 10.1016/j.febslet.2012.07.014

  • Heissler SM, Manstein DJ (2012)
    Functional characterization of the human myosin-7a motor domain.
    Cell Mol Life Sci., doi: 10.1007/s00018-011-0749-8, rdcu.be/mD3m  

  • Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S (2012)
    Structure of the Rigor Actin-Tropomyosin-Myosin Complex.
    Cell, doi: 10.1016/j.cell.2012.05.037

  • Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein DJ (2011)
    Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.
    Cell Mol Life Sci. 68:2751-2767, rdcu.be/mD4t, doi: 10.1007/s00018-010-0590-5

  • Preller M, Chinthalapudi K, Martin R, Knölker H-J, Manstein DJ (2011)
    Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
    J Med Chem., doi: 10.1021/jm200259f

  • Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ (2011)
    Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.
    J Biol Chem., doi: 10.1074/jbc.M111.265298

  • Polonais V, Javier Foth B, Chinthalapudi K, Marq JB, Manstein DJ, Soldati-Favre D, Frenal K (2011)
    Unusual anchor of a motor complex (MyoD-MLC2) to the plasma membrane of Toxoplasma gondii.
    Traffic., doi: 10.1111/j.1600-0854.2010.01148.x

  • Naue N, Fedorov R, Pich A, Manstein DJ, Curth U (2011)
    Site-directed mutagenesis of the chi subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
    Nucleic Acids Res., doi: 10.1093/nar/gkq988

  • Heissler SM, Manstein DJ (2011)
    Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms.
    J Biol Chem., doi: 10.1074/jbc.M110.212290

  • Diensthuber RP, Muller M, Heissler SM, Taft MH, Chizhov I, Manstein DJ (2011)
    Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
    FEBS Lett., doi: 10.1016/j.febslet.2011.01.042

  • Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker H-J, Coluccio LM, Manstein DJ (2011)
    Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
    J Biol Chem., doi: 10.1074/jbc.M111.239210

  • Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein DJ, Welte T, Mahadeva R, Janciauskiene S (2011)
    The acute phase protein, alpha1-antitrypsin, inhibits neutrophil calpain I and induces random migration. 
    Mol Med., doi: 10.2119/molmed.2011.00089

  • Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basanez G, Meda P, Martinou JC (2010)
    Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.
    Cell., doi: 10.1016/j.cell.2010.08.017

  • Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B. and Tsiavaliaris, G. (2010)
    Targeted optimization of a protein nanomachine for operation in biohybrid devices.
    Angew Chem Int Ed Engl., doi: 10.1002/anie.200905200

  • Martin, R., Jäger, A., Böhl, M., Richter, S., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.J. (2009)
    Total synthesis of pentabromo- and pentachloropseudilin,
    and synthetic analogues--allosteric inhibitors of myosin ATPase.
    Angew Chem Int Ed Engl., doi: 10.1002/anie.200903743

  • Knoth, T., Warburg, K. ,Katzka, C. ,Rai, A. ,Wolf, A. Brockmeyer, A. Janning, P.  Reubold, T.F., Eschenburg, S., Manstein, D.J. Hubel, K. Kaiser, M. and Waldmann, H. (2009)
    The Ras Pathway Modulator Melophlin A Targets Dynamins.
    Angew Chem Int Ed Engl., doi: 10.1002/anie.200902023

  • Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F. K., Taft, M. H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H. O., and Manstein, D. J. (2009).
    The mechanism of pentabromopseudilin inhibition of myosin motor activity.
    Nat. Struct. Mol. Biol. 16, 80-88, rdcu.be/mD13 , doi: 10.1038/nsmb.1542

  • Tsiavaliaris, G., Fujita-Becker, S., Dürrwang, U., Diensthuber, R. P., Geeves, M. A., and Manstein, D. J. (2008).
    Mechanism, Regulation, and Functional Properties of Dictyostelium Myosin-1B.
    J Biol Chem 283, 4520-4527. (Abstract) (pdf, 350 kB)

  • Taft, M. H., Hartmann, F. K., Rump, A., Keller, H., Chizhov, I., Manstein, D. J., and Tsiavaliaris, G. (2008).
    Dictyostelium Myosin-5b is a conditional processive motor.
    J Biol. Chem 283, 26902-26910. (Abstract) (pdf, 390 kB)

  • Stolboushkina, E., Nikonov, S., Nikulin, A., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, O. (2008).
    Crystal structure of the intact archaeal translation initiation factor 2 demonstrates very high conformational flexibility in the alpha- and beta-subunits.
    J Mol. Biol. 382, 680-691. (Abstract)  (pdf, 3.2 MB)

  • Nikonov, O., Stolboushkina, E., Nikulin, A., Hasenohrl, D., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, S. (2007).
    New insights into the interactions of the translation initiation factor 2 from archaea with guanine nucleotides and initiator tRNA.
    J Mol Biol 373, 328-336. (Abstract) (pdf, 2.5 MB)

  • Hachikubo, Y., Ito, K., Schiefelbein, J., Manstein, D. J., and Yamamoto, K. (2007).
    Enzymatic activity and motility of recombinant Arabidopsis myosin XI. MYA1
    Plant Cell Physiol 48, 886-891. (Abstract) (pdf, 174 kB)

  • Fujita-Becker, S.,Tsiavaliaris, G., Ohkura, R., Shimada, T., Manstein, D.J., and Sutoh, K. (2006).
    Functional characterization of the N-terminal region of myosin-2.
    J Biol Chem 281, 36102-36109. (Abstract)(pdf)

  • Fedorov, R., Witte, G., Urbanke, C., Manstein, D.J., and Curth, U. (2006).
    3D structure of Thermus aquaticus single-stranded DNA-binding protein gives insight into the functioning of SSB proteins.
    Nucleic Acids Res 34, 6708-6717. (Abstract) (pdf 5.7 MB)

  • Ulrike Dürrwang, Setsuko Fujita-Becker, Muriel Erent, F. Jon Kull, Georgios Tsiavaliaris, Michael A. Geeves, and Dietmar J. Manstein (2006)
    Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
    J. Cell Science 119, 550-558 (Abstract) (pdf)

  • Reubold, T. F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S. L., Vallee, R. B., Kull, F. J. and Manstein, D. J. (2005)
    Crystal structure of the GTPase domain of rat dynamin 1
    Proc. Natl. Acad. Sci. U.S.A. 102, 13093-13098 (pdf)

  • Fujita-Becker, S., Dürrwang, U., Erent, M., Clark, R. J., Geeves, M. A. and Manstein, D. J. (2005)
    Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin
    J. Biol. Chem. 280, 6064-6071 (pdf)

  • Van Dijk, J., Lafont, C., Knetsch, M. L., Derancourt, J., Manstein, D. J., Long, E. C. and Chaussepied, P. (2004)
    Conformational changes in actin-myosin isoforms probed by Ni(II).Gly-Gly-His reactivity
    J. Muscle Res. Cell Motil. 25, 527-537 (pdf)

  • Tsiavaliaris, G., Fujita-Becker, S. & Manstein, D.J. (2004)
    Molecular engineering of a backwards moving myosin motor
    Nature 427, 558-561, rdcu.be/mD1F, (Abstract)(pdf)

  • Schlosser, A., Klockow, B., Manstein, D.J., & Lehmann, W.D. (2003)
    Analysis of post-translational modification and characterization of the domain structure of dynamin A from Dictyostelium discoideum.
    J. Mass. Spectrom. 38 (3) 277-282 (Abstract)(pdf)

  • Reubold, T.F., Eschenburg, S., Becker, A., Kull, F.J. & Manstein, D.J. (2003)
    A structural model for actin-induced nucleotide release in myosin
    Nature Struct. Biol., 10, 826-830. rdcu.be/mD2y , (Abstract)(pdf)

  • Krylyshkina, O., Anderson, K.I., Kaverina, I., Upmann, I., Manstein, D.J., Small, J.V. & Toomre, D.K.
    Nanometer targeting of microtubules to focal adhesions
    J. Cell Biol., 161, 853-859. (Abstract)(pdf)

  • Ito K., Kashiyama T., Shimada K, Yamaguchi A., Awata J, Hachikubo Y., Manstein D.J., Yamamoto K. (2003)
    Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity
    Biochem. Biophys. Res. Commun. 312, 958-64. (Abstract) (pdf)

  • Ballweber, E., Kiessling, P., Manstein, D.J., & Mannherz, H.G. (2003)
    Interaction of Myosin subfragment 1 with forms of monomeric actin
    Biochemistry 42 (10) 3060-3069 (Abstract)

  • Tsiavaliaris, G., Fujita-Becker, S., Batra, R., Levitsky, D.I., Kull, F.J., Geeves, M.A. & Manstein, D.J. (2002)
    Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium
    EMBO Reports, 3, 1099-1105 (Abstract) (pdf)

  • Linke, W.A., Kulke, M., Li, H., Fujita-Becker S., Neagoe C., Manstein, D.J., Gautel, M., Fernandez, J.M. (2002)
    PEVK Domain of Titin: An Entropic Spring with Actin-Binding Properties
    J. Struct. Biol. 137, 194-205. (Abstract)

  • Kollmar, M. Dürrwang, U., Kliche, W., Manstein, D.J., & Kull, F.J. (2002)
    Crystal structure of the motor domain of a class-I myosin
    EMBO J. 21, 2517-25 (Abstract)

  • Knetsch, M.L.W., Tsiavaliaris, G., Zimmermann, S., Rühl, S., &. Manstein, D.J. (2002)
    Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum
    J. Mus. Res. Cell Motil. 23, 605-611 (Abstract)

  • Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002)
    The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes
    EMBO J. 21, 240-250. (Abstract) (pdf, 500 kB)

  • Herm-Gotz, A., Weiss, S., Fujita-Becker, S., Ruff, C., Meyhöfer, E., Soldati, T., Manstein, D.J., Geeves, M.A., & Soldati, D. (2002)
    Toxoplasma gondii class XIV myosin is a fast, single-headed, plus-end directed motor
    EMBO J. 21, 2149-2158. (Abstract) (pdf, 400 kB

  • Ruff, C., Furch, M., Brenner, B., Manstein, D.J. & Meyhöfer, E. (2001)
    Single-molecule tracking of myosins with genetically engineered amplifier domains
    Nature Struct. Biol., 8, 226-229. (Abstract) (pdf, 590 kB)

  • Niemann, H.H., Knetsch, M.L.W. Scherer, A., Manstein, D.J., & Kull, F.J. (2001)
    Crystal structure of a dynamin GTPase domain
    EMBO J., 21, 5813-5821. (Abstract) (pdf, 400 kB)

  • Kulke, M., Fujita-Becker, S., Rostkova, E., Neagoe, C., Labeit, D., Manstein, D.J., Gautel, M., & Linke, W.A. (2001)
    Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
    Circ. Res., 89, 874-881. (Abstract)

  • Knetsch, M.L.W., Schäfers, N., Horstmann, H. & Manstein, D. J. (2001)
    A Bcr/Abr-related protein controls the organization of a tubolocisternal organelle, F-Actin dynamics, and cytokinesis in Dictyostelium
    EMBO J., 20, 1620-1629. (Abstract) (pdf, 350 kB)

  • Kliche, W., Fujita-Becker, S., Kollmar, M., Manstein, D.J. & Kull, F.J. (2001)
    Structure of a genetically engineered molecular motor
    EMBO J., 20, 40-46. (Abstract) (pdf)

  • Ponomarev, M.A., Furch, M., Levitsky, D.I. & Manstein, D.J. (2000)
    Charge changes in loop 2 affect the thermal unfolding of the myosin motor domain bound to F-actin
    Biochemistry, 39, 4527-4532. (Abstract) (pdf)

  • Furch, M., Remmel, B., Geeves, M.A. & Manstein, D.J. (2000)
    Stabilization of the actomyosin complex by negative charges on myosin
    Biochemistry 39, 11602-11608. (Abstract) (pdf)

  • Wienke, D.C., Knetsch, M.L.W., Neuhaus, E.M., Reedy, M.C. & Manstein, D.J. (1999)
    Disruption of a dynamin homologue affects en­docytosis, organelle morphology and cytokinesis in Dictyostelium discoideum
    Mol. Biol. Cell 10, 225-243. (Abstract) (pdf, 966 kB)

  • Van Dijk, J., Furch, M., Lafont, C., Manstein, D.J., & Chaussepied, P. (1999)
    Functional characterization of the secondary actin binding site of myosin II
    Biochemistry, 38, 15078-15085. (Abstract) (pdf, 160 kB)

  • Van Dijk, J., Furch, M., Derancourt, J., Batra, R., Knetsch, M.L.W., Manstein, D.J., & Chaussepied, P.(1999)
    Differences in the interaction of actin with the motor domains of non-muscle and muscle myosin II
    Europ. J. Biochem. 260, 672-683. (Abstract) (pdf, 844 kB)

  • Knetsch, M.L.W., Uyeda, T.Q.P., & Manstein, D.J. (1999)
    Disturbed communication between actin- and nucleotide binding sites in a myosin II with truncated 50K/20K junction
    J. Biol. Chem. 274, 20133-20138. (Abstract) (pdf, 122 kB)

  • Furch, M., Fujita-Becker, S., Geeves, M.A., Holmes, K.C. & Manstein, D.J. (1999)
    Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin
    J. Mol. Biol. 290, 797-809. (Abstract) (pdf, 330 kB)

  • Batra, R. & Manstein, D.J. (1999)
    Functional characterisation of Dictyostelium myosin II with conserved tryptophanyl residue 501 mutated to tyrosine
    Biol. Chem. 380, 1017-1023. (Abstract) (pdf)

  • Batra, R., Geeves, M.A., &. Manstein, D.J. (1999)
    Kinetic analysis of myosin motor domains with glycine-to-alanine mutations in the reactive thiol region 
    Biochemistry 38, 6126-6134 (Abstract) (pdf)

  • Levitsky, D.I., Ponomarev, M.A., Geeves, M.A., Shnyrov, V.L. & Manstein, D.J. (1998)
    Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II
    Europ. J. Biochem. 251, 275-280. (Abstract) (pdf, 11 MB)

  • Furch, M., Geeves, M.A. & Manstein, D.J. (1998)
    Modulation of actin affinity and actomyosin ATPase by charge changes in the myosin motor domain
    Biochemistry 37, 6317-6326. (Abstract)

  • Friedman, A. L., Geeves, M. A., Manstein, D.J. & Spudich, J.A. (1998)
    Kinetic Characterization of myosin head fragments with long-lived myosin.ATP states
    Biochemistry 37, 9679-9687. (Abstract) (pdf)

  • Kurzawa, S.E., Manstein, D.J. & Geeves, M.A. (1997)
    Dictyostelium discoideum myosin II: characterization of functional motor fragments
    Biochemistry 36, 317-323. (Abstract) (pdf, 163 kB)

  • Anson, M. Geeves, M.A., Kurzawa, S. & Manstein, D.J. (1996)
    Myosins with artificial lever arms
    EMBO J. 15, 6069-6074. (Abstract) (pdf, 15 MB)

  • Woodward, S.K.A., Geeves, M.A. & Manstein, D.J. (1995)
    Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin
    Biochemistry 34, 16056-16064. (Abstract) (pdf, 15 MB)

  • Manstein, D.J. & Hunt, D.M. (1995)
    Overexpression of myosin motor domains in Dictyostelium discoideum: Screening of transformants and pu­rification of the affinity tagged protein
    J. Mus. Res. Cell Motil. 16, 325-332. (Abstract) (pdf, 13 MB)

  • Manstein, D.J., Schuster, H.-P., Morandini, P. & Hunt, D.M. (1995)
    Cloning vectors for the production of proteins in Dictyostelium discoideum
    Gene 162, 129-134. (Abstract) (pdf, 436 kB)

  • Schröder, R.R., Manstein, D.J., Jahn, W., Holden, H.M., Rayment, I., Holmes, K.C. & Spudich, J.A. (1993)
    Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1
    Nature 364, 171-174. rdcu.be/mD1p, (Abstract) (pdf, 4.9 MB)

  • Ritchie, M.D., Geeves, M.A., Woodward, S.K.A. & Manstein, D.J. (1993)
    Kinetic characterization of a cytoplasmic motor domain expressed in Dictyostelium discoideum
    Proc. Natl. Acad. Sci. USA 90, 8619-8623. (Abstract) (pdf)

  • Manstein, D.J., Ruppel, K.M., Kubalek, L. & Spudich, J.A. (1991)
    Manipulation and expression of molecular motors in Dictyostelium discoideum
    J. Cell Science, 14s, 63-65. (Abstract) (pdf)

  • Egelhoff, T.T., Manstein, D.J. & Spudich, J.A. (1990)
    Complementation of myosin null mutants in Dictyostelium discoideum by direct functional selection
    Develop. Biol. 137, 359-367. (Abstract)

  • Manstein, D.J., Titus, M.A., De Lozanne, A. & Spudich, J.A. (1989)
    Gene replacement in Dictyostelium: generation of myosin null mutants
    EMBO J. 8, 923-932. (Abstract) (pdf)

  • Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1989)
    Expression and cha­racterization of a functional myosin head fragment in Dictyostelium discoideum
    Science 246, 656-658. (Abstract) (pdf, 5.6 MB)

  • Egelhoff, T.T., Brown, S.S., Manstein, D.J. & Spudich, J.A. (1989)
    Hygromycin resistance as a selectable marker in Dictyostelium
    Mol. Cell. Biol. 9, 1965-1968. (Abstract) (pdf,15 MB)

  • Manstein, D.J., Massey, V., Ghisla, S. & Pai, E.F., (1988)
    Stereochemistry and accessibility of prosthetic groups in flavoproteins
    Biochemistry 27, 2300-2305. (Abstract) (pdf, 17 MB)

  • Manstein, D.J., Pai, E.F., Schopfer, L.M., & Massey, V. (1986)
    Absolute stereochemistry of flavins in enzyme catalyzed reactions
    Biochemistry 25, 6807-6816. (Abstract) (pdf)

  • Manstein, D.J. & Pai, E.F. (1986)
    Purification and characterization of FAD synthetase from Brevibacterium ammoniagenes
    J. Biol. Chem. 261, 16169-16973. (Abstract) (pdf, 9 MB)

  • Manstein, D.J., Berriman, J., Leonard, K. & Rosenbusch, J.P. (1986)
    Ultrastructure of native lipoprotein from Escherichia coli envelopes
    J. Mol. Biol. 189, 701-707. (Abstract) (pdf, 14 MB)

Review Articles and Book Chapters

  • Preller, M. and Manstein, D. J. (2017)
    Myosin Motors: Structural Aspects and Functionality.

    In Reference Module in Life Sciences, (Egelman, E.-i.-C. E. H., ed.) Elsevier, Amsterdam dx.doi.org/10.1016/B978-0-12-809633-8.08058-4

  • Manstein, D. J. and Mulvihill D. P. (2016)
    Tropomyosin-mediated Regulation of Cytoplasmic Myosins.
    Traffic,  (2016). doi: 10.1111/tra.12399

  • Preller, M. and Manstein, D.J. (2012) 
    4.8 Myosin Motors: Structural Aspects and Functionality.
    In Comprehensive Biophysics. (Editor-in-Chief: Edward, H.E., ed.), pp. 118-150. Elsevier, Amsterdam.

  • Heissler, S.M. and Manstein, D.J. (2012). 
    Nonmuscle myosin-2: mix and match.
    in Cell Mol Life Sci 70: 1-21. rdcu.be/mD3v

  • Martin, R. et al. (2010)
    Biomolecular Chemistry Directed Towards Drug Development.
    in Med Chem Res 19, S23-S26.

  • Oiwa, K. and Manstein, D.J. (2007)
    How linear motor proteins work
    in Lecture Notes in Physics, 711, Controlled Nanoscale Motion – Nobel Symposium 131, H. Linke, A. Mansson (eds.) Springer, Berlin, Heidelberg, New York, pp. 41-59. (pdf, 880 kB)

  • Geeves, M.A., Fedorov, R. and Manstein, D.J. (2005)
    Molecular mechanism of actomyosin-based motility.
    in Cell Mol Life Sci 62, 1462-77. (pdf) http://rdcu.be/mD36

  • Manstein, D.J. (2004)
    Molecular engineering of myosin.
    in Philos Trans R Soc Lond B Biol Sci 359, 1907-12. (Abstract)

  • Toomre, D. & Manstein, D.J. (2001)
    Lighting up the cell surface with evanescent wave microscopy
    Trends Cell Biol., 11, 298-303. (Abstract) (pdf, 2.5 MB)

  • Manstein, D.J. (1993)
    Myosin function in the motile behaviour of cells
    in Cell Behaviour: Adhesion & Motility, Jones, G., Wigley, C., Warn, R. (eds.), The company of Biologists Limited, Cambridge UK, pp. 375-381. (pdf, 11 MB)

  • Forke, R., Gruner, K.K., Knott, K.E., Auschill, S., Agarwal, S., Martin, R.,Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.-J. (2010)
    Total Synthesis of Biologically Active Alkaloids Using Transition Metals
    Pure Appl. Chem. 82:1975-1991. (pdf 2MB)

  • Schröder, R.R., Manstein, D., Jahn, W., & Spudich, J.A. (1993)
    Energy filtering and correction for the contrast transfer function (CTF) of frozen hydrated objects as illustrated by a reconstruction of Dictyostelium S1 decorated Actin
    in Proc. 51st Annual Meeting of the Microscopy Society of America; Bailey, G.W. and Rieder C.L. (eds.), MSA, San Francisco Press, San Francisco, CA, pp. 118-119.

  • Egelhoff, T.T., Titus, M.A., Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1991)
    Molecular genetic tools for the study of the cytoskeleton in Dictyostelium
    Meth. Enzymol. 196, 319-334. (Abstract) (pdf, 14 MB)

  • Manstein, D.J., Massey, V. & Pai E.F. (1987)
    Absolute stereochemistry of flavins
    in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 3-12. (Abstract)

  • Manstein, D.J. & Pai, E.F. (1987)
    Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniagenes
    in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 455-458. (Abstract)

Patents

  • Manstein, D., Preller, M., Furch, M., Kalesse, M. and Diaz-Gomez, N. (2016) Biphenyl compounds for use in treating malaria and other parasitic disorders. US9499471 B2, published on 22. Nov. 2016

  • Manstein, D.J., Preller, M., Kalesse, M.
    Novel means and methods for treating malaria and other parasitic disorders.
    EP 2727911 B1, published 21. Dec. 2016

  • Manstein, D., Fedorov, R., Tsiavaliaris, G., KNÖLKER, H. J., Martin, R., Kirst, J., Gutzeit, H. and BÖHL, M. (2016) Means for treating myosin-related diseases. EP2277124 B1, published on 9. Nov. 2016

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